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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hlx

Z-value: 0.52

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Transcription factors associated with Hlx

Gene Symbol Gene ID Gene Info
Hlx
ENSMUSG00000039377.8 Hlx

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hlxmm39_v1_chr1_-_184464810_184464824-0.281.9e-02Click!

Activity profile of Hlx motif

Sorted Z-values of Hlx motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hlx

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_7555053 7.01 ENSMUST00000090679.9
ENSMUST00000184986.2
Tac1
tachykinin 1
chr15_-_8740218 5.26 ENSMUST00000005493.14
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_99134885 5.12 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr12_+_37930305 4.76 ENSMUST00000220990.2
Dgkb
diacylglycerol kinase, beta
chr15_-_8739893 4.55 ENSMUST00000157065.2
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_144738526 3.66 ENSMUST00000029919.7
Clca1
chloride channel accessory 1
chr3_-_59127571 3.53 ENSMUST00000199675.2
ENSMUST00000170388.6
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chrX_-_142716200 2.82 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
Dcx
doublecortin
chr12_+_37930169 2.69 ENSMUST00000221176.2
Dgkb
diacylglycerol kinase, beta
chr10_+_101994841 2.17 ENSMUST00000020039.13
Mgat4c
MGAT4 family, member C
chr1_-_53011187 2.13 ENSMUST00000186266.2
1700019D03Rik
RIKEN cDNA 1700019D03 gene
chr3_-_33136153 1.76 ENSMUST00000108225.10
Pex5l
peroxisomal biogenesis factor 5-like
chr1_+_179936757 1.73 ENSMUST00000143176.8
ENSMUST00000135056.8
Cdc42bpa
CDC42 binding protein kinase alpha
chr10_+_101994719 1.70 ENSMUST00000138522.8
ENSMUST00000163753.8
ENSMUST00000138016.8
Mgat4c
MGAT4 family, member C
chr3_+_32490525 0.55 ENSMUST00000108242.2
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chrX_-_142716085 0.55 ENSMUST00000087313.10
Dcx
doublecortin
chr1_-_74639723 0.44 ENSMUST00000127938.8
ENSMUST00000154874.8
Rnf25
ring finger protein 25
chr2_-_88577230 0.11 ENSMUST00000099814.2
Olfr1198
olfactory receptor 1198
chrX_+_132751729 0.03 ENSMUST00000033602.9
Tnmd
tenomodulin
chr1_+_106866678 0.02 ENSMUST00000112724.3
Serpinb12
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 9.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.8 7.0 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.9 3.5 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.8 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.2 3.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 7.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 0.5 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 1.7 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 3.7 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 3.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 3.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.1 GO:0005882 intermediate filament(GO:0005882)
0.0 9.8 GO:0043197 dendritic spine(GO:0043197)
0.0 10.4 GO:0030424 axon(GO:0030424)
0.0 1.7 GO:0042641 actomyosin(GO:0042641)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 7.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 3.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3 3.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 1.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 7.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 3.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.2 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 7.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 3.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 9.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 7.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling