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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for GUAGUGU

Z-value: 0.81

Motif logo

logo of

miRNA associated with seed GUAGUGU

NamemiRBASE accession
mmu-miR-142a-3p.1
MIMAT0000155

Activity profile of GUAGUGU motif

Sorted Z-values of GUAGUGU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GUAGUGU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_32074754 8.10 ENSMUST00000024839.6
Sik1
salt inducible kinase 1
chr11_+_115714853 6.58 ENSMUST00000103032.11
ENSMUST00000133250.8
ENSMUST00000177736.8
Llgl2
LLGL2 scribble cell polarity complex component
chr5_+_65127412 6.24 ENSMUST00000031080.15
Fam114a1
family with sequence similarity 114, member A1
chr12_-_55033113 5.24 ENSMUST00000038926.13
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr2_-_169973076 5.14 ENSMUST00000063710.13
Zfp217
zinc finger protein 217
chr19_+_41471067 4.82 ENSMUST00000067795.13
Lcor
ligand dependent nuclear receptor corepressor
chr15_-_73056713 4.40 ENSMUST00000044113.12
Ago2
argonaute RISC catalytic subunit 2
chr16_+_42727926 4.16 ENSMUST00000151244.8
ENSMUST00000114694.9
Zbtb20
zinc finger and BTB domain containing 20
chr13_+_81031512 4.13 ENSMUST00000099356.10
Arrdc3
arrestin domain containing 3
chr15_-_96953823 3.97 ENSMUST00000023101.10
Slc38a4
solute carrier family 38, member 4
chr2_-_103133524 3.85 ENSMUST00000090475.10
Ehf
ets homologous factor
chr12_+_33003882 3.83 ENSMUST00000076698.13
Sypl
synaptophysin-like protein
chr16_+_87495792 3.77 ENSMUST00000026703.6
Bach1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr5_+_103902020 3.58 ENSMUST00000054979.10
Aff1
AF4/FMR2 family, member 1
chr7_+_18828519 3.56 ENSMUST00000049454.6
Six5
sine oculis-related homeobox 5
chr11_-_88609048 3.52 ENSMUST00000107909.8
Msi2
musashi RNA-binding protein 2
chr15_-_102165884 3.49 ENSMUST00000043172.15
Rarg
retinoic acid receptor, gamma
chr5_-_148989821 3.37 ENSMUST00000139443.8
ENSMUST00000085546.13
Hmgb1
high mobility group box 1
chr13_-_113755082 3.36 ENSMUST00000109241.5
Snx18
sorting nexin 18
chrX_-_7054952 3.35 ENSMUST00000004428.14
Clcn5
chloride channel, voltage-sensitive 5
chr15_+_10177709 2.81 ENSMUST00000124470.8
Prlr
prolactin receptor
chr15_-_77726333 2.60 ENSMUST00000016771.13
Myh9
myosin, heavy polypeptide 9, non-muscle
chr12_-_51876282 2.58 ENSMUST00000042052.9
ENSMUST00000179265.8
Hectd1
HECT domain E3 ubiquitin protein ligase 1
chr17_+_53873964 2.57 ENSMUST00000000724.15
Kat2b
K(lysine) acetyltransferase 2B
chr19_+_43600738 2.53 ENSMUST00000057178.11
Nkx2-3
NK2 homeobox 3
chr2_-_60793536 2.49 ENSMUST00000028347.13
Rbms1
RNA binding motif, single stranded interacting protein 1
chr10_-_37014859 2.37 ENSMUST00000092584.6
Marcks
myristoylated alanine rich protein kinase C substrate
chr10_-_7831979 2.34 ENSMUST00000146444.8
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr7_+_44667377 2.33 ENSMUST00000044111.10
Rras
related RAS viral (r-ras) oncogene
chr1_-_151304191 2.26 ENSMUST00000064771.12
Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr3_+_9315662 2.23 ENSMUST00000155203.2
Zbtb10
zinc finger and BTB domain containing 10
chr3_+_65435825 2.20 ENSMUST00000047906.10
Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
chr8_-_80784619 2.19 ENSMUST00000079038.4
Hhip
Hedgehog-interacting protein
chr5_+_143389573 1.99 ENSMUST00000110731.4
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr17_-_84495364 1.99 ENSMUST00000060366.7
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr16_+_10306075 1.98 ENSMUST00000023147.8
Ciita
class II transactivator
chr4_+_47353217 1.98 ENSMUST00000007757.15
Tgfbr1
transforming growth factor, beta receptor I
chr17_+_27276262 1.94 ENSMUST00000049308.9
Itpr3
inositol 1,4,5-triphosphate receptor 3
chr4_-_135749032 1.94 ENSMUST00000030427.6
Eloa
elongin A
chr18_-_88912446 1.92 ENSMUST00000070116.12
ENSMUST00000125362.8
Socs6
suppressor of cytokine signaling 6
chrX_-_13712746 1.87 ENSMUST00000115436.9
ENSMUST00000033321.11
ENSMUST00000115438.10
Cask
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr3_+_52175757 1.85 ENSMUST00000053764.7
Foxo1
forkhead box O1
chrX_-_55643429 1.84 ENSMUST00000059899.3
Mmgt1
membrane magnesium transporter 1
chr18_+_66591604 1.78 ENSMUST00000025399.9
ENSMUST00000237161.2
ENSMUST00000236933.2
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr18_-_39623698 1.75 ENSMUST00000115567.8
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr9_-_90152759 1.74 ENSMUST00000041767.14
ENSMUST00000128874.3
Tbc1d2b
TBC1 domain family, member 2B
chr12_-_102844537 1.64 ENSMUST00000045652.8
ENSMUST00000223554.2
Btbd7
BTB (POZ) domain containing 7
chr3_-_115800989 1.62 ENSMUST00000067485.4
Slc30a7
solute carrier family 30 (zinc transporter), member 7
chr9_-_43017249 1.59 ENSMUST00000165665.9
Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr4_+_130390588 1.59 ENSMUST00000030315.13
Pum1
pumilio RNA-binding family member 1
chr6_+_128339882 1.57 ENSMUST00000073316.13
Foxm1
forkhead box M1
chr3_+_88857929 1.56 ENSMUST00000186583.7
Ash1l
ASH1 like histone lysine methyltransferase
chr7_+_89779564 1.55 ENSMUST00000208742.2
ENSMUST00000049537.9
Picalm
phosphatidylinositol binding clathrin assembly protein
chr4_-_151142351 1.53 ENSMUST00000030797.4
Vamp3
vesicle-associated membrane protein 3
chr15_+_6737853 1.51 ENSMUST00000061656.8
Rictor
RPTOR independent companion of MTOR, complex 2
chr19_+_16110176 1.49 ENSMUST00000025541.6
Gnaq
guanine nucleotide binding protein, alpha q polypeptide
chr8_-_94739469 1.43 ENSMUST00000053766.14
Amfr
autocrine motility factor receptor
chr3_-_41037427 1.40 ENSMUST00000058578.8
Pgrmc2
progesterone receptor membrane component 2
chrX_+_100298134 1.39 ENSMUST00000062000.6
Foxo4
forkhead box O4
chr6_-_39702381 1.37 ENSMUST00000002487.15
Braf
Braf transforming gene
chr1_+_139349912 1.34 ENSMUST00000200243.5
ENSMUST00000039867.10
Zbtb41
zinc finger and BTB domain containing 41
chr17_+_28128307 1.34 ENSMUST00000233525.2
ENSMUST00000025058.15
ENSMUST00000233866.2
Anks1
ankyrin repeat and SAM domain containing 1
chrX_-_107877909 1.32 ENSMUST00000101283.4
ENSMUST00000150434.8
Brwd3
bromodomain and WD repeat domain containing 3
chr10_+_69932930 1.30 ENSMUST00000147545.8
Ccdc6
coiled-coil domain containing 6
chr2_-_12306722 1.28 ENSMUST00000028106.11
Itga8
integrin alpha 8
chr10_-_120312374 1.26 ENSMUST00000072777.14
ENSMUST00000159699.2
Hmga2
high mobility group AT-hook 2
chr9_-_101128976 1.23 ENSMUST00000075941.12
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr5_+_123532819 1.22 ENSMUST00000111596.8
ENSMUST00000068237.12
Mlxip
MLX interacting protein
chr2_-_45003270 1.19 ENSMUST00000202935.4
ENSMUST00000068415.11
ENSMUST00000127520.8
Zeb2
zinc finger E-box binding homeobox 2
chr1_+_151631088 1.15 ENSMUST00000188145.7
ENSMUST00000059498.12
Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr1_-_37580084 1.15 ENSMUST00000151952.8
Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr5_-_76452365 1.13 ENSMUST00000075159.5
Clock
circadian locomotor output cycles kaput
chr10_+_21870565 1.13 ENSMUST00000020145.12
Sgk1
serum/glucocorticoid regulated kinase 1
chr12_+_111540920 1.11 ENSMUST00000075281.8
ENSMUST00000084953.13
Mark3
MAP/microtubule affinity regulating kinase 3
chr1_-_96799832 1.11 ENSMUST00000071985.6
Slco4c1
solute carrier organic anion transporter family, member 4C1
chr10_+_7556948 1.08 ENSMUST00000165952.9
Lats1
large tumor suppressor
chr6_-_52185674 1.07 ENSMUST00000062829.9
Hoxa6
homeobox A6
chr10_-_127124718 1.06 ENSMUST00000156208.2
ENSMUST00000026476.13
Mbd6
methyl-CpG binding domain protein 6
chr5_-_143513732 1.04 ENSMUST00000100489.4
ENSMUST00000080537.14
Rac1
Rac family small GTPase 1
chr15_-_94487751 1.01 ENSMUST00000023087.13
ENSMUST00000152590.2
Twf1
twinfilin actin binding protein 1
chr2_+_6327431 1.00 ENSMUST00000114937.8
Usp6nl
USP6 N-terminal like
chr8_-_81607109 0.99 ENSMUST00000034150.10
Gab1
growth factor receptor bound protein 2-associated protein 1
chr17_+_36132567 0.96 ENSMUST00000003635.7
Ier3
immediate early response 3
chr13_+_38010203 0.89 ENSMUST00000128570.9
Rreb1
ras responsive element binding protein 1
chr11_+_23206001 0.85 ENSMUST00000020538.13
ENSMUST00000109551.8
ENSMUST00000102870.8
ENSMUST00000102869.8
Xpo1
exportin 1
chr12_-_51738666 0.83 ENSMUST00000013130.15
ENSMUST00000169503.4
Strn3
striatin, calmodulin binding protein 3
chr2_+_155223728 0.80 ENSMUST00000043237.14
ENSMUST00000174685.8
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr12_-_54909568 0.77 ENSMUST00000078124.8
Cfl2
cofilin 2, muscle
chr11_-_23447866 0.73 ENSMUST00000128559.2
ENSMUST00000147157.8
ENSMUST00000109539.8
Ahsa2
AHA1, activator of heat shock protein ATPase 2
chr14_-_21102487 0.72 ENSMUST00000154460.8
ENSMUST00000130291.8
Ap3m1
adaptor-related protein complex 3, mu 1 subunit
chr3_-_122413361 0.72 ENSMUST00000239148.2
ENSMUST00000162409.8
ENSMUST00000162947.3
Fnbp1l
formin binding protein 1-like
chr4_+_150366028 0.68 ENSMUST00000105682.9
Rere
arginine glutamic acid dipeptide (RE) repeats
chr4_-_82423985 0.68 ENSMUST00000107245.9
ENSMUST00000107246.2
Nfib
nuclear factor I/B
chr14_-_72947422 0.67 ENSMUST00000089017.12
Fndc3a
fibronectin type III domain containing 3A
chr7_+_138968988 0.66 ENSMUST00000106098.8
ENSMUST00000026550.14
Inpp5a
inositol polyphosphate-5-phosphatase A
chr9_-_44792575 0.65 ENSMUST00000114689.8
ENSMUST00000002095.11
ENSMUST00000128768.3
Kmt2a
lysine (K)-specific methyltransferase 2A
chr15_-_9529898 0.61 ENSMUST00000228782.2
ENSMUST00000003981.6
Il7r
interleukin 7 receptor
chr2_-_166838018 0.60 ENSMUST00000049412.12
Stau1
staufen double-stranded RNA binding protein 1
chr3_-_144426076 0.58 ENSMUST00000198254.5
ENSMUST00000163279.6
Sh3glb1
SH3-domain GRB2-like B1 (endophilin)
chrX_+_18028814 0.56 ENSMUST00000044484.13
ENSMUST00000052368.9
Kdm6a
lysine (K)-specific demethylase 6A
chr17_+_83658354 0.55 ENSMUST00000096766.12
ENSMUST00000049503.10
ENSMUST00000112363.10
ENSMUST00000234460.2
Eml4
echinoderm microtubule associated protein like 4
chr12_-_91556761 0.51 ENSMUST00000021345.14
Gtf2a1
general transcription factor II A, 1
chr6_-_83418656 0.51 ENSMUST00000089622.11
Tet3
tet methylcytosine dioxygenase 3
chr13_+_51562675 0.51 ENSMUST00000087978.5
S1pr3
sphingosine-1-phosphate receptor 3
chr12_+_16944896 0.50 ENSMUST00000020904.8
Rock2
Rho-associated coiled-coil containing protein kinase 2
chrX_-_47297436 0.49 ENSMUST00000037960.11
Zdhhc9
zinc finger, DHHC domain containing 9
chr4_+_116578117 0.48 ENSMUST00000045542.13
ENSMUST00000106459.8
Tesk2
testis-specific kinase 2
chr4_+_44004437 0.45 ENSMUST00000107846.10
Clta
clathrin, light polypeptide (Lca)
chr1_+_131838294 0.45 ENSMUST00000062264.8
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr15_-_4025190 0.44 ENSMUST00000046633.10
AW549877
expressed sequence AW549877
chr7_-_117842787 0.41 ENSMUST00000032891.15
Smg1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chrX_-_73067514 0.40 ENSMUST00000033769.15
ENSMUST00000114352.8
ENSMUST00000068286.12
ENSMUST00000114360.10
ENSMUST00000114354.10
Irak1
interleukin-1 receptor-associated kinase 1
chr7_-_144107401 0.39 ENSMUST00000168134.10
Ppfia1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chrX_+_68403900 0.38 ENSMUST00000033532.7
Aff2
AF4/FMR2 family, member 2
chr10_-_89279751 0.37 ENSMUST00000219351.2
ENSMUST00000220128.2
ENSMUST00000099374.9
ENSMUST00000105298.3
Gas2l3
growth arrest-specific 2 like 3
chr7_-_66339319 0.37 ENSMUST00000124899.8
Asb7
ankyrin repeat and SOCS box-containing 7
chr10_+_111309020 0.37 ENSMUST00000065917.16
ENSMUST00000219961.2
ENSMUST00000217908.2
Nap1l1
nucleosome assembly protein 1-like 1
chr18_+_5591864 0.34 ENSMUST00000025081.13
ENSMUST00000159390.8
Zeb1
zinc finger E-box binding homeobox 1
chr15_-_82108531 0.33 ENSMUST00000109535.3
ENSMUST00000089161.10
Tnfrsf13c
tumor necrosis factor receptor superfamily, member 13c
chr7_-_63588610 0.31 ENSMUST00000063694.10
Klf13
Kruppel-like factor 13
chr8_-_122379631 0.31 ENSMUST00000046386.5
Zcchc14
zinc finger, CCHC domain containing 14
chr2_+_83554741 0.31 ENSMUST00000028499.11
Itgav
integrin alpha V
chr2_-_52632178 0.27 ENSMUST00000102759.8
ENSMUST00000127316.8
Stam2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr5_-_62923463 0.27 ENSMUST00000076623.8
ENSMUST00000159470.3
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_48704121 0.24 ENSMUST00000063886.4
Acvr2a
activin receptor IIA
chr4_+_131649001 0.22 ENSMUST00000094666.4
Tmem200b
transmembrane protein 200B
chr10_+_20188207 0.22 ENSMUST00000092678.10
ENSMUST00000043881.12
Bclaf1
BCL2-associated transcription factor 1
chr7_-_16348862 0.20 ENSMUST00000171937.2
ENSMUST00000075845.11
Arhgap35
Rho GTPase activating protein 35
chr8_-_35432783 0.18 ENSMUST00000033929.6
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr11_+_75570085 0.17 ENSMUST00000017920.14
ENSMUST00000108426.8
ENSMUST00000108425.8
ENSMUST00000093115.4
Crk
v-crk avian sarcoma virus CT10 oncogene homolog
chrX_-_7607527 0.17 ENSMUST00000033490.13
Ccdc120
coiled-coil domain containing 120
chr13_+_112600604 0.14 ENSMUST00000183663.8
ENSMUST00000184311.8
ENSMUST00000183886.8
Il6st
interleukin 6 signal transducer
chr3_-_51184895 0.13 ENSMUST00000108051.8
ENSMUST00000108053.9
Elf2
E74-like factor 2
chr8_+_26092252 0.10 ENSMUST00000136107.9
ENSMUST00000146919.8
ENSMUST00000139966.8
ENSMUST00000142395.8
ENSMUST00000143445.2
Nsd3
nuclear receptor binding SET domain protein 3
chr9_-_77452152 0.10 ENSMUST00000183873.8
Lrrc1
leucine rich repeat containing 1
chr4_+_34550918 0.09 ENSMUST00000084299.6
Akirin2
akirin 2
chr11_+_80319424 0.09 ENSMUST00000173938.8
ENSMUST00000017572.14
Psmd11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr7_-_144024451 0.08 ENSMUST00000033407.13
Cttn
cortactin
chr16_-_56537808 0.06 ENSMUST00000065515.14
Tfg
Trk-fused gene
chr18_+_42408418 0.03 ENSMUST00000091920.6
ENSMUST00000046972.14
ENSMUST00000236240.2
Rbm27
RNA binding motif protein 27

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.6 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
1.1 3.4 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
1.1 4.4 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.0 4.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
1.0 8.1 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.8 3.8 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.7 3.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.7 2.0 GO:1905223 epicardium morphogenesis(GO:1905223)
0.7 2.6 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.5 1.6 GO:1903699 tarsal gland development(GO:1903699)
0.5 2.8 GO:0038161 prolactin signaling pathway(GO:0038161)
0.4 2.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.4 2.6 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.4 3.4 GO:0036089 cleavage furrow formation(GO:0036089)
0.4 2.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.3 2.4 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.3 1.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.3 1.9 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.3 1.8 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 2.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 1.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.3 1.5 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.3 1.3 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.2 1.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.2 3.6 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.2 2.7 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.2 2.0 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.2 1.2 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.2 2.0 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.2 1.2 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.2 1.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.2 0.7 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.2 0.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 0.7 GO:2001025 positive regulation of response to drug(GO:2001025)
0.2 1.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.0 GO:0032667 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667)
0.1 2.0 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 1.8 GO:0006824 cobalt ion transport(GO:0006824)
0.1 0.8 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 1.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.6 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 1.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 1.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 1.3 GO:0060613 fat pad development(GO:0060613)
0.1 0.5 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 1.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.0 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.5 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.1 0.3 GO:2000536 negative regulation of entry of bacterium into host cell(GO:2000536)
0.1 0.6 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.6 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.1 0.5 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 1.6 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 1.6 GO:0090344 negative regulation of cell aging(GO:0090344)
0.1 4.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.6 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 2.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 2.2 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 0.9 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.0 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.1 0.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 4.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.3 GO:0031296 B cell costimulation(GO:0031296)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.2 GO:0046881 positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.1 0.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.4 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 2.2 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.1 5.1 GO:0007569 cell aging(GO:0007569)
0.0 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.8 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.1 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.0 3.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.7 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 5.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 1.9 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.0 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.7 GO:0060009 Sertoli cell development(GO:0060009)
0.0 1.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.4 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 1.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 2.3 GO:0051896 regulation of protein kinase B signaling(GO:0051896)
0.0 2.4 GO:0048864 stem cell development(GO:0048864)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0008623 CHRAC(GO:0008623)
0.4 4.4 GO:0070578 micro-ribonucleoprotein complex(GO:0035068) RISC-loading complex(GO:0070578)
0.4 2.4 GO:0042585 germinal vesicle(GO:0042585)
0.3 1.9 GO:0070449 elongin complex(GO:0070449)
0.2 1.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 2.6 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 0.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 2.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 3.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.9 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.5 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 1.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.3 GO:0034683 integrin alphav-beta3 complex(GO:0034683)
0.1 1.0 GO:0060091 kinocilium(GO:0060091)
0.1 0.9 GO:0005642 annulate lamellae(GO:0005642)
0.1 2.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.5 GO:0001940 male pronucleus(GO:0001940)
0.1 3.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 5.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 3.3 GO:0005844 polysome(GO:0005844)
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.0 3.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.9 GO:0001772 immunological synapse(GO:0001772)
0.0 2.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.0 2.0 GO:0005901 caveola(GO:0005901)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.3 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0098808 mRNA cap binding(GO:0098808)
1.1 3.4 GO:0000401 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
1.0 4.1 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.6 2.8 GO:0004925 prolactin receptor activity(GO:0004925)
0.5 1.5 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.5 1.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 4.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.4 2.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 1.8 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 1.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.3 2.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.2 2.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 3.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 1.8 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.2 1.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2 3.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 2.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 3.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.6 GO:0043495 protein anchor(GO:0043495)
0.1 2.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.0 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 1.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 3.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 1.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 0.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 0.9 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.5 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.7 GO:0042731 PH domain binding(GO:0042731)
0.0 0.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 1.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 2.7 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 4.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 8.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 9.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 1.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 2.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.6 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.0 0.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 8.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 5.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 2.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 7.8 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 3.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 7.3 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 3.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.1 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.5 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 2.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 4.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 3.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 3.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 1.1 PID FOXO PATHWAY FoxO family signaling
0.0 1.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 1.8 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 3.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 2.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 1.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 3.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.0 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 1.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.9 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.0 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.1 4.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 1.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 2.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL