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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Gbx2

Z-value: 0.77

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Transcription factors associated with Gbx2

Gene Symbol Gene ID Gene Info
Gbx2
ENSMUSG00000034486.9 Gbx2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gbx2mm39_v1_chr1_-_89858901_898589200.362.0e-03Click!

Activity profile of Gbx2 motif

Sorted Z-values of Gbx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gbx2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_79394904 10.37 ENSMUST00000164465.3
Omg
oligodendrocyte myelin glycoprotein
chr2_+_70392351 7.86 ENSMUST00000094934.11
Gad1
glutamate decarboxylase 1
chr2_+_70392491 6.18 ENSMUST00000148210.8
Gad1
glutamate decarboxylase 1
chr14_-_9015639 6.06 ENSMUST00000112656.4
Synpr
synaptoporin
chr12_+_74044435 6.05 ENSMUST00000221220.2
Syt16
synaptotagmin XVI
chr7_-_141014477 5.87 ENSMUST00000106007.10
ENSMUST00000150026.2
ENSMUST00000202840.4
ENSMUST00000133206.9
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr19_+_17114108 5.67 ENSMUST00000223920.2
ENSMUST00000225351.2
Prune2
prune homolog 2
chr7_-_141014445 5.47 ENSMUST00000133021.2
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr9_+_108708939 5.18 ENSMUST00000192235.2
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr7_-_141014192 5.17 ENSMUST00000201127.5
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr7_-_141014336 5.09 ENSMUST00000136354.8
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr7_-_140402037 4.72 ENSMUST00000106052.2
ENSMUST00000080651.13
Zfp941
zinc finger protein 941
chrX_-_42256694 4.72 ENSMUST00000115058.8
ENSMUST00000115059.8
Tenm1
teneurin transmembrane protein 1
chr10_-_5144699 4.35 ENSMUST00000215467.2
Syne1
spectrin repeat containing, nuclear envelope 1
chr6_+_114435480 4.29 ENSMUST00000160780.2
Hrh1
histamine receptor H1
chr7_-_105230395 4.25 ENSMUST00000188726.2
ENSMUST00000188440.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr7_-_105230807 4.25 ENSMUST00000191011.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr7_-_105230698 4.16 ENSMUST00000189378.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr4_+_110254858 4.14 ENSMUST00000106589.9
ENSMUST00000106587.9
ENSMUST00000106591.8
ENSMUST00000106592.8
Agbl4
ATP/GTP binding protein-like 4
chr14_-_9015757 3.66 ENSMUST00000153954.8
Synpr
synaptoporin
chr18_+_37125424 3.47 ENSMUST00000194038.2
Pcdha8
protocadherin alpha 8
chr10_+_116013256 3.15 ENSMUST00000155606.8
ENSMUST00000128399.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_-_5315968 3.03 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
Cdk14
cyclin-dependent kinase 14
chr5_-_31453206 2.95 ENSMUST00000041266.11
ENSMUST00000172435.8
ENSMUST00000201417.2
Fndc4
fibronectin type III domain containing 4
chr3_-_113371392 2.83 ENSMUST00000067980.12
Amy1
amylase 1, salivary
chr4_+_110254907 2.72 ENSMUST00000097920.9
ENSMUST00000080744.13
Agbl4
ATP/GTP binding protein-like 4
chr10_+_116013122 2.63 ENSMUST00000148731.8
Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_+_117919082 2.36 ENSMUST00000138579.3
Nos1
nitric oxide synthase 1, neuronal
chr1_+_179936757 2.13 ENSMUST00000143176.8
ENSMUST00000135056.8
Cdc42bpa
CDC42 binding protein kinase alpha
chr2_-_17465410 2.11 ENSMUST00000145492.2
Nebl
nebulette
chrM_+_14138 2.04 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr17_-_33028814 1.99 ENSMUST00000234594.2
Zfp811
zinc finger protein 811
chr14_-_66451001 1.99 ENSMUST00000178730.8
Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr2_-_157408239 1.98 ENSMUST00000109528.9
ENSMUST00000088494.3
Blcap
bladder cancer associated protein
chr18_+_77877611 1.69 ENSMUST00000238172.2
Pstpip2
proline-serine-threonine phosphatase-interacting protein 2
chr16_-_36605286 1.61 ENSMUST00000168279.2
ENSMUST00000164579.9
ENSMUST00000023616.11
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr14_-_48904958 1.56 ENSMUST00000144465.8
ENSMUST00000133479.8
ENSMUST00000119070.8
ENSMUST00000226501.2
Otx2
orthodenticle homeobox 2
chr4_-_139695337 1.55 ENSMUST00000105031.4
Klhdc7a
kelch domain containing 7A
chr3_-_86827664 1.52 ENSMUST00000194452.2
ENSMUST00000191752.6
Dclk2
doublecortin-like kinase 2
chr16_-_36605147 1.51 ENSMUST00000165531.9
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr2_-_18806629 1.43 ENSMUST00000181515.2
Carlr
cardiac and apoptosis-related long non-coding RNA
chr5_+_113873864 1.38 ENSMUST00000065698.7
Ficd
FIC domain containing
chr4_-_26346882 1.35 ENSMUST00000041374.8
ENSMUST00000153813.2
Manea
mannosidase, endo-alpha
chr19_-_39729431 1.26 ENSMUST00000099472.4
Cyp2c68
cytochrome P450, family 2, subfamily c, polypeptide 68
chr3_-_141687987 1.09 ENSMUST00000029948.15
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr11_+_59197746 1.03 ENSMUST00000000128.10
ENSMUST00000108783.4
Wnt9a
wingless-type MMTV integration site family, member 9A
chr14_+_69585036 1.03 ENSMUST00000064831.6
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chrM_-_14061 1.03 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr1_-_52991993 1.02 ENSMUST00000050567.11
1700019D03Rik
RIKEN cDNA 1700019D03 gene
chr3_-_86827640 1.02 ENSMUST00000195561.6
Dclk2
doublecortin-like kinase 2
chr2_+_87609827 1.02 ENSMUST00000105210.3
Olfr152
olfactory receptor 152
chr18_-_67378886 0.97 ENSMUST00000073054.5
Mppe1
metallophosphoesterase 1
chr11_+_97206542 0.95 ENSMUST00000019026.10
ENSMUST00000132168.2
Mrpl45
mitochondrial ribosomal protein L45
chr1_-_155293141 0.92 ENSMUST00000111775.8
ENSMUST00000111774.2
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr11_-_21320452 0.83 ENSMUST00000102875.11
Ugp2
UDP-glucose pyrophosphorylase 2
chr2_-_89675315 0.79 ENSMUST00000099762.2
Olfr48
olfactory receptor 48
chr17_-_37974666 0.69 ENSMUST00000215414.2
ENSMUST00000213638.3
Olfr117
olfactory receptor 117
chr2_-_73410632 0.68 ENSMUST00000028515.4
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr4_+_118818775 0.65 ENSMUST00000058651.5
Lao1
L-amino acid oxidase 1
chr10_-_95337783 0.64 ENSMUST00000075829.3
ENSMUST00000217777.2
ENSMUST00000218893.2
Mrpl42
mitochondrial ribosomal protein L42
chr3_-_89905927 0.61 ENSMUST00000197725.5
ENSMUST00000197767.5
ENSMUST00000197786.5
ENSMUST00000079724.9
Hax1
HCLS1 associated X-1
chr4_+_32657105 0.61 ENSMUST00000071642.11
ENSMUST00000178134.2
Mdn1
midasin AAA ATPase 1
chr1_-_74932266 0.58 ENSMUST00000006721.3
Cryba2
crystallin, beta A2
chr19_-_12313274 0.56 ENSMUST00000208398.3
Olfr1438-ps1
olfactory receptor 1438, pseudogene 1
chr2_-_85966272 0.54 ENSMUST00000216566.3
ENSMUST00000214364.2
Olfr1039
olfactory receptor 1039
chr10_-_23112973 0.53 ENSMUST00000218049.2
Eya4
EYA transcriptional coactivator and phosphatase 4
chr17_+_85264134 0.51 ENSMUST00000112305.10
Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr6_-_129077867 0.50 ENSMUST00000032258.8
Clec2e
C-type lectin domain family 2, member e
chr10_-_128918779 0.42 ENSMUST00000213579.2
Olfr767
olfactory receptor 767
chr8_+_72837021 0.41 ENSMUST00000213940.2
Olfr373
olfactory receptor 373
chr14_+_54418031 0.39 ENSMUST00000103704.2
Traj38
T cell receptor alpha joining 38
chr4_+_114020581 0.37 ENSMUST00000079915.10
ENSMUST00000164297.8
Skint11
selection and upkeep of intraepithelial T cells 11
chr3_+_88523440 0.37 ENSMUST00000177498.8
ENSMUST00000176500.8
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr7_-_78432774 0.34 ENSMUST00000032841.7
Mrpl46
mitochondrial ribosomal protein L46
chr2_-_87838612 0.33 ENSMUST00000215457.2
Olfr1160
olfactory receptor 1160
chr3_-_10396418 0.33 ENSMUST00000191670.6
ENSMUST00000065938.15
ENSMUST00000118410.8
Impa1
inositol (myo)-1(or 4)-monophosphatase 1
chr10_-_116732813 0.32 ENSMUST00000048229.9
Myrfl
myelin regulatory factor-like
chr7_+_78432867 0.27 ENSMUST00000032840.5
Mrps11
mitochondrial ribosomal protein S11
chr2_+_67004178 0.23 ENSMUST00000239009.2
ENSMUST00000238912.2
Xirp2
xin actin-binding repeat containing 2
chr2_-_111324108 0.19 ENSMUST00000208881.2
ENSMUST00000208695.2
ENSMUST00000217611.2
Olfr1290
olfactory receptor 1290
chr4_+_114020656 0.17 ENSMUST00000145797.8
ENSMUST00000151810.2
Skint11
selection and upkeep of intraepithelial T cells 11
chr14_+_54436898 0.17 ENSMUST00000103721.3
Traj20
T cell receptor alpha joining 20
chr9_+_37656402 0.10 ENSMUST00000216982.2
Olfr874
olfactory receptor 874
chr14_-_50390356 0.08 ENSMUST00000215451.2
ENSMUST00000213163.2
ENSMUST00000215327.2
Olfr729
olfactory receptor 729
chr12_-_98225676 0.03 ENSMUST00000021390.9
Galc
galactosylceramidase
chr14_-_48904998 0.00 ENSMUST00000152018.8
Otx2
orthodenticle homeobox 2
chr11_-_73707875 0.00 ENSMUST00000118463.4
ENSMUST00000144724.3
Olfr392
olfactory receptor 392

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.7 GO:0050758 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
2.0 14.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.4 6.9 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
1.0 5.2 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
1.0 5.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.7 4.3 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.7 21.6 GO:0015813 L-glutamate transport(GO:0015813)
0.7 2.0 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.6 4.3 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.6 2.4 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.4 3.1 GO:0042938 dipeptide transport(GO:0042938)
0.4 10.4 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.3 0.8 GO:0019255 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.3 2.0 GO:0033762 response to glucagon(GO:0033762)
0.2 1.6 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 1.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.4 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.1 2.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.1 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.5 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.1 0.9 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 4.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.0 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.7 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 6.0 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.8 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.8 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 2.2 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 12.7 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.6 3.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.4 4.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3 9.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 14.0 GO:0060077 inhibitory synapse(GO:0060077)
0.3 1.0 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.3 1.0 GO:0070469 respiratory chain(GO:0070469)
0.2 2.0 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 2.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 2.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 6.9 GO:0005814 centriole(GO:0005814)
0.0 9.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 21.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.4 GO:0042641 actomyosin(GO:0042641)
0.0 0.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.3 21.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.1 4.3 GO:0051381 histamine binding(GO:0051381)
1.0 3.1 GO:0042936 dipeptide transporter activity(GO:0042936)
0.7 2.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.5 2.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.4 2.8 GO:0004556 alpha-amylase activity(GO:0004556)
0.4 12.7 GO:0048156 tau protein binding(GO:0048156)
0.3 2.0 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 6.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 0.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 1.4 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 4.3 GO:0005521 lamin binding(GO:0005521)
0.1 1.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.8 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.1 1.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 6.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 0.3 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 3.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.6 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 1.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 6.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0042166 acetylcholine binding(GO:0042166)
0.0 1.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.8 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 14.8 GO:0042803 protein homodimerization activity(GO:0042803)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 10.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 2.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 2.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 4.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 4.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 10.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.4 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 3.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification