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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Foxo3

Z-value: 1.01

Motif logo

Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
ENSMUSG00000048756.12 Foxo3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3mm39_v1_chr10_-_42152684_421527590.001.0e+00Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_-_49549489 12.03 ENSMUST00000029987.10
aldolase B, fructose-bisphosphate
chr3_+_63203516 6.17 ENSMUST00000029400.7
membrane metallo endopeptidase
chr14_-_52150804 6.06 ENSMUST00000004673.15
ENSMUST00000111632.5
N-myc downstream regulated gene 2
chr14_-_52011035 5.94 ENSMUST00000073860.6
angiogenin, ribonuclease A family, member 4
chr14_-_52151026 5.56 ENSMUST00000228164.2
N-myc downstream regulated gene 2
chr17_+_43700327 5.51 ENSMUST00000113599.2
ENSMUST00000224278.2
ENSMUST00000225466.2
adhesion G protein-coupled receptor F5
chr3_+_63203235 5.12 ENSMUST00000194134.6
membrane metallo endopeptidase
chr2_+_124452493 4.81 ENSMUST00000103239.10
ENSMUST00000103240.9
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr1_+_171052623 4.71 ENSMUST00000111321.8
ENSMUST00000005824.12
ENSMUST00000111320.8
ENSMUST00000111319.2
apolipoprotein A-II
chr3_+_85946145 4.57 ENSMUST00000238331.2
SH3 domain protein D19
chr4_+_135455427 4.09 ENSMUST00000102546.4
interleukin 22 receptor, alpha 1
chr10_+_103203552 4.09 ENSMUST00000179636.3
ENSMUST00000217905.2
ENSMUST00000074204.12
solute carrier family 6 (neurotransmitter transporter), member 15
chr14_+_51333816 3.79 ENSMUST00000169895.3
ribonuclease, RNase A family 4
chr15_-_78352801 3.62 ENSMUST00000229124.2
ENSMUST00000230226.2
ENSMUST00000017086.5
transmembrane serine protease 6
chr2_+_4722956 3.51 ENSMUST00000056914.7
BEN domain containing 7
chr1_-_140111138 3.29 ENSMUST00000111976.9
ENSMUST00000066859.13
complement component factor h
chr1_-_180023518 3.17 ENSMUST00000162769.8
ENSMUST00000161379.2
ENSMUST00000027766.13
ENSMUST00000161814.8
coenzyme Q8A
chr1_-_140111018 3.14 ENSMUST00000192880.6
ENSMUST00000111977.8
complement component factor h
chr14_-_121935829 3.09 ENSMUST00000040700.9
ENSMUST00000212181.2
dedicator of cytokinesis 9
chr9_-_48747232 3.05 ENSMUST00000093852.5
zinc finger and BTB domain containing 16
chr11_+_101258368 2.95 ENSMUST00000019469.3
glucose-6-phosphatase, catalytic
chr11_-_60243695 2.90 ENSMUST00000095254.12
ENSMUST00000102683.11
ENSMUST00000093048.13
ENSMUST00000093046.13
ENSMUST00000064019.15
ENSMUST00000102682.5
target of myb1-like 2 (chicken)
chr2_+_124452194 2.86 ENSMUST00000051419.15
ENSMUST00000076335.12
ENSMUST00000078621.12
ENSMUST00000077847.12
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr4_-_155430153 2.74 ENSMUST00000103178.11
protein kinase C, zeta
chr16_-_34083315 2.73 ENSMUST00000114953.8
kalirin, RhoGEF kinase
chr4_+_105014536 2.72 ENSMUST00000064139.8
phospholipid phosphatase 3
chr11_-_99313078 2.70 ENSMUST00000017741.4
keratin 12
chr8_-_45835234 2.65 ENSMUST00000093526.13
family with sequence similarity 149, member A
chr1_-_180023467 2.51 ENSMUST00000161746.2
ENSMUST00000160879.7
coenzyme Q8A
chr5_-_151113619 2.34 ENSMUST00000062015.15
ENSMUST00000110483.9
StAR-related lipid transfer (START) domain containing 13
chr6_-_69835868 2.31 ENSMUST00000103369.2
immunoglobulin kappa chain variable 12-41
chr19_-_7780025 2.28 ENSMUST00000065634.8
solute carrier family 22 (organic cation transporter), member 26
chr8_-_41469786 2.26 ENSMUST00000117735.8
mitochondrial tumor suppressor 1
chr10_-_5019044 2.23 ENSMUST00000095899.5
spectrin repeat containing, nuclear envelope 1
chr1_+_172525613 2.22 ENSMUST00000038495.5
C-reactive protein, pentraxin-related
chr11_-_103844870 2.16 ENSMUST00000103075.11
N-ethylmaleimide sensitive fusion protein
chr8_+_59365291 2.12 ENSMUST00000160055.2
cDNA sequence BC030500
chr4_+_94627513 2.07 ENSMUST00000073939.13
ENSMUST00000102798.8
TEK receptor tyrosine kinase
chr11_-_65636651 2.07 ENSMUST00000138093.2
mitogen-activated protein kinase kinase 4
chr5_+_65288418 2.02 ENSMUST00000101191.10
ENSMUST00000204348.3
kelch-like 5
chr13_+_83723743 1.99 ENSMUST00000198217.5
ENSMUST00000199210.5
myocyte enhancer factor 2C
chr15_-_77129706 1.95 ENSMUST00000228361.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_-_91264670 1.94 ENSMUST00000107109.9
ENSMUST00000107111.9
ENSMUST00000107120.8
ELAV like RNA binding protein 1
chr18_-_39622932 1.90 ENSMUST00000152853.2
nuclear receptor subfamily 3, group C, member 1
chr1_+_66426127 1.87 ENSMUST00000145419.8
microtubule-associated protein 2
chr9_+_65268304 1.86 ENSMUST00000147185.3
ubiquitin-associated protein 1-like
chr9_-_56151334 1.85 ENSMUST00000188142.7
pseudopodium-enriched atypical kinase 1
chr8_+_105996419 1.83 ENSMUST00000036127.9
ENSMUST00000163734.9
heat shock transcription factor 4
chr2_+_155360015 1.81 ENSMUST00000103142.12
acyl-CoA synthetase short-chain family member 2
chr4_-_91264727 1.76 ENSMUST00000107124.10
ELAV like RNA binding protein 1
chr14_-_57371041 1.73 ENSMUST00000039380.9
gap junction protein, beta 6
chr8_-_41469332 1.73 ENSMUST00000131965.2
mitochondrial tumor suppressor 1
chr1_+_66360865 1.71 ENSMUST00000114013.8
microtubule-associated protein 2
chr10_+_112107026 1.66 ENSMUST00000219301.2
ENSMUST00000092175.4
potassium voltage gated channel, Shaw-related subfamily, member 2
chr2_+_143388062 1.54 ENSMUST00000028905.10
proprotein convertase subtilisin/kexin type 2
chr8_-_64659004 1.54 ENSMUST00000066166.6
tolloid-like
chr2_-_104324035 1.53 ENSMUST00000111124.8
homeodomain interacting protein kinase 3
chr17_+_17669082 1.47 ENSMUST00000140134.2
limb and CNS expressed 1
chr13_+_60749995 1.44 ENSMUST00000044083.9
death associated protein kinase 1
chr11_+_19874403 1.41 ENSMUST00000093298.12
sprouty-related EVH1 domain containing 2
chr18_-_39622829 1.39 ENSMUST00000025300.13
nuclear receptor subfamily 3, group C, member 1
chr11_-_100244866 1.39 ENSMUST00000173630.8
huntingtin-associated protein 1
chr1_+_75119472 1.37 ENSMUST00000189650.7
reticulophagy regulator family member 2
chr13_+_83720457 1.34 ENSMUST00000196730.5
myocyte enhancer factor 2C
chr8_-_26275182 1.32 ENSMUST00000038498.10
BCL2-associated athanogene 4
chr7_+_29991101 1.32 ENSMUST00000150892.2
ENSMUST00000126216.2
ENSMUST00000014065.16
CAP-GLY domain containing linker protein 3
chr3_-_145355725 1.32 ENSMUST00000029846.5
cellular communication network factor 1
chr6_-_69741999 1.29 ENSMUST00000103365.3
immunoglobulin kappa variable 12-46
chr2_+_131052421 1.29 ENSMUST00000110206.2
adaptor-related protein 5 complex, sigma 1 subunit
chr13_+_83720484 1.25 ENSMUST00000196207.5
myocyte enhancer factor 2C
chr4_-_116263183 1.23 ENSMUST00000123072.8
ENSMUST00000144281.2
microtubule associated serine/threonine kinase 2
chr7_+_29991366 1.23 ENSMUST00000144508.2
CAP-GLY domain containing linker protein 3
chrX_-_47297746 1.23 ENSMUST00000088935.4
zinc finger, DHHC domain containing 9
chr11_+_69657275 1.21 ENSMUST00000132528.8
ENSMUST00000153943.2
zinc finger and BTB domain containing 4
chr18_-_75094323 1.20 ENSMUST00000066532.5
lipase, endothelial
chr4_+_134042423 1.20 ENSMUST00000105875.8
ENSMUST00000030638.7
tripartite motif-containing 63
chr12_-_46863726 1.19 ENSMUST00000219330.2
NOVA alternative splicing regulator 1
chr6_+_55813862 1.18 ENSMUST00000044729.7
ITPR interacting domain containing 1
chr19_+_56414114 1.17 ENSMUST00000238892.2
caspase 7
chr10_+_25308466 1.14 ENSMUST00000219224.2
ENSMUST00000219166.2
erythrocyte membrane protein band 4.1 like 2
chr7_+_113365235 1.14 ENSMUST00000046687.16
spondin 1, (f-spondin) extracellular matrix protein
chr11_-_48836975 1.08 ENSMUST00000104958.2
protease (prosome, macropain) activator subunit 2B
chr4_+_130001349 1.07 ENSMUST00000030563.6
penta-EF hand domain containing 1
chr2_+_25293140 1.06 ENSMUST00000154809.8
ENSMUST00000055921.14
ENSMUST00000141567.8
neural proliferation, differentiation and control 1
chr19_-_42074777 1.06 ENSMUST00000051772.10
MORN repeat containing 4
chr2_+_164328763 1.06 ENSMUST00000109349.9
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_-_65020955 1.05 ENSMUST00000102592.10
tight junction protein 1
chr2_+_155359868 1.04 ENSMUST00000029135.15
ENSMUST00000065973.9
acyl-CoA synthetase short-chain family member 2
chr1_-_127782735 1.02 ENSMUST00000208183.3
mitogen-activated protein kinase kinase kinase 19
chr11_+_60244132 1.01 ENSMUST00000070805.13
ENSMUST00000094140.9
ENSMUST00000108723.9
ENSMUST00000108722.5
dynein regulatory complex subunit 3
chr7_+_141056305 1.00 ENSMUST00000117634.2
tetraspanin 4
chr4_-_119272667 0.98 ENSMUST00000238609.2
coiled-coil domain containing 30
chr1_+_20801127 0.97 ENSMUST00000027061.5
interleukin 17A
chr11_+_7147779 0.97 ENSMUST00000020704.8
insulin-like growth factor binding protein 1
chr17_+_25059079 0.96 ENSMUST00000164251.8
hydroxyacyl glutathione hydrolase
chr18_+_37100672 0.95 ENSMUST00000193777.6
ENSMUST00000193389.2
protocadherin alpha 6
chr13_-_6686686 0.95 ENSMUST00000136585.2
phosphofructokinase, platelet
chr6_+_34840057 0.93 ENSMUST00000074949.4
transmembrane protein 140
chr7_+_113365356 0.93 ENSMUST00000084696.6
spondin 1, (f-spondin) extracellular matrix protein
chr16_-_56533179 0.92 ENSMUST00000136394.8
Trk-fused gene
chr10_-_49659355 0.92 ENSMUST00000105484.10
ENSMUST00000218598.2
ENSMUST00000079751.9
ENSMUST00000218441.2
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr2_-_51039112 0.92 ENSMUST00000154545.2
ENSMUST00000017288.9
Rho family GTPase 3
chr1_-_126665904 0.86 ENSMUST00000160693.2
NCK-associated protein 5
chr12_+_38831093 0.80 ENSMUST00000161513.9
ets variant 1
chr2_+_76505619 0.80 ENSMUST00000111920.2
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chr1_+_75119419 0.79 ENSMUST00000097694.11
ENSMUST00000190240.7
reticulophagy regulator family member 2
chr13_+_83723255 0.79 ENSMUST00000199167.5
ENSMUST00000195904.5
myocyte enhancer factor 2C
chr2_-_51862941 0.78 ENSMUST00000145481.8
ENSMUST00000112705.9
N-myc (and STAT) interactor
chr18_-_66155651 0.77 ENSMUST00000143990.2
lectin, mannose-binding, 1
chr11_+_82802079 0.74 ENSMUST00000018989.14
ENSMUST00000164945.3
unc-45 myosin chaperone B
chr8_-_13939964 0.73 ENSMUST00000209371.2
coordinator of PRMT5, differentiation stimulator
chr3_-_146475974 0.72 ENSMUST00000106137.8
protein kinase, cAMP dependent, catalytic, beta
chr6_-_83808717 0.71 ENSMUST00000058383.9
poly(A) binding protein interacting protein 2B
chr6_-_69792108 0.67 ENSMUST00000103367.3
immunoglobulin kappa variable 12-44
chr2_+_138120401 0.66 ENSMUST00000075410.5
BTB (POZ) domain containing 3
chr13_+_108180957 0.65 ENSMUST00000095458.6
ENSMUST00000223808.2
ENSMUST00000226042.2
ENSMUST00000225972.2
small integral membrane protein 15
chr14_+_30601157 0.64 ENSMUST00000040715.8
musculoskeletal, embryonic nuclear protein 1
chr19_+_5927821 0.64 ENSMUST00000145200.8
ENSMUST00000025732.14
ENSMUST00000125114.8
ENSMUST00000155697.8
solute carrier family 25, member 45
chr2_+_91541197 0.63 ENSMUST00000128140.2
ENSMUST00000140183.2
harbinger transposase derived 1
chr6_-_69920632 0.63 ENSMUST00000198880.5
ENSMUST00000103371.3
immunoglobulin kappa chain variable 12-38
chr19_-_19088543 0.62 ENSMUST00000112832.8
RAR-related orphan receptor beta
chr7_-_65020655 0.62 ENSMUST00000032729.8
tight junction protein 1
chr2_+_91541245 0.62 ENSMUST00000142692.2
ENSMUST00000090608.6
harbinger transposase derived 1
chr3_-_152931392 0.62 ENSMUST00000199707.2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr1_-_163231196 0.61 ENSMUST00000045138.6
golgin, RAB6-interacting
chr15_+_25752963 0.61 ENSMUST00000022882.12
ENSMUST00000135173.8
myosin X
chr19_+_34268071 0.59 ENSMUST00000112472.4
ENSMUST00000235232.2
Fas (TNF receptor superfamily member 6)
chr11_+_19874354 0.57 ENSMUST00000093299.13
sprouty-related EVH1 domain containing 2
chr1_-_154692678 0.56 ENSMUST00000238369.2
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr2_+_127696548 0.53 ENSMUST00000028859.8
acyl-Coenzyme A oxidase-like
chr17_+_29309942 0.52 ENSMUST00000119901.9
cyclin-dependent kinase inhibitor 1A (P21)
chr19_+_22670134 0.50 ENSMUST00000237470.2
ENSMUST00000099564.10
ENSMUST00000099569.10
ENSMUST00000099566.5
ENSMUST00000235712.2
transient receptor potential cation channel, subfamily M, member 3
chr3_+_107137924 0.47 ENSMUST00000179399.3
RIKEN cDNA A630076J17 gene
chr6_+_34840151 0.46 ENSMUST00000202010.2
transmembrane protein 140
chr19_+_5927876 0.42 ENSMUST00000235340.2
solute carrier family 25, member 45
chr4_-_137512682 0.41 ENSMUST00000133473.2
alkaline phosphatase, liver/bone/kidney
chr9_+_98372575 0.40 ENSMUST00000035029.3
retinol binding protein 2, cellular
chr12_-_85317359 0.40 ENSMUST00000166821.8
ENSMUST00000019378.8
ENSMUST00000220854.2
mutL homolog 3
chr9_+_114560235 0.36 ENSMUST00000035007.10
CKLF-like MARVEL transmembrane domain containing 6
chr7_-_70010341 0.36 ENSMUST00000032768.15
nuclear receptor subfamily 2, group F, member 2
chr18_-_39622295 0.35 ENSMUST00000131885.2
nuclear receptor subfamily 3, group C, member 1
chr5_-_137529465 0.33 ENSMUST00000150063.9
guanine nucleotide binding protein (G protein), beta 2
chr2_+_164328375 0.33 ENSMUST00000069385.15
ENSMUST00000143690.8
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr5_-_137529251 0.32 ENSMUST00000132525.8
guanine nucleotide binding protein (G protein), beta 2
chr11_-_68277799 0.32 ENSMUST00000135141.2
netrin 1
chr9_+_78020554 0.29 ENSMUST00000009972.6
ENSMUST00000117330.8
ENSMUST00000044551.8
ciliogenesis associated kinase 1
chr11_-_68277631 0.29 ENSMUST00000021284.4
netrin 1
chr2_+_3514071 0.27 ENSMUST00000036350.3
cerebral dopamine neurotrophic factor
chr1_-_20854490 0.24 ENSMUST00000039046.10
interleukin 17F
chr3_+_5283577 0.24 ENSMUST00000175866.8
zinc finger homeodomain 4
chr12_+_30934320 0.23 ENSMUST00000067087.7
ALK and LTK ligand 2
chr10_-_128948380 0.23 ENSMUST00000050915.5
olfactory receptor 769
chr10_+_102348076 0.22 ENSMUST00000219445.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr2_-_51863203 0.22 ENSMUST00000028314.9
N-myc (and STAT) interactor
chr3_+_5283606 0.21 ENSMUST00000026284.13
zinc finger homeodomain 4
chr18_+_24338358 0.20 ENSMUST00000000430.14
polypeptide N-acetylgalactosaminyltransferase 1
chr4_-_134642286 0.17 ENSMUST00000105863.2
ENSMUST00000030626.12
transmembrane protein 50A
chr11_-_101676076 0.13 ENSMUST00000164750.8
ENSMUST00000107176.8
ENSMUST00000017868.7
ets variant 4
chr13_-_95615229 0.10 ENSMUST00000022186.5
S100 calcium binding protein, zeta
chr19_-_34856853 0.06 ENSMUST00000036584.13
pantothenate kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 12.0 GO:0006116 NADH oxidation(GO:0006116)
1.9 11.6 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.6 11.3 GO:0071492 cellular response to UV-A(GO:0071492)
1.2 4.7 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.9 2.8 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.7 6.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.6 1.7 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.5 2.7 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330)
0.5 3.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.5 1.5 GO:0030070 insulin processing(GO:0030070)
0.5 4.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.5 1.0 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.5 2.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.4 5.4 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.4 1.3 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.4 2.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.4 5.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.4 1.2 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.4 1.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.4 2.7 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.4 1.1 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.3 2.7 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 3.1 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 2.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 2.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.3 2.6 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.3 1.4 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.3 2.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 5.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.2 1.2 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.2 2.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 0.6 GO:0031104 dendrite regeneration(GO:0031104)
0.2 1.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.2 7.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 4.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 3.6 GO:0097264 self proteolysis(GO:0097264)
0.2 2.7 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.2 5.8 GO:0019731 antibacterial humoral response(GO:0019731)
0.2 2.3 GO:0015747 urate transport(GO:0015747)
0.2 2.0 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.6 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.1 1.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.7 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 1.0 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 4.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.1 2.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.9 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.3 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.1 1.2 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 1.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.9 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 0.2 GO:0070376 regulation of ERK5 cascade(GO:0070376)
0.1 1.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.6 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 3.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.1 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.6 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 0.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 4.1 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 2.2 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.2 GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0 0.6 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.4 GO:0007144 female meiosis I(GO:0007144)
0.0 1.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 2.9 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.8 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.5 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 1.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.6 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.0 3.8 GO:0009267 cellular response to starvation(GO:0009267)
0.0 3.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 1.3 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 12.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 3.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 4.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 2.7 GO:0045179 apical cortex(GO:0045179)
0.2 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 2.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 1.9 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.4 GO:0005712 chiasma(GO:0005712)
0.1 0.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 14.2 GO:0044306 neuron projection terminus(GO:0044306)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.8 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 4.6 GO:0016605 PML body(GO:0016605)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 2.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 2.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 3.6 GO:0043197 dendritic spine(GO:0043197)
0.0 2.8 GO:0030175 filopodium(GO:0030175)
0.0 1.1 GO:0099738 cell cortex region(GO:0099738)
0.0 5.4 GO:0072562 blood microparticle(GO:0072562)
0.0 6.6 GO:0043292 contractile fiber(GO:0043292)
0.0 2.1 GO:0043204 perikaryon(GO:0043204)
0.0 2.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 5.3 GO:0045177 apical part of cell(GO:0045177)
0.0 2.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 16.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 4.1 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0042015 interleukin-20 binding(GO:0042015)
1.2 12.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.2 4.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.9 6.4 GO:0001851 complement component C3b binding(GO:0001851)
0.7 2.9 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.7 2.7 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.6 3.6 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.6 2.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.5 2.6 GO:0097001 ceramide binding(GO:0097001)
0.4 4.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 1.2 GO:0010428 methyl-CpNpG binding(GO:0010428)
0.4 3.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 2.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.4 7.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 2.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.3 2.2 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 5.4 GO:0003680 AT DNA binding(GO:0003680)
0.2 0.9 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 3.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 0.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 0.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.6 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 2.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.7 GO:0071253 connexin binding(GO:0071253)
0.1 0.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 1.0 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 2.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 2.7 GO:0004697 protein kinase C activity(GO:0004697)
0.1 4.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 5.7 GO:0043531 ADP binding(GO:0043531)
0.1 11.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.1 GO:0042731 PH domain binding(GO:0042731)
0.1 1.2 GO:0031432 titin binding(GO:0031432)
0.1 2.2 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.1 2.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 8.0 GO:0004540 ribonuclease activity(GO:0004540)
0.1 0.4 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 1.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0005537 mannose binding(GO:0005537)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 2.9 GO:0030276 clathrin binding(GO:0030276)
0.0 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 5.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 1.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 3.3 GO:0003823 antigen binding(GO:0003823)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.3 GO:0051087 chaperone binding(GO:0051087)
0.0 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.1 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 19.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 11.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.7 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 4.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 3.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 2.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 3.7 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 8.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.0 PID P73PATHWAY p73 transcription factor network
0.0 0.2 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 2.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 7.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.3 13.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.3 2.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 4.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 4.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 5.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 2.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 3.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 2.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 2.9 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 2.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 2.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 2.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 4.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME MEIOSIS Genes involved in Meiosis