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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Grhl1

Z-value: 3.34

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Transcription factors associated with Grhl1

Gene Symbol Gene ID Gene Info
Grhl1
ENSMUSG00000020656.17 Grhl1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Grhl1mm39_v1_chr12_+_24622274_246223070.352.2e-03Click!

Activity profile of Grhl1 motif

Sorted Z-values of Grhl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Grhl1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_88455556 62.06 ENSMUST00000131775.2
ENSMUST00000008745.13
Rab25
RAB25, member RAS oncogene family
chr3_+_92123106 44.91 ENSMUST00000074449.7
ENSMUST00000090871.3
Sprr2a1
Sprr2a2
small proline-rich protein 2A1
small proline-rich protein 2A2
chrX_-_111608339 44.48 ENSMUST00000039887.4
Pof1b
premature ovarian failure 1B
chr7_+_30487322 42.11 ENSMUST00000189673.7
ENSMUST00000190990.7
ENSMUST00000189962.7
ENSMUST00000187493.7
ENSMUST00000098559.3
Krtdap
keratinocyte differentiation associated protein
chr3_+_92195873 41.74 ENSMUST00000090872.7
Sprr2a3
small proline-rich protein 2A3
chr4_+_128999325 39.67 ENSMUST00000106064.10
ENSMUST00000030575.15
ENSMUST00000030577.11
Tmem54
transmembrane protein 54
chr17_+_87943401 37.92 ENSMUST00000235125.2
ENSMUST00000053577.9
ENSMUST00000234009.2
Epcam
epithelial cell adhesion molecule
chr1_+_135746330 37.06 ENSMUST00000038760.10
Lad1
ladinin
chr9_+_78197205 35.54 ENSMUST00000119823.8
ENSMUST00000121273.2
Gsta5
glutathione S-transferase alpha 5
chr18_-_64794338 34.68 ENSMUST00000025482.10
Atp8b1
ATPase, class I, type 8B, member 1
chr6_-_131293361 31.09 ENSMUST00000121078.2
Styk1
serine/threonine/tyrosine kinase 1
chr15_-_63680596 31.07 ENSMUST00000110125.9
ENSMUST00000173503.3
Gsdmc
gasdermin C
chr9_+_43222104 28.48 ENSMUST00000034511.7
Trim29
tripartite motif-containing 29
chr16_-_35951553 27.88 ENSMUST00000161638.2
ENSMUST00000096090.3
Csta1
cystatin A1
chr2_-_127383305 25.68 ENSMUST00000103214.3
Prom2
prominin 2
chr2_-_179931672 25.21 ENSMUST00000038529.2
Rbbp8nl
RBBP8 N-terminal like
chr17_-_56312555 24.15 ENSMUST00000043785.8
Stap2
signal transducing adaptor family member 2
chr2_+_24167275 24.11 ENSMUST00000114490.7
ENSMUST00000147885.4
Il1f5
interleukin 1 family, member 5 (delta)
chr2_-_127383332 23.85 ENSMUST00000028855.14
Prom2
prominin 2
chr9_-_78254422 23.83 ENSMUST00000034902.12
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
chr2_+_24166920 23.52 ENSMUST00000168941.8
ENSMUST00000028360.8
ENSMUST00000123053.8
Il1f5
interleukin 1 family, member 5 (delta)
chr10_-_79369584 23.15 ENSMUST00000218241.2
ENSMUST00000166804.2
ENSMUST00000063879.13
Plpp2
phospholipid phosphatase 2
chr8_-_93956143 22.46 ENSMUST00000176282.2
ENSMUST00000034173.14
Ces1e
carboxylesterase 1E
chr19_-_5610628 22.04 ENSMUST00000025861.3
Ovol1
ovo like zinc finger 1
chr9_-_78254443 21.74 ENSMUST00000129247.2
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
chr3_+_92223927 21.03 ENSMUST00000061038.4
Sprr2b
small proline-rich protein 2B
chr15_-_75886166 18.98 ENSMUST00000060807.12
Fam83h
family with sequence similarity 83, member H
chr17_+_35844091 18.66 ENSMUST00000025273.9
Psors1c2
psoriasis susceptibility 1 candidate 2 (human)
chr5_-_86616849 18.25 ENSMUST00000101073.3
Tmprss11a
transmembrane protease, serine 11a
chr11_+_72326391 17.39 ENSMUST00000100903.3
Ggt6
gamma-glutamyltransferase 6
chr7_+_12661337 17.20 ENSMUST00000045870.5
Rnf225
ring finger protein 225
chr3_-_10400710 16.85 ENSMUST00000078748.4
Slc10a5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr7_+_100970435 16.61 ENSMUST00000210192.2
ENSMUST00000172630.8
Stard10
START domain containing 10
chr9_+_15150341 16.12 ENSMUST00000034413.8
Vstm5
V-set and transmembrane domain containing 5
chr7_+_100970910 15.44 ENSMUST00000174291.8
ENSMUST00000167888.9
ENSMUST00000172662.2
Stard10
START domain containing 10
chr2_-_144174066 14.33 ENSMUST00000037423.4
Ovol2
ovo like zinc finger 2
chr7_+_100971034 13.20 ENSMUST00000173270.8
Stard10
START domain containing 10
chr4_+_135455427 13.00 ENSMUST00000102546.4
Il22ra1
interleukin 22 receptor, alpha 1
chr4_+_140970161 12.88 ENSMUST00000138096.8
ENSMUST00000006618.9
ENSMUST00000125392.8
Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr2_-_30095784 12.82 ENSMUST00000113662.8
Kyat1
kynurenine aminotransferase 1
chr18_+_56565188 12.27 ENSMUST00000070166.6
Gramd3
GRAM domain containing 3
chr2_-_30095805 11.54 ENSMUST00000113663.9
ENSMUST00000044038.10
Kyat1
kynurenine aminotransferase 1
chr5_-_86666408 11.18 ENSMUST00000140095.2
ENSMUST00000134179.8
Tmprss11g
transmembrane protease, serine 11g
chr4_+_112089442 10.70 ENSMUST00000038455.12
ENSMUST00000170945.2
Skint3
selection and upkeep of intraepithelial T cells 3
chr4_+_133793208 10.16 ENSMUST00000137053.2
Crybg2
crystallin beta-gamma domain containing 2
chr4_-_155170738 9.95 ENSMUST00000030914.4
Rer1
retention in endoplasmic reticulum sorting receptor 1
chr7_+_45204317 9.60 ENSMUST00000107752.12
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr13_+_8935537 9.59 ENSMUST00000169314.9
Idi1
isopentenyl-diphosphate delta isomerase
chr1_-_159981132 9.34 ENSMUST00000039178.12
Tnn
tenascin N
chrX_-_37545311 9.20 ENSMUST00000074913.12
ENSMUST00000016678.14
ENSMUST00000061755.9
Lamp2
lysosomal-associated membrane protein 2
chr2_-_151815307 7.87 ENSMUST00000109863.2
Fam110a
family with sequence similarity 110, member A
chr6_+_139576475 7.64 ENSMUST00000187618.7
ENSMUST00000186585.3
Pik3c2g
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr12_+_24622274 7.27 ENSMUST00000085553.13
Grhl1
grainyhead like transcription factor 1
chr2_+_172392678 7.12 ENSMUST00000099058.10
Tfap2c
transcription factor AP-2, gamma
chr7_+_45204350 6.22 ENSMUST00000210300.2
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr7_-_29217967 5.94 ENSMUST00000181975.8
Sipa1l3
signal-induced proliferation-associated 1 like 3
chr19_+_4008645 5.78 ENSMUST00000179433.8
Aldh3b3
aldehyde dehydrogenase 3 family, member B3
chr1_-_131207279 5.65 ENSMUST00000062108.10
Ikbke
inhibitor of kappaB kinase epsilon
chr4_-_19570073 5.38 ENSMUST00000029885.5
Cpne3
copine III
chr2_+_84891281 5.33 ENSMUST00000238769.2
Tnks1bp1
tankyrase 1 binding protein 1
chr14_+_79718604 5.04 ENSMUST00000040131.13
Elf1
E74-like factor 1
chr5_-_86824205 4.57 ENSMUST00000038448.7
Tmprss11b
transmembrane protease, serine 11B
chrX_+_99773784 4.34 ENSMUST00000113744.2
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr17_-_66191912 3.87 ENSMUST00000024905.11
Ralbp1
ralA binding protein 1
chrX_+_99773523 3.73 ENSMUST00000019503.14
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr1_-_52766615 3.69 ENSMUST00000156876.8
ENSMUST00000087701.4
Mfsd6
major facilitator superfamily domain containing 6
chr7_-_101714251 3.41 ENSMUST00000130074.2
ENSMUST00000131104.3
ENSMUST00000096639.12
Rnf121
ring finger protein 121
chr18_-_46413886 3.35 ENSMUST00000236999.2
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr11_-_69563133 3.19 ENSMUST00000163666.3
Eif4a1
eukaryotic translation initiation factor 4A1
chr12_-_54703281 2.90 ENSMUST00000056228.8
Sptssa
serine palmitoyltransferase, small subunit A
chr17_+_35960600 2.81 ENSMUST00000171166.3
Sfta2
surfactant associated 2
chr19_-_18609118 2.61 ENSMUST00000025631.7
ENSMUST00000236615.2
Ostf1
osteoclast stimulating factor 1
chr5_+_124585244 2.48 ENSMUST00000198451.2
Kmt5a
lysine methyltransferase 5A
chr4_+_108691798 2.45 ENSMUST00000030296.9
Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr12_+_17778198 2.36 ENSMUST00000222944.2
Hpcal1
hippocalcin-like 1
chr11_-_8614667 2.01 ENSMUST00000239111.2
Tns3
tensin 3
chr19_+_5618029 1.97 ENSMUST00000235575.2
ENSMUST00000235542.2
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr16_+_43993599 1.95 ENSMUST00000119746.8
ENSMUST00000088356.10
ENSMUST00000169582.3
Usf3
upstream transcription factor family member 3
chr14_+_64181115 1.88 ENSMUST00000079652.7
Sox7
SRY (sex determining region Y)-box 7
chr4_+_155171034 1.62 ENSMUST00000030915.11
ENSMUST00000155775.8
ENSMUST00000127457.2
Morn1
MORN repeat containing 1
chr9_-_7873017 1.49 ENSMUST00000013949.15
Birc3
baculoviral IAP repeat-containing 3
chr10_-_128401773 1.46 ENSMUST00000026425.13
ENSMUST00000131728.4
Pa2g4
proliferation-associated 2G4
chr2_-_30857858 1.42 ENSMUST00000028200.9
Tor1a
torsin family 1, member A (torsin A)
chr8_-_96580129 1.31 ENSMUST00000212628.2
ENSMUST00000040481.4
ENSMUST00000212270.2
Slc38a7
solute carrier family 38, member 7
chr2_+_28403255 1.22 ENSMUST00000028170.15
Ralgds
ral guanine nucleotide dissociation stimulator
chr3_+_103739877 0.86 ENSMUST00000062945.12
Bcl2l15
BCLl2-like 15
chr9_-_7873171 0.75 ENSMUST00000159323.2
ENSMUST00000115673.3
Birc3
baculoviral IAP repeat-containing 3
chr3_-_87171005 0.75 ENSMUST00000146512.2
Fcrls
Fc receptor-like S, scavenger receptor
chr14_-_73622638 0.71 ENSMUST00000228637.2
ENSMUST00000022704.9
Itm2b
integral membrane protein 2B
chr3_-_87170903 0.37 ENSMUST00000090986.11
Fcrls
Fc receptor-like S, scavenger receptor
chr19_+_18609291 0.18 ENSMUST00000042392.14
ENSMUST00000237347.2
Nmrk1
nicotinamide riboside kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.4 49.5 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
8.1 24.4 GO:0097052 L-kynurenine metabolic process(GO:0097052)
7.6 37.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
7.3 22.0 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
6.0 47.6 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
4.5 45.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
4.3 34.7 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
3.1 9.2 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
3.0 62.1 GO:0031268 pseudopodium organization(GO:0031268)
2.3 9.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
1.8 7.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.7 55.2 GO:0035634 response to stilbenoid(GO:0035634)
1.6 14.3 GO:0060214 endocardium formation(GO:0060214)
1.5 107.2 GO:0018149 peptide cross-linking(GO:0018149)
1.2 17.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.9 5.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.8 3.9 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.7 9.9 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.6 44.5 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.6 7.3 GO:0002934 desmosome organization(GO:0002934)
0.6 31.1 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.5 15.8 GO:0006706 steroid catabolic process(GO:0006706)
0.5 8.1 GO:0090527 actin filament reorganization(GO:0090527)
0.4 23.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.4 3.4 GO:0051771 protein geranylgeranylation(GO:0018344) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.4 20.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.2 7.6 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.2 26.0 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.2 5.6 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.2 2.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.2 5.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 5.3 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 13.0 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 5.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.7 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 42.1 GO:0008544 epidermis development(GO:0008544)
0.1 2.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 1.5 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.1 27.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 1.9 GO:0006491 N-glycan processing(GO:0006491)
0.1 5.8 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 3.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 18.2 GO:0006814 sodium ion transport(GO:0006814)
0.1 12.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.9 GO:0001706 endoderm formation(GO:0001706)
0.0 2.0 GO:0048286 lung alveolus development(GO:0048286)
0.0 27.5 GO:0006508 proteolysis(GO:0006508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.9 49.5 GO:0044393 microspike(GO:0044393)
3.0 62.1 GO:0031143 pseudopodium(GO:0031143)
2.5 45.2 GO:0046581 intercellular canaliculus(GO:0046581)
2.4 135.1 GO:0001533 cornified envelope(GO:0001533)
2.3 9.2 GO:0097637 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
2.1 42.1 GO:0042599 lamellar body(GO:0042599)
1.4 44.5 GO:0030057 desmosome(GO:0030057)
0.7 5.9 GO:0061689 tricellular tight junction(GO:0061689)
0.5 19.0 GO:0045095 keratin filament(GO:0045095)
0.4 37.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.4 34.7 GO:0032420 stereocilium(GO:0032420)
0.3 2.9 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 37.1 GO:0005604 basement membrane(GO:0005604)
0.2 33.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 7.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 1.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 9.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 12.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 31.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 5.6 GO:0016605 PML body(GO:0016605)
0.0 2.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 21.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 9.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.2 GO:0005903 brush border(GO:0005903)
0.0 8.1 GO:0030027 lamellipodium(GO:0030027)
0.0 31.1 GO:0005815 microtubule organizing center(GO:0005815)
0.0 2.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 187.8 GO:0005576 extracellular region(GO:0005576)
0.0 30.0 GO:0005739 mitochondrion(GO:0005739)
0.0 7.3 GO:0005794 Golgi apparatus(GO:0005794)
0.0 1.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.0 GO:0005925 focal adhesion(GO:0005925)
0.0 121.0 GO:0016021 integral component of membrane(GO:0016021)
0.0 23.1 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 47.6 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
8.1 24.4 GO:0047945 L-phenylalanine:pyruvate aminotransferase activity(GO:0047312) glutamine-phenylpyruvate transaminase activity(GO:0047316) L-glutamine:pyruvate aminotransferase activity(GO:0047945)
4.3 13.0 GO:0042015 interleukin-20 binding(GO:0042015)
3.5 34.7 GO:1901612 cardiolipin binding(GO:1901612)
2.7 19.0 GO:1990254 keratin filament binding(GO:1990254)
2.6 66.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
2.3 15.8 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
2.2 62.1 GO:0031489 myosin V binding(GO:0031489)
2.1 16.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.9 9.6 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
1.6 45.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.5 23.1 GO:0042577 lipid phosphatase activity(GO:0042577)
1.4 17.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
1.1 22.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.9 5.6 GO:0008384 IkappaB kinase activity(GO:0008384)
0.8 2.4 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.8 8.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.8 5.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.6 5.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.6 49.5 GO:0015485 cholesterol binding(GO:0015485)
0.6 2.9 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.6 3.4 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.4 7.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 31.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 1.3 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.3 9.9 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.3 44.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 29.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 34.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 99.4 GO:0005198 structural molecule activity(GO:0005198)
0.1 36.3 GO:0051015 actin filament binding(GO:0051015)
0.1 3.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 29.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 12.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 5.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 9.3 GO:0005178 integrin binding(GO:0005178)
0.1 7.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 41.4 GO:0008289 lipid binding(GO:0008289)
0.0 3.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 19.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.4 GO:0019894 kinesin binding(GO:0019894)
0.0 7.2 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 2.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 5.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 7.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 9.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 2.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 81.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.6 34.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.3 7.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.3 9.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 5.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.3 8.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 9.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 7.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases