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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 3.95
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Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smarcc2 | mm39_v1_chr10_+_128295159_128295197 | 0.82 | 2.6e-18 | Click! |
| Hcfc1 | mm39_v1_chrX_-_73009933_73009982 | 0.78 | 9.5e-16 | Click! |
| Zfp143 | mm39_v1_chr7_+_109660887_109660950 | 0.61 | 1.7e-08 | Click! |
| Six5 | mm39_v1_chr7_+_18828519_18828558 | 0.14 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_148574353 Show fit | 18.70 |
ENSMUST00000028926.13
|
N-ethylmaleimide sensitive fusion protein attachment protein beta |
|
| chr11_-_50718508 Show fit | 18.66 |
ENSMUST00000109135.9
|
zinc finger protein 354C |
|
| chr16_-_55755208 Show fit | 17.56 |
ENSMUST00000121129.8
ENSMUST00000023270.14 |
centrosomal protein 97 |
|
| chr1_+_72622404 Show fit | 15.31 |
ENSMUST00000145868.8
ENSMUST00000133123.8 ENSMUST00000047615.15 |
SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 |
|
| chr16_-_55755160 Show fit | 13.47 |
ENSMUST00000122280.8
ENSMUST00000121703.3 |
centrosomal protein 97 |
|
| chr8_+_111646548 Show fit | 12.95 |
ENSMUST00000117534.8
ENSMUST00000034197.5 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
|
| chr18_-_35836161 Show fit | 12.94 |
ENSMUST00000025208.7
|
DnaJ heat shock protein family (Hsp40) member C18 |
|
| chr7_-_27374017 Show fit | 12.51 |
ENSMUST00000036453.14
ENSMUST00000108341.2 |
mitogen-activated protein kinase kinase kinase 10 |
|
| chr6_-_34153955 Show fit | 12.42 |
ENSMUST00000019143.9
|
solute carrier family 35, member B4 |
|
| chr13_-_110416637 Show fit | 12.08 |
ENSMUST00000167824.3
ENSMUST00000224180.2 |
RAB3C, member RAS oncogene family |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 246.5 | GO:0006355 | regulation of transcription, DNA-templated(GO:0006355) |
| 2.4 | 40.9 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 2.5 | 27.9 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.9 | 22.9 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 2.2 | 22.0 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.3 | 19.4 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 4.6 | 18.3 | GO:0042245 | RNA repair(GO:0042245) |
| 1.5 | 18.3 | GO:0010807 | regulation of synaptic vesicle priming(GO:0010807) |
| 0.1 | 17.6 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.1 | 17.4 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 128.2 | GO:0005634 | nucleus(GO:0005634) |
| 0.1 | 58.8 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 46.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 42.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.0 | 33.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 32.7 | GO:0005874 | microtubule(GO:0005874) |
| 0.1 | 28.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.3 | 24.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 1.4 | 23.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 20.1 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 216.7 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 36.5 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.4 | 35.9 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 35.6 | GO:0003677 | DNA binding(GO:0003677) |
| 0.1 | 33.7 | GO:0008514 | organic anion transmembrane transporter activity(GO:0008514) |
| 3.2 | 31.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 31.2 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 0.0 | 22.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.5 | 21.0 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 3.4 | 20.6 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 24.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.6 | 21.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.4 | 20.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 16.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.3 | 15.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 13.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 12.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 12.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 10.8 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 48.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 47.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.6 | 29.0 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.9 | 22.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.6 | 19.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 18.8 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 16.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.7 | 13.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.5 | 13.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.5 | 13.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |