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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hoxb6

Z-value: 0.84

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Transcription factors associated with Hoxb6

Gene Symbol Gene ID Gene Info
Hoxb6
ENSMUSG00000000690.6 Hoxb6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb6mm39_v1_chr11_+_96189963_961899970.066.0e-01Click!

Activity profile of Hoxb6 motif

Sorted Z-values of Hoxb6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_-_19079594 11.02 ENSMUST00000103752.3
ENSMUST00000197518.2
Iglv2
immunoglobulin lambda variable 2
chr11_-_99134885 7.72 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr1_-_138102972 6.56 ENSMUST00000195533.6
ENSMUST00000183301.8
Ptprc
protein tyrosine phosphatase, receptor type, C
chr1_-_138103021 6.25 ENSMUST00000182755.8
ENSMUST00000193650.2
ENSMUST00000182283.8
Ptprc
protein tyrosine phosphatase, receptor type, C
chr16_-_18904240 5.55 ENSMUST00000103746.3
Iglv1
immunoglobulin lambda variable 1
chrX_+_106132055 5.42 ENSMUST00000150494.2
P2ry10
purinergic receptor P2Y, G-protein coupled 10
chr4_+_15881256 4.87 ENSMUST00000029876.2
Calb1
calbindin 1
chr2_+_164611812 4.02 ENSMUST00000088248.13
ENSMUST00000001439.7
Ube2c
ubiquitin-conjugating enzyme E2C
chr3_+_64884839 3.66 ENSMUST00000239069.2
Kcnab1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_45866618 3.54 ENSMUST00000024742.9
ENSMUST00000233929.2
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chrX_+_56257374 3.42 ENSMUST00000033466.2
Cd40lg
CD40 ligand
chr8_+_31601837 3.00 ENSMUST00000046941.8
ENSMUST00000217278.2
Rnf122
ring finger protein 122
chr8_-_106198112 2.57 ENSMUST00000014990.13
Tppp3
tubulin polymerization-promoting protein family member 3
chr6_-_69245427 2.47 ENSMUST00000103348.3
Igkv4-70
immunoglobulin kappa chain variable 4-70
chr10_-_117628565 2.45 ENSMUST00000167943.8
ENSMUST00000064848.7
Nup107
nucleoporin 107
chr11_-_69686756 2.41 ENSMUST00000045971.9
Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr3_+_94320548 2.19 ENSMUST00000166032.8
ENSMUST00000200486.5
ENSMUST00000196386.5
ENSMUST00000045245.10
ENSMUST00000197901.5
ENSMUST00000198041.2
Tdrkh
Gm42463
tudor and KH domain containing protein
predicted gene 42463
chr8_-_78337226 2.12 ENSMUST00000034030.15
Tmem184c
transmembrane protein 184C
chr9_-_56151334 1.92 ENSMUST00000188142.7
Peak1
pseudopodium-enriched atypical kinase 1
chr3_-_79053182 1.80 ENSMUST00000118340.7
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_+_66892979 1.74 ENSMUST00000162362.8
ENSMUST00000065074.14
ENSMUST00000065047.13
Rsrc1
arginine/serine-rich coiled-coil 1
chr3_+_68479578 1.74 ENSMUST00000170788.9
Schip1
schwannomin interacting protein 1
chr6_+_142359099 1.69 ENSMUST00000126521.9
ENSMUST00000211094.2
Spx
spexin hormone
chr2_+_29236815 1.67 ENSMUST00000028139.11
ENSMUST00000113830.11
Med27
mediator complex subunit 27
chr9_-_35481689 1.64 ENSMUST00000115110.5
Hyls1
HYLS1, centriolar and ciliogenesis associated
chr8_-_78337297 1.60 ENSMUST00000141202.2
ENSMUST00000152168.8
Tmem184c
transmembrane protein 184C
chr18_+_37864045 1.59 ENSMUST00000192535.2
Pcdhgb5
protocadherin gamma subfamily B, 5
chr6_+_142244145 1.57 ENSMUST00000041993.3
Iapp
islet amyloid polypeptide
chr16_+_44167484 1.52 ENSMUST00000050897.7
Spice1
spindle and centriole associated protein 1
chr6_+_86348286 1.51 ENSMUST00000089558.7
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr2_-_88157559 1.50 ENSMUST00000214207.2
Olfr1175
olfactory receptor 1175
chr5_-_123804745 1.49 ENSMUST00000149410.2
Clip1
CAP-GLY domain containing linker protein 1
chr10_-_18103221 1.45 ENSMUST00000174592.8
Ccdc28a
coiled-coil domain containing 28A
chr12_-_119202527 1.35 ENSMUST00000026360.9
Itgb8
integrin beta 8
chr3_-_100876960 1.32 ENSMUST00000076941.12
Ttf2
transcription termination factor, RNA polymerase II
chr7_+_112806672 1.30 ENSMUST00000047321.9
ENSMUST00000210074.2
ENSMUST00000210238.2
Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr9_-_70048766 1.27 ENSMUST00000034749.16
Fam81a
family with sequence similarity 81, member A
chr15_+_34306812 1.26 ENSMUST00000226766.2
ENSMUST00000163455.9
ENSMUST00000022947.7
ENSMUST00000228570.2
ENSMUST00000227759.2
Matn2
matrilin 2
chr9_+_74959259 1.21 ENSMUST00000170310.2
ENSMUST00000166549.2
Arpp19
cAMP-regulated phosphoprotein 19
chr1_-_36312482 1.20 ENSMUST00000056946.8
Neurl3
neuralized E3 ubiquitin protein ligase 3
chr1_-_179572765 1.18 ENSMUST00000211943.3
ENSMUST00000131716.4
ENSMUST00000221136.2
Kif28
kinesin family member 28
chr11_-_72106418 1.17 ENSMUST00000021157.9
Med31
mediator complex subunit 31
chr19_+_26725589 1.14 ENSMUST00000207812.2
ENSMUST00000175791.9
ENSMUST00000207118.2
ENSMUST00000209085.2
ENSMUST00000112637.10
ENSMUST00000207054.2
ENSMUST00000208589.2
ENSMUST00000176475.9
ENSMUST00000176698.9
ENSMUST00000207832.2
ENSMUST00000177252.9
ENSMUST00000208712.2
ENSMUST00000208186.2
ENSMUST00000208806.2
ENSMUST00000208027.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_85809620 1.06 ENSMUST00000056849.3
Olfr1030
olfactory receptor 1030
chr10_-_63926044 1.03 ENSMUST00000105439.2
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_-_125624754 1.00 ENSMUST00000053699.13
Secisbp2l
SECIS binding protein 2-like
chr4_+_33062999 0.97 ENSMUST00000108162.8
ENSMUST00000024035.9
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr2_+_83642910 0.92 ENSMUST00000051454.4
Fam171b
family with sequence similarity 171, member B
chr11_-_65636651 0.88 ENSMUST00000138093.2
Map2k4
mitogen-activated protein kinase kinase 4
chr11_-_96868483 0.84 ENSMUST00000107624.8
Sp2
Sp2 transcription factor
chrX_-_8118541 0.84 ENSMUST00000115594.8
ENSMUST00000115595.8
ENSMUST00000033513.10
Ftsj1
FtsJ RNA methyltransferase homolog 1 (E. coli)
chr5_+_88731386 0.84 ENSMUST00000031229.11
Rufy3
RUN and FYVE domain containing 3
chr1_-_175319842 0.76 ENSMUST00000195324.6
ENSMUST00000192227.6
ENSMUST00000194555.6
Rgs7
regulator of G protein signaling 7
chr15_-_43733389 0.72 ENSMUST00000067469.6
Tmem74
transmembrane protein 74
chr5_+_88731366 0.72 ENSMUST00000199312.5
Rufy3
RUN and FYVE domain containing 3
chrX_-_100266032 0.71 ENSMUST00000120389.8
ENSMUST00000156473.8
ENSMUST00000077876.4
Snx12
sorting nexin 12
chr11_-_74615496 0.70 ENSMUST00000021091.15
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr14_-_57353340 0.65 ENSMUST00000159455.2
Gm4491
predicted gene 4491
chr6_-_3494587 0.62 ENSMUST00000049985.15
Hepacam2
HEPACAM family member 2
chr6_-_69377328 0.52 ENSMUST00000198345.2
Igkv4-62
immunoglobulin kappa variable 4-62
chr12_-_79211820 0.44 ENSMUST00000162569.8
Vti1b
vesicle transport through interaction with t-SNAREs 1B
chrX_+_37689503 0.42 ENSMUST00000000365.3
Mcts1
malignant T cell amplified sequence 1
chr5_-_52723607 0.35 ENSMUST00000199942.5
Lgi2
leucine-rich repeat LGI family, member 2
chr6_-_133032779 0.31 ENSMUST00000095391.3
Tas2r140
taste receptor, type 2, member 140
chr7_-_115459082 0.28 ENSMUST00000206123.2
Sox6
SRY (sex determining region Y)-box 6
chr11_+_49410475 0.25 ENSMUST00000204706.3
Olfr1383
olfactory receptor 1383
chr16_+_58967409 0.25 ENSMUST00000216957.3
Olfr195
olfactory receptor 195
chr2_-_166902307 0.25 ENSMUST00000155281.8
Znfx1
zinc finger, NFX1-type containing 1
chr5_-_52723700 0.20 ENSMUST00000039750.7
Lgi2
leucine-rich repeat LGI family, member 2
chr3_-_57202546 0.20 ENSMUST00000196506.2
Tm4sf1
transmembrane 4 superfamily member 1
chr5_+_31684331 0.20 ENSMUST00000114533.9
ENSMUST00000202214.4
ENSMUST00000201858.4
ENSMUST00000202950.4
Slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr10_-_58511476 0.19 ENSMUST00000003312.5
Edar
ectodysplasin-A receptor
chr5_-_31684036 0.17 ENSMUST00000202421.2
ENSMUST00000201769.4
ENSMUST00000065388.11
Supt7l
SPT7-like, STAGA complex gamma subunit
chr2_-_86640362 0.14 ENSMUST00000216117.2
Olfr141
olfactory receptor 141
chr10_+_78816884 0.13 ENSMUST00000058991.5
ENSMUST00000203973.2
Olfr1352
olfactory receptor 1352
chr2_+_111329683 0.12 ENSMUST00000219064.3
Olfr1291-ps1
olfactory receptor 1291, pseudogene 1
chr10_-_38998272 0.11 ENSMUST00000136546.8
Fam229b
family with sequence similarity 229, member B
chr19_+_46385448 0.09 ENSMUST00000118440.3
Sufu
SUFU negative regulator of hedgehog signaling
chr17_-_37481536 0.09 ENSMUST00000174673.3
Olfr753-ps1
olfactory receptor 753, pseudogene 1
chr19_-_6902698 0.02 ENSMUST00000237380.2
Catsperz
cation channel sperm associated auxiliary subunit zeta

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.8 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
1.2 4.9 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.1 3.4 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.9 3.5 GO:0032329 serine transport(GO:0032329)
0.6 1.8 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.5 4.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.5 2.5 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.4 1.3 GO:0031104 dendrite regeneration(GO:0031104)
0.3 1.5 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.3 1.3 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 0.7 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 1.7 GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.2 1.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 2.4 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 5.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 3.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.7 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.0 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 2.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.4 GO:0002188 translation reinitiation(GO:0002188)
0.1 1.7 GO:0001553 luteinization(GO:0001553)
0.1 1.5 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 1.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 1.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 1.3 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 1.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.2 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 8.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.7 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 1.2 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.6 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.1 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 1.2 GO:0072384 organelle transport along microtubule(GO:0072384)
0.0 0.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0071547 piP-body(GO:0071547)
0.3 1.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.2 3.7 GO:1990635 proximal dendrite(GO:1990635)
0.2 2.6 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.5 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.2 GO:0070847 core mediator complex(GO:0070847)
0.1 1.5 GO:0005687 U4 snRNP(GO:0005687)
0.1 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.7 GO:0000235 astral microtubule(GO:0000235)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.1 1.3 GO:0033391 chromatoid body(GO:0033391)
0.1 1.6 GO:0071437 invadopodium(GO:0071437)
0.1 7.7 GO:0005882 intermediate filament(GO:0005882)
0.0 1.1 GO:0071564 npBAF complex(GO:0071564)
0.0 1.7 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.0 4.9 GO:0043195 terminal bouton(GO:0043195)
0.0 16.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.6 4.9 GO:0005499 vitamin D binding(GO:0005499)
0.4 12.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 5.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.9 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 3.7 GO:0070402 NADPH binding(GO:0070402)
0.1 1.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034) beta-1 adrenergic receptor binding(GO:0031697)
0.1 1.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 2.4 GO:0042166 acetylcholine binding(GO:0042166)
0.1 1.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 1.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.8 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 1.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 2.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 4.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 11.0 GO:0003823 antigen binding(GO:0003823)
0.0 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 3.5 ST GAQ PATHWAY G alpha q Pathway
0.1 3.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 1.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 12.8 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3 5.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 4.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 1.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 2.5 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 3.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 3.5 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.9 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 2.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 2.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions