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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Hnf4g
Z-value: 3.78
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Transcription factors associated with Hnf4g
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf4g | mm39_v1_chr3_+_3573084_3573129 | 0.24 | 4.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf4g
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 142.8 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 7.4 | 88.5 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 5.4 | 87.0 | GO:0032782 | bile acid secretion(GO:0032782) |
| 4.9 | 82.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 4.8 | 81.1 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 2.7 | 80.4 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 1.8 | 72.8 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 1.3 | 61.8 | GO:0006953 | acute-phase response(GO:0006953) |
| 14.2 | 56.6 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 2.5 | 53.9 | GO:0046415 | urate metabolic process(GO:0046415) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 321.1 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.9 | 232.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 184.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 177.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 136.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 118.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.5 | 98.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.7 | 86.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 2.8 | 83.2 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 6.7 | 80.9 | GO:0042627 | chylomicron(GO:0042627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 205.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 191.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.9 | 106.1 | GO:0070330 | aromatase activity(GO:0070330) |
| 7.9 | 103.1 | GO:0035473 | lipase binding(GO:0035473) |
| 14.1 | 84.9 | GO:0030294 | receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294) |
| 18.4 | 73.4 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 2.2 | 62.5 | GO:0001848 | complement binding(GO:0001848) |
| 2.5 | 60.7 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 3.9 | 59.2 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 1.9 | 58.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 189.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.4 | 188.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.3 | 79.0 | PID BMP PATHWAY | BMP receptor signaling |
| 1.3 | 73.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.4 | 30.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.9 | 27.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 27.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.9 | 23.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.3 | 22.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 20.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 179.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 168.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.4 | 111.7 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 3.1 | 106.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 3.2 | 96.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 5.8 | 81.8 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 2.2 | 77.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.9 | 61.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 3.0 | 57.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 2.8 | 52.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |