ISMARA results: Irf2_Irf1_Irf8_Irf9

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.12

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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 Ensembl NCBI MGI UniProt	ENSMUSG00000031627.10	Irf2
Irf1 Ensembl NCBI MGI UniProt	ENSMUSG00000018899.18	Irf1
Irf8 Ensembl NCBI MGI UniProt	ENSMUSG00000041515.11	Irf8
Irf9 Ensembl NCBI MGI UniProt	ENSMUSG00000002325.16	Irf9
Irf7 Ensembl NCBI MGI UniProt	ENSMUSG00000025498.16	Irf7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf7	mm39_v1_chr7_-_140846328_140846394	0.91	3.7e-29	Click!
Irf1	mm39_v1_chr11_+_53660834_53660886	0.88	3.4e-24	Click!
Irf9	mm39_v1_chr14_+_55842002_55842036	0.83	1.1e-19	Click!
Irf8	mm39_v1_chr8_+_121463090_121463124	0.72	6.2e-13	Click!
Irf2	mm39_v1_chr8_+_47192767_47192829	0.56	2.9e-07	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Promoter	Score	Transcript	Gene	Gene Info
chr11_+_48977852 Show fit	51.69	ENSMUST00000046704.7 ENSMUST00000203810.3 ENSMUST00000203149.3	Ifi47 Ensembl NCBI MGI UniProt Show fit Olfr56 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47 olfactory receptor 56
chr4_-_156285247 Show fit	48.34	ENSMUST00000085425.6	Isg15 Ensembl NCBI MGI UniProt Show fit	ISG15 ubiquitin-like modifier
chr6_+_121222865 Show fit	45.89	ENSMUST00000032198.11	Usp18 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 18
chr11_+_48977888 Show fit	45.28	ENSMUST00000214804.2	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr13_-_113237505 Show fit	45.16	ENSMUST00000224282.2 ENSMUST00000023897.7	Gzma Ensembl NCBI MGI UniProt Show fit	granzyme A
chr2_-_173060647 Show fit	44.53	ENSMUST00000109116.3 ENSMUST00000029018.14	Zbp1 Ensembl NCBI MGI UniProt Show fit	Z-DNA binding protein 1
chr7_-_140846328 Show fit	44.23	ENSMUST00000106023.8 ENSMUST00000097952.9 ENSMUST00000026571.11	Irf7 Ensembl NCBI MGI UniProt Show fit	interferon regulatory factor 7
chr3_+_142326363 Show fit	42.34	ENSMUST00000165774.8	Gbp2 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2
chr14_+_78141679 Show fit	37.71	ENSMUST00000022591.16 ENSMUST00000169978.2 ENSMUST00000227903.2	Epsti1 Ensembl NCBI MGI UniProt Show fit	epithelial stromal interaction 1 (breast)
chr17_-_34406193 Show fit	35.27	ENSMUST00000173831.3	Psmb9 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.1	533.1	GO:0035458	cellular response to interferon-beta(GO:0035458)
2.8	97.6	GO:0042832	defense response to protozoan(GO:0042832)
11.5	91.7	GO:0032020	ISG15-protein conjugation(GO:0032020)
5.8	87.0	GO:0060330	regulation of response to interferon-gamma(GO:0060330)
2.6	82.5	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
5.9	70.7	GO:0035456	response to interferon-beta(GO:0035456)
0.4	68.2	GO:0051607	defense response to virus(GO:0051607)
4.1	61.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.4	60.4	GO:0006958	complement activation, classical pathway(GO:0006958)
9.5	56.9	GO:0035549	interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)

Showing 1 to 10 of 446 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	334.6	GO:0005730	nucleolus(GO:0005730)
0.1	315.2	GO:0005829	cytosol(GO:0005829)
0.5	279.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	212.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
13.7	191.3	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	136.0	GO:0005576	extracellular region(GO:0005576)
0.9	129.7	GO:0016605	PML body(GO:0016605)
8.4	118.1	GO:0042612	MHC class I protein complex(GO:0042612)
9.3	74.4	GO:0042825	TAP complex(GO:0042825)
0.1	70.4	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)

Showing 1 to 10 of 165 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	372.9	GO:0003924	GTPase activity(GO:0003924)
1.0	276.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
5.8	174.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
5.1	96.9	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
6.4	95.8	GO:0046977	TAP binding(GO:0046977)
2.8	94.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4	90.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
6.4	76.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	65.9	GO:0003677	DNA binding(GO:0003677)
0.5	63.0	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Showing 1 to 10 of 303 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	127.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.4	91.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	66.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.4	55.2	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.1	52.3	PID TRAIL PATHWAY	TRAIL signaling pathway
3.9	42.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
1.0	37.6	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	33.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.0	31.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4	31.6	PID IL4 2PATHWAY	IL4-mediated signaling events

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.1	448.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
3.7	151.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
1.5	127.7	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
1.5	82.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
4.7	80.5	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
5.7	68.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
3.4	63.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.5	63.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.9	60.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
2.7	53.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI

Showing 1 to 10 of 118 entries

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.12

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: