ISMARA results: Hnf4a

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hnf4a

Z-value: 8.01

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Transcription factors associated with Hnf4a

Gene Symbol	Gene ID	Gene Info
Hnf4a Ensembl NCBI MGI UniProt	ENSMUSG00000017950.17	Hnf4a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf4a	mm39_v1_chr2_+_163389068_163389108	0.93	1.1e-32	Click!

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

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Promoter	Score	Transcript	Gene	Gene Info
chr14_-_55995912 Show fit	187.08	ENSMUST00000001497.9	Cideb Ensembl NCBI MGI UniProt Show fit	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr3_+_122688721 Show fit	151.91	ENSMUST00000023820.6	Fabp2 Ensembl NCBI MGI UniProt Show fit	fatty acid binding protein 2, intestinal
chr2_+_172994841 Show fit	143.36	ENSMUST00000029017.6	Pck1 Ensembl NCBI MGI UniProt Show fit	phosphoenolpyruvate carboxykinase 1, cytosolic
chrX_+_10118544 Show fit	131.50	ENSMUST00000049910.13	Otc Ensembl NCBI MGI UniProt Show fit	ornithine transcarbamylase
chrX_+_10118600 Show fit	112.51	ENSMUST00000115528.3	Otc Ensembl NCBI MGI UniProt Show fit	ornithine transcarbamylase
chr19_-_39729431 Show fit	110.01	ENSMUST00000099472.4	Cyp2c68 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily c, polypeptide 68
chr10_-_128796834 Show fit	106.31	ENSMUST00000026398.5	Mettl7b Ensembl NCBI MGI UniProt Show fit	methyltransferase like 7B
chr11_+_101258368 Show fit	102.74	ENSMUST00000019469.3	G6pc Ensembl NCBI MGI UniProt Show fit	glucose-6-phosphatase, catalytic
chr15_-_82678490 Show fit	101.55	ENSMUST00000006094.6	Cyp2d26 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily d, polypeptide 26
chr15_+_98997293 Show fit	99.29	ENSMUST00000061295.7	Dnajc22 Ensembl NCBI MGI UniProt Show fit	DnaJ heat shock protein family (Hsp40) member C22

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
20.2	666.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
9.7	405.6	GO:0019369	arachidonic acid metabolic process(GO:0019369)
81.3	244.0	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
5.5	225.4	GO:0050892	intestinal absorption(GO:0050892)
11.8	201.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
1.5	191.5	GO:0046889	positive regulation of lipid biosynthetic process(GO:0046889)
4.0	178.0	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
18.9	170.4	GO:0042866	pyruvate biosynthetic process(GO:0042866)
17.5	157.3	GO:0006572	tyrosine catabolic process(GO:0006572)
35.8	143.4	GO:0061402	glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)

Showing 1 to 10 of 167 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1093.6	GO:0070062	extracellular exosome(GO:0070062)
0.5	1053.0	GO:0005783	endoplasmic reticulum(GO:0005783)
3.6	407.7	GO:0005811	lipid particle(GO:0005811)
0.9	342.5	GO:0016324	apical plasma membrane(GO:0016324)
0.6	311.5	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	266.5	GO:0005739	mitochondrion(GO:0005739)
1.2	250.6	GO:0005903	brush border(GO:0005903)
0.9	235.1	GO:0072562	blood microparticle(GO:0072562)
20.8	229.3	GO:0045179	apical cortex(GO:0045179)
0.2	214.6	GO:0005615	extracellular space(GO:0005615)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
16.3	440.1	GO:0070330	aromatase activity(GO:0070330)
34.7	312.6	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
12.5	249.8	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
1.1	247.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
61.0	244.0	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
5.9	172.0	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
34.1	170.4	GO:0004743	pyruvate kinase activity(GO:0004743)
4.7	164.4	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
5.5	160.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.2	158.9	GO:0016491	oxidoreductase activity(GO:0016491)

Showing 1 to 10 of 148 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.8	544.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.6	452.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.6	326.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
3.6	98.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.7	91.6	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.8	42.5	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.3	29.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	26.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.1	24.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	22.8	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	432.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
15.3	306.9	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
2.6	251.5	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
6.3	221.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
9.9	197.9	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
9.8	157.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
9.0	143.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
9.5	133.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
2.1	119.4	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
8.3	108.4	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport

Showing 1 to 10 of 59 entries

Results for Hnf4a

Z-value: 8.01

Motif logo

Transcription factors associated with Hnf4a

Activity-expression correlation:

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: