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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hoxc10

Z-value: 0.93

Motif logo

Transcription factors associated with Hoxc10

Gene Symbol Gene ID Gene Info
ENSMUSG00000022484.8 Hoxc10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc10mm39_v1_chr15_+_102875229_102875248-0.362.2e-03Click!

Activity profile of Hoxc10 motif

Sorted Z-values of Hoxc10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc10

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_31363245 8.71 ENSMUST00000024826.8
trefoil factor 2 (spasmolytic protein 1)
chr3_+_69129745 7.06 ENSMUST00000183126.2
ADP-ribosylation factor-like 14
chr1_-_45542442 6.84 ENSMUST00000086430.5
collagen, type V, alpha 2
chr3_-_63758672 6.80 ENSMUST00000162269.9
ENSMUST00000159676.9
ENSMUST00000175947.8
phospholipase C, eta 1
chr8_-_62576140 6.69 ENSMUST00000034052.14
ENSMUST00000034054.9
annexin A10
chr11_-_100036792 6.63 ENSMUST00000007317.8
keratin 19
chr1_-_149836974 4.66 ENSMUST00000190507.2
ENSMUST00000070200.15
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr18_-_70274639 4.53 ENSMUST00000121693.8
RAB27B, member RAS oncogene family
chr17_+_31652073 3.59 ENSMUST00000237363.2
phosphodiesterase 9A
chr9_+_75682637 3.36 ENSMUST00000012281.8
bone morphogenetic protein 5
chr17_+_31652029 3.30 ENSMUST00000136384.9
phosphodiesterase 9A
chr16_-_38620688 3.21 ENSMUST00000057767.6
uroplakin 1B
chr7_-_129867967 3.09 ENSMUST00000117872.8
ENSMUST00000120187.9
fibroblast growth factor receptor 2
chr19_+_39102342 3.07 ENSMUST00000087234.3
cytochrome P450, family 2, subfamily c, polypeptide 66
chr1_-_160079007 3.00 ENSMUST00000191909.6
RAB GTPase activating protein 1-like
chr16_-_55659194 2.81 ENSMUST00000096026.9
ENSMUST00000036273.13
ENSMUST00000114457.8
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr7_-_129867921 2.81 ENSMUST00000122054.8
fibroblast growth factor receptor 2
chr17_-_35293447 2.64 ENSMUST00000007259.4
lymphocyte antigen 6 complex, locus G6D
chr11_-_79394904 2.36 ENSMUST00000164465.3
oligodendrocyte myelin glycoprotein
chr16_+_41353360 2.33 ENSMUST00000099761.10
limbic system-associated membrane protein
chr11_-_83957889 2.33 ENSMUST00000108101.8
dual specificity phosphatase 14
chr11_-_43492367 2.28 ENSMUST00000020672.5
fatty acid binding protein 6
chr11_-_97591150 2.28 ENSMUST00000018681.14
polycomb group ring finger 2
chr16_+_29884153 2.21 ENSMUST00000023171.8
hes family bHLH transcription factor 1
chrX_+_138464065 2.11 ENSMUST00000113027.8
ring finger protein 128
chr10_+_90412827 1.97 ENSMUST00000182550.8
ENSMUST00000099364.12
ankyrin repeat and sterile alpha motif domain containing 1B
chr15_-_101441254 1.94 ENSMUST00000023720.8
keratin 84
chr9_+_21914083 1.93 ENSMUST00000216344.2
protein kinase C substrate 80K-H
chr7_-_30312246 1.92 ENSMUST00000006476.6
uroplakin 1A
chrX_+_95498965 1.89 ENSMUST00000033553.14
hephaestin
chr1_-_144124871 1.89 ENSMUST00000189061.7
regulator of G-protein signaling 1
chr7_+_43339842 1.83 ENSMUST00000056329.7
kallikrein related-peptidase 14
chr1_-_182109773 1.80 ENSMUST00000133052.2
delta(4)-desaturase, sphingolipid 1
chr3_+_3699205 1.79 ENSMUST00000108394.3
hepatocyte nuclear factor 4, gamma
chr15_-_101336669 1.72 ENSMUST00000081945.5
keratin 87
chr3_+_63988968 1.71 ENSMUST00000029406.6
vomeronasal 2, receptor 1
chr11_+_100902572 1.59 ENSMUST00000092663.4
ATPase, H+ transporting, lysosomal V0 subunit A1
chr12_-_69838004 1.58 ENSMUST00000221646.2
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr10_-_6930376 1.47 ENSMUST00000105617.8
interaction protein for cytohesin exchange factors 1
chr7_-_30750856 1.47 ENSMUST00000073892.6
FXYD domain-containing ion transport regulator 7
chr14_+_27598021 1.46 ENSMUST00000211684.2
ENSMUST00000210924.2
ELKS/RAB6-interacting/CAST family member 2
chr1_+_66426127 1.41 ENSMUST00000145419.8
microtubule-associated protein 2
chr12_+_117621644 1.40 ENSMUST00000222105.2
Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_107439145 1.37 ENSMUST00000009356.11
ENSMUST00000064916.9
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr2_+_3115250 1.31 ENSMUST00000072955.12
family with sequence similarity 171, member A1
chr11_+_96085118 1.31 ENSMUST00000062709.4
homeobox B13
chr3_-_146475974 1.28 ENSMUST00000106137.8
protein kinase, cAMP dependent, catalytic, beta
chr19_+_56536685 1.24 ENSMUST00000071423.7
NHL repeat containing 2
chr6_-_136852792 1.24 ENSMUST00000032342.3
matrix Gla protein
chr7_-_30750828 1.23 ENSMUST00000206341.2
FXYD domain-containing ion transport regulator 7
chr3_+_89173859 1.22 ENSMUST00000040824.2
dolichyl-phosphate mannosyltransferase polypeptide 3
chr1_-_22551594 1.17 ENSMUST00000239255.2
regulating synaptic membrane exocytosis 1
chr18_-_43032359 1.14 ENSMUST00000117687.8
protein phosphatase 2, regulatory subunit B, beta
chr9_-_116004386 1.13 ENSMUST00000035014.8
transforming growth factor, beta receptor II
chr19_-_7319157 1.13 ENSMUST00000164205.8
ENSMUST00000165286.8
ENSMUST00000168324.2
ENSMUST00000032557.15
MAP/microtubule affinity regulating kinase 2
chr9_+_53678801 1.11 ENSMUST00000048670.10
solute carrier family 35, member F2
chr1_+_179788675 1.09 ENSMUST00000076687.12
ENSMUST00000097450.10
ENSMUST00000212756.2
CDC42 binding protein kinase alpha
chr2_+_83642910 1.09 ENSMUST00000051454.4
family with sequence similarity 171, member B
chr8_+_94537910 1.08 ENSMUST00000138659.9
guanine nucleotide binding protein, alpha O
chr5_+_43672856 1.08 ENSMUST00000076939.10
C1q and tumor necrosis factor related protein 7
chr19_-_56536443 1.06 ENSMUST00000182059.2
DNA cross-link repair 1A
chr1_-_86039692 1.05 ENSMUST00000027431.7
5-hydroxytryptamine (serotonin) receptor 2B
chr3_-_117153802 1.02 ENSMUST00000197743.2
phospholipid phosphatase related 4
chr19_-_56536646 1.01 ENSMUST00000182276.2
DNA cross-link repair 1A
chr10_+_69816153 1.01 ENSMUST00000182207.8
ankyrin 3, epithelial
chr17_-_34043502 1.00 ENSMUST00000087342.13
ENSMUST00000173844.8
ribosomal protein S28
chr10_-_49659355 0.99 ENSMUST00000105484.10
ENSMUST00000218598.2
ENSMUST00000079751.9
ENSMUST00000218441.2
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr2_+_163348728 0.98 ENSMUST00000143911.8
hepatic nuclear factor 4, alpha
chrX_+_55493325 0.98 ENSMUST00000079663.7
predicted gene 2174
chr11_+_115824108 0.96 ENSMUST00000140991.2
SAP30 binding protein
chr2_+_80145805 0.95 ENSMUST00000028392.8
DnaJ heat shock protein family (Hsp40) member C10
chr3_-_49711706 0.94 ENSMUST00000191794.2
protocadherin 18
chr19_-_7319211 0.91 ENSMUST00000171393.8
MAP/microtubule affinity regulating kinase 2
chr2_-_32278245 0.90 ENSMUST00000192241.2
lipocalin 2
chr1_-_144124787 0.89 ENSMUST00000185714.2
regulator of G-protein signaling 1
chr14_+_54923655 0.87 ENSMUST00000038539.8
ENSMUST00000228027.2
RIKEN cDNA 1700123O20 gene
chr3_+_31956814 0.81 ENSMUST00000192429.6
ENSMUST00000191869.6
ENSMUST00000178668.2
ENSMUST00000119970.8
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr17_-_90395771 0.80 ENSMUST00000197268.5
ENSMUST00000173917.8
neurexin I
chr17_-_34043320 0.80 ENSMUST00000173879.8
ENSMUST00000166693.3
ENSMUST00000173019.8
ribosomal protein S28
chr2_+_113235475 0.77 ENSMUST00000238883.2
formin 1
chr2_-_32277773 0.76 ENSMUST00000050785.14
lipocalin 2
chr2_+_65499097 0.73 ENSMUST00000200829.4
sodium channel, voltage-gated, type II, alpha
chr12_-_113912416 0.71 ENSMUST00000103464.3
immunoglobulin heavy variable 4-1
chr3_-_49711765 0.70 ENSMUST00000035931.13
protocadherin 18
chr12_+_59142439 0.70 ENSMUST00000219140.3
MIA SH3 domain ER export factor 2
chr13_+_25127127 0.69 ENSMUST00000021773.13
glycosylphosphatidylinositol specific phospholipase D1
chr5_+_71857261 0.68 ENSMUST00000031122.9
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr15_+_25774070 0.68 ENSMUST00000125667.3
myosin X
chr11_+_96214078 0.67 ENSMUST00000093944.10
homeobox B3
chr11_+_108811168 0.65 ENSMUST00000052915.14
axin 2
chr15_+_6451721 0.65 ENSMUST00000163082.2
disabled 2, mitogen-responsive phosphoprotein
chrX_+_132809189 0.65 ENSMUST00000113304.2
sushi-repeat-containing protein, X-linked 2
chr14_-_9015639 0.65 ENSMUST00000112656.4
synaptoporin
chr12_+_105570350 0.65 ENSMUST00000041229.5
bradykinin receptor, beta 1
chr2_-_86180622 0.64 ENSMUST00000099894.5
ENSMUST00000213564.3
olfactory receptor 1055
chr5_-_62923463 0.64 ENSMUST00000076623.8
ENSMUST00000159470.3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_44473146 0.64 ENSMUST00000215293.2
chemokine (C-X-C motif) receptor 5
chr4_+_11758147 0.62 ENSMUST00000029871.12
ENSMUST00000108303.2
cadherin 17
chr4_+_102111936 0.61 ENSMUST00000106907.9
phosphodiesterase 4B, cAMP specific
chr13_+_38223023 0.59 ENSMUST00000226110.2
RIO kinase 1
chr4_-_58787716 0.58 ENSMUST00000216719.2
olfactory receptor 267
chr1_+_189460461 0.58 ENSMUST00000097442.9
protein tyrosine phosphatase, non-receptor type 14
chr18_-_43032535 0.57 ENSMUST00000120632.2
protein phosphatase 2, regulatory subunit B, beta
chrX_+_168468186 0.51 ENSMUST00000112107.8
ENSMUST00000112104.8
midline 1
chr11_-_115824290 0.50 ENSMUST00000021097.10
RecQ protein-like 5
chr13_+_104424359 0.49 ENSMUST00000065766.7
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr2_+_87687521 0.48 ENSMUST00000061081.2
olfactory receptor 1151
chr5_+_43673093 0.48 ENSMUST00000144558.3
C1q and tumor necrosis factor related protein 7
chr15_-_101389384 0.46 ENSMUST00000023718.9
keratin 83
chr19_-_50667079 0.46 ENSMUST00000209413.2
ENSMUST00000072685.13
ENSMUST00000164039.9
sortilin-related VPS10 domain containing receptor 1
chr2_+_73102269 0.45 ENSMUST00000090813.6
trans-acting transcription factor 9
chr11_+_108811626 0.44 ENSMUST00000140821.2
axin 2
chr11_-_102210568 0.43 ENSMUST00000173870.8
upstream binding transcription factor, RNA polymerase I
chr15_+_91722524 0.42 ENSMUST00000109276.8
ENSMUST00000088555.10
ENSMUST00000100293.9
ENSMUST00000126508.8
ENSMUST00000239545.1
submandibular gland protein C
mucin 19
chr4_-_154721288 0.40 ENSMUST00000030902.13
ENSMUST00000105637.8
ENSMUST00000070313.14
ENSMUST00000105636.8
ENSMUST00000105638.9
ENSMUST00000097759.9
ENSMUST00000124771.2
PR domain containing 16
chr15_-_101422054 0.40 ENSMUST00000230067.3
predicted gene, 49425
chr14_-_54923517 0.40 ENSMUST00000125265.2
apoptotic chromatin condensation inducer 1
chr17_-_37523969 0.40 ENSMUST00000060728.7
ENSMUST00000216318.2
olfactory receptor 95
chr1_+_17672117 0.39 ENSMUST00000088476.4
peptidase inhibitor 15
chr10_+_129153986 0.39 ENSMUST00000215503.2
olfactory receptor 780
chr7_-_29605504 0.38 ENSMUST00000053521.15
zinc finger protein 27
chr6_+_29694181 0.38 ENSMUST00000046750.14
ENSMUST00000115250.4
tetraspanin 33
chr5_-_67256578 0.38 ENSMUST00000012664.11
paired-like homeobox 2b
chr7_+_108143734 0.37 ENSMUST00000078162.4
ENSMUST00000211693.2
olfactory receptor 503
chr14_+_66043281 0.36 ENSMUST00000022612.10
PDZ binding kinase
chr5_+_128677863 0.34 ENSMUST00000117102.4
frizzled class receptor 10
chr2_-_129213050 0.34 ENSMUST00000028881.14
interleukin 1 beta
chr10_+_94350687 0.33 ENSMUST00000065060.12
transmembrane and coiled coil domains 3
chr2_+_89804937 0.33 ENSMUST00000214630.2
ENSMUST00000111512.10
ENSMUST00000144710.3
ENSMUST00000216678.2
olfactory receptor 1260
chr19_+_55882942 0.33 ENSMUST00000142291.8
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_36958319 0.32 ENSMUST00000120704.2
olfactory receptor 360
chr18_+_44249254 0.32 ENSMUST00000212114.2
predicted gene, 37797
chr1_+_179788037 0.30 ENSMUST00000097453.9
ENSMUST00000111117.8
CDC42 binding protein kinase alpha
chr6_-_133014064 0.28 ENSMUST00000032317.4
taste receptor, type 2, member 103
chr1_-_36283326 0.28 ENSMUST00000046875.14
UDP-glucose glycoprotein glucosyltransferase 1
chr11_-_24025054 0.24 ENSMUST00000068360.2
RIKEN cDNA A830031A19 gene
chr8_-_18791557 0.22 ENSMUST00000033846.7
angiopoietin 2
chr2_+_177783713 0.21 ENSMUST00000103066.10
phosphatase and actin regulator 3
chr7_-_73187369 0.20 ENSMUST00000172704.6
chromodomain helicase DNA binding protein 2
chr10_-_12689345 0.20 ENSMUST00000217899.2
utrophin
chr18_-_43032514 0.19 ENSMUST00000236238.2
protein phosphatase 2, regulatory subunit B, beta
chr6_-_24168082 0.15 ENSMUST00000031713.9
solute carrier family 13 (sodium/sulfate symporters), member 1
chr4_-_110148081 0.14 ENSMUST00000142722.2
ELAV like RNA binding protein 4
chr8_-_112718888 0.13 ENSMUST00000034427.12
ENSMUST00000139820.8
adenosine deaminase, tRNA-specific 1
chr17_+_37670473 0.13 ENSMUST00000178766.3
ENSMUST00000215398.2
olfactory receptor 104, pseudogene
chr7_-_10009278 0.12 ENSMUST00000060374.5
vomeronasal 1 receptor 66
chr10_-_89270554 0.12 ENSMUST00000220071.2
growth arrest-specific 2 like 3
chrX_-_49108236 0.10 ENSMUST00000213556.3
ENSMUST00000213463.2
olfactory receptor 1323
chr10_+_87926932 0.10 ENSMUST00000048621.8
pro-melanin-concentrating hormone
chr15_-_78947038 0.10 ENSMUST00000151889.8
ENSMUST00000040676.11
ankyrin repeat domain 54
chr10_-_129023288 0.09 ENSMUST00000072976.4
olfactory receptor 773
chr5_+_143864993 0.08 ENSMUST00000172367.3
predicted gene, 42421
chrX_-_166907286 0.07 ENSMUST00000239138.2
FERM and PDZ domain containing 4
chr10_-_129951252 0.05 ENSMUST00000213145.2
olfactory receptor 823
chr14_-_50479323 0.05 ENSMUST00000214152.2
olfactory receptor 731
chr19_+_26725589 0.05 ENSMUST00000207812.2
ENSMUST00000175791.9
ENSMUST00000207118.2
ENSMUST00000209085.2
ENSMUST00000112637.10
ENSMUST00000207054.2
ENSMUST00000208589.2
ENSMUST00000176475.9
ENSMUST00000176698.9
ENSMUST00000207832.2
ENSMUST00000177252.9
ENSMUST00000208712.2
ENSMUST00000208186.2
ENSMUST00000208806.2
ENSMUST00000208027.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr11_-_58614840 0.04 ENSMUST00000214728.2
olfactory receptor 318
chr7_-_139162706 0.04 ENSMUST00000106095.3
NK6 homeobox 2
chr1_-_97689263 0.04 ENSMUST00000171129.8
diphosphoinositol pentakisphosphate kinase 2
chr11_-_99457456 0.04 ENSMUST00000055502.5
keratin associated protein 3-1
chr2_+_89821565 0.03 ENSMUST00000111509.3
ENSMUST00000213909.3
olfactory receptor 1261
chr16_-_19425453 0.02 ENSMUST00000078603.3
ENSMUST00000218837.2
olfactory receptor 170
chr11_-_73215442 0.02 ENSMUST00000021119.9
aspartoacylase
chr1_-_63153414 0.02 ENSMUST00000153992.2
ENSMUST00000165066.8
ENSMUST00000172416.8
ENSMUST00000137511.8
INO80 complex subunit D
chr17_+_37689924 0.01 ENSMUST00000215518.2
olfactory receptor 105, pseudogene

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365)
1.7 6.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.2 8.7 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
1.1 2.2 GO:2000978 negative regulation of forebrain neuron differentiation(GO:2000978)
0.8 3.4 GO:0021502 neural fold elevation formation(GO:0021502)
0.7 4.7 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.6 4.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.6 1.7 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.4 1.1 GO:0002661 B cell tolerance induction(GO:0002514) regulation of tolerance induction to self antigen(GO:0002649) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.3 1.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.3 1.0 GO:0010534 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.3 6.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 1.1 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.3 2.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 1.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 0.6 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 1.1 GO:0061181 regulation of mismatch repair(GO:0032423) regulation of chondrocyte development(GO:0061181) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.2 2.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 0.7 GO:0006507 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
0.2 0.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.8 GO:0007320 insemination(GO:0007320)
0.1 6.6 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.1 0.4 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 0.5 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.6 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.3 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.7 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.8 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.7 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 1.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 2.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 3.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.9 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.7 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.6 GO:1903831 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 2.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 3.0 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.7 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.6 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 1.9 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126) gephyrin clustering involved in postsynaptic density assembly(GO:0097116) guanylate kinase-associated protein clustering(GO:0097117)
0.1 1.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 2.3 GO:0008206 bile acid metabolic process(GO:0008206)
0.1 2.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 2.1 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 0.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.4 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 1.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 1.4 GO:0045616 regulation of keratinocyte differentiation(GO:0045616)
0.0 0.3 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 1.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.8 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 2.7 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.3 GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 1.1 GO:0006825 copper ion transport(GO:0006825)
0.0 0.7 GO:0071420 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)
0.0 1.8 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.4 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.2 GO:0007527 adult somatic muscle development(GO:0007527)
0.0 6.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.6 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 1.0 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 2.5 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.6 GO:0048535 lymph node development(GO:0048535)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.7 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 1.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.8 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 2.3 GO:0016573 histone acetylation(GO:0016573)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0005588 collagen type V trimer(GO:0005588)
0.7 6.6 GO:1990357 terminal web(GO:1990357)
0.5 4.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.4 1.9 GO:0017177 glucosidase II complex(GO:0017177)
0.3 1.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.2 1.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.2 2.3 GO:0001739 sex chromatin(GO:0001739)
0.2 2.0 GO:0097427 microtubule bundle(GO:0097427)
0.2 1.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 4.7 GO:0042588 zymogen granule(GO:0042588)
0.1 1.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 1.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 6.9 GO:0043204 perikaryon(GO:0043204)
0.0 7.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 1.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 4.9 GO:0005938 cell cortex(GO:0005938)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0071820 N-box binding(GO:0071820)
0.6 8.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.6 3.1 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.5 5.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 4.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 1.8 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.4 1.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.3 1.0 GO:0070540 stearic acid binding(GO:0070540)
0.3 1.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.3 2.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 6.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 2.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.3 3.4 GO:0070700 BMP receptor binding(GO:0070700)
0.2 6.9 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 1.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 0.6 GO:0004947 bradykinin receptor activity(GO:0004947)
0.2 2.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 1.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 4.5 GO:0031489 myosin V binding(GO:0031489)
0.2 8.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 0.6 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 2.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 6.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 6.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.7 GO:0004630 phospholipase D activity(GO:0004630)
0.1 1.1 GO:0051378 serotonin binding(GO:0051378)
0.1 0.4 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 1.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.7 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.9 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 1.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.7 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 4.6 GO:0044325 ion channel binding(GO:0044325)
0.0 1.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 5.7 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 6.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 8.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 1.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 5.9 PID FGF PATHWAY FGF signaling pathway
0.0 3.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.3 PID IL3 PATHWAY IL3-mediated signaling events
0.0 2.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 8.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID ATR PATHWAY ATR signaling pathway
0.0 0.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.8 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 3.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 5.9 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 7.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 6.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 5.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling