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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Hoxd10

Z-value: 0.64

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Transcription factors associated with Hoxd10

Gene Symbol Gene ID Gene Info
Hoxd10
ENSMUSG00000050368.5 Hoxd10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd10mm39_v1_chr2_+_74522258_74522284-0.181.4e-01Click!

Activity profile of Hoxd10 motif

Sorted Z-values of Hoxd10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd10

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_110717062 12.99 ENSMUST00000001720.14
ENSMUST00000143741.2
Tat
tyrosine aminotransferase
chr16_+_22877000 4.46 ENSMUST00000039492.14
ENSMUST00000023589.15
ENSMUST00000089902.8
Kng1
kininogen 1
chr14_+_103750814 3.84 ENSMUST00000095576.5
Scel
sciellin
chr14_+_103750763 3.79 ENSMUST00000227322.2
Scel
sciellin
chr16_-_22847808 3.28 ENSMUST00000115349.9
Kng2
kininogen 2
chr19_+_20470056 3.19 ENSMUST00000225337.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr1_+_139429430 3.03 ENSMUST00000027615.7
F13b
coagulation factor XIII, beta subunit
chr16_-_22847760 2.95 ENSMUST00000039338.13
Kng2
kininogen 2
chr19_+_20470114 2.87 ENSMUST00000225313.2
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr16_-_22847829 2.83 ENSMUST00000100046.9
Kng2
kininogen 2
chr1_-_130589349 2.62 ENSMUST00000027657.14
C4bp
complement component 4 binding protein
chr1_-_130589321 2.60 ENSMUST00000137276.3
C4bp
complement component 4 binding protein
chr3_-_14873406 2.42 ENSMUST00000181860.8
ENSMUST00000144327.3
Car1
carbonic anhydrase 1
chr3_+_137983250 2.24 ENSMUST00000004232.10
Adh1
alcohol dehydrogenase 1 (class I)
chr16_-_22848153 2.15 ENSMUST00000232459.2
Kng2
kininogen 2
chr15_-_12493574 1.87 ENSMUST00000186113.2
Pdzd2
PDZ domain containing 2
chr1_-_132318039 1.82 ENSMUST00000132435.2
Tmcc2
transmembrane and coiled-coil domains 2
chr17_+_71511642 1.73 ENSMUST00000126681.8
Lpin2
lipin 2
chr19_+_34078333 1.70 ENSMUST00000025685.8
Lipm
lipase, family member M
chr12_-_4891435 1.62 ENSMUST00000219880.2
ENSMUST00000020964.7
Fkbp1b
FK506 binding protein 1b
chr3_-_106126794 1.59 ENSMUST00000082219.6
Chil4
chitinase-like 4
chr10_+_128626772 1.56 ENSMUST00000219404.2
ENSMUST00000026411.8
Mmp19
matrix metallopeptidase 19
chr6_+_96090127 1.52 ENSMUST00000122120.8
Tafa1
TAFA chemokine like family member 1
chr1_-_71454041 1.50 ENSMUST00000087268.7
Abca12
ATP-binding cassette, sub-family A (ABC1), member 12
chr6_-_92458324 1.49 ENSMUST00000113445.2
Prickle2
prickle planar cell polarity protein 2
chr10_+_23727325 1.39 ENSMUST00000020190.8
Vnn3
vanin 3
chr2_+_65451100 1.33 ENSMUST00000144254.6
ENSMUST00000028377.14
Scn2a
sodium channel, voltage-gated, type II, alpha
chr9_+_27702243 1.32 ENSMUST00000115243.9
Opcml
opioid binding protein/cell adhesion molecule-like
chr13_-_24098951 1.27 ENSMUST00000021769.16
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr4_+_102112189 1.23 ENSMUST00000106908.9
Pde4b
phosphodiesterase 4B, cAMP specific
chr13_-_72111832 1.22 ENSMUST00000077337.9
Irx1
Iroquois homeobox 1
chr7_+_43339842 1.07 ENSMUST00000056329.7
Klk14
kallikrein related-peptidase 14
chr9_-_54381409 1.05 ENSMUST00000127880.8
Dmxl2
Dmx-like 2
chr2_+_21372338 1.00 ENSMUST00000055946.8
Gpr158
G protein-coupled receptor 158
chr7_+_51530060 0.94 ENSMUST00000145049.2
Gas2
growth arrest specific 2
chr4_+_43401232 0.93 ENSMUST00000125399.2
Rusc2
RUN and SH3 domain containing 2
chr2_+_109522781 0.93 ENSMUST00000111050.10
Bdnf
brain derived neurotrophic factor
chr4_+_100336003 0.89 ENSMUST00000133493.9
ENSMUST00000092730.5
Ube2u
ubiquitin-conjugating enzyme E2U (putative)
chr13_+_38529062 0.89 ENSMUST00000171970.3
Bmp6
bone morphogenetic protein 6
chr12_+_117652526 0.80 ENSMUST00000222185.2
Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_66361252 0.79 ENSMUST00000123647.8
Map2
microtubule-associated protein 2
chr16_-_37681508 0.74 ENSMUST00000205931.2
Gm36028
predicted gene, 36028
chrX_+_65696608 0.69 ENSMUST00000036043.5
Slitrk2
SLIT and NTRK-like family, member 2
chr17_-_37462942 0.67 ENSMUST00000171679.2
Olfr93
olfactory receptor 93
chr3_+_114874614 0.60 ENSMUST00000051309.9
Olfm3
olfactomedin 3
chr18_-_43925932 0.49 ENSMUST00000237926.2
ENSMUST00000096570.4
Gm94
predicted gene 94
chrX_-_9335525 0.49 ENSMUST00000015484.10
Cybb
cytochrome b-245, beta polypeptide
chrX_-_142716200 0.47 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
Dcx
doublecortin
chr14_-_48904958 0.46 ENSMUST00000144465.8
ENSMUST00000133479.8
ENSMUST00000119070.8
ENSMUST00000226501.2
Otx2
orthodenticle homeobox 2
chr1_-_124773767 0.45 ENSMUST00000239072.2
Dpp10
dipeptidylpeptidase 10
chrX_+_7628891 0.45 ENSMUST00000077680.10
ENSMUST00000079542.13
ENSMUST00000115679.8
ENSMUST00000137467.8
Tfe3
transcription factor E3
chr17_-_37397128 0.44 ENSMUST00000070808.3
Olfr90
olfactory receptor 90
chr9_+_38755745 0.40 ENSMUST00000217350.2
Olfr924
olfactory receptor 924
chr3_+_55369149 0.40 ENSMUST00000199585.5
ENSMUST00000070418.9
Dclk1
doublecortin-like kinase 1
chr5_+_150218847 0.40 ENSMUST00000239118.2
Fry
FRY microtubule binding protein
chr6_+_70663930 0.40 ENSMUST00000103402.2
Igkv3-3
immunoglobulin kappa variable 3-3
chrX_-_142716085 0.38 ENSMUST00000087313.10
Dcx
doublecortin
chr10_-_30494333 0.37 ENSMUST00000019925.7
Hint3
histidine triad nucleotide binding protein 3
chr13_-_21740190 0.37 ENSMUST00000068163.2
Olfr1535
olfactory receptor 1535
chr18_+_52748978 0.32 ENSMUST00000072666.4
ENSMUST00000209270.2
Zfp474
zinc finger protein 474
chr10_-_30494431 0.31 ENSMUST00000161074.8
Hint3
histidine triad nucleotide binding protein 3
chr19_-_11816583 0.30 ENSMUST00000214887.2
Olfr1417
olfactory receptor 1417
chr16_-_23751144 0.25 ENSMUST00000231038.2
Rtp2
receptor transporter protein 2
chr19_+_12972378 0.24 ENSMUST00000207997.3
Olfr1451
olfactory receptor 1451
chr14_-_48904998 0.18 ENSMUST00000152018.8
Otx2
orthodenticle homeobox 2
chr9_-_40041480 0.15 ENSMUST00000214981.3
Olfr985
olfactory receptor 985
chr15_+_44059531 0.15 ENSMUST00000038856.14
ENSMUST00000110289.4
Trhr
thyrotropin releasing hormone receptor
chr4_-_36136463 0.12 ENSMUST00000098151.9
Lingo2
leucine rich repeat and Ig domain containing 2
chr19_-_11838430 0.11 ENSMUST00000214796.2
Olfr1418
olfactory receptor 1418
chr2_+_111327525 0.10 ENSMUST00000121345.4
Olfr1291-ps1
olfactory receptor 1291, pseudogene 1
chr14_-_70945434 0.08 ENSMUST00000228346.2
Xpo7
exportin 7
chr7_+_44545501 0.03 ENSMUST00000071207.14
ENSMUST00000209132.2
ENSMUST00000207069.2
ENSMUST00000209039.2
ENSMUST00000207939.3
ENSMUST00000207485.2
ENSMUST00000208179.2
Fuz
fuzzy planar cell polarity protein
chr13_-_21722197 0.02 ENSMUST00000168629.2
ENSMUST00000218154.2
Olfr1366
olfactory receptor 1366
chr10_-_107747995 0.01 ENSMUST00000165341.5
Otogl
otogelin-like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 13.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.7 6.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.6 2.2 GO:0006069 ethanol oxidation(GO:0006069)
0.5 1.5 GO:0035627 ceramide transport(GO:0035627)
0.3 0.9 GO:0061193 taste bud development(GO:0061193)
0.3 1.2 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.3 1.5 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.2 15.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.2 1.6 GO:0051775 response to redox state(GO:0051775)
0.2 1.6 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.9 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 1.3 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.4 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.1 1.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 1.1 GO:0007320 insemination(GO:0007320)
0.1 1.0 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.5 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1 1.6 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 2.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 7.2 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.4 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 1.7 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 1.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 2.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 3.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.9 GO:0016574 histone ubiquitination(GO:0016574)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0043291 RAVE complex(GO:0043291)
0.3 1.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.9 GO:0033503 HULC complex(GO:0033503)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.9 GO:0030061 mitochondrial crista(GO:0030061)
0.0 13.1 GO:0072562 blood microparticle(GO:0072562)
0.0 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 2.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.2 6.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.7 2.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.5 1.5 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.3 0.9 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.2 2.4 GO:0004064 arylesterase activity(GO:0004064)
0.2 1.6 GO:0004568 chitinase activity(GO:0004568)
0.1 15.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 1.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 1.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 4.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 3.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 4.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 13.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation