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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Gata2_Gata1
Z-value: 2.45
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Transcription factors associated with Gata2_Gata1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gata1 | mm39_v1_chrX_-_7834057_7834149 | 0.45 | 8.3e-05 | Click! |
| Gata2 | mm39_v1_chr6_+_88175312_88175316 | -0.13 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gata2_Gata1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 114.6 | GO:0007586 | digestion(GO:0007586) |
| 7.1 | 42.5 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 1.3 | 37.7 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 2.3 | 34.3 | GO:0061365 | positive regulation of triglyceride lipase activity(GO:0061365) |
| 8.3 | 33.1 | GO:2000473 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 2.1 | 32.1 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 0.8 | 31.3 | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) |
| 8.6 | 25.7 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
| 4.2 | 25.4 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 3.0 | 24.1 | GO:0002432 | granuloma formation(GO:0002432) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 200.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 72.1 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 62.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 52.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 6.1 | 42.5 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.2 | 40.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.1 | 34.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 2.8 | 27.8 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 26.5 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 20.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 105.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 46.7 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 6.1 | 42.5 | GO:0030172 | troponin C binding(GO:0030172) |
| 1.3 | 40.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.6 | 37.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 36.0 | GO:0005178 | integrin binding(GO:0005178) |
| 1.6 | 34.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 1.1 | 33.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 2.6 | 31.3 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.9 | 29.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.5 | 37.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.4 | 35.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 30.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 27.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 27.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.2 | 25.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.7 | 24.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 19.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 16.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 57.6 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.3 | 44.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.6 | 42.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.7 | 41.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 2.2 | 32.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 1.4 | 25.7 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 1.6 | 23.0 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.5 | 20.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.7 | 14.7 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.5 | 14.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |