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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hoxc6

Z-value: 0.60

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Transcription factors associated with Hoxc6

Gene Symbol Gene ID Gene Info
ENSMUSG00000001661.6 Hoxc6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc6mm39_v1_chr15_+_102917977_1029180110.262.9e-02Click!

Activity profile of Hoxc6 motif

Sorted Z-values of Hoxc6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_-_129518723 4.07 ENSMUST00000199615.5
ENSMUST00000197079.5
epidermal growth factor
chrX_+_162945162 2.91 ENSMUST00000131543.2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr1_+_88062508 2.77 ENSMUST00000113134.8
ENSMUST00000140092.8
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr3_+_151143524 2.71 ENSMUST00000046977.12
adhesion G protein-coupled receptor L4
chr3_+_151143557 2.61 ENSMUST00000196970.3
adhesion G protein-coupled receptor L4
chr3_-_10273628 2.60 ENSMUST00000029041.6
fatty acid binding protein 4, adipocyte
chr19_+_32597379 2.56 ENSMUST00000236290.2
ENSMUST00000025833.7
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr3_-_92393193 2.38 ENSMUST00000054599.8
small proline-rich protein 1A
chr14_-_64654397 2.38 ENSMUST00000210428.2
methionine sulfoxide reductase A
chr1_+_88030951 2.24 ENSMUST00000113135.6
ENSMUST00000113138.8
UDP glucuronosyltransferase 1 family, polypeptide A7C
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr3_-_144738526 2.17 ENSMUST00000029919.7
chloride channel accessory 1
chrM_+_14138 1.95 ENSMUST00000082421.1
mitochondrially encoded cytochrome b
chrM_+_9459 1.92 ENSMUST00000082411.1
mitochondrially encoded NADH dehydrogenase 3
chr1_+_19279138 1.89 ENSMUST00000027059.11
transcription factor AP-2 beta
chr14_-_64654592 1.85 ENSMUST00000210363.2
methionine sulfoxide reductase A
chrM_-_14061 1.81 ENSMUST00000082419.1
mitochondrially encoded NADH dehydrogenase 6
chr9_-_27066685 1.61 ENSMUST00000034472.16
junction adhesion molecule 3
chr1_+_19279178 1.60 ENSMUST00000187754.7
transcription factor AP-2 beta
chr14_+_79086492 1.58 ENSMUST00000040990.7
von Willebrand factor A domain containing 8
chr7_+_51537645 1.56 ENSMUST00000208711.2
growth arrest specific 2
chr8_-_110688716 1.52 ENSMUST00000001722.14
ENSMUST00000051430.7
MARVEL (membrane-associating) domain containing 3
chrM_+_8603 1.50 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr10_+_5543769 1.49 ENSMUST00000051809.10
myc target 1
chr19_+_24853039 1.43 ENSMUST00000073080.7
predicted gene 10053
chr7_+_45204317 1.41 ENSMUST00000107752.12
hydroxysteroid (17-beta) dehydrogenase 14
chr3_-_151455514 1.37 ENSMUST00000029671.9
interferon-induced protein 44
chr2_+_128704867 1.35 ENSMUST00000110324.8
fibulin 7
chr5_-_83502966 1.30 ENSMUST00000053543.11
trans-2,3-enoyl-CoA reductase-like
chr6_+_36364990 1.29 ENSMUST00000172278.8
cholinergic receptor, muscarinic 2, cardiac
chr6_-_3494587 1.24 ENSMUST00000049985.15
HEPACAM family member 2
chrX_-_93256244 1.19 ENSMUST00000113922.2
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr5_-_83502793 1.19 ENSMUST00000146669.2
trans-2,3-enoyl-CoA reductase-like
chr18_-_56705960 1.15 ENSMUST00000174518.8
aldehyde dehydrogenase family 7, member A1
chr17_+_13094921 0.99 ENSMUST00000075296.4
MAS-related GPR, member H
chr7_+_73390026 0.94 ENSMUST00000107456.4
family with sequence similarity 174, member B
chr2_-_174188505 0.92 ENSMUST00000168292.2
predicted gene, 20721
chr1_-_189654535 0.92 ENSMUST00000027897.8
SET and MYND domain containing 2
chr15_-_50752437 0.90 ENSMUST00000183997.8
ENSMUST00000183757.8
transcriptional repressor GATA binding 1
chrX_-_93256291 0.88 ENSMUST00000050328.15
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr3_+_92840279 0.88 ENSMUST00000046234.5
late cornified envelope 3B
chr5_+_119970733 0.86 ENSMUST00000202723.4
T-box 5
chr15_-_50753061 0.85 ENSMUST00000165201.9
ENSMUST00000184458.8
transcriptional repressor GATA binding 1
chr2_+_150628655 0.78 ENSMUST00000045441.8
brain glycogen phosphorylase
chr11_-_70560110 0.74 ENSMUST00000129434.2
ENSMUST00000018431.13
sperm associated antigen 7
chr16_-_56533179 0.73 ENSMUST00000136394.8
Trk-fused gene
chrX_-_135641869 0.72 ENSMUST00000166930.8
ENSMUST00000113095.8
mortality factor 4 like 2
chrX_-_135642025 0.70 ENSMUST00000155207.8
ENSMUST00000080411.13
ENSMUST00000169418.8
mortality factor 4 like 2
chr10_-_129591354 0.67 ENSMUST00000059038.3
olfactory receptor 807
chr14_+_75479727 0.66 ENSMUST00000022576.10
carboxypeptidase B2 (plasma)
chr7_+_45204350 0.65 ENSMUST00000210300.2
hydroxysteroid (17-beta) dehydrogenase 14
chr2_+_111329683 0.57 ENSMUST00000219064.3
olfactory receptor 1291, pseudogene 1
chr3_-_113325938 0.57 ENSMUST00000132353.2
amylase 2a1
chr15_+_44482667 0.53 ENSMUST00000228648.2
ENSMUST00000226165.2
estrogen receptor-binding fragment-associated gene 9
chr4_+_33062999 0.52 ENSMUST00000108162.8
ENSMUST00000024035.9
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr10_-_62285458 0.52 ENSMUST00000020273.16
suppressor of var1, 3-like 1 (S. cerevisiae)
chr2_-_89172273 0.51 ENSMUST00000215469.2
olfactory receptor 1233
chr19_+_12972378 0.50 ENSMUST00000207997.3
olfactory receptor 1451
chr2_-_111062182 0.48 ENSMUST00000099620.5
olfactory receptor 1275
chr11_+_73973733 0.47 ENSMUST00000178159.2
zinc finger protein 616
chr5_-_121329385 0.46 ENSMUST00000054547.9
ENSMUST00000100770.9
protein tyrosine phosphatase, non-receptor type 11
chr17_+_38082190 0.45 ENSMUST00000217119.2
olfactory receptor 122
chr2_-_51039112 0.44 ENSMUST00000154545.2
ENSMUST00000017288.9
Rho family GTPase 3
chr15_+_91557378 0.40 ENSMUST00000060642.7
leucine-rich repeat kinase 2
chr10_+_23814470 0.40 ENSMUST00000079134.5
trace amine-associated receptor 2
chr4_-_84464521 0.39 ENSMUST00000177040.2
basonuclin 2
chr6_-_123830422 0.39 ENSMUST00000162046.3
vomeronasal 2, receptor 25
chr2_-_87524291 0.38 ENSMUST00000077471.5
olfactory receptor 1136
chr8_-_84976330 0.38 ENSMUST00000019506.9
DNA segment, Chr 8, ERATO Doi 738, expressed
chr8_+_46111778 0.36 ENSMUST00000143820.8
sorbin and SH3 domain containing 2
chr6_-_129894613 0.36 ENSMUST00000118060.8
killer cell lectin-like receptor, subfamily A, member 5
chr11_-_94673526 0.35 ENSMUST00000100554.8
transmembrane protein 92
chr7_-_13856967 0.34 ENSMUST00000098809.4
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr11_-_58624049 0.31 ENSMUST00000075607.5
olfactory receptor 317
chr14_-_52593865 0.31 ENSMUST00000215147.2
olfactory receptor 1513
chr19_+_6414587 0.30 ENSMUST00000155973.2
splicing factor 1
chr6_-_132755125 0.29 ENSMUST00000065532.2
taste receptor, type 2, member 136
chr7_+_108064533 0.29 ENSMUST00000217616.3
olfactory receptor 498
chr2_-_85193571 0.28 ENSMUST00000215511.2
olfactory receptor 988
chr10_-_129463803 0.27 ENSMUST00000204979.3
olfactory receptor 798
chrX_-_95400846 0.26 ENSMUST00000179832.8
heat shock transcription factor 3
chr15_+_44482944 0.25 ENSMUST00000022964.9
estrogen receptor-binding fragment-associated gene 9
chr10_+_19588318 0.24 ENSMUST00000020185.5
interleukin 20 receptor, alpha
chr2_-_121211410 0.24 ENSMUST00000038389.15
stereocilin
chr9_-_39237341 0.21 ENSMUST00000216132.2
olfactory receptor 948
chr12_-_114226570 0.20 ENSMUST00000103479.4
ENSMUST00000195619.2
immunoglobulin heavy variable 3-5
chrX_+_55958781 0.19 ENSMUST00000168724.2
adhesion G protein-coupled receptor G4
chr9_-_76120939 0.19 ENSMUST00000074880.6
GDNF family receptor alpha like
chr5_+_17779273 0.19 ENSMUST00000030568.14
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr10_-_13199971 0.19 ENSMUST00000105543.9
phosphatase and actin regulator 2
chr3_+_133942244 0.15 ENSMUST00000181904.3
CXXC finger 4
chr19_+_11872971 0.14 ENSMUST00000072784.4
olfactory receptor 1420
chr14_-_52616625 0.13 ENSMUST00000214980.2
olfactory receptor 1512
chr14_+_26722319 0.13 ENSMUST00000035433.10
homeobox gene expressed in ES cells
chr2_-_88562710 0.12 ENSMUST00000213118.2
olfactory receptor 1197
chr17_+_3532455 0.09 ENSMUST00000227604.2
T cell lymphoma invasion and metastasis 2
chr1_-_22386016 0.09 ENSMUST00000164877.8
regulating synaptic membrane exocytosis 1
chr9_+_19351562 0.09 ENSMUST00000217273.2
olfactory receptor 849
chr9_-_39161290 0.09 ENSMUST00000213472.2
olfactory receptor 1537
chr6_-_57340712 0.08 ENSMUST00000228156.2
ENSMUST00000227186.2
ENSMUST00000228294.2
ENSMUST00000228342.2
vomeronasal 1 receptor 17
chr3_+_145855929 0.08 ENSMUST00000098524.5
mucolipin 2
chr19_-_12870888 0.07 ENSMUST00000216805.3
ENSMUST00000207741.2
olfactory receptor 1446
chr5_-_129030367 0.05 ENSMUST00000111346.6
ENSMUST00000200470.5
RIMS binding protein 2
chr7_-_85974838 0.05 ENSMUST00000214977.2
olfactory receptor 308
chr7_+_5023375 0.04 ENSMUST00000076251.7
zinc finger protein 865
chrX_+_48552803 0.01 ENSMUST00000130558.8
Rho GTPase activating protein 36
chr2_-_89172742 0.00 ENSMUST00000216561.2
olfactory receptor 1233
chr2_-_88590813 0.00 ENSMUST00000124021.3
olfactory receptor 1199

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0097273 creatinine homeostasis(GO:0097273) cellular ammonia homeostasis(GO:0097275) cellular creatinine homeostasis(GO:0097276) cellular urea homeostasis(GO:0097277)
0.7 2.2 GO:0006711 estrogen catabolic process(GO:0006711)
0.7 2.9 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.6 2.6 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.5 4.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.3 0.9 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.3 2.8 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 1.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 1.9 GO:0033762 response to glucagon(GO:0033762)
0.2 0.5 GO:2000850 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.2 0.7 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 2.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 0.4 GO:2000469 negative regulation of peroxidase activity(GO:2000469)
0.1 0.5 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 1.6 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 2.5 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 1.5 GO:1902414 protein localization to cell junction(GO:1902414)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 2.1 GO:0006706 steroid catabolic process(GO:0006706)
0.1 2.4 GO:0031424 keratinization(GO:0031424)
0.1 1.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 1.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.0 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 1.9 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.8 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 2.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 1.5 GO:0009060 aerobic respiration(GO:0009060)
0.0 4.2 GO:0007568 aging(GO:0007568)
0.0 0.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.4 GO:0043586 tongue development(GO:0043586)
0.0 2.1 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.6 GO:0033010 paranodal junction(GO:0033010)
0.2 1.9 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.4 GO:0044753 amphisome(GO:0044753)
0.1 2.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 3.3 GO:0001533 cornified envelope(GO:0001533)
0.0 3.7 GO:0070469 respiratory chain(GO:0070469)
0.0 1.4 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 4.1 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.6 2.6 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 2.9 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.4 2.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.3 1.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.3 2.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.3 1.2 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 1.9 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.8 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.2 4.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.0 GO:0001595 angiotensin receptor activity(GO:0001595)
0.1 5.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 3.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.4 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.1 0.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.1 2.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 1.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 2.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.5 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 4.1 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 2.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions