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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Gata6

Z-value: 0.56

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Transcription factors associated with Gata6

Gene Symbol Gene ID Gene Info
Gata6
ENSMUSG00000005836.11 Gata6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata6mm39_v1_chr18_+_11052458_110524790.327.0e-03Click!

Activity profile of Gata6 motif

Sorted Z-values of Gata6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_58658838 5.95 ENSMUST00000238108.2
Pnlip
pancreatic lipase
chr17_+_44445659 5.92 ENSMUST00000239215.2
Clic5
chloride intracellular channel 5
chr19_+_58658779 5.90 ENSMUST00000057270.9
Pnlip
pancreatic lipase
chr10_+_53213763 4.33 ENSMUST00000219491.2
ENSMUST00000163319.9
ENSMUST00000220197.2
ENSMUST00000046221.8
ENSMUST00000218468.2
ENSMUST00000219921.2
Pln
phospholamban
chr6_+_30639217 3.76 ENSMUST00000031806.10
Cpa1
carboxypeptidase A1, pancreatic
chr10_+_116881246 3.44 ENSMUST00000073834.5
Lrrc10
leucine rich repeat containing 10
chr4_-_137157824 2.95 ENSMUST00000102522.5
Cela3b
chymotrypsin-like elastase family, member 3B
chr2_-_17465410 2.94 ENSMUST00000145492.2
Nebl
nebulette
chr7_+_141276575 2.64 ENSMUST00000185406.8
Muc2
mucin 2
chr8_-_86091970 2.52 ENSMUST00000121972.8
Mylk3
myosin light chain kinase 3
chr18_+_11052458 2.38 ENSMUST00000047762.10
Gata6
GATA binding protein 6
chr8_-_86091946 2.34 ENSMUST00000034133.14
Mylk3
myosin light chain kinase 3
chr2_+_90948481 2.33 ENSMUST00000137942.8
ENSMUST00000111430.10
ENSMUST00000169776.2
Mybpc3
myosin binding protein C, cardiac
chr7_-_135130374 2.28 ENSMUST00000053716.8
Clrn3
clarin 3
chr11_-_46280281 2.15 ENSMUST00000101306.4
Itk
IL2 inducible T cell kinase
chr2_+_110427643 2.08 ENSMUST00000045972.13
ENSMUST00000111026.3
Slc5a12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr6_-_136852792 2.05 ENSMUST00000032342.3
Mgp
matrix Gla protein
chr14_-_70761507 1.95 ENSMUST00000022692.5
Sftpc
surfactant associated protein C
chr10_+_101517348 1.75 ENSMUST00000179929.8
ENSMUST00000219195.2
ENSMUST00000127504.9
Mgat4c
MGAT4 family, member C
chr3_-_75177378 1.73 ENSMUST00000039047.5
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr1_+_12762501 1.46 ENSMUST00000177608.8
ENSMUST00000180062.8
Sulf1
sulfatase 1
chr8_+_46081213 1.37 ENSMUST00000130850.8
Sorbs2
sorbin and SH3 domain containing 2
chr11_-_46280298 1.34 ENSMUST00000109237.9
Itk
IL2 inducible T cell kinase
chr8_+_57774010 1.29 ENSMUST00000040104.5
Hand2
heart and neural crest derivatives expressed 2
chr11_-_46280336 1.19 ENSMUST00000020664.13
Itk
IL2 inducible T cell kinase
chr4_-_137137088 1.18 ENSMUST00000024200.7
Cela3a
chymotrypsin-like elastase family, member 3A
chr9_-_95697441 1.09 ENSMUST00000119760.2
Pls1
plastin 1 (I-isoform)
chr1_+_45350698 1.04 ENSMUST00000087883.13
Col3a1
collagen, type III, alpha 1
chr9_+_48896765 1.01 ENSMUST00000047349.8
Usp28
ubiquitin specific peptidase 28
chr5_+_90920353 0.99 ENSMUST00000202625.2
Pf4
platelet factor 4
chr6_+_58810674 0.97 ENSMUST00000041401.11
Herc3
hect domain and RLD 3
chr3_+_79793237 0.92 ENSMUST00000029567.9
Gask1b
golgi associated kinase 1B
chr3_+_108272205 0.76 ENSMUST00000090563.7
Mybphl
myosin binding protein H-like
chr16_+_35861554 0.70 ENSMUST00000042203.10
Wdr5b
WD repeat domain 5B
chr17_+_34823790 0.67 ENSMUST00000173242.8
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr10_+_115653152 0.66 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
Tspan8
tetraspanin 8
chr13_+_19398273 0.66 ENSMUST00000103558.3
Trgc1
T cell receptor gamma, constant 1
chr10_-_62178453 0.62 ENSMUST00000143179.2
ENSMUST00000130422.8
Hk1
hexokinase 1
chr3_-_30194559 0.60 ENSMUST00000108271.10
Mecom
MDS1 and EVI1 complex locus
chr9_+_22011488 0.53 ENSMUST00000213607.2
Cnn1
calponin 1
chr11_+_87471867 0.48 ENSMUST00000018544.12
ENSMUST00000063156.11
ENSMUST00000107960.8
Septin4
septin 4
chr3_+_90201388 0.46 ENSMUST00000199607.5
Gatad2b
GATA zinc finger domain containing 2B
chr10_+_101517556 0.46 ENSMUST00000156751.8
Mgat4c
MGAT4 family, member C
chr1_-_144052997 0.43 ENSMUST00000111941.2
ENSMUST00000052375.8
Rgs13
regulator of G-protein signaling 13
chr17_+_88933957 0.42 ENSMUST00000163588.8
ENSMUST00000064035.13
Ston1
stonin 1
chr4_+_150233362 0.42 ENSMUST00000059893.8
Slc2a7
solute carrier family 2 (facilitated glucose transporter), member 7
chr11_-_70111796 0.41 ENSMUST00000060010.3
ENSMUST00000190533.2
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr2_-_59778560 0.40 ENSMUST00000153136.2
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr16_-_95260104 0.37 ENSMUST00000176345.10
ENSMUST00000121809.11
ENSMUST00000233664.2
ENSMUST00000122199.10
Erg
ETS transcription factor
chr2_-_77000936 0.35 ENSMUST00000164114.9
ENSMUST00000049544.14
Ccdc141
coiled-coil domain containing 141
chr12_+_95658987 0.33 ENSMUST00000057324.4
Flrt2
fibronectin leucine rich transmembrane protein 2
chrX_-_111608339 0.33 ENSMUST00000039887.4
Pof1b
premature ovarian failure 1B
chr2_-_7086018 0.33 ENSMUST00000114923.3
ENSMUST00000182706.8
Celf2
CUGBP, Elav-like family member 2
chr13_-_103042554 0.33 ENSMUST00000171791.8
Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_76988444 0.31 ENSMUST00000120639.9
ENSMUST00000163347.8
ENSMUST00000121851.2
Cracd
capping protein inhibiting regulator of actin
chr16_+_91444730 0.29 ENSMUST00000119368.8
ENSMUST00000114037.9
ENSMUST00000114036.9
ENSMUST00000122302.8
Son
Son DNA binding protein
chr2_-_7400690 0.28 ENSMUST00000182404.8
Celf2
CUGBP, Elav-like family member 2
chr11_-_53598078 0.24 ENSMUST00000124352.2
ENSMUST00000020649.14
Rad50
RAD50 double strand break repair protein
chr9_+_62249730 0.22 ENSMUST00000156461.2
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr11_+_97917520 0.22 ENSMUST00000092425.11
Rpl19
ribosomal protein L19
chr1_-_144651157 0.19 ENSMUST00000027603.4
Rgs18
regulator of G-protein signaling 18
chr1_-_131161312 0.18 ENSMUST00000212202.2
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr2_+_143757193 0.17 ENSMUST00000103172.4
Dstn
destrin
chr2_-_7086066 0.16 ENSMUST00000183209.8
Celf2
CUGBP, Elav-like family member 2
chr8_+_46080840 0.15 ENSMUST00000135336.9
Sorbs2
sorbin and SH3 domain containing 2
chr14_+_54423447 0.15 ENSMUST00000103709.2
Traj32
T cell receptor alpha joining 32
chr6_+_58808733 0.13 ENSMUST00000126292.8
ENSMUST00000031823.12
Herc3
hect domain and RLD 3
chr13_-_103042294 0.12 ENSMUST00000167462.8
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_+_80447389 0.10 ENSMUST00000028384.5
Dusp19
dual specificity phosphatase 19
chr15_-_38518458 0.10 ENSMUST00000127848.2
Azin1
antizyme inhibitor 1
chr13_+_24986003 0.10 ENSMUST00000155575.2
BC005537
cDNA sequence BC005537
chr11_+_97917746 0.10 ENSMUST00000017548.7
Rpl19
ribosomal protein L19
chr18_-_39622295 0.09 ENSMUST00000131885.2
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr9_+_64939695 0.09 ENSMUST00000034960.14
Dpp8
dipeptidylpeptidase 8
chr11_-_115968373 0.08 ENSMUST00000174822.8
Unc13d
unc-13 homolog D
chr8_-_84771610 0.07 ENSMUST00000061923.5
Rln3
relaxin 3
chr19_-_42190589 0.07 ENSMUST00000018966.8
Sfrp5
secreted frizzled-related sequence protein 5
chr9_+_66257747 0.07 ENSMUST00000042824.13
Herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr2_+_72306503 0.06 ENSMUST00000102691.11
ENSMUST00000157019.2
Cdca7
cell division cycle associated 7
chr10_+_52293617 0.06 ENSMUST00000023830.16
Nus1
NUS1 dehydrodolichyl diphosphate synthase subunit
chr11_-_115967873 0.05 ENSMUST00000153408.8
Unc13d
unc-13 homolog D
chr7_+_100435548 0.05 ENSMUST00000216021.2
Fam168a
family with sequence similarity 168, member A
chr2_+_109522781 0.05 ENSMUST00000111050.10
Bdnf
brain derived neurotrophic factor
chr2_+_125701054 0.05 ENSMUST00000028636.13
ENSMUST00000125084.8
Galk2
galactokinase 2
chr15_-_73114855 0.05 ENSMUST00000227686.2
Ptk2
PTK2 protein tyrosine kinase 2
chr5_-_73349191 0.03 ENSMUST00000176910.3
Fryl
FRY like transcription coactivator
chr3_-_59170245 0.00 ENSMUST00000050360.14
ENSMUST00000199609.2
P2ry12
purinergic receptor P2Y, G-protein coupled 12

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.9 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.5 2.4 GO:0007493 endodermal cell fate determination(GO:0007493)
0.5 9.0 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.4 4.3 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.3 5.9 GO:0002024 diet induced thermogenesis(GO:0002024)
0.3 1.1 GO:1902896 terminal web assembly(GO:1902896)
0.2 1.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 4.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 1.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.2 1.3 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.2 3.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 2.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.6 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.4 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.1 0.1 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 0.7 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.6 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.1 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 3.6 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 2.8 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.1 GO:0061193 taste bud development(GO:0061193)
0.0 0.1 GO:0002432 granuloma formation(GO:0002432)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 1.0 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.7 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 1.4 GO:0030500 regulation of bone mineralization(GO:0030500)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.2 2.0 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 4.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.1 GO:1990357 terminal web(GO:1990357)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 5.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.0 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.0 4.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.6 11.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.5 4.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 2.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 1.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 2.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 1.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 3.1 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 3.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 3.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 5.9 GO:0005254 chloride channel activity(GO:0005254)
0.0 2.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.3 GO:0050733 RS domain binding(GO:0050733)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014) G-quadruplex DNA binding(GO:0051880)
0.0 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.0 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.7 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 2.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 7.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 4.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production