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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Hnf1a
Z-value: 5.10
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Transcription factors associated with Hnf1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf1a | mm39_v1_chr5_-_115109118_115109138 | 0.85 | 7.7e-21 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 341.6 | GO:0043434 | response to peptide hormone(GO:0043434) |
| 61.7 | 185.0 | GO:0042977 | regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569) |
| 1.0 | 154.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 2.7 | 138.3 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.1 | 134.7 | GO:0006508 | proteolysis(GO:0006508) |
| 12.2 | 121.7 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) |
| 28.2 | 112.9 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 4.8 | 95.7 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 1.5 | 90.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 7.1 | 85.7 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 813.7 | GO:0005615 | extracellular space(GO:0005615) |
| 1.4 | 365.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 336.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.4 | 239.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 223.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 12.5 | 112.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 107.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.2 | 105.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 3.2 | 85.7 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 82.9 | GO:0008021 | synaptic vesicle(GO:0008021) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 584.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.0 | 236.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 61.7 | 185.0 | GO:0070540 | stearic acid binding(GO:0070540) |
| 3.6 | 145.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 42.7 | 128.2 | GO:0008431 | vitamin E binding(GO:0008431) |
| 40.6 | 121.7 | GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124) |
| 23.9 | 95.7 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 3.8 | 95.6 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 15.8 | 95.0 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 4.8 | 85.7 | GO:0005243 | gap junction channel activity(GO:0005243) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 432.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 254.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 3.2 | 112.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.5 | 72.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.7 | 51.1 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 37.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.8 | 36.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.6 | 35.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.4 | 29.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 26.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 210.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 10.4 | 177.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.5 | 135.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.4 | 132.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 9.8 | 108.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 4.8 | 101.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 2.3 | 95.7 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 3.7 | 85.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 3.8 | 82.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 7.0 | 76.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |