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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Grhl1
Z-value: 3.34
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Transcription factors associated with Grhl1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Grhl1 | mm39_v1_chr12_+_24622274_24622307 | 0.35 | 2.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Grhl1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 107.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 3.0 | 62.1 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 1.7 | 55.2 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 12.4 | 49.5 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 6.0 | 47.6 | GO:1902714 | negative regulation of interferon-gamma secretion(GO:1902714) |
| 4.5 | 45.2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.6 | 44.5 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.1 | 42.1 | GO:0008544 | epidermis development(GO:0008544) |
| 7.6 | 37.9 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 4.3 | 34.7 | GO:0021650 | vestibulocochlear nerve formation(GO:0021650) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 187.8 | GO:0005576 | extracellular region(GO:0005576) |
| 2.4 | 135.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 121.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 3.0 | 62.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 9.9 | 49.5 | GO:0044393 | microspike(GO:0044393) |
| 2.5 | 45.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.4 | 44.5 | GO:0030057 | desmosome(GO:0030057) |
| 2.1 | 42.1 | GO:0042599 | lamellar body(GO:0042599) |
| 0.4 | 37.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 37.1 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 99.4 | GO:0005198 | structural molecule activity(GO:0005198) |
| 2.6 | 66.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 2.2 | 62.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.6 | 49.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 11.9 | 47.6 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 1.6 | 45.6 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.3 | 44.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 41.4 | GO:0008289 | lipid binding(GO:0008289) |
| 0.1 | 36.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 3.5 | 34.7 | GO:1901612 | cardiolipin binding(GO:1901612) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.6 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 7.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 3.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.2 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 81.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.6 | 34.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 9.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 9.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 8.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.3 | 7.6 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 7.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 5.6 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 3.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |