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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Hoxb7
Z-value: 4.40
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Transcription factors associated with Hoxb7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb7 | mm39_v1_chr11_+_96177449_96177480 | -0.16 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 340.8 | GO:0007416 | synapse assembly(GO:0007416) |
| 19.8 | 237.8 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 16.6 | 182.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 7.7 | 176.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 4.3 | 173.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 1.4 | 172.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.6 | 114.6 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114) |
| 0.8 | 111.0 | GO:0030038 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.8 | 98.5 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 4.4 | 92.4 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 785.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 1.6 | 488.4 | GO:0060076 | excitatory synapse(GO:0060076) |
| 3.3 | 318.0 | GO:0008328 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.5 | 301.5 | GO:0043005 | neuron projection(GO:0043005) |
| 0.6 | 269.3 | GO:0045202 | synapse(GO:0045202) |
| 0.9 | 227.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.8 | 212.5 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.2 | 182.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 6.4 | 178.6 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 174.4 | GO:0016021 | integral component of membrane(GO:0016021) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 223.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 3.1 | 199.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 1.9 | 185.4 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 1.1 | 180.2 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.4 | 167.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.4 | 156.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 3.0 | 127.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 3.3 | 125.9 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.4 | 107.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 6.7 | 107.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 252.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 1.6 | 176.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 1.1 | 106.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 3.4 | 105.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 1.1 | 84.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.6 | 70.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.9 | 65.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.5 | 46.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.6 | 45.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 1.1 | 44.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 257.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 7.6 | 181.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 3.4 | 175.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 3.3 | 118.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 2.7 | 106.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.3 | 103.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 1.0 | 101.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.4 | 100.0 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.7 | 96.5 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 2.2 | 91.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |