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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hnf1a

Z-value: 5.10

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
Hnf1a
ENSMUSG00000029556.13 Hnf1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1amm39_v1_chr5_-_115109118_1151091380.857.7e-21Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_90666791 128.24 ENSMUST00000113179.9
ENSMUST00000128740.2
Afm
afamin
chr2_+_163389068 113.28 ENSMUST00000109411.8
ENSMUST00000018094.13
Hnf4a
hepatic nuclear factor 4, alpha
chr12_-_103739847 99.65 ENSMUST00000078869.6
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr12_-_103829810 96.60 ENSMUST00000085056.8
ENSMUST00000072876.12
ENSMUST00000124717.2
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr5_-_89605622 95.68 ENSMUST00000049209.13
Gc
vitamin D binding protein
chr12_-_103704417 90.09 ENSMUST00000095450.11
ENSMUST00000187220.2
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr19_+_42034231 80.96 ENSMUST00000172244.8
ENSMUST00000081714.5
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr17_-_35351026 77.74 ENSMUST00000025249.7
Apom
apolipoprotein M
chr5_+_90608751 76.90 ENSMUST00000031314.10
Alb
albumin
chr1_+_88139678 74.59 ENSMUST00000073049.7
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr12_-_103923145 73.48 ENSMUST00000085054.5
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr17_+_12597490 72.10 ENSMUST00000014578.7
Plg
plasminogen
chr19_+_56276375 72.06 ENSMUST00000166049.8
Habp2
hyaluronic acid binding protein 2
chr11_+_101258368 71.94 ENSMUST00000019469.3
G6pc
glucose-6-phosphatase, catalytic
chr12_-_103871146 71.84 ENSMUST00000074051.6
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr2_+_163348728 71.69 ENSMUST00000143911.8
Hnf4a
hepatic nuclear factor 4, alpha
chr3_-_82957104 67.99 ENSMUST00000048246.5
Fgb
fibrinogen beta chain
chr2_-_91466739 64.17 ENSMUST00000111335.2
ENSMUST00000028681.15
F2
coagulation factor II
chr10_+_60925130 63.72 ENSMUST00000020298.8
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr5_+_35198853 62.44 ENSMUST00000030985.10
ENSMUST00000202573.2
Hgfac
hepatocyte growth factor activator
chr6_+_141575226 62.07 ENSMUST00000042812.9
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr19_+_56276343 61.68 ENSMUST00000095948.11
Habp2
hyaluronic acid binding protein 2
chr3_+_129630380 59.70 ENSMUST00000077918.7
Cfi
complement component factor i
chr12_-_103623418 59.09 ENSMUST00000044159.7
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr10_+_60925108 58.01 ENSMUST00000218005.2
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr7_+_30193047 51.87 ENSMUST00000058280.13
ENSMUST00000133318.8
ENSMUST00000142575.8
ENSMUST00000131040.2
Prodh2
proline dehydrogenase (oxidase) 2
chr2_+_162829250 51.39 ENSMUST00000018012.14
Sgk2
serum/glucocorticoid regulated kinase 2
chrX_+_100420873 51.34 ENSMUST00000052130.14
Gjb1
gap junction protein, beta 1
chr1_+_172525613 51.06 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr1_-_130589349 48.64 ENSMUST00000027657.14
C4bp
complement component 4 binding protein
chr7_+_140343652 48.38 ENSMUST00000026552.9
ENSMUST00000209253.2
ENSMUST00000210235.2
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr2_-_34990689 46.94 ENSMUST00000226631.2
ENSMUST00000045776.5
ENSMUST00000226972.2
AI182371
expressed sequence AI182371
chr1_-_130589321 46.26 ENSMUST00000137276.3
C4bp
complement component 4 binding protein
chr9_+_21746785 45.55 ENSMUST00000058777.8
Angptl8
angiopoietin-like 8
chr3_+_82933383 44.92 ENSMUST00000029630.15
ENSMUST00000166581.4
Fga
fibrinogen alpha chain
chr11_-_11848107 44.73 ENSMUST00000178704.8
Ddc
dopa decarboxylase
chr2_+_162829422 44.22 ENSMUST00000117123.2
Sgk2
serum/glucocorticoid regulated kinase 2
chr12_-_103597663 43.34 ENSMUST00000121625.2
ENSMUST00000044231.12
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_133237516 40.73 ENSMUST00000094557.7
ENSMUST00000192465.2
ENSMUST00000193888.6
ENSMUST00000194044.6
ENSMUST00000184603.8
Golt1a
Gm28040
Gm28040
golgi transport 1A
predicted gene, 28040
predicted gene, 28040
chr4_+_138694422 38.67 ENSMUST00000116094.5
ENSMUST00000239443.2
Rnf186
ring finger protein 186
chr5_+_33261563 38.60 ENSMUST00000011178.5
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr14_+_51333816 38.53 ENSMUST00000169895.3
Rnase4
ribonuclease, RNase A family 4
chr11_-_11848044 38.14 ENSMUST00000066237.10
Ddc
dopa decarboxylase
chr1_+_88066086 37.68 ENSMUST00000014263.6
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr7_-_79492091 37.13 ENSMUST00000049004.8
Anpep
alanyl (membrane) aminopeptidase
chr2_-_34951443 36.57 ENSMUST00000028233.7
Hc
hemolytic complement
chr15_+_10216041 35.90 ENSMUST00000130720.8
Prlr
prolactin receptor
chr9_-_70841881 35.17 ENSMUST00000214995.2
Lipc
lipase, hepatic
chrX_+_100419965 34.35 ENSMUST00000119080.8
Gjb1
gap junction protein, beta 1
chr1_+_87998487 33.62 ENSMUST00000073772.5
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr9_-_106035308 32.95 ENSMUST00000159809.2
ENSMUST00000162562.2
ENSMUST00000036382.13
Glyctk
glycerate kinase
chr9_-_70842090 32.08 ENSMUST00000034731.10
Lipc
lipase, hepatic
chr5_+_31454787 31.23 ENSMUST00000201166.4
ENSMUST00000072228.9
Gckr
glucokinase regulatory protein
chr11_+_70410445 29.54 ENSMUST00000179000.2
Gltpd2
glycolipid transfer protein domain containing 2
chr8_-_122671588 29.40 ENSMUST00000057653.8
Car5a
carbonic anhydrase 5a, mitochondrial
chr13_+_55300453 29.39 ENSMUST00000005452.6
Fgfr4
fibroblast growth factor receptor 4
chr13_+_54849268 29.16 ENSMUST00000037145.8
Cdhr2
cadherin-related family member 2
chr4_+_150938376 29.03 ENSMUST00000073600.9
Errfi1
ERBB receptor feedback inhibitor 1
chr5_+_31454939 28.98 ENSMUST00000201675.3
Gckr
glucokinase regulatory protein
chr11_+_7147779 28.89 ENSMUST00000020704.8
Igfbp1
insulin-like growth factor binding protein 1
chr9_-_106035332 28.16 ENSMUST00000112543.9
Glyctk
glycerate kinase
chr16_-_38253507 27.75 ENSMUST00000002926.8
Pla1a
phospholipase A1 member A
chr10_+_34359513 27.01 ENSMUST00000170771.3
Frk
fyn-related kinase
chr10_+_34359395 25.81 ENSMUST00000019913.15
Frk
fyn-related kinase
chr7_+_127865472 25.80 ENSMUST00000033045.11
Slc5a2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr3_+_3573084 25.08 ENSMUST00000108393.8
Hnf4g
hepatocyte nuclear factor 4, gamma
chr7_+_140795866 24.97 ENSMUST00000210993.2
ENSMUST00000133763.8
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr11_-_78313043 24.24 ENSMUST00000001122.6
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr7_+_51537645 24.07 ENSMUST00000208711.2
Gas2
growth arrest specific 2
chr1_-_173105344 23.67 ENSMUST00000111224.5
Mptx2
mucosal pentraxin 2
chr7_+_140796537 23.41 ENSMUST00000141804.2
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr11_-_84058292 23.29 ENSMUST00000050771.8
Gm11437
predicted gene 11437
chr18_-_43870622 21.67 ENSMUST00000025381.4
Spink1
serine peptidase inhibitor, Kazal type 1
chr4_-_94538370 21.60 ENSMUST00000053419.9
Lrrc19
leucine rich repeat containing 19
chr2_+_110427643 21.38 ENSMUST00000045972.13
ENSMUST00000111026.3
Slc5a12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr7_+_140796096 21.28 ENSMUST00000153081.2
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr7_-_119078472 21.14 ENSMUST00000209095.2
ENSMUST00000033263.6
ENSMUST00000207261.2
Umod
uromodulin
chr9_-_76953070 20.99 ENSMUST00000034911.7
Tinag
tubulointerstitial nephritis antigen
chr17_+_12803019 20.09 ENSMUST00000046959.9
ENSMUST00000233066.2
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
chrX_+_162873183 19.96 ENSMUST00000015545.10
Cltrn
collectrin, amino acid transport regulator
chr19_-_43879031 19.38 ENSMUST00000212048.2
Dnmbp
dynamin binding protein
chr1_-_20688196 19.14 ENSMUST00000088448.12
Pkhd1
polycystic kidney and hepatic disease 1
chr10_+_87695117 18.73 ENSMUST00000105300.9
Igf1
insulin-like growth factor 1
chr7_-_119078330 18.28 ENSMUST00000207460.2
Umod
uromodulin
chr15_-_58261093 17.80 ENSMUST00000227274.3
Anxa13
annexin A13
chr10_+_87694924 17.78 ENSMUST00000095360.11
Igf1
insulin-like growth factor 1
chr12_-_103623354 16.66 ENSMUST00000152517.2
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr11_+_83742961 16.60 ENSMUST00000146786.8
Hnf1b
HNF1 homeobox B
chr11_+_70410009 16.46 ENSMUST00000057685.3
Gltpd2
glycolipid transfer protein domain containing 2
chr12_+_59142439 15.76 ENSMUST00000219140.3
Mia2
MIA SH3 domain ER export factor 2
chr2_-_32314017 15.72 ENSMUST00000113307.9
Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr4_-_63090355 15.00 ENSMUST00000156618.9
ENSMUST00000030042.3
Kif12
kinesin family member 12
chrX_-_137985960 14.81 ENSMUST00000033626.15
ENSMUST00000060824.4
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_71070506 14.54 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr2_-_134396268 13.73 ENSMUST00000028704.3
Hao1
hydroxyacid oxidase 1, liver
chr6_-_52217821 12.55 ENSMUST00000121043.2
Hoxa10
homeobox A10
chr4_+_119494901 12.08 ENSMUST00000024015.3
Guca2a
guanylate cyclase activator 2a (guanylin)
chr3_+_14545751 11.67 ENSMUST00000037321.8
ENSMUST00000120484.8
ENSMUST00000120801.2
Slc7a12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr8_-_65489791 11.17 ENSMUST00000124790.8
Apela
apelin receptor early endogenous ligand
chr11_+_115802828 10.58 ENSMUST00000132961.2
Smim6
small integral membrane protein 6
chr8_-_105350881 8.20 ENSMUST00000211903.2
Cdh16
cadherin 16
chr14_+_80237691 7.95 ENSMUST00000228749.2
ENSMUST00000088735.4
Olfm4
olfactomedin 4
chr8_-_105350533 7.35 ENSMUST00000212662.2
Cdh16
cadherin 16
chr8_-_65489834 7.17 ENSMUST00000142822.4
Apela
apelin receptor early endogenous ligand
chr8_-_105350816 7.15 ENSMUST00000212447.2
Cdh16
cadherin 16
chrX_-_137985979 7.07 ENSMUST00000152457.2
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr8_-_105350898 6.98 ENSMUST00000212882.2
ENSMUST00000163783.4
Cdh16
cadherin 16
chr8_+_117822593 6.96 ENSMUST00000034308.16
ENSMUST00000176860.2
Bco1
beta-carotene oxygenase 1
chr8_-_95869114 6.74 ENSMUST00000212554.2
ENSMUST00000169748.9
ENSMUST00000034240.15
Kifc3
kinesin family member C3
chr7_-_44711771 6.67 ENSMUST00000210101.2
ENSMUST00000209219.2
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr10_-_125164399 6.60 ENSMUST00000063318.10
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr2_+_74557418 6.35 ENSMUST00000111980.4
Hoxd4
homeobox D4
chr8_+_123920682 6.12 ENSMUST00000212409.2
Dpep1
dipeptidase 1
chr8_-_105350842 5.86 ENSMUST00000212324.2
Cdh16
cadherin 16
chr12_+_76580386 5.41 ENSMUST00000219063.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr8_-_107792264 5.20 ENSMUST00000034393.7
Tmed6
transmembrane p24 trafficking protein 6
chr1_+_174158083 4.63 ENSMUST00000027816.5
Mptx1
mucosal pentraxin 1
chr7_-_101519872 4.51 ENSMUST00000106986.9
Folr1
folate receptor 1 (adult)
chr10_+_75983285 4.03 ENSMUST00000020450.4
Slc5a4a
solute carrier family 5, member 4a
chr7_-_101519791 3.73 ENSMUST00000124026.8
Folr1
folate receptor 1 (adult)
chr5_+_88032867 3.54 ENSMUST00000129757.9
Odam
odontogenic, ameloblast asssociated
chr8_+_123920233 3.45 ENSMUST00000212773.2
Dpep1
dipeptidase 1
chr17_+_71511642 3.41 ENSMUST00000126681.8
Lpin2
lipin 2
chr11_+_78068931 2.79 ENSMUST00000147819.8
Tlcd1
TLC domain containing 1
chr5_+_88635834 2.61 ENSMUST00000199104.5
ENSMUST00000031222.9
Enam
enamelin
chr10_+_115653152 2.51 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
Tspan8
tetraspanin 8
chr5_-_114796425 2.45 ENSMUST00000112225.8
ENSMUST00000071968.9
Trpv4
transient receptor potential cation channel, subfamily V, member 4
chr6_+_29859685 2.35 ENSMUST00000134438.2
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr6_-_23248361 2.08 ENSMUST00000031709.7
Fezf1
Fez family zinc finger 1
chr4_+_11758147 1.87 ENSMUST00000029871.12
ENSMUST00000108303.2
Cdh17
cadherin 17
chr7_-_101519914 1.84 ENSMUST00000106985.8
ENSMUST00000151706.8
Folr1
folate receptor 1 (adult)
chr6_+_29859660 1.71 ENSMUST00000128927.9
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr11_+_118319029 1.05 ENSMUST00000124861.2
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr6_+_29859372 0.74 ENSMUST00000115238.10
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr7_-_103218350 0.63 ENSMUST00000217293.2
Olfr616
olfactory receptor 616
chr5_+_122529941 0.54 ENSMUST00000102525.11
Arpc3
actin related protein 2/3 complex, subunit 3
chr15_+_7840327 0.53 ENSMUST00000022744.5
Gdnf
glial cell line derived neurotrophic factor
chr18_+_65158873 0.46 ENSMUST00000226058.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr1_-_82746169 0.32 ENSMUST00000027331.3
Tm4sf20
transmembrane 4 L six family member 20
chr19_-_47907628 0.27 ENSMUST00000237029.2
Itprip
inositol 1,4,5-triphosphate receptor interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
61.7 185.0 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
28.2 112.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
25.9 77.7 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
25.6 76.9 GO:0051659 maintenance of mitochondrion location(GO:0051659)
24.9 74.6 GO:0018879 biphenyl metabolic process(GO:0018879)
20.2 81.0 GO:0009436 glyoxylate catabolic process(GO:0009436)
17.3 51.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
14.4 72.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
13.4 67.2 GO:0034371 chylomicron remodeling(GO:0034371)
12.8 64.2 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
12.2 121.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
11.8 82.9 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
9.9 39.4 GO:0072023 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
9.8 29.4 GO:0061144 alveolar secondary septum development(GO:0061144)
8.6 60.2 GO:0009750 response to fructose(GO:0009750)
7.7 38.6 GO:0001951 intestinal D-glucose absorption(GO:0001951)
7.6 45.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
7.3 36.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
7.3 21.9 GO:0033189 response to vitamin A(GO:0033189)
7.3 29.0 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
7.2 71.9 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
7.1 85.7 GO:0015868 purine ribonucleotide transport(GO:0015868)
6.5 71.3 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
6.4 51.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
6.0 35.9 GO:0038161 prolactin signaling pathway(GO:0038161)
5.8 29.2 GO:1904970 brush border assembly(GO:1904970)
5.4 21.7 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
5.2 36.5 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
4.8 95.7 GO:0042359 vitamin D metabolic process(GO:0042359)
4.2 16.6 GO:0061206 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
4.0 63.9 GO:0006857 oligopeptide transport(GO:0006857)
3.6 14.5 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
2.7 13.7 GO:0009441 glycolate metabolic process(GO:0009441)
2.7 138.3 GO:0051180 vitamin transport(GO:0051180)
2.4 9.6 GO:0016999 antibiotic metabolic process(GO:0016999)
2.4 75.8 GO:0008211 glucocorticoid metabolic process(GO:0008211)
1.9 48.4 GO:0017144 drug metabolic process(GO:0017144)
1.8 37.1 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
1.5 90.1 GO:0006953 acute-phase response(GO:0006953)
1.2 28.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.1 20.1 GO:0015697 quaternary ammonium group transport(GO:0015697)
1.0 35.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.0 154.6 GO:0006958 complement activation, classical pathway(GO:0006958)
1.0 6.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.9 6.6 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.9 2.6 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.8 2.5 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production(GO:0071640)
0.8 341.6 GO:0043434 response to peptide hormone(GO:0043434)
0.7 7.9 GO:1904659 glucose transmembrane transport(GO:1904659)
0.7 34.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.6 52.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 15.8 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.4 15.7 GO:0032094 response to food(GO:0032094)
0.4 73.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.4 7.0 GO:0042574 retinal metabolic process(GO:0042574)
0.4 19.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.3 12.6 GO:0060065 uterus development(GO:0060065)
0.3 2.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 21.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 65.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.2 38.5 GO:0009267 cellular response to starvation(GO:0009267)
0.2 45.6 GO:0006814 sodium ion transport(GO:0006814)
0.2 0.5 GO:0072107 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.1 24.1 GO:0007050 cell cycle arrest(GO:0007050)
0.1 3.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 34.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 7.9 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 1.0 GO:0090331 negative regulation of platelet aggregation(GO:0090331) positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 2.5 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 15.0 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.1 17.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 24.6 GO:0016042 lipid catabolic process(GO:0016042)
0.1 134.7 GO:0006508 proteolysis(GO:0006508)
0.1 8.6 GO:0006865 amino acid transport(GO:0006865)
0.1 10.7 GO:0007369 gastrulation(GO:0007369)
0.1 3.5 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 15.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 4.3 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 77.7 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
12.5 112.9 GO:0005577 fibrinogen complex(GO:0005577)
12.0 72.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
5.0 74.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
4.6 36.6 GO:0005579 membrane attack complex(GO:0005579)
3.7 36.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
3.2 85.7 GO:0005922 connexon complex(GO:0005922)
2.9 29.2 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
2.7 37.1 GO:0031983 vesicle lumen(GO:0031983)
1.9 67.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.4 365.0 GO:0072562 blood microparticle(GO:0072562)
0.8 27.7 GO:0002080 acrosomal membrane(GO:0002080)
0.5 71.3 GO:0031526 brush border membrane(GO:0031526)
0.5 62.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.5 107.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.5 15.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.4 6.7 GO:0005915 zonula adherens(GO:0005915)
0.4 813.7 GO:0005615 extracellular space(GO:0005615)
0.4 81.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 239.2 GO:0005667 transcription factor complex(GO:0005667)
0.3 82.9 GO:0008021 synaptic vesicle(GO:0008021)
0.2 29.4 GO:0030133 transport vesicle(GO:0030133)
0.2 57.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 15.0 GO:0005871 kinesin complex(GO:0005871)
0.2 105.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 15.7 GO:0072686 mitotic spindle(GO:0072686)
0.1 13.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 223.7 GO:0005739 mitochondrion(GO:0005739)
0.1 336.3 GO:0005576 extracellular region(GO:0005576)
0.1 32.3 GO:0009986 cell surface(GO:0009986)
0.1 37.7 GO:0005815 microtubule organizing center(GO:0005815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
61.7 185.0 GO:0070540 stearic acid binding(GO:0070540)
42.7 128.2 GO:0008431 vitamin E binding(GO:0008431)
40.6 121.7 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
23.9 95.7 GO:1902271 D3 vitamins binding(GO:1902271)
20.7 82.9 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
20.2 81.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
18.0 71.9 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
15.8 95.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
7.2 35.9 GO:0004925 prolactin receptor activity(GO:0004925)
7.1 63.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
6.7 20.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) norepinephrine transmembrane transporter activity(GO:0005333) acetate ester transmembrane transporter activity(GO:1901375)
6.4 51.1 GO:0001849 complement component C1q binding(GO:0001849)
6.0 60.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
5.8 64.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
4.8 85.7 GO:0005243 gap junction channel activity(GO:0005243)
4.5 72.1 GO:1990405 protein antigen binding(GO:1990405)
4.0 76.9 GO:0015643 toxic substance binding(GO:0015643)
3.9 46.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
3.8 95.6 GO:0017081 chloride channel regulator activity(GO:0017081)
3.6 145.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
3.5 584.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
3.4 13.7 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
3.3 39.4 GO:0019864 IgG binding(GO:0019864)
3.1 28.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
2.9 14.5 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
2.9 28.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
2.7 29.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.0 12.1 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
1.6 29.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
1.6 17.8 GO:1901611 phosphatidylglycerol binding(GO:1901611)
1.4 15.7 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
1.4 37.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
1.4 51.9 GO:0071949 FAD binding(GO:0071949)
1.4 9.6 GO:0070573 metallodipeptidase activity(GO:0070573)
1.3 48.4 GO:0016712 arachidonic acid epoxygenase activity(GO:0008392) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
1.0 236.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 10.1 GO:0051870 methotrexate binding(GO:0051870)
0.9 2.6 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.8 36.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.8 2.5 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.7 4.8 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.6 77.7 GO:0016209 antioxidant activity(GO:0016209)
0.6 52.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5 68.0 GO:0051087 chaperone binding(GO:0051087)
0.3 43.5 GO:0005179 hormone activity(GO:0005179)
0.3 36.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.3 25.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 30.2 GO:0004540 ribonuclease activity(GO:0004540)
0.2 6.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 44.9 GO:0030674 protein binding, bridging(GO:0030674)
0.2 7.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 8.6 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.2 15.0 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.5 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.1 3.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 29.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 13.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 22.0 GO:0015293 symporter activity(GO:0015293)
0.1 56.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 6.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 8.9 GO:0008017 microtubule binding(GO:0008017)
0.0 32.4 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 2.5 GO:0005178 integrin binding(GO:0005178)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 17.1 GO:0032403 protein complex binding(GO:0032403)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 432.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
3.2 112.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.5 72.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.9 254.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8 36.5 PID IGF1 PATHWAY IGF1 pathway
0.7 51.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.6 35.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.4 29.4 PID FGF PATHWAY FGF signaling pathway
0.3 12.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 37.1 PID CMYB PATHWAY C-MYB transcription factor network
0.3 19.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 20.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 5.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 21.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 26.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 48.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
10.4 177.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
9.8 108.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
7.0 76.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
6.4 51.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
6.0 210.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
4.8 101.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
4.6 59.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
3.8 82.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
3.7 85.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
2.4 132.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
2.3 95.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
2.3 67.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.8 30.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.4 20.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.4 29.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.2 35.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
1.0 14.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.8 16.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.7 24.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 64.4 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.5 135.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 3.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 3.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 6.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis