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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Hnf1b
Z-value: 5.98
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Transcription factors associated with Hnf1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf1b | mm39_v1_chr11_+_83741657_83741681 | 0.70 | 7.8e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf1b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_89605622 Show fit | 115.81 |
ENSMUST00000049209.13
|
vitamin D binding protein |
|
| chr13_-_4329421 Show fit | 101.60 |
ENSMUST00000021632.5
|
aldo-keto reductase family 1, member C12 |
|
| chr2_+_163389068 Show fit | 100.41 |
ENSMUST00000109411.8
ENSMUST00000018094.13 |
hepatic nuclear factor 4, alpha |
|
| chr8_-_5155347 Show fit | 95.74 |
ENSMUST00000023835.3
|
solute carrier family 10, member 2 |
|
| chr5_-_87716882 Show fit | 95.35 |
ENSMUST00000113314.3
|
sulfotransferase family 1D, member 1 |
|
| chr13_+_4241149 Show fit | 93.10 |
ENSMUST00000021634.4
|
aldo-keto reductase family 1, member C13 |
|
| chr5_+_90666791 Show fit | 82.27 |
ENSMUST00000113179.9
ENSMUST00000128740.2 |
afamin |
|
| chr13_+_4283729 Show fit | 77.65 |
ENSMUST00000081326.7
|
aldo-keto reductase family 1, member C19 |
|
| chr19_+_43770619 Show fit | 73.14 |
ENSMUST00000026208.6
|
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
|
| chr10_+_62897353 Show fit | 72.33 |
ENSMUST00000178684.3
ENSMUST00000020266.15 |
phenazine biosynthesis-like protein domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 28.7 | 344.1 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 3.5 | 219.3 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 11.9 | 179.2 | GO:0015747 | urate transport(GO:0015747) |
| 19.8 | 178.1 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 53.5 | 160.6 | GO:1902569 | regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569) |
| 13.3 | 132.9 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) |
| 0.9 | 129.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 6.4 | 115.8 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.7 | 107.7 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 3.3 | 101.4 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 884.8 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.2 | 306.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.2 | 298.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 270.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.3 | 198.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.3 | 183.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.3 | 166.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 13.9 | 125.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 121.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 100.6 | GO:0005829 | cytosol(GO:0005829) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.4 | 469.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 15.5 | 248.5 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 1.3 | 215.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 7.2 | 194.7 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 53.5 | 160.6 | GO:0070540 | stearic acid binding(GO:0070540) |
| 28.5 | 142.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.6 | 138.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 44.3 | 132.9 | GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124) |
| 29.0 | 115.8 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 4.7 | 98.1 | GO:0034185 | apolipoprotein binding(GO:0034185) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 312.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 245.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.9 | 110.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.0 | 58.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 57.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 53.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.6 | 51.9 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 44.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 41.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 34.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 204.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.5 | 183.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 16.4 | 180.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 4.6 | 160.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 13.5 | 148.3 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 3.0 | 124.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 5.8 | 98.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 1.7 | 96.9 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 3.3 | 94.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.8 | 78.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |