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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hmx3

Z-value: 0.68

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Transcription factors associated with Hmx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000040148.6 Hmx3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmx3mm39_v1_chr7_+_131144596_1311445960.209.0e-02Click!

Activity profile of Hmx3 motif

Sorted Z-values of Hmx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_-_103114105 4.91 ENSMUST00000111174.8
ets homologous factor
chr16_+_34815177 4.73 ENSMUST00000231589.2
myosin, light polypeptide kinase
chr3_-_49711706 4.65 ENSMUST00000191794.2
protocadherin 18
chr3_-_49711765 4.62 ENSMUST00000035931.13
protocadherin 18
chr1_-_93088562 4.61 ENSMUST00000143419.2
mab-21-like 4
chr5_-_53864874 4.40 ENSMUST00000031093.5
cholecystokinin A receptor
chr11_+_96209093 4.26 ENSMUST00000049241.9
homeobox B4
chr2_+_27055245 3.94 ENSMUST00000000910.7
dopamine beta hydroxylase
chr1_-_45542442 3.62 ENSMUST00000086430.5
collagen, type V, alpha 2
chr2_+_74528071 3.32 ENSMUST00000059272.10
homeobox D9
chr3_+_3699205 3.29 ENSMUST00000108394.3
hepatocyte nuclear factor 4, gamma
chrX_+_138464065 3.06 ENSMUST00000113027.8
ring finger protein 128
chr1_-_149836974 2.92 ENSMUST00000190507.2
ENSMUST00000070200.15
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr9_-_110453427 2.65 ENSMUST00000196876.2
ENSMUST00000035069.14
neurotrophin receptor associated death domain
chr2_+_57887896 2.60 ENSMUST00000112616.8
ENSMUST00000166729.2
polypeptide N-acetylgalactosaminyltransferase 5
chr7_+_78922947 2.47 ENSMUST00000037315.13
abhydrolase domain containing 2
chr3_-_86455575 2.12 ENSMUST00000077524.4
mab-21-like 2
chr7_+_83281193 2.04 ENSMUST00000117410.2
StAR-related lipid transfer (START) domain containing 5
chr7_-_45159739 1.98 ENSMUST00000211682.2
ENSMUST00000033096.16
ENSMUST00000209436.2
ENSMUST00000211343.2
nucleobindin 1
chr6_-_87312743 1.97 ENSMUST00000042025.12
ENSMUST00000205033.2
anthrax toxin receptor 1
chr7_+_79944198 1.89 ENSMUST00000163812.9
ENSMUST00000047558.14
ENSMUST00000174199.8
ENSMUST00000173824.8
ENSMUST00000174172.8
protein regulator of cytokinesis 1
chr5_+_110987839 1.82 ENSMUST00000200172.2
ENSMUST00000066160.3
checkpoint kinase 2
chr4_+_135870808 1.82 ENSMUST00000008016.3
inhibitor of DNA binding 3
chr6_-_87312681 1.79 ENSMUST00000204805.3
anthrax toxin receptor 1
chr14_+_51333816 1.77 ENSMUST00000169895.3
ribonuclease, RNase A family 4
chr4_-_45532470 1.74 ENSMUST00000147448.2
src homology 2 domain-containing transforming protein B
chr2_-_150510116 1.68 ENSMUST00000028944.4
acyl-CoA synthetase short-chain family member 1
chr12_-_104439589 1.63 ENSMUST00000021513.6
goosecoid homeobox
chr11_+_114559350 1.62 ENSMUST00000106602.10
ENSMUST00000077915.10
ENSMUST00000106599.8
ENSMUST00000082092.5
ribosomal protein L38
chr7_-_45159790 1.59 ENSMUST00000211765.2
nucleobindin 1
chr17_-_36501112 1.49 ENSMUST00000025312.13
ENSMUST00000102675.10
histocompatibility 2, T region locus 3
chr7_+_43339842 1.33 ENSMUST00000056329.7
kallikrein related-peptidase 14
chr6_-_129599645 1.28 ENSMUST00000032252.8
killer cell lectin-like receptor subfamily K, member 1
chr18_-_88912446 1.27 ENSMUST00000070116.12
ENSMUST00000125362.8
suppressor of cytokine signaling 6
chr4_+_19818718 1.21 ENSMUST00000035890.8
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr6_+_86348286 1.20 ENSMUST00000089558.7
small nuclear ribonucleoprotein polypeptide G
chr14_-_73286535 1.06 ENSMUST00000169168.3
cysteinyl leukotriene receptor 2
chr14_-_73286504 1.04 ENSMUST00000044664.12
cysteinyl leukotriene receptor 2
chr2_-_45002902 1.04 ENSMUST00000076836.13
ENSMUST00000176732.8
ENSMUST00000200844.4
zinc finger E-box binding homeobox 2
chr14_+_53562089 1.03 ENSMUST00000178100.3
T cell receptor alpha variable 7N-6
chr11_-_99265721 1.00 ENSMUST00000006963.3
keratin 28
chr12_-_83968507 0.90 ENSMUST00000222439.2
ENSMUST00000135962.8
ENSMUST00000155112.8
ENSMUST00000136848.8
ENSMUST00000126943.2
ENSMUST00000117217.8
NUMB endocytic adaptor protein
chr4_+_134124691 0.90 ENSMUST00000105870.8
platelet-activating factor acetylhydrolase 2
chr15_-_101801351 0.89 ENSMUST00000100179.2
keratin 76
chr17_-_24054717 0.82 ENSMUST00000059906.8
protease, serine 33
chr2_-_152857239 0.79 ENSMUST00000028972.9
p53 and DNA damage regulated 1
chr17_-_57554631 0.75 ENSMUST00000233568.2
ENSMUST00000005975.8
G protein-coupled receptor 108
chr18_-_88912415 0.68 ENSMUST00000145120.3
suppressor of cytokine signaling 6
chr3_-_154034271 0.67 ENSMUST00000204403.2
LIM homeobox protein 8
chr5_+_110988095 0.65 ENSMUST00000198373.2
checkpoint kinase 2
chr15_+_101371353 0.64 ENSMUST00000088049.5
keratin 86
chr17_-_36008863 0.62 ENSMUST00000146472.8
discoidin domain receptor family, member 1
chr19_-_56810593 0.61 ENSMUST00000118592.8
coiled-coil domain containing 186
chr4_+_80752535 0.56 ENSMUST00000102831.8
tyrosinase-related protein 1
chr5_-_87630117 0.54 ENSMUST00000079811.13
ENSMUST00000144144.3
UDP glucuronosyltransferase 2 family, polypeptide A2
chr7_+_126808016 0.54 ENSMUST00000206204.2
ENSMUST00000206772.2
myosin light chain, phosphorylatable, fast skeletal muscle
chr13_+_23930717 0.52 ENSMUST00000099703.5
H2B clustered histone 3
chr10_-_107321938 0.51 ENSMUST00000000445.2
myogenic factor 5
chr10_-_80257681 0.49 ENSMUST00000156244.2
transcription factor 3
chr1_-_144427302 0.43 ENSMUST00000184189.3
regulator of G-protein signalling 21
chr2_-_84545504 0.42 ENSMUST00000035840.6
zinc finger, DHHC domain containing 5
chr13_+_118851214 0.41 ENSMUST00000022246.9
fibroblast growth factor 10
chr10_+_99099084 0.39 ENSMUST00000020118.5
ENSMUST00000220291.2
dual specificity phosphatase 6
chr7_-_4909515 0.33 ENSMUST00000210663.2
predicted gene, 36210
chr11_+_62770275 0.29 ENSMUST00000014321.5
trans-golgi network vesicle protein 23B
chr9_+_106048116 0.29 ENSMUST00000020490.13
WD repeat domain containing 82
chr4_+_80752360 0.28 ENSMUST00000133655.8
ENSMUST00000006151.13
tyrosinase-related protein 1
chr19_-_41921676 0.27 ENSMUST00000075280.12
ENSMUST00000112123.4
exosome component 1
chr14_+_53698556 0.27 ENSMUST00000181728.3
T cell receptor alpha variable 7-4
chr11_-_99494134 0.26 ENSMUST00000072306.4
predicted gene 11938
chr5_+_73164226 0.21 ENSMUST00000031127.11
ENSMUST00000201304.2
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr11_+_6366259 0.20 ENSMUST00000213200.2
peptidylprolyl isomerase A
chr7_-_106341163 0.19 ENSMUST00000050541.5
olfactory receptor 697
chr3_+_96537484 0.17 ENSMUST00000200647.2
RNA binding motif protein 8a
chr8_-_33374825 0.16 ENSMUST00000238791.2
neuregulin 1
chr9_-_56151334 0.16 ENSMUST00000188142.7
pseudopodium-enriched atypical kinase 1
chr3_+_96537235 0.15 ENSMUST00000048915.11
ENSMUST00000196456.5
ENSMUST00000198027.5
RNA binding motif protein 8a
chr19_-_12209960 0.13 ENSMUST00000207710.3
olfactory receptor 1432
chr16_-_58940431 0.12 ENSMUST00000072608.2
olfactory receptor 194
chr8_-_23727639 0.10 ENSMUST00000033950.7
GINS complex subunit 4 (Sld5 homolog)
chr14_+_52892115 0.08 ENSMUST00000198019.2
T cell receptor alpha variable 7-1
chr3_+_59914164 0.07 ENSMUST00000169794.2
arylacetamide deacetylase like 2
chr14_+_53007210 0.06 ENSMUST00000178768.4
T cell receptor alpha variable 7D-4
chr4_+_136038243 0.05 ENSMUST00000131671.8
heterogeneous nuclear ribonucleoprotein R
chr19_-_12147438 0.03 ENSMUST00000207679.3
ENSMUST00000219261.2
olfactory receptor 1555, pseudogene 1
chr2_+_3115250 0.03 ENSMUST00000072955.12
family with sequence similarity 171, member A1
chr7_-_126496534 0.03 ENSMUST00000120007.8
transmembrane protein 219
chr7_+_140147799 0.02 ENSMUST00000210973.3
olfactory receptor 538
chr6_+_136530970 0.00 ENSMUST00000189535.2
activating transcription factor 7 interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.9 4.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.9 3.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 4.4 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023) positive regulation of somatostatin secretion(GO:0090274)
0.6 3.8 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.6 2.5 GO:0051325 interphase(GO:0051325) mitotic interphase(GO:0051329)
0.6 1.7 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.5 4.3 GO:0048539 bone marrow development(GO:0048539)
0.4 1.3 GO:0030887 positive regulation of myeloid dendritic cell activation(GO:0030887)
0.4 2.9 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.3 0.9 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.3 0.8 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.3 9.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 1.0 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.6 GO:0014029 neural crest formation(GO:0014029)
0.1 1.6 GO:0048318 axial mesoderm development(GO:0048318)
0.1 0.4 GO:0060435 bronchiole development(GO:0060435) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.1 2.5 GO:0032570 response to progesterone(GO:0032570)
0.1 1.3 GO:0007320 insemination(GO:0007320)
0.1 1.9 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.0 GO:0035376 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 0.5 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 3.1 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.1 0.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.1 0.5 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 2.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 1.8 GO:0030903 notochord development(GO:0030903)
0.0 0.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.9 GO:0048733 sebaceous gland development(GO:0048733)
0.0 1.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.9 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 2.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.3 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 1.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
1.2 3.6 GO:0005588 collagen type V trimer(GO:0005588)
0.6 3.6 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.5 1.6 GO:0070992 translation initiation complex(GO:0070992)
0.2 3.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 2.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 2.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.2 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.9 GO:0070938 contractile ring(GO:0070938)
0.1 2.9 GO:0042588 zymogen granule(GO:0042588)
0.1 0.8 GO:0016272 prefoldin complex(GO:0016272)
0.1 4.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 1.9 GO:0001772 immunological synapse(GO:0001772)
0.0 4.4 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.5 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.5 4.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.4 1.3 GO:0032394 MHC class Ib receptor activity(GO:0032394)
0.4 2.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 1.7 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 2.7 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.3 2.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 2.0 GO:0032052 bile acid binding(GO:0032052)
0.2 2.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.8 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 2.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 0.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 3.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.8 GO:0005518 collagen binding(GO:0005518)
0.0 3.3 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.3 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 4.4 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 1.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.9 GO:0019894 kinesin binding(GO:0019894)
0.0 1.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.8 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.2 GO:0015297 antiporter activity(GO:0015297)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 4.7 PID AURORA B PATHWAY Aurora B signaling
0.1 2.5 PID ATM PATHWAY ATM pathway
0.1 3.6 NABA COLLAGENS Genes encoding collagen proteins
0.1 5.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 3.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 3.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 2.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 1.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 3.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 4.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.9 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 2.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 2.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 4.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.9 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling