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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hnf1b

Z-value: 5.98

Motif logo

Transcription factors associated with Hnf1b

Gene Symbol Gene ID Gene Info
ENSMUSG00000020679.12 Hnf1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1bmm39_v1_chr11_+_83741657_837416810.707.8e-12Click!

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_-_89605622 115.81 ENSMUST00000049209.13
vitamin D binding protein
chr13_-_4329421 101.60 ENSMUST00000021632.5
aldo-keto reductase family 1, member C12
chr2_+_163389068 100.41 ENSMUST00000109411.8
ENSMUST00000018094.13
hepatic nuclear factor 4, alpha
chr8_-_5155347 95.74 ENSMUST00000023835.3
solute carrier family 10, member 2
chr5_-_87716882 95.35 ENSMUST00000113314.3
sulfotransferase family 1D, member 1
chr13_+_4241149 93.10 ENSMUST00000021634.4
aldo-keto reductase family 1, member C13
chr5_+_90666791 82.27 ENSMUST00000113179.9
ENSMUST00000128740.2
afamin
chr13_+_4283729 77.65 ENSMUST00000081326.7
aldo-keto reductase family 1, member C19
chr19_+_43770619 73.14 ENSMUST00000026208.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr10_+_62897353 72.33 ENSMUST00000178684.3
ENSMUST00000020266.15
phenazine biosynthesis-like protein domain containing 1
chr10_+_60925130 69.44 ENSMUST00000020298.8
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr11_+_101258368 69.26 ENSMUST00000019469.3
glucose-6-phosphatase, catalytic
chr1_+_87983099 67.77 ENSMUST00000138182.8
ENSMUST00000113142.10
UDP glycosyltransferase 1 family, polypeptide A10
chr13_+_24023428 66.74 ENSMUST00000091698.12
ENSMUST00000110422.3
ENSMUST00000166467.9
solute carrier family 17 (sodium phosphate), member 3
chr13_+_93810911 66.73 ENSMUST00000048001.8
dimethylglycine dehydrogenase precursor
chr1_+_88139678 65.90 ENSMUST00000073049.7
UDP glucuronosyltransferase 1 family, polypeptide A1
chr7_+_30193047 65.56 ENSMUST00000058280.13
ENSMUST00000133318.8
ENSMUST00000142575.8
ENSMUST00000131040.2
proline dehydrogenase (oxidase) 2
chr10_+_60925108 63.42 ENSMUST00000218005.2
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr2_+_163348728 60.16 ENSMUST00000143911.8
hepatic nuclear factor 4, alpha
chr19_+_30210320 59.65 ENSMUST00000025797.7
mannose-binding lectin (protein C) 2
chr14_-_49482846 59.42 ENSMUST00000227113.2
ENSMUST00000130853.2
ENSMUST00000228936.2
ENSMUST00000022398.15
coiled-coil domain containing 198
chr1_+_88093726 58.85 ENSMUST00000097659.5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr3_+_129630380 58.54 ENSMUST00000077918.7
complement component factor i
chr10_-_89369432 58.35 ENSMUST00000105297.2
nuclear receptor subfamily 1, group H, member 4
chr7_+_119773070 57.42 ENSMUST00000033201.7
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_+_108286114 56.19 ENSMUST00000000049.6
apolipoprotein H
chr3_-_82957104 55.69 ENSMUST00000048246.5
fibrinogen beta chain
chr1_+_87998487 52.94 ENSMUST00000073772.5
UDP glucuronosyltransferase 1 family, polypeptide A9
chr5_+_90608751 52.57 ENSMUST00000031314.10
albumin
chr17_+_12597490 52.24 ENSMUST00000014578.7
plasminogen
chr6_+_90310252 52.09 ENSMUST00000046128.12
ENSMUST00000164761.6
urocanase domain containing 1
chr4_+_98919183 51.90 ENSMUST00000030280.7
angiopoietin-like 3
chr1_+_87983189 51.87 ENSMUST00000173325.2
UDP glycosyltransferase 1 family, polypeptide A10
chr13_+_24023386 50.17 ENSMUST00000039721.14
solute carrier family 17 (sodium phosphate), member 3
chr13_+_23991010 49.37 ENSMUST00000006786.11
ENSMUST00000099697.3
solute carrier family 17 (sodium phosphate), member 2
chr1_-_172722589 48.53 ENSMUST00000027824.7
serum amyloid P-component
chr17_-_35351026 48.15 ENSMUST00000025249.7
apolipoprotein M
chr2_+_162829250 47.59 ENSMUST00000018012.14
serum/glucocorticoid regulated kinase 2
chr19_+_56276375 47.34 ENSMUST00000166049.8
hyaluronic acid binding protein 2
chr7_+_119160922 47.13 ENSMUST00000130583.2
ENSMUST00000084647.13
acyl-CoA synthetase medium-chain family member 2
chr5_-_87682972 47.12 ENSMUST00000120150.2
sulfotransferase family 1B, member 1
chr1_+_88066086 46.78 ENSMUST00000014263.6
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr13_-_93810808 46.27 ENSMUST00000015941.8
betaine-homocysteine methyltransferase 2
chr5_-_87240405 45.93 ENSMUST00000132667.2
ENSMUST00000145617.8
ENSMUST00000094649.11
UDP glucuronosyltransferase 2 family, polypeptide B36
chr3_-_137837117 45.89 ENSMUST00000029805.13
microsomal triglyceride transfer protein
chr16_+_22769822 45.42 ENSMUST00000023590.9
histidine-rich glycoprotein
chr19_+_42034231 45.04 ENSMUST00000172244.8
ENSMUST00000081714.5
4-hydroxy-2-oxoglutarate aldolase 1
chr13_-_24098981 42.82 ENSMUST00000110407.4
solute carrier family 17 (sodium phosphate), member 4
chr5_+_35198853 42.18 ENSMUST00000030985.10
ENSMUST00000202573.2
hepatocyte growth factor activator
chr9_+_21746785 41.91 ENSMUST00000058777.8
angiopoietin-like 8
chr6_-_24168082 41.69 ENSMUST00000031713.9
solute carrier family 13 (sodium/sulfate symporters), member 1
chr5_-_87054796 41.37 ENSMUST00000031181.16
ENSMUST00000113333.2
UDP glucuronosyltransferase 2 family, polypeptide B34
chr19_+_56276343 41.05 ENSMUST00000095948.11
hyaluronic acid binding protein 2
chr3_-_98364359 41.03 ENSMUST00000188356.3
ENSMUST00000167753.8
predicted gene 4450
chr2_+_162829422 40.84 ENSMUST00000117123.2
serum/glucocorticoid regulated kinase 2
chr3_-_98471301 40.19 ENSMUST00000058728.10
predicted gene 10681
chr13_-_24098951 39.41 ENSMUST00000021769.16
solute carrier family 17 (sodium phosphate), member 4
chr4_+_138694422 39.30 ENSMUST00000116094.5
ENSMUST00000239443.2
ring finger protein 186
chr19_-_8382424 39.10 ENSMUST00000064507.12
ENSMUST00000120540.2
ENSMUST00000096269.11
solute carrier family 22, member 30
chr11_-_11848107 38.62 ENSMUST00000178704.8
dopa decarboxylase
chrX_+_100419965 37.14 ENSMUST00000119080.8
gap junction protein, beta 1
chr1_-_130589349 36.86 ENSMUST00000027657.14
complement component 4 binding protein
chr16_+_22769844 36.85 ENSMUST00000232422.2
histidine-rich glycoprotein
chr4_-_106321363 36.63 ENSMUST00000049507.6
proprotein convertase subtilisin/kexin type 9
chr11_-_75330302 35.37 ENSMUST00000043696.9
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr5_-_87485023 35.25 ENSMUST00000031195.3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr9_-_76953070 35.23 ENSMUST00000034911.7
tubulointerstitial nephritis antigen
chr11_-_78313043 35.01 ENSMUST00000001122.6
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr1_-_130589321 34.73 ENSMUST00000137276.3
complement component 4 binding protein
chr11_-_75330415 34.27 ENSMUST00000128330.8
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr12_+_59142439 34.18 ENSMUST00000219140.3
MIA SH3 domain ER export factor 2
chr15_+_10216041 34.02 ENSMUST00000130720.8
prolactin receptor
chr1_+_133237516 33.91 ENSMUST00000094557.7
ENSMUST00000192465.2
ENSMUST00000193888.6
ENSMUST00000194044.6
ENSMUST00000184603.8
golgi transport 1A
predicted gene, 28040
predicted gene, 28040
chr12_-_103597663 33.88 ENSMUST00000121625.2
ENSMUST00000044231.12
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_34990689 32.91 ENSMUST00000226631.2
ENSMUST00000045776.5
ENSMUST00000226972.2
expressed sequence AI182371
chr3_-_98417830 32.57 ENSMUST00000196861.2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4
chr11_-_11848044 32.56 ENSMUST00000066237.10
dopa decarboxylase
chrX_+_162873183 32.25 ENSMUST00000015545.10
collectrin, amino acid transport regulator
chr13_+_55300453 31.26 ENSMUST00000005452.6
fibroblast growth factor receptor 4
chr15_-_79169671 30.90 ENSMUST00000170955.2
ENSMUST00000165408.8
BAI1-associated protein 2-like 2
chr16_-_56984137 30.72 ENSMUST00000231733.2
nitrilase family, member 2
chr11_-_84058292 30.23 ENSMUST00000050771.8
predicted gene 11437
chr11_+_4833186 30.18 ENSMUST00000139737.2
nipsnap homolog 1
chr4_-_108002186 30.12 ENSMUST00000130776.2
sterol carrier protein 2, liver
chr5_-_108823435 29.89 ENSMUST00000051757.14
solute carrier family 26 (sulfate transporter), member 1
chr11_-_73217298 29.58 ENSMUST00000155630.9
aspartoacylase
chr7_+_51537645 28.01 ENSMUST00000208711.2
growth arrest specific 2
chr9_-_106035308 27.89 ENSMUST00000159809.2
ENSMUST00000162562.2
ENSMUST00000036382.13
glycerate kinase
chr13_-_73826124 27.59 ENSMUST00000022105.15
ENSMUST00000109680.10
ENSMUST00000221026.2
ENSMUST00000109679.4
solute carrier family 6 (neurotransmitter transporter), member 18
chr2_-_164063525 26.37 ENSMUST00000018355.11
ENSMUST00000109376.9
WAP four-disulfide core domain 15B
chr7_-_119078472 26.30 ENSMUST00000209095.2
ENSMUST00000033263.6
ENSMUST00000207261.2
uromodulin
chr4_-_63090355 26.28 ENSMUST00000156618.9
ENSMUST00000030042.3
kinesin family member 12
chr2_-_34951443 26.28 ENSMUST00000028233.7
hemolytic complement
chr13_-_73826108 26.24 ENSMUST00000222029.2
ENSMUST00000223074.2
ENSMUST00000220650.2
ENSMUST00000221987.2
solute carrier family 6 (neurotransmitter transporter), member 18
chr11_+_78356523 26.10 ENSMUST00000001126.4
solute carrier family 46, member 1
chr2_+_124994425 25.69 ENSMUST00000110494.9
ENSMUST00000110495.3
ENSMUST00000028630.9
solute carrier family 12, member 1
chrX_-_161747552 25.06 ENSMUST00000038769.3
S100 calcium binding protein G
chr4_+_150938376 24.93 ENSMUST00000073600.9
ERBB receptor feedback inhibitor 1
chr15_+_100202079 24.80 ENSMUST00000230252.2
ENSMUST00000231166.2
methyltransferase like 7A1
chr13_+_54849268 24.76 ENSMUST00000037145.8
cadherin-related family member 2
chr3_+_154302989 24.63 ENSMUST00000140644.8
ENSMUST00000144764.8
ENSMUST00000155232.2
crystallin, zeta
chr9_-_70841881 24.40 ENSMUST00000214995.2
lipase, hepatic
chr17_+_57369231 24.28 ENSMUST00000097299.10
ENSMUST00000169543.8
ENSMUST00000163763.2
crumbs family member 3
chr11_+_7147779 23.91 ENSMUST00000020704.8
insulin-like growth factor binding protein 1
chr1_-_20688196 23.71 ENSMUST00000088448.12
polycystic kidney and hepatic disease 1
chr9_+_95441652 23.63 ENSMUST00000079597.7
progestin and adipoQ receptor family member IX
chr10_-_95678786 23.49 ENSMUST00000211096.2
predicted gene, 33543
chr9_-_106035332 23.29 ENSMUST00000112543.9
glycerate kinase
chr2_-_134396268 23.18 ENSMUST00000028704.3
hydroxyacid oxidase 1, liver
chr4_-_6275629 22.88 ENSMUST00000029905.2
cytochrome P450, family 7, subfamily a, polypeptide 1
chr15_+_100202061 22.60 ENSMUST00000229574.2
ENSMUST00000229217.2
methyltransferase like 7A1
chr5_+_65505657 22.46 ENSMUST00000031096.11
klotho beta
chr11_+_70410445 22.34 ENSMUST00000179000.2
glycolipid transfer protein domain containing 2
chr4_+_119494901 22.29 ENSMUST00000024015.3
guanylate cyclase activator 2a (guanylin)
chr18_-_43870622 22.15 ENSMUST00000025381.4
serine peptidase inhibitor, Kazal type 1
chr9_-_70842090 22.11 ENSMUST00000034731.10
lipase, hepatic
chr11_+_115725140 21.46 ENSMUST00000173289.8
ENSMUST00000137900.2
LLGL2 scribble cell polarity complex component
chr11_-_73217633 21.43 ENSMUST00000134079.2
aspartoacylase
chr7_-_127494750 21.27 ENSMUST00000033074.8
vitamin K epoxide reductase complex, subunit 1
chr15_+_100202021 21.01 ENSMUST00000230472.2
methyltransferase like 7A1
chr7_-_119078330 20.69 ENSMUST00000207460.2
uromodulin
chr1_+_180878797 18.45 ENSMUST00000036819.7
RIKEN cDNA 9130409I23 gene
chr15_+_54274151 18.14 ENSMUST00000036737.4
collectin sub-family member 10
chr7_-_44753168 18.10 ENSMUST00000211085.2
ENSMUST00000210642.2
ENSMUST00000003512.9
Fc fragment of IgG receptor and transporter
chr3_-_116506345 18.00 ENSMUST00000169530.2
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_+_14545751 17.99 ENSMUST00000037321.8
ENSMUST00000120484.8
ENSMUST00000120801.2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr8_-_105350881 17.31 ENSMUST00000211903.2
cadherin 16
chr6_-_38101503 17.05 ENSMUST00000040259.8
ATPase, H+ transporting, lysosomal V0 subunit A4
chr19_-_46661321 17.04 ENSMUST00000026012.8
cytochrome P450, family 17, subfamily a, polypeptide 1
chr10_-_125225298 16.73 ENSMUST00000210780.2
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr8_-_105350898 16.58 ENSMUST00000212882.2
ENSMUST00000163783.4
cadherin 16
chr7_-_28661751 16.21 ENSMUST00000068045.14
ENSMUST00000217157.2
actinin alpha 4
chr6_-_52217821 15.67 ENSMUST00000121043.2
homeobox A10
chr8_-_105350533 15.66 ENSMUST00000212662.2
cadherin 16
chr11_+_115802828 15.35 ENSMUST00000132961.2
small integral membrane protein 6
chr7_-_28661648 15.21 ENSMUST00000127210.8
actinin alpha 4
chr8_-_107792264 15.15 ENSMUST00000034393.7
transmembrane p24 trafficking protein 6
chr8_+_71176713 15.10 ENSMUST00000034307.14
ENSMUST00000239435.2
ENSMUST00000239487.2
ENSMUST00000110095.3
phosphodiesterase 4C, cAMP specific
chr8_-_105350816 14.87 ENSMUST00000212447.2
cadherin 16
chr3_-_116506294 14.55 ENSMUST00000029569.9
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr15_-_58261093 14.51 ENSMUST00000227274.3
annexin A13
chr11_+_83742961 14.50 ENSMUST00000146786.8
HNF1 homeobox B
chr9_-_119038162 14.40 ENSMUST00000084797.6
solute carrier family 22 (organic cation transporter), member 13
chr12_-_25147139 14.22 ENSMUST00000221761.2
inhibitor of DNA binding 2
chr10_-_95678748 14.01 ENSMUST00000210336.2
predicted gene, 33543
chr4_+_19818718 14.00 ENSMUST00000035890.8
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr5_+_31454939 13.89 ENSMUST00000201675.3
glucokinase regulatory protein
chr5_+_31454787 13.77 ENSMUST00000201166.4
ENSMUST00000072228.9
glucokinase regulatory protein
chr8_+_117822593 13.55 ENSMUST00000034308.16
ENSMUST00000176860.2
beta-carotene oxygenase 1
chr18_-_66155651 13.45 ENSMUST00000143990.2
lectin, mannose-binding, 1
chr19_-_46661501 13.30 ENSMUST00000236174.2
cytochrome P450, family 17, subfamily a, polypeptide 1
chr9_-_48516447 13.20 ENSMUST00000034808.12
ENSMUST00000119426.2
nicotinamide N-methyltransferase
chr15_-_57128522 13.16 ENSMUST00000137764.2
ENSMUST00000022995.13
solute carrier family 22 (organic cation transporter), member 22
chr15_+_99291491 13.04 ENSMUST00000159531.3
transmembrane BAX inhibitor motif containing 6
chr8_-_105350842 12.82 ENSMUST00000212324.2
cadherin 16
chr15_+_99291455 12.79 ENSMUST00000162624.8
transmembrane BAX inhibitor motif containing 6
chr11_+_114566257 12.58 ENSMUST00000045779.6
tweety family member 2
chrX_-_137985960 12.44 ENSMUST00000033626.15
ENSMUST00000060824.4
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_-_38649291 12.10 ENSMUST00000129099.8
solute carrier family 2 (facilitated glucose transporter), member 9
chr17_+_57369490 11.97 ENSMUST00000163628.2
crumbs family member 3
chr1_-_136888118 11.93 ENSMUST00000192357.6
ENSMUST00000027649.14
nuclear receptor subfamily 5, group A, member 2
chr1_+_58834621 11.81 ENSMUST00000191201.7
caspase 8
chr5_-_35886605 11.25 ENSMUST00000070203.14
SH3 domain and tetratricopeptide repeats 1
chr1_+_130659700 11.18 ENSMUST00000039323.8
expressed sequence AA986860
chr11_+_70410009 10.74 ENSMUST00000057685.3
glycolipid transfer protein domain containing 2
chr5_-_44259010 10.53 ENSMUST00000087441.11
prominin 1
chr2_+_3771709 10.51 ENSMUST00000177037.2
family with sequence similarity 107, member B
chr7_-_119494669 10.22 ENSMUST00000098080.9
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr8_+_123920682 10.20 ENSMUST00000212409.2
dipeptidase 1
chr1_+_19279138 10.05 ENSMUST00000027059.11
transcription factor AP-2 beta
chr11_+_110858882 9.81 ENSMUST00000125692.2
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_-_134289670 9.78 ENSMUST00000049470.11
transmembrane protein 183A
chr7_+_140796096 9.54 ENSMUST00000153081.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr5_-_44259293 9.48 ENSMUST00000074113.13
prominin 1
chr12_-_8589545 9.36 ENSMUST00000095863.10
ENSMUST00000165657.3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
chr1_+_19279178 9.36 ENSMUST00000187754.7
transcription factor AP-2 beta
chr11_+_110858842 9.12 ENSMUST00000180023.8
ENSMUST00000106636.8
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_+_58834532 8.87 ENSMUST00000027189.15
caspase 8
chr19_-_8196196 8.82 ENSMUST00000113298.9
solute carrier family 22. member 29
chr3_-_144555062 8.76 ENSMUST00000159989.2
chloride channel accessory 3B
chr3_+_85946145 8.69 ENSMUST00000238331.2
SH3 domain protein D19
chr3_-_108133914 8.32 ENSMUST00000141387.4
synaptophysin-like 2
chr7_-_44711771 7.66 ENSMUST00000210101.2
ENSMUST00000209219.2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr1_+_133173826 7.37 ENSMUST00000105082.9
ENSMUST00000038295.15
pleckstrin homology domain containing, family A member 6
chr4_-_150993886 7.33 ENSMUST00000128075.8
Parkinson disease (autosomal recessive, early onset) 7
chr10_+_101994841 7.22 ENSMUST00000020039.13
MGAT4 family, member C
chr8_+_123920233 7.16 ENSMUST00000212773.2
dipeptidase 1
chr19_+_5928649 7.01 ENSMUST00000136833.8
ENSMUST00000141362.2
solute carrier family 25, member 45
chr16_-_92155762 6.47 ENSMUST00000166707.3
potassium voltage-gated channel, Isk-related subfamily, member 1
chr6_+_139564196 6.43 ENSMUST00000188066.2
ENSMUST00000190962.7
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr17_-_35265514 6.39 ENSMUST00000007250.14
mutS homolog 5
chr7_+_130633776 6.18 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
deleted in malignant brain tumors 1
chr10_-_89457115 6.13 ENSMUST00000020102.14
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr6_-_129077867 6.13 ENSMUST00000032258.8
C-type lectin domain family 2, member e
chr17_+_74702601 5.83 ENSMUST00000024870.9
ENSMUST00000179074.9
ENSMUST00000233799.2
ENSMUST00000233042.2
solute carrier family 30 (zinc transporter), member 6
chrX_-_137985979 5.74 ENSMUST00000152457.2
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_71070506 5.69 ENSMUST00000074465.9
aquaporin 9
chr7_-_101519872 5.56 ENSMUST00000106986.9
folate receptor 1 (adult)
chr3_+_69129745 5.42 ENSMUST00000183126.2
ADP-ribosylation factor-like 14
chr1_+_171954316 5.37 ENSMUST00000075895.9
ENSMUST00000111252.4
peroxisomal biogenesis factor 19

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
53.5 160.6 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
28.7 344.1 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
27.4 82.3 GO:0097037 heme export(GO:0097037)
24.1 72.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
22.6 90.5 GO:0016999 antibiotic metabolic process(GO:0016999)
21.9 65.6 GO:0010133 proline catabolic process to glutamate(GO:0010133)
19.8 178.1 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
17.5 52.6 GO:0051659 maintenance of mitochondrion location(GO:0051659)
16.4 82.2 GO:1904970 brush border assembly(GO:1904970)
16.2 48.5 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
16.1 48.2 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
15.7 47.1 GO:0009812 flavonoid metabolic process(GO:0009812)
15.6 93.8 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
14.6 58.3 GO:0038183 histone H3-R17 methylation(GO:0034971) bile acid signaling pathway(GO:0038183)
13.9 55.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
13.6 95.4 GO:0000103 sulfate assimilation(GO:0000103)
13.3 132.9 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
13.2 13.2 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
11.9 179.2 GO:0015747 urate transport(GO:0015747)
11.7 47.0 GO:0072023 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
11.3 45.0 GO:0009436 glyoxylate catabolic process(GO:0009436)
10.4 31.3 GO:0061144 alveolar secondary septum development(GO:0061144)
10.4 52.1 GO:0006548 histidine catabolic process(GO:0006548)
10.2 71.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
9.5 37.8 GO:0052695 cellular glucuronidation(GO:0052695)
9.3 46.5 GO:0034371 chylomicron remodeling(GO:0034371)
9.2 36.6 GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
7.9 31.4 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
7.9 47.1 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
7.7 46.3 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
7.5 30.1 GO:1901373 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
7.5 22.5 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
7.4 66.7 GO:0019695 choline metabolic process(GO:0019695)
7.4 22.2 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
7.3 51.0 GO:0006083 acetate metabolic process(GO:0006083)
7.1 21.3 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
6.9 69.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
6.6 45.9 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
6.5 26.1 GO:0015886 heme transport(GO:0015886)
6.5 32.6 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
6.5 19.4 GO:0097275 creatinine homeostasis(GO:0097273) cellular ammonia homeostasis(GO:0097275) cellular creatinine homeostasis(GO:0097276) cellular urea homeostasis(GO:0097277)
6.4 115.8 GO:0042359 vitamin D metabolic process(GO:0042359)
6.2 24.9 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
6.1 30.5 GO:0009441 glycolate metabolic process(GO:0009441)
6.1 18.2 GO:0033189 response to vitamin A(GO:0033189)
5.7 34.0 GO:0038161 prolactin signaling pathway(GO:0038161)
5.4 21.5 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
5.3 26.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
5.2 25.8 GO:0031438 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
5.1 25.7 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
5.0 29.9 GO:0019532 oxalate transport(GO:0019532)
4.7 14.2 GO:0001966 thigmotaxis(GO:0001966)
4.6 59.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
4.6 22.9 GO:1904253 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
4.0 20.0 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
4.0 27.7 GO:0009750 response to fructose(GO:0009750)
3.6 14.5 GO:0061295 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
3.5 219.3 GO:0006805 xenobiotic metabolic process(GO:0006805)
3.4 30.7 GO:0006528 asparagine metabolic process(GO:0006528)
3.3 36.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
3.3 101.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
3.1 37.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
3.1 21.5 GO:1901475 pyruvate transmembrane transport(GO:1901475)
3.0 41.7 GO:0008272 sulfate transport(GO:0008272)
2.1 77.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
2.1 20.7 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
1.9 96.1 GO:0051180 vitamin transport(GO:0051180)
1.4 21.8 GO:0042448 progesterone metabolic process(GO:0042448)
1.3 5.1 GO:0009608 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
1.2 17.0 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.2 32.6 GO:0035634 response to stilbenoid(GO:0035634)
1.2 67.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
1.1 34.2 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
1.0 30.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
1.0 11.9 GO:0061113 pancreas morphogenesis(GO:0061113)
0.9 5.4 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.9 12.1 GO:0046415 urate metabolic process(GO:0046415)
0.9 129.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.8 98.6 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.8 13.5 GO:0042574 retinal metabolic process(GO:0042574)
0.7 3.6 GO:0070295 glycerol transport(GO:0015793) renal water absorption(GO:0070295)
0.7 2.8 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.7 23.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.7 107.7 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.7 4.0 GO:0060523 prostate epithelial cord elongation(GO:0060523) mammary gland branching involved in pregnancy(GO:0060745)
0.6 3.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.6 2.5 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.5 18.9 GO:0010107 potassium ion import(GO:0010107)
0.5 3.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 15.7 GO:0060065 uterus development(GO:0060065)
0.4 23.7 GO:0010824 regulation of centrosome duplication(GO:0010824) negative regulation of protein kinase B signaling(GO:0051898)
0.4 4.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 8.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 4.4 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.4 15.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.4 5.8 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.4 3.3 GO:0009249 protein lipoylation(GO:0009249)
0.3 6.1 GO:0015813 L-glutamate transport(GO:0015813)
0.3 10.2 GO:0045116 protein neddylation(GO:0045116)
0.3 3.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 4.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 2.5 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.2 6.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 5.5 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.2 2.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.2 18.1 GO:1904888 cranial skeletal system development(GO:1904888)
0.1 22.0 GO:0006865 amino acid transport(GO:0006865)
0.1 28.0 GO:0007050 cell cycle arrest(GO:0007050)
0.1 13.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 18.0 GO:0006814 sodium ion transport(GO:0006814)
0.1 0.5 GO:0009816 defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.1 2.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 2.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 3.0 GO:0045109 intermediate filament organization(GO:0045109)
0.1 8.5 GO:0006821 chloride transport(GO:0006821)
0.1 11.5 GO:0019233 sensory perception of pain(GO:0019233)
0.1 19.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.2 GO:0010159 specification of organ position(GO:0010159)
0.1 18.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 13.5 GO:0042742 defense response to bacterium(GO:0042742)
0.0 8.0 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 1.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 7.0 GO:0006839 mitochondrial transport(GO:0006839)
0.0 45.7 GO:0006508 proteolysis(GO:0006508)
0.0 0.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 1.1 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
27.4 82.3 GO:0061474 phagolysosome membrane(GO:0061474)
13.9 125.3 GO:0005577 fibrinogen complex(GO:0005577)
12.2 36.6 GO:1990667 PCSK9-LDLR complex(GO:1990666) PCSK9-AnxA2 complex(GO:1990667)
9.6 48.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
8.7 52.2 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
4.4 65.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
4.1 20.7 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
4.1 73.1 GO:0046581 intercellular canaliculus(GO:0046581)
3.3 26.3 GO:0005579 membrane attack complex(GO:0005579)
3.0 56.2 GO:0042627 chylomicron(GO:0042627)
2.9 20.0 GO:0071914 prominosome(GO:0071914)
2.5 24.8 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
2.4 30.9 GO:0071439 clathrin complex(GO:0071439)
2.3 30.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
2.1 17.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
1.8 46.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.5 31.4 GO:0031143 pseudopodium(GO:0031143)
1.4 4.2 GO:1904602 serotonin-activated cation-selective channel complex(GO:1904602)
1.4 37.1 GO:0005922 connexon complex(GO:0005922)
1.3 183.3 GO:0005902 microvillus(GO:0005902)
1.2 58.3 GO:0005719 nuclear euchromatin(GO:0005719)
1.2 298.3 GO:0072562 blood microparticle(GO:0072562)
1.1 38.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.9 97.7 GO:0031526 brush border membrane(GO:0031526)
0.9 6.1 GO:0097441 basilar dendrite(GO:0097441)
0.7 13.5 GO:0030430 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.7 270.1 GO:0016324 apical plasma membrane(GO:0016324)
0.7 77.8 GO:0005581 collagen trimer(GO:0005581)
0.7 4.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.7 68.4 GO:0005811 lipid particle(GO:0005811)
0.6 6.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.6 2.8 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.5 2.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.4 12.6 GO:0034707 chloride channel complex(GO:0034707)
0.4 42.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.4 121.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 166.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 198.6 GO:0005667 transcription factor complex(GO:0005667)
0.3 1.2 GO:0044299 C-fiber(GO:0044299)
0.3 35.2 GO:0005604 basement membrane(GO:0005604)
0.3 50.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.3 884.8 GO:0070062 extracellular exosome(GO:0070062)
0.2 45.9 GO:0005769 early endosome(GO:0005769)
0.2 306.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 6.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 24.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 23.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 17.6 GO:0031966 mitochondrial membrane(GO:0031966)
0.1 2.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 17.8 GO:0000139 Golgi membrane(GO:0000139)
0.1 30.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 86.7 GO:0005576 extracellular region(GO:0005576)
0.0 6.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 100.6 GO:0005829 cytosol(GO:0005829)
0.0 1.1 GO:0030667 secretory granule membrane(GO:0030667)
0.0 15.4 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
53.5 160.6 GO:0070540 stearic acid binding(GO:0070540)
44.3 132.9 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
29.0 115.8 GO:1902271 D3 vitamins binding(GO:1902271)
28.5 142.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
27.4 82.3 GO:0008431 vitamin E binding(GO:0008431)
19.4 58.3 GO:0038181 bile acid receptor activity(GO:0038181)
17.8 71.2 GO:0004058 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
17.3 69.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
17.0 51.0 GO:0019807 aspartoacylase activity(GO:0019807)
16.7 66.7 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
15.5 248.5 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
13.2 39.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
12.0 95.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
11.4 469.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
11.3 45.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
9.4 56.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
9.3 46.5 GO:0035478 chylomicron binding(GO:0035478)
7.5 30.1 GO:1904121 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
7.5 59.7 GO:0005534 galactose binding(GO:0005534)
7.2 194.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
7.1 21.3 GO:0047057 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
6.8 34.0 GO:0004925 prolactin receptor activity(GO:0004925)
6.4 25.7 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
6.3 25.1 GO:0005499 vitamin D binding(GO:0005499)
6.2 24.6 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
6.1 48.5 GO:0001849 complement component C1q binding(GO:0001849)
5.9 47.1 GO:0003996 acyl-CoA ligase activity(GO:0003996)
5.8 23.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
5.8 46.3 GO:0008172 S-methyltransferase activity(GO:0008172)
5.5 66.1 GO:0019864 IgG binding(GO:0019864)
5.2 20.7 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
4.7 51.9 GO:0004859 phospholipase inhibitor activity(GO:0004859)
4.7 98.1 GO:0034185 apolipoprotein binding(GO:0034185)
4.6 18.5 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
4.4 26.1 GO:0015232 heme transporter activity(GO:0015232)
4.3 25.8 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
4.0 60.0 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
3.8 71.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
3.7 22.3 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
3.4 88.4 GO:0017081 chloride channel regulator activity(GO:0017081)
3.1 21.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
2.8 31.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.8 52.6 GO:0015643 toxic substance binding(GO:0015643)
2.8 27.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
2.5 17.4 GO:0070573 metallodipeptidase activity(GO:0070573)
2.4 23.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
2.1 37.1 GO:0005243 gap junction channel activity(GO:0005243)
2.1 6.2 GO:0035375 zymogen binding(GO:0035375)
2.0 32.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
1.9 9.3 GO:0015254 glycerol channel activity(GO:0015254)
1.8 7.3 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
1.8 65.6 GO:0071949 FAD binding(GO:0071949)
1.7 53.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
1.5 30.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
1.4 31.6 GO:0005537 mannose binding(GO:0005537)
1.3 4.0 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
1.3 14.5 GO:1901611 phosphatidylglycerol binding(GO:1901611)
1.3 215.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.3 13.8 GO:0051870 methotrexate binding(GO:0051870)
1.3 32.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
1.1 3.3 GO:0031177 phosphopantetheine binding(GO:0031177)
1.0 27.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.9 49.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.9 30.2 GO:0042165 neurotransmitter binding(GO:0042165)
0.8 4.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.8 17.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.7 22.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.7 52.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.7 2.0 GO:0032767 copper-dependent protein binding(GO:0032767)
0.7 7.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.6 138.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 22.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.6 5.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.6 47.5 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.5 72.1 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.5 73.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.5 18.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.5 53.2 GO:0016209 antioxidant activity(GO:0016209)
0.5 55.7 GO:0051087 chaperone binding(GO:0051087)
0.4 31.4 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.4 13.5 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 35.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.4 6.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4 10.2 GO:0097602 cullin family protein binding(GO:0097602)
0.4 15.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 60.0 GO:0016853 isomerase activity(GO:0016853)
0.3 30.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 6.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 18.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 21.1 GO:0005179 hormone activity(GO:0005179)
0.1 16.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 5.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.5 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 21.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 10.4 GO:0015293 symporter activity(GO:0015293)
0.1 3.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 14.2 GO:0044325 ion channel binding(GO:0044325)
0.1 4.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 21.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 2.5 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 7.4 GO:0005543 phospholipid binding(GO:0005543)
0.0 13.5 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 312.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.9 110.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.3 20.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
1.0 58.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.9 245.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 34.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.6 51.9 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.5 53.7 PID FGF PATHWAY FGF signaling pathway
0.4 15.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 28.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.3 57.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 41.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 14.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 44.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 6.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 4.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 15.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 5.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 3.9 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
16.4 180.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
13.5 148.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
7.5 59.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
5.8 98.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
4.6 160.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
4.2 58.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
3.5 55.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
3.4 47.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
3.3 94.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
3.2 71.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
3.0 124.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
2.8 53.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
2.4 50.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2.4 21.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.3 53.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.8 78.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
1.7 48.5 REACTOME AMYLOIDS Genes involved in Amyloids
1.7 96.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
1.6 37.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
1.5 183.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
1.5 31.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.4 48.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.4 22.5 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
1.3 26.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
1.2 34.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
1.0 12.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.8 204.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.8 32.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.7 43.1 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.7 9.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.6 32.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.5 25.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.4 57.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 15.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 18.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 6.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 13.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 4.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 4.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 3.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases