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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Hic2
Z-value: 2.34
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Transcription factors associated with Hic2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hic2 | mm39_v1_chr16_+_17051423_17051528 | 0.06 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hic2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 50.9 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.4 | 40.3 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
| 5.6 | 33.8 | GO:0099551 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) |
| 2.2 | 33.7 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 2.8 | 27.6 | GO:0046959 | habituation(GO:0046959) |
| 0.0 | 21.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 2.3 | 20.3 | GO:0009448 | gamma-aminobutyric acid metabolic process(GO:0009448) |
| 6.7 | 20.2 | GO:0032242 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.4 | 18.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 17.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 96.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 69.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 56.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 5.7 | 50.9 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.2 | 45.8 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.2 | 44.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 37.3 | GO:0045202 | synapse(GO:0045202) |
| 0.5 | 32.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.0 | 26.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 1.5 | 25.1 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 50.9 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 13.1 | 39.3 | GO:0016492 | G-protein coupled neurotensin receptor activity(GO:0016492) |
| 1.0 | 35.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 5.6 | 33.8 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.3 | 26.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.2 | 26.3 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.7 | 21.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 21.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 1.1 | 20.5 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
| 0.1 | 20.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 50.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 35.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 22.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 20.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.6 | 20.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.3 | 20.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 16.9 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 14.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 11.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 11.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 65.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.4 | 52.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.6 | 30.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.9 | 25.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.5 | 25.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 22.8 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 0.6 | 21.4 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.4 | 21.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 20.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.3 | 18.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |