ISMARA results: Irf2_Irf1_Irf8_Irf9

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.12

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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 Ensembl NCBI MGI UniProt	ENSMUSG00000031627.10	Irf2
Irf1 Ensembl NCBI MGI UniProt	ENSMUSG00000018899.18	Irf1
Irf8 Ensembl NCBI MGI UniProt	ENSMUSG00000041515.11	Irf8
Irf9 Ensembl NCBI MGI UniProt	ENSMUSG00000002325.16	Irf9
Irf7 Ensembl NCBI MGI UniProt	ENSMUSG00000025498.16	Irf7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf7	mm39_v1_chr7_-_140846328_140846394	0.91	3.7e-29	Click!
Irf1	mm39_v1_chr11_+_53660834_53660886	0.88	3.4e-24	Click!
Irf9	mm39_v1_chr14_+_55842002_55842036	0.83	1.1e-19	Click!
Irf8	mm39_v1_chr8_+_121463090_121463124	0.72	6.2e-13	Click!
Irf2	mm39_v1_chr8_+_47192767_47192829	0.56	2.9e-07	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr11_+_48977852 Show fit	51.69	ENSMUST00000046704.7 ENSMUST00000203810.3 ENSMUST00000203149.3	Ifi47 Ensembl NCBI MGI UniProt Show fit Olfr56 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47 olfactory receptor 56
chr4_-_156285247 Show fit	48.34	ENSMUST00000085425.6	Isg15 Ensembl NCBI MGI UniProt Show fit	ISG15 ubiquitin-like modifier
chr6_+_121222865 Show fit	45.89	ENSMUST00000032198.11	Usp18 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 18
chr11_+_48977888 Show fit	45.28	ENSMUST00000214804.2	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr13_-_113237505 Show fit	45.16	ENSMUST00000224282.2 ENSMUST00000023897.7	Gzma Ensembl NCBI MGI UniProt Show fit	granzyme A
chr2_-_173060647 Show fit	44.53	ENSMUST00000109116.3 ENSMUST00000029018.14	Zbp1 Ensembl NCBI MGI UniProt Show fit	Z-DNA binding protein 1
chr7_-_140846328 Show fit	44.23	ENSMUST00000106023.8 ENSMUST00000097952.9 ENSMUST00000026571.11	Irf7 Ensembl NCBI MGI UniProt Show fit	interferon regulatory factor 7
chr3_+_142326363 Show fit	42.34	ENSMUST00000165774.8	Gbp2 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2
chr14_+_78141679 Show fit	37.71	ENSMUST00000022591.16 ENSMUST00000169978.2 ENSMUST00000227903.2	Epsti1 Ensembl NCBI MGI UniProt Show fit	epithelial stromal interaction 1 (breast)
chr17_-_34406193 Show fit	35.27	ENSMUST00000173831.3	Psmb9 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr1_-_173426640 Show fit	35.16	ENSMUST00000150649.9 ENSMUST00000180215.2 ENSMUST00000097462.9	Ifi213 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 213
chr11_-_70350783 Show fit	34.97	ENSMUST00000019064.9	Cxcl16 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 16
chr11_+_119283887 Show fit	34.26	ENSMUST00000093902.12 ENSMUST00000131035.10	Rnf213 Ensembl NCBI MGI UniProt Show fit	ring finger protein 213
chr16_+_35758836 Show fit	33.93	ENSMUST00000114878.8	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr1_+_173501215 Show fit	33.75	ENSMUST00000085876.12	Ifi208 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 208
chr1_-_173770010 Show fit	33.42	ENSMUST00000042228.15 ENSMUST00000081216.12 ENSMUST00000129829.8 ENSMUST00000123708.8	Ifi203 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 203
chr15_-_77417512 Show fit	33.20	ENSMUST00000062562.7 ENSMUST00000230863.2	Apol7c Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 7c
chr2_+_121978156 Show fit	32.73	ENSMUST00000102476.5	B2m Ensembl NCBI MGI UniProt Show fit	beta-2 microglobulin
chr1_+_85577709 Show fit	31.70	ENSMUST00000155094.8 ENSMUST00000054279.15 ENSMUST00000147552.8 ENSMUST00000153574.8 ENSMUST00000150967.8	Sp100 Ensembl NCBI MGI UniProt Show fit	nuclear antigen Sp100
chr19_+_34618271 Show fit	31.37	ENSMUST00000102824.4	Ifit1 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr1_-_173318607 Show fit	30.95	ENSMUST00000160565.4	Ifi206 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 206
chr1_+_85577766 Show fit	30.61	ENSMUST00000066427.11	Sp100 Ensembl NCBI MGI UniProt Show fit	nuclear antigen Sp100
chr16_+_35759346 Show fit	30.57	ENSMUST00000023622.13	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr1_-_173859321 Show fit	30.15	ENSMUST00000059226.7	Ifi205 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 205
chr1_-_173707677 Show fit	29.85	ENSMUST00000190651.4 ENSMUST00000188804.7	Mndal Ensembl NCBI MGI UniProt Show fit	myeloid nuclear differentiation antigen like
chr6_+_145067457 Show fit	28.95	ENSMUST00000032396.13	Lrmp Ensembl NCBI MGI UniProt Show fit	lymphoid-restricted membrane protein
chr18_+_60515755 Show fit	28.37	ENSMUST00000237185.2	Iigp1 Ensembl NCBI MGI UniProt Show fit	interferon inducible GTPase 1
chr9_+_107852733 Show fit	27.82	ENSMUST00000035216.11	Uba7 Ensembl NCBI MGI UniProt Show fit	ubiquitin-like modifier activating enzyme 7
chr19_+_29344846 Show fit	27.45	ENSMUST00000016640.8	Cd274 Ensembl NCBI MGI UniProt Show fit	CD274 antigen
chr3_+_27371168 Show fit	27.39	ENSMUST00000046383.12	Tnfsf10 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 10
chr3_-_151455514 Show fit	27.35	ENSMUST00000029671.9	Ifi44 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein 44
chr11_-_78875689 Show fit	27.33	ENSMUST00000108269.10 ENSMUST00000108268.10	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr19_+_56385531 Show fit	26.95	ENSMUST00000026062.10	Casp7 Ensembl NCBI MGI UniProt Show fit	caspase 7
chr11_-_48955028 Show fit	26.14	ENSMUST00000046745.7	Tgtp2 Ensembl NCBI MGI UniProt Show fit	T cell specific GTPase 2
chr7_+_103893658 Show fit	26.11	ENSMUST00000106849.9 ENSMUST00000060315.12	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr11_-_78875657 Show fit	25.88	ENSMUST00000073001.5	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr1_-_85526517 Show fit	25.45	ENSMUST00000093508.7	Sp110 Ensembl NCBI MGI UniProt Show fit	Sp110 nuclear body protein
chr8_-_71990085 Show fit	25.13	ENSMUST00000051672.9	Bst2 Ensembl NCBI MGI UniProt Show fit	bone marrow stromal cell antigen 2
chr15_-_76127600 Show fit	24.75	ENSMUST00000165738.8 ENSMUST00000075689.7	Parp10 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 10
chr16_-_35759461 Show fit	24.75	ENSMUST00000081933.14 ENSMUST00000114885.3	Dtx3l Ensembl NCBI MGI UniProt Show fit	deltex 3-like, E3 ubiquitin ligase
chr4_-_40239700 Show fit	24.38	ENSMUST00000142055.2	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD/H box helicase 58
chr7_+_103893672 Show fit	24.01	ENSMUST00000106848.8	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr16_+_23428650 Show fit	23.46	ENSMUST00000038423.6 ENSMUST00000211349.2	Rtp4 Ensembl NCBI MGI UniProt Show fit	receptor transporter protein 4
chr17_+_34406523 Show fit	23.37	ENSMUST00000170086.8	Tap1 Ensembl NCBI MGI UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_46701619 Show fit	23.21	ENSMUST00000068877.7	Timd4 Ensembl NCBI MGI UniProt Show fit	T cell immunoglobulin and mucin domain containing 4
chr11_-_48883053 Show fit	23.08	ENSMUST00000059930.3 ENSMUST00000068063.4	Gm12185 Ensembl NCBI MGI UniProt Show fit Tgtp1 Ensembl NCBI MGI UniProt Show fit	predicted gene 12185 T cell specific GTPase 1
chr1_-_173363523 Show fit	22.98	ENSMUST00000139092.8	Ifi214 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 214
chr7_-_140590605 Show fit	22.90	ENSMUST00000026565.7	Ifitm3 Ensembl NCBI MGI UniProt Show fit	interferon induced transmembrane protein 3
chr4_-_40239778 Show fit	22.83	ENSMUST00000037907.13	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD/H box helicase 58
chr15_+_75734159 Show fit	22.68	ENSMUST00000023238.6 ENSMUST00000230514.2 ENSMUST00000229331.2	Gsdmd Ensembl NCBI MGI UniProt Show fit	gasdermin D
chr18_+_60345152 Show fit	22.30	ENSMUST00000031549.6	Gm4951 Ensembl NCBI MGI UniProt Show fit	predicted gene 4951
chr4_-_155013002 Show fit	22.29	ENSMUST00000152687.8 ENSMUST00000137803.8 ENSMUST00000145296.2	Tnfrsf14 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chrX_-_9335525 Show fit	22.06	ENSMUST00000015484.10	Cybb Ensembl NCBI MGI UniProt Show fit	cytochrome b-245, beta polypeptide
chr17_-_35081129 Show fit	21.96	ENSMUST00000154526.8	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr4_-_42773987 Show fit	21.89	ENSMUST00000095114.5	Ccl21a Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 21A (serine)
chr17_-_36353582 Show fit	21.53	ENSMUST00000058801.15 ENSMUST00000080015.12 ENSMUST00000077960.7	H2-T22 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, T region locus 22
chr5_-_92496730 Show fit	21.34	ENSMUST00000038816.13 ENSMUST00000118006.3	Cxcl10 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 10
chr8_-_71219299 Show fit	21.26	ENSMUST00000222087.4	Ifi30 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 30
chr7_-_102214636 Show fit	21.24	ENSMUST00000106913.3 ENSMUST00000033264.12	Trim21 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 21
chr2_-_51863203 Show fit	21.03	ENSMUST00000028314.9	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr4_-_46536088 Show fit	20.94	ENSMUST00000102924.3 ENSMUST00000046897.13	Trim14 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 14
chr17_+_34406762 Show fit	20.85	ENSMUST00000041633.15	Tap1 Ensembl NCBI MGI UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_48762170 Show fit	20.77	ENSMUST00000049519.4 ENSMUST00000097271.4	Irgm1 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 1
chr1_+_175459559 Show fit	20.68	ENSMUST00000040250.15	Kmo Ensembl NCBI MGI UniProt Show fit	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_+_111383864 Show fit	20.47	ENSMUST00000220537.2 ENSMUST00000223050.2 ENSMUST00000072646.8 ENSMUST00000223431.2 ENSMUST00000221144.2 ENSMUST00000222437.2	Exoc3l4 Ensembl NCBI MGI UniProt Show fit	exocyst complex component 3-like 4
chr7_+_78563513 Show fit	20.14	ENSMUST00000038142.15	Isg20 Ensembl NCBI MGI UniProt Show fit	interferon-stimulated protein
chr11_+_101473062 Show fit	20.03	ENSMUST00000039581.14 ENSMUST00000100403.9 ENSMUST00000107194.8 ENSMUST00000128614.2	Tmem106a Ensembl NCBI MGI UniProt Show fit	transmembrane protein 106A
chr9_+_5298669 Show fit	19.87	ENSMUST00000238505.2	Casp1 Ensembl NCBI MGI UniProt Show fit	caspase 1
chr5_+_115034997 Show fit	19.84	ENSMUST00000031542.13 ENSMUST00000146072.8 ENSMUST00000150361.2	Oasl2 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase-like 2
chr12_-_26506422 Show fit	19.49	ENSMUST00000020970.10	Rsad2 Ensembl NCBI MGI UniProt Show fit	radical S-adenosyl methionine domain containing 2
chr6_-_38331187 Show fit	19.45	ENSMUST00000114900.8 ENSMUST00000143702.5	Zc3hav1 Ensembl NCBI MGI UniProt Show fit	zinc finger CCCH type, antiviral 1
chr15_+_77613239 Show fit	19.39	ENSMUST00000230979.2 ENSMUST00000109775.4	Apol9b Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9b
chr5_-_105287405 Show fit	19.13	ENSMUST00000100961.5 ENSMUST00000031235.13 ENSMUST00000197799.2 ENSMUST00000199629.2 ENSMUST00000196677.5 ENSMUST00000100962.8	Gbp9 Ensembl NCBI MGI UniProt Show fit Gbp8 Ensembl NCBI MGI UniProt Show fit Gbp4 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 9 guanylate-binding protein 8 guanylate binding protein 4
chr1_+_130754413 Show fit	18.86	ENSMUST00000027675.14 ENSMUST00000133792.8	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr5_-_105441554 Show fit	18.50	ENSMUST00000050011.10 ENSMUST00000196520.2	Gm43302 Ensembl NCBI MGI UniProt Show fit Gbp6 Ensembl NCBI MGI UniProt Show fit	predicted gene 43302 guanylate binding protein 6
chr4_-_155012534 Show fit	18.45	ENSMUST00000219534.3	Tnfrsf14 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr2_-_51862941 Show fit	18.34	ENSMUST00000145481.8 ENSMUST00000112705.9	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr9_-_88613967 Show fit	18.30	ENSMUST00000098486.4	Bcl2a1d Ensembl NCBI MGI UniProt Show fit	B cell leukemia/lymphoma 2 related protein A1d
chr4_-_155012643 Show fit	18.17	ENSMUST00000123514.8	Tnfrsf14 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr11_+_88890202 Show fit	18.05	ENSMUST00000100627.9 ENSMUST00000107896.10 ENSMUST00000000284.7	Trim25 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 25
chr1_-_173740467 Show fit	17.17	ENSMUST00000009340.10	Ifi211 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 211
chr19_+_29388312 Show fit	16.97	ENSMUST00000112576.4	Pdcd1lg2 Ensembl NCBI MGI UniProt Show fit	programmed cell death 1 ligand 2
chr6_-_125208738 Show fit	16.96	ENSMUST00000043422.8	Tapbpl Ensembl NCBI MGI UniProt Show fit	TAP binding protein-like
chr1_-_173594475 Show fit	16.65	ENSMUST00000111214.4	Ifi204 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 204
chr1_+_175459735 Show fit	16.58	ENSMUST00000097458.4	Kmo Ensembl NCBI MGI UniProt Show fit	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr8_-_45786226 Show fit	16.41	ENSMUST00000095328.6	Cyp4v3 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 4, subfamily v, polypeptide 3
chr1_-_156501860 Show fit	16.33	ENSMUST00000188964.7 ENSMUST00000190607.2 ENSMUST00000079625.11	Tor3a Ensembl NCBI MGI UniProt Show fit	torsin family 3, member A
chr3_+_27371206 Show fit	16.10	ENSMUST00000174840.2	Tnfsf10 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 10
chr5_-_105258142 Show fit	15.90	ENSMUST00000031238.13	Gbp9 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 9
chr17_-_35081456 Show fit	15.65	ENSMUST00000025229.11 ENSMUST00000176203.9 ENSMUST00000128767.8	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr17_+_34573760 Show fit	15.62	ENSMUST00000178562.2 ENSMUST00000025198.15	Btnl2 Ensembl NCBI MGI UniProt Show fit	butyrophilin-like 2
chr13_+_120761861 Show fit	15.56	ENSMUST00000225029.2	BC147527 Ensembl NCBI MGI UniProt Show fit	cDNA sequence BC147527
chr14_+_14475188 Show fit	15.43	ENSMUST00000026315.8	Dnase1l3 Ensembl NCBI MGI UniProt Show fit	deoxyribonuclease 1-like 3
chr9_+_88838953 Show fit	15.39	ENSMUST00000098485.4	Bcl2a1a Ensembl NCBI MGI UniProt Show fit	B cell leukemia/lymphoma 2 related protein A1a
chr2_+_84629172 Show fit	15.34	ENSMUST00000102642.9 ENSMUST00000150325.2	Ube2l6 Ensembl NCBI MGI UniProt Show fit	ubiquitin-conjugating enzyme E2L 6
chr5_-_120915693 Show fit	15.26	ENSMUST00000044833.9	Oas3 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase 3
chr7_-_104002534 Show fit	15.02	ENSMUST00000130139.3 ENSMUST00000059037.15	Trim12c Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 12C
chr13_-_100454182 Show fit	14.85	ENSMUST00000118574.8	Naip6 Ensembl NCBI MGI UniProt Show fit	NLR family, apoptosis inhibitory protein 6
chr11_+_48977495 Show fit	14.67	ENSMUST00000152914.2	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr18_+_60936910 Show fit	14.63	ENSMUST00000097563.9 ENSMUST00000050487.16 ENSMUST00000167610.2	Cd74 Ensembl NCBI MGI UniProt Show fit	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr6_+_70703409 Show fit	14.54	ENSMUST00000103410.3	Igkc Ensembl NCBI MGI UniProt Show fit	immunoglobulin kappa constant
chr7_+_78563964 Show fit	14.54	ENSMUST00000120331.4	Isg20 Ensembl NCBI MGI UniProt Show fit	interferon-stimulated protein
chr6_+_39358036 Show fit	14.51	ENSMUST00000031986.5	Rab19 Ensembl NCBI MGI UniProt Show fit	RAB19, member RAS oncogene family
chr18_+_60509101 Show fit	14.44	ENSMUST00000032473.7 ENSMUST00000066912.13	Iigp1 Ensembl NCBI MGI UniProt Show fit	interferon inducible GTPase 1
chr5_-_134258435 Show fit	14.27	ENSMUST00000016094.13 ENSMUST00000111275.8 ENSMUST00000144086.2	Ncf1 Ensembl NCBI MGI UniProt Show fit	neutrophil cytosolic factor 1
chr11_-_53750016 Show fit	14.20	ENSMUST00000117316.8 ENSMUST00000120776.8 ENSMUST00000121435.2	Gm12216 Ensembl NCBI MGI UniProt Show fit	predicted gene 12216
chr19_+_6214416 Show fit	13.98	ENSMUST00000045042.8 ENSMUST00000237511.2	Batf2 Ensembl NCBI MGI UniProt Show fit	basic leucine zipper transcription factor, ATF-like 2
chr5_-_120887864 Show fit	13.77	ENSMUST00000053909.13 ENSMUST00000081491.13	Oas2 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase 2
chr17_+_35658131 Show fit	13.62	ENSMUST00000071951.14 ENSMUST00000116598.10 ENSMUST00000078205.14 ENSMUST00000076256.8	H2-Q7 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 7
chr16_-_10603389 Show fit	13.61	ENSMUST00000229866.2 ENSMUST00000038099.6	Socs1 Ensembl NCBI MGI UniProt Show fit	suppressor of cytokine signaling 1
chr5_+_115061293 Show fit	13.33	ENSMUST00000031540.11 ENSMUST00000112143.4	Oasl1 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase-like 1
chr2_+_24275321 Show fit	13.33	ENSMUST00000056641.15 ENSMUST00000142522.8 ENSMUST00000131930.2	Psd4 Ensembl NCBI MGI UniProt Show fit	pleckstrin and Sec7 domain containing 4
chr9_-_106353571 Show fit	13.32	ENSMUST00000123555.8 ENSMUST00000125850.2	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr10_-_34003933 Show fit	13.31	ENSMUST00000062784.8	Calhm6 Ensembl NCBI MGI UniProt Show fit	calcium homeostasis modulator family member 6
chr19_+_34560922 Show fit	13.27	ENSMUST00000102825.4	Ifit3 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr19_-_29344694 Show fit	13.15	ENSMUST00000138051.2	Plgrkt Ensembl NCBI MGI UniProt Show fit	plasminogen receptor, C-terminal lysine transmembrane protein
chr11_-_100595019 Show fit	13.11	ENSMUST00000017974.13	Dhx58 Ensembl NCBI MGI UniProt Show fit	DEXH (Asp-Glu-X-His) box polypeptide 58
chr8_-_106665060 Show fit	12.94	ENSMUST00000034369.10	Psmb10 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 10
chr8_-_112064783 Show fit	12.90	ENSMUST00000056157.14 ENSMUST00000120432.3	Mlkl Ensembl NCBI MGI UniProt Show fit	mixed lineage kinase domain-like
chr17_+_34138699 Show fit	12.77	ENSMUST00000234320.2	Tapbp Ensembl NCBI MGI UniProt Show fit	TAP binding protein
chr7_-_104157006 Show fit	12.75	ENSMUST00000033211.14 ENSMUST00000071069.13	Trim30d Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 30D
chr16_-_35691914 Show fit	12.69	ENSMUST00000042665.9	Parp14 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 14
chr13_+_56757389 Show fit	12.66	ENSMUST00000045173.10	Tgfbi Ensembl NCBI MGI UniProt Show fit	transforming growth factor, beta induced
chr4_-_144973423 Show fit	12.61	ENSMUST00000030336.11	Tnfrsf1b Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor receptor superfamily, member 1b
chr5_-_105387395 Show fit	12.60	ENSMUST00000065588.7	Gbp10 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 10
chr3_+_95434093 Show fit	12.58	ENSMUST00000015667.9 ENSMUST00000116304.3	Ctss Ensembl NCBI MGI UniProt Show fit	cathepsin S
chr7_+_78564062 Show fit	12.52	ENSMUST00000205981.2	Isg20 Ensembl NCBI MGI UniProt Show fit	interferon-stimulated protein
chr1_-_184464810 Show fit	12.49	ENSMUST00000048572.7	Hlx Ensembl NCBI MGI UniProt Show fit	H2.0-like homeobox
chr14_+_55815999 Show fit	12.36	ENSMUST00000172738.2 ENSMUST00000089619.13	Psme1 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_142236086 Show fit	12.34	ENSMUST00000171263.8 ENSMUST00000045097.11	Gbp7 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 7
chr11_+_58090382 Show fit	12.26	ENSMUST00000035266.11 ENSMUST00000094169.11 ENSMUST00000168280.2 ENSMUST00000058704.9	Igtp Ensembl NCBI MGI UniProt Show fit Irgm2 Ensembl NCBI MGI UniProt Show fit	interferon gamma induced GTPase immunity-related GTPase family M member 2
chr2_+_84818538 Show fit	12.17	ENSMUST00000028466.12	Prg3 Ensembl NCBI MGI UniProt Show fit	proteoglycan 3
chr6_-_38331482 Show fit	12.09	ENSMUST00000031850.10 ENSMUST00000114898.3	Zc3hav1 Ensembl NCBI MGI UniProt Show fit	zinc finger CCCH type, antiviral 1
chr13_+_74787952 Show fit	12.03	ENSMUST00000221822.2 ENSMUST00000221526.2	Erap1 Ensembl NCBI MGI UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr14_-_66071412 Show fit	12.01	ENSMUST00000022613.10	Esco2 Ensembl NCBI MGI UniProt Show fit	establishment of sister chromatid cohesion N-acetyltransferase 2
chr17_+_36432553 Show fit	11.96	ENSMUST00000173128.2	Gm19684 Ensembl NCBI MGI UniProt Show fit	predicted gene, 19684
chr3_-_7678785 Show fit	11.93	ENSMUST00000194279.6	Il7 Ensembl NCBI MGI UniProt Show fit	interleukin 7
chr9_+_5345405 Show fit	11.87	ENSMUST00000027009.11	Casp12 Ensembl NCBI MGI UniProt Show fit	caspase 12
chr1_+_52158599 Show fit	11.87	ENSMUST00000186574.7 ENSMUST00000070968.14 ENSMUST00000191435.7 ENSMUST00000186857.7 ENSMUST00000188681.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr7_-_140535899 Show fit	11.83	ENSMUST00000081649.10	Ifitm2 Ensembl NCBI MGI UniProt Show fit	interferon induced transmembrane protein 2
chr17_-_34219225 Show fit	11.79	ENSMUST00000238098.2 ENSMUST00000087189.7 ENSMUST00000173075.3 ENSMUST00000172912.8 ENSMUST00000236740.2 ENSMUST00000025181.18	H2-K1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, K1, K region
chr14_+_55815879 Show fit	11.74	ENSMUST00000174563.8	Psme1 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_+_85454323 Show fit	11.52	ENSMUST00000239236.2	Gm7592 Ensembl NCBI MGI UniProt Show fit	predicted gene 7592
chr1_+_153627692 Show fit	11.51	ENSMUST00000183241.8	Rnasel Ensembl NCBI MGI UniProt Show fit	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr17_+_34138611 Show fit	11.50	ENSMUST00000234247.2	Tapbp Ensembl NCBI MGI UniProt Show fit	TAP binding protein
chr3_-_7678796 Show fit	11.48	ENSMUST00000192202.6	Il7 Ensembl NCBI MGI UniProt Show fit	interleukin 7
chr17_+_37504783 Show fit	11.34	ENSMUST00000038844.7	Ubd Ensembl NCBI MGI UniProt Show fit	ubiquitin D
chr1_+_52158693 Show fit	11.31	ENSMUST00000189347.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr11_+_101339233 Show fit	11.23	ENSMUST00000010502.13	Ifi35 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein 35
chr3_+_142266113 Show fit	11.20	ENSMUST00000106221.8	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr9_+_5345450 Show fit	10.96	ENSMUST00000151332.2	Casp12 Ensembl NCBI MGI UniProt Show fit	caspase 12
chr6_+_40619913 Show fit	10.95	ENSMUST00000238599.2	Mgam Ensembl NCBI MGI UniProt Show fit	maltase-glucoamylase
chr17_-_79190002 Show fit	10.94	ENSMUST00000024884.5	Eif2ak2 Ensembl NCBI MGI UniProt Show fit	eukaryotic translation initiation factor 2-alpha kinase 2
chr14_+_55815817 Show fit	10.91	ENSMUST00000174259.8	Psme1 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_+_142014546 Show fit	10.87	ENSMUST00000105968.8 ENSMUST00000018963.11 ENSMUST00000105967.8	Lsp1 Ensembl NCBI MGI UniProt Show fit	lymphocyte specific 1
chr4_+_134847949 Show fit	10.87	ENSMUST00000056977.14	Runx3 Ensembl NCBI MGI UniProt Show fit	runt related transcription factor 3
chr19_-_34579356 Show fit	10.85	ENSMUST00000168254.3	Ifit1bl1 Ensembl NCBI MGI UniProt Show fit	interferon induced protein with tetratricpeptide repeats 1B like 1
chr15_+_79776597 Show fit	10.81	ENSMUST00000175714.8 ENSMUST00000109620.10 ENSMUST00000165537.8 ENSMUST00000175752.8 ENSMUST00000176325.8	Apobec3 Ensembl NCBI MGI UniProt Show fit	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr15_-_77480311 Show fit	10.75	ENSMUST00000089465.6	Apol10b Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 10B
chr7_-_44785815 Show fit	10.70	ENSMUST00000146760.7	Flt3l Ensembl NCBI MGI UniProt Show fit	FMS-like tyrosine kinase 3 ligand
chr3_+_142265904 Show fit	10.44	ENSMUST00000128609.8 ENSMUST00000029935.14	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr2_-_103114105 Show fit	10.40	ENSMUST00000111174.8	Ehf Ensembl NCBI MGI UniProt Show fit	ets homologous factor
chr5_-_137145030 Show fit	10.37	ENSMUST00000054384.6 ENSMUST00000152207.2	Trim56 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 56
chr1_-_172418058 Show fit	10.36	ENSMUST00000065679.8	Slamf8 Ensembl NCBI MGI UniProt Show fit	SLAM family member 8
chr19_+_10819896 Show fit	10.34	ENSMUST00000025646.3	Slc15a3 Ensembl NCBI MGI UniProt Show fit	solute carrier family 15, member 3
chr16_-_97264099 Show fit	10.28	ENSMUST00000023655.13	Mx1 Ensembl NCBI MGI UniProt Show fit	MX dynamin-like GTPase 1
chr1_-_69725045 Show fit	10.16	ENSMUST00000190771.7	Ikzf2 Ensembl NCBI MGI UniProt Show fit	IKAROS family zinc finger 2
chr12_-_79054050 Show fit	10.04	ENSMUST00000056660.13 ENSMUST00000174721.8	Tmem229b Ensembl NCBI MGI UniProt Show fit	transmembrane protein 229B
chr19_-_3955230 Show fit	10.02	ENSMUST00000145791.8	Tcirg1 Ensembl NCBI MGI UniProt Show fit	T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
chr3_+_142265787 Show fit	9.91	ENSMUST00000199325.5 ENSMUST00000106222.9	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr7_-_44785709 Show fit	9.90	ENSMUST00000211429.2	Flt3l Ensembl NCBI MGI UniProt Show fit	FMS-like tyrosine kinase 3 ligand
chr17_+_35481702 Show fit	9.88	ENSMUST00000172785.8	H2-D1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, D region locus 1
chr9_-_106353303 Show fit	9.87	ENSMUST00000156426.8	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr7_-_140535828 Show fit	9.82	ENSMUST00000211129.2	Gm45717 Ensembl NCBI MGI UniProt Show fit	predicted gene 45717
chr7_-_44785480 Show fit	9.74	ENSMUST00000211246.2 ENSMUST00000210197.2	Flt3l Ensembl NCBI MGI UniProt Show fit	FMS-like tyrosine kinase 3 ligand
chr14_+_55815580 Show fit	9.72	ENSMUST00000174484.8	Psme1 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_-_130148984 Show fit	9.70	ENSMUST00000160289.9	Nsmce4a Ensembl NCBI MGI UniProt Show fit	NSE4 homolog A, SMC5-SMC6 complex component
chr2_+_118428690 Show fit	9.66	ENSMUST00000038341.8	Bub1b Ensembl NCBI MGI UniProt Show fit	BUB1B, mitotic checkpoint serine/threonine kinase
chr19_+_34585322 Show fit	9.64	ENSMUST00000076249.6	Ifit3b Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3B
chr17_-_34218301 Show fit	9.58	ENSMUST00000235463.2	H2-K1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, K1, K region
chr16_+_97337275 Show fit	9.49	ENSMUST00000024112.8	Mx2 Ensembl NCBI MGI UniProt Show fit	MX dynamin-like GTPase 2
chr11_+_83066009 Show fit	9.46	ENSMUST00000000208.13 ENSMUST00000167596.2	Slfn4 Ensembl NCBI MGI UniProt Show fit	schlafen 4
chr15_-_77295234 Show fit	9.41	ENSMUST00000089452.6 ENSMUST00000081776.11	Apol9a Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9a
chr11_-_48870105 Show fit	9.34	ENSMUST00000141200.2 ENSMUST00000097494.9 ENSMUST00000093153.2	9930111J21Rik1 Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 9930111J21 gene 1
chr19_-_11243530 Show fit	9.33	ENSMUST00000169159.3	Ms4a1 Ensembl NCBI MGI UniProt Show fit	membrane-spanning 4-domains, subfamily A, member 1
chr6_-_69626340 Show fit	9.31	ENSMUST00000198328.2	Igkv4-53 Ensembl NCBI MGI UniProt Show fit	immunoglobulin kappa variable 4-53
chr1_-_144651157 Show fit	9.22	ENSMUST00000027603.4	Rgs18 Ensembl NCBI MGI UniProt Show fit	regulator of G-protein signaling 18
chr1_-_69724939 Show fit	9.18	ENSMUST00000027146.9	Ikzf2 Ensembl NCBI MGI UniProt Show fit	IKAROS family zinc finger 2
chr1_+_58750647 Show fit	9.14	ENSMUST00000097722.9 ENSMUST00000114313.8	Cflar Ensembl NCBI MGI UniProt Show fit	CASP8 and FADD-like apoptosis regulator
chr6_+_34722926 Show fit	9.10	ENSMUST00000126181.8	Cald1 Ensembl NCBI MGI UniProt Show fit	caldesmon 1
chr1_+_52158721 Show fit	9.06	ENSMUST00000186057.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr8_+_95161006 Show fit	8.95	ENSMUST00000211816.2	Nlrc5 Ensembl NCBI MGI UniProt Show fit	NLR family, CARD domain containing 5
chr10_-_88192852 Show fit	8.87	ENSMUST00000020249.2	Dram1 Ensembl NCBI MGI UniProt Show fit	DNA-damage regulated autophagy modulator 1
chr2_+_164897547 Show fit	8.85	ENSMUST00000017799.12 ENSMUST00000073707.9	Cd40 Ensembl NCBI MGI UniProt Show fit	CD40 antigen
chr12_-_103409912 Show fit	8.78	ENSMUST00000055071.9	Ifi27l2a Ensembl NCBI MGI UniProt Show fit	interferon, alpha-inducible protein 27 like 2A
chr6_-_54949587 Show fit	8.74	ENSMUST00000060655.15	Nod1 Ensembl NCBI MGI UniProt Show fit	nucleotide-binding oligomerization domain containing 1
chr4_+_52439237 Show fit	8.73	ENSMUST00000102915.10 ENSMUST00000117280.8 ENSMUST00000142227.3	Smc2 Ensembl NCBI MGI UniProt Show fit	structural maintenance of chromosomes 2
chr3_+_142300601 Show fit	8.68	ENSMUST00000029936.5	Gbp2b Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2b
chr17_+_35598583 Show fit	8.67	ENSMUST00000081435.5	H2-Q4 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 4
chr14_+_55842002 Show fit	8.60	ENSMUST00000138037.2	Irf9 Ensembl NCBI MGI UniProt Show fit	interferon regulatory factor 9

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
19.6	39.1	GO:0002481	antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
16.7	50.1	GO:0046967	cytosol to ER transport(GO:0046967)
13.1	39.4	GO:1902524	positive regulation of protein K48-linked ubiquitination(GO:1902524)
12.0	12.0	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483)
11.5	91.7	GO:0032020	ISG15-protein conjugation(GO:0032020)
11.1	44.2	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
10.7	32.2	GO:0034240	negative regulation of macrophage fusion(GO:0034240)
10.6	53.2	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
10.1	533.1	GO:0035458	cellular response to interferon-beta(GO:0035458)
9.6	28.7	GO:2000547	regulation of dendritic cell dendrite assembly(GO:2000547)
9.5	56.9	GO:0035549	interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
9.4	37.4	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
8.5	51.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
7.8	31.2	GO:0002484	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
7.6	15.3	GO:0060700	regulation of ribonuclease activity(GO:0060700)
7.6	30.5	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
7.4	44.2	GO:0019805	quinolinate biosynthetic process(GO:0019805)
6.8	6.8	GO:0002428	antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
6.5	19.5	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
6.3	18.9	GO:0002414	immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414)
6.1	24.3	GO:0050822	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
5.9	70.7	GO:0035456	response to interferon-beta(GO:0035456)
5.9	17.6	GO:0002590	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
5.9	29.3	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
5.8	87.0	GO:0060330	regulation of response to interferon-gamma(GO:0060330)
5.7	22.7	GO:0051673	membrane disruption in other organism(GO:0051673)
5.4	27.0	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
5.1	35.7	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
5.1	50.8	GO:0032074	negative regulation of nuclease activity(GO:0032074)
4.9	44.5	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
4.9	29.5	GO:1990166	protein localization to site of double-strand break(GO:1990166)
4.8	14.3	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
4.7	23.4	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
4.6	13.9	GO:0045083	negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
4.3	21.3	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
4.2	12.6	GO:0034769	basement membrane disassembly(GO:0034769)
4.1	61.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
3.9	27.5	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
3.9	15.4	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
3.8	11.3	GO:0030887	positive regulation of myeloid dendritic cell activation(GO:0030887)
3.7	7.5	GO:0002649	regulation of tolerance induction to self antigen(GO:0002649)
3.7	18.7	GO:0070543	response to linoleic acid(GO:0070543)
3.7	18.7	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
3.3	10.0	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
3.3	9.9	GO:2001200	positive regulation of dendritic cell differentiation(GO:2001200)
3.1	15.4	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
3.0	23.7	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
3.0	47.3	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
2.9	14.7	GO:0034421	post-translational protein acetylation(GO:0034421)
2.9	14.6	GO:0071350	interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
2.8	31.1	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.8	97.6	GO:0042832	defense response to protozoan(GO:0042832)
2.7	30.2	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
2.7	16.4	GO:0060369	positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
2.7	26.5	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
2.6	82.5	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
2.5	12.5	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
2.4	7.1	GO:0036275	response to 5-fluorouracil(GO:0036275)
2.4	37.6	GO:0006957	complement activation, alternative pathway(GO:0006957)
2.3	7.0	GO:0031104	dendrite regeneration(GO:0031104)
2.1	6.3	GO:0060809	CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
2.1	6.3	GO:0002632	regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
2.1	22.9	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
2.0	48.9	GO:0019884	antigen processing and presentation of exogenous antigen(GO:0019884)
1.9	7.7	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.9	22.8	GO:0016540	protein autoprocessing(GO:0016540)
1.9	13.1	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
1.9	9.4	GO:0097309	cap1 mRNA methylation(GO:0097309)
1.9	50.0	GO:0035634	response to stilbenoid(GO:0035634)
1.8	35.0	GO:0010818	T cell chemotaxis(GO:0010818)
1.8	5.5	GO:0060220	camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
1.8	9.2	GO:0001692	histamine metabolic process(GO:0001692)
1.8	5.5	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
1.8	5.3	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
1.7	13.8	GO:0018377	protein myristoylation(GO:0018377)
1.6	6.5	GO:0006272	leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
1.6	8.1	GO:0051754	meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.6	4.8	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
1.5	4.6	GO:0071288	cellular response to mercury ion(GO:0071288)
1.5	14.8	GO:0070269	pyroptosis(GO:0070269)
1.5	4.4	GO:2000769	positive regulation of NMDA glutamate receptor activity(GO:1904783) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771)
1.5	17.5	GO:1900225	regulation of NLRP3 inflammasome complex assembly(GO:1900225)
1.3	5.3	GO:0034499	late endosome to Golgi transport(GO:0034499)
1.3	4.0	GO:0032701	negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685) negative regulation of interleukin-18 production(GO:0032701)
1.3	23.7	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
1.3	9.2	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.3	5.2	GO:0051329	interphase(GO:0051325) mitotic interphase(GO:0051329)
1.3	3.9	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.3	10.3	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.3	17.6	GO:0045351	type I interferon biosynthetic process(GO:0045351)
1.2	1.2	GO:0038018	Wnt receptor catabolic process(GO:0038018)
1.2	20.9	GO:0032897	negative regulation of viral transcription(GO:0032897)
1.2	30.6	GO:0008053	mitochondrial fusion(GO:0008053)
1.2	2.4	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
1.2	12.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
1.2	20.5	GO:0051601	exocyst localization(GO:0051601)
1.2	14.2	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
1.2	15.0	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
1.2	5.8	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
1.1	4.6	GO:0090096	lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
1.1	4.5	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)
1.1	18.0	GO:0032825	positive regulation of natural killer cell differentiation(GO:0032825)
1.1	15.6	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
1.1	7.7	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
1.1	4.4	GO:0002838	negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
1.1	6.3	GO:0019364	pyridine nucleotide catabolic process(GO:0019364)
1.0	3.1	GO:1903976	negative regulation of glial cell migration(GO:1903976)
1.0	40.4	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
1.0	5.1	GO:0001783	B cell apoptotic process(GO:0001783)
1.0	3.1	GO:1903632	positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
1.0	8.1	GO:0035726	common myeloid progenitor cell proliferation(GO:0035726)
1.0	2.9	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
1.0	2.9	GO:0045226	extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.0	35.3	GO:0019882	antigen processing and presentation(GO:0019882)
0.9	3.7	GO:0006227	dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.9	3.7	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.9	4.5	GO:1904975	response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.9	0.9	GO:1990009	retinal cell apoptotic process(GO:1990009)
0.9	16.0	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.9	8.7	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.9	5.2	GO:0006116	NADH oxidation(GO:0006116)
0.9	35.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.8	3.3	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.8	2.5	GO:0014739	positive regulation of muscle hyperplasia(GO:0014739)
0.8	2.5	GO:1990918	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705) double-strand break repair involved in meiotic recombination(GO:1990918)
0.8	24.0	GO:0002360	T cell lineage commitment(GO:0002360)
0.8	6.4	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.8	3.2	GO:0016584	nucleosome positioning(GO:0016584)
0.8	3.2	GO:0006447	regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.8	3.2	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.8	2.4	GO:0030221	basophil differentiation(GO:0030221)
0.8	3.1	GO:0072086	specification of loop of Henle identity(GO:0072086)
0.8	14.0	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.8	2.3	GO:0032348	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.8	3.1	GO:0072355	histone H3-T3 phosphorylation(GO:0072355)
0.8	3.1	GO:0043328	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.8	0.8	GO:0061763	multivesicular body-lysosome fusion(GO:0061763)
0.8	6.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.7	6.0	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.7	5.2	GO:0002827	positive regulation of T-helper 1 type immune response(GO:0002827)
0.7	2.2	GO:0018900	dichloromethane metabolic process(GO:0018900)
0.7	2.2	GO:0021558	trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.7	0.7	GO:0002884	negative regulation of hypersensitivity(GO:0002884)
0.7	6.5	GO:0033184	positive regulation of histone ubiquitination(GO:0033184)
0.7	2.2	GO:0090367	negative regulation of mRNA modification(GO:0090367)
0.7	5.0	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.7	2.1	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.7	4.9	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.7	18.7	GO:0051205	protein insertion into membrane(GO:0051205)
0.7	3.4	GO:0018101	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.7	3.4	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.7	3.4	GO:0046947	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.7	2.7	GO:0006982	response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.7	4.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.7	5.3	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.7	2.0	GO:0098583	mastication(GO:0071626) learned vocalization behavior(GO:0098583)
0.7	5.9	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.6	7.1	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.6	3.8	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.6	1.9	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.6	4.4	GO:0044351	macropinocytosis(GO:0044351)
0.6	4.9	GO:0016554	cytidine to uridine editing(GO:0016554)
0.6	17.3	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.6	2.5	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.6	2.4	GO:0061386	closure of optic fissure(GO:0061386)
0.6	10.3	GO:0006857	oligopeptide transport(GO:0006857)
0.6	4.2	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.6	6.6	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.6	2.4	GO:0016332	establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.6	3.6	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.6	4.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.6	1.8	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.6	3.5	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.6	1.8	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.6	1.7	GO:1903904	negative regulation of establishment of T cell polarity(GO:1903904)
0.6	1.7	GO:0046061	DNA protection(GO:0042262) dATP catabolic process(GO:0046061)
0.6	3.5	GO:0031642	negative regulation of myelination(GO:0031642)
0.6	2.3	GO:0038156	interleukin-3-mediated signaling pathway(GO:0038156)
0.6	7.9	GO:0051490	negative regulation of filopodium assembly(GO:0051490)
0.6	5.6	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.6	1.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.6	2.2	GO:0009816	defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.5	8.2	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.5	12.6	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5	2.7	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.5	3.2	GO:0061511	centriole elongation(GO:0061511)
0.5	7.0	GO:0006968	cellular defense response(GO:0006968)
0.5	2.1	GO:1902896	terminal web assembly(GO:1902896)
0.5	2.6	GO:0036023	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.5	3.0	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.5	2.5	GO:0021622	optic cup structural organization(GO:0003409) oculomotor nerve development(GO:0021557) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.5	3.5	GO:0016266	O-glycan processing(GO:0016266)
0.5	2.0	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.5	6.8	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.5	1.5	GO:0045013	carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.5	2.4	GO:0006041	glucosamine metabolic process(GO:0006041)
0.5	3.8	GO:0032494	response to peptidoglycan(GO:0032494)
0.5	1.4	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.5	9.8	GO:0070266	necroptotic process(GO:0070266)
0.5	1.4	GO:0006553	lysine metabolic process(GO:0006553)
0.5	0.5	GO:2000642	negative regulation of early endosome to late endosome transport(GO:2000642)
0.5	2.8	GO:0007296	vitellogenesis(GO:0007296)
0.5	13.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.4	10.6	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.4	5.3	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.4	11.4	GO:0019731	antibacterial humoral response(GO:0019731)
0.4	6.1	GO:0048525	negative regulation of viral process(GO:0048525)
0.4	6.1	GO:0019985	translesion synthesis(GO:0019985)
0.4	3.0	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4	3.4	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.4	68.2	GO:0051607	defense response to virus(GO:0051607)
0.4	2.6	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.4	2.1	GO:0017185	peptidyl-lysine hydroxylation(GO:0017185)
0.4	3.8	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.4	6.8	GO:0045779	negative regulation of bone resorption(GO:0045779)
0.4	60.4	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	2.9	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
0.4	3.7	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.4	4.5	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)
0.4	1.2	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.4	4.8	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.4	0.4	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.4	1.2	GO:0036090	cleavage furrow ingression(GO:0036090)
0.4	3.5	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.4	3.5	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.4	14.1	GO:0010390	histone monoubiquitination(GO:0010390)
0.4	8.1	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.4	4.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.4	1.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.4	11.5	GO:0035855	megakaryocyte development(GO:0035855)
0.4	1.1	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.4	1.1	GO:0006583	melanin biosynthetic process from tyrosine(GO:0006583)
0.4	1.4	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.4	4.6	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.4	3.2	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3	1.7	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.3	2.8	GO:0090344	negative regulation of cell aging(GO:0090344)
0.3	5.5	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.3	1.4	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.3	1.3	GO:2000348	regulation of CD40 signaling pathway(GO:2000348)
0.3	7.6	GO:0051639	actin filament network formation(GO:0051639)
0.3	2.3	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.3	1.3	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
0.3	2.8	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3	2.2	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.3	2.5	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.3	6.8	GO:0051923	sulfation(GO:0051923)
0.3	1.5	GO:0044375	regulation of peroxisome size(GO:0044375)
0.3	3.8	GO:0002347	response to tumor cell(GO:0002347)
0.3	0.9	GO:1904735	negative regulation of electron carrier activity(GO:1904733) regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:1904735) negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:1904736)
0.3	3.7	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.3	1.7	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.3	3.6	GO:0042541	hemoglobin biosynthetic process(GO:0042541)
0.3	1.6	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.3	4.4	GO:0043248	proteasome assembly(GO:0043248)
0.3	1.4	GO:0031639	plasminogen activation(GO:0031639)
0.3	3.8	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.3	3.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.3	2.7	GO:0042407	cristae formation(GO:0042407)
0.3	1.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.3	2.4	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.3	22.7	GO:0006940	regulation of smooth muscle contraction(GO:0006940)
0.3	5.9	GO:0042119	neutrophil activation(GO:0042119)
0.3	2.0	GO:0051095	regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.3	6.8	GO:0048247	lymphocyte chemotaxis(GO:0048247)
0.3	1.0	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.3	0.8	GO:0035037	sperm entry(GO:0035037)
0.2	9.1	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2	2.7	GO:0035878	nail development(GO:0035878)
0.2	1.2	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.2	6.6	GO:0017144	drug metabolic process(GO:0017144)
0.2	2.2	GO:0006528	asparagine metabolic process(GO:0006528)
0.2	0.9	GO:1902965	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2	2.1	GO:0046884	follicle-stimulating hormone secretion(GO:0046884)
0.2	1.8	GO:0046533	regulation of photoreceptor cell differentiation(GO:0046532) negative regulation of photoreceptor cell differentiation(GO:0046533)
0.2	3.3	GO:0090527	actin filament reorganization(GO:0090527)
0.2	4.6	GO:0016322	neuron remodeling(GO:0016322)
0.2	1.3	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.2	5.5	GO:0070208	protein heterotrimerization(GO:0070208)
0.2	0.6	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.2	1.3	GO:0090160	positive regulation of pinocytosis(GO:0048549) Golgi to lysosome transport(GO:0090160)
0.2	1.4	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.2	1.4	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.2	1.4	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.2	0.8	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.2	4.2	GO:0031000	response to caffeine(GO:0031000)
0.2	0.4	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
0.2	1.9	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.2	1.7	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.2	0.8	GO:0032887	regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.2	6.3	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2	4.6	GO:1903441	protein localization to ciliary membrane(GO:1903441)
0.2	3.1	GO:0006622	protein targeting to lysosome(GO:0006622)
0.2	5.0	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.2	14.7	GO:1900046	regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.2	1.5	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.2	3.7	GO:1903427	negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.2	0.4	GO:2001176	mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.2	1.4	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2	34.2	GO:0002377	immunoglobulin production(GO:0002377)
0.2	0.9	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.2	3.3	GO:0042088	T-helper 1 type immune response(GO:0042088)
0.2	1.6	GO:0006271	DNA strand elongation involved in DNA replication(GO:0006271)
0.2	0.8	GO:0034334	adherens junction maintenance(GO:0034334)
0.2	0.8	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.2	4.1	GO:0009072	aromatic amino acid family metabolic process(GO:0009072)
0.2	0.8	GO:0016075	rRNA catabolic process(GO:0016075)
0.2	1.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.2	2.0	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2	16.1	GO:0019395	fatty acid oxidation(GO:0019395)
0.1	4.0	GO:0045116	protein neddylation(GO:0045116)
0.1	7.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.1	1.8	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.1	2.8	GO:0006465	signal peptide processing(GO:0006465)
0.1	5.2	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.1	8.9	GO:0002224	toll-like receptor signaling pathway(GO:0002224)
0.1	2.4	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.1	2.7	GO:0000460	maturation of 5.8S rRNA(GO:0000460)
0.1	1.9	GO:1904659	glucose transmembrane transport(GO:1904659)
0.1	12.1	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1	2.1	GO:0021702	cerebellar Purkinje cell differentiation(GO:0021702)
0.1	0.4	GO:0032218	riboflavin transport(GO:0032218)
0.1	5.9	GO:0050829	defense response to Gram-negative bacterium(GO:0050829)
0.1	1.7	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.1	1.7	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.1	1.7	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.1	1.4	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1	1.4	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1	0.5	GO:0032298	positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
0.1	1.7	GO:1904778	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1	3.2	GO:0001780	neutrophil homeostasis(GO:0001780)
0.1	1.0	GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1	0.7	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1	3.8	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1	3.2	GO:0006911	phagocytosis, engulfment(GO:0006911)
0.1	0.7	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1	0.4	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.1	0.4	GO:0006669	sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1	0.3	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1	0.9	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1	1.4	GO:0015838	amino-acid betaine transport(GO:0015838)
0.1	1.7	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1	4.2	GO:1901998	toxin transport(GO:1901998)
0.1	1.4	GO:0032801	receptor catabolic process(GO:0032801)
0.1	3.5	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.1	2.7	GO:0006491	N-glycan processing(GO:0006491)
0.1	7.8	GO:0042632	cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1	0.4	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1	0.1	GO:0001914	regulation of T cell mediated cytotoxicity(GO:0001914)
0.1	1.5	GO:0050832	defense response to fungus(GO:0050832)
0.1	0.4	GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1	3.8	GO:0000132	establishment of mitotic spindle orientation(GO:0000132)
0.1	8.8	GO:0006487	protein N-linked glycosylation(GO:0006487)
0.1	4.9	GO:0006695	cholesterol biosynthetic process(GO:0006695)
0.1	0.8	GO:0032836	glomerular basement membrane development(GO:0032836)
0.1	2.1	GO:0060712	spongiotrophoblast layer development(GO:0060712)
0.1	1.6	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.1	3.6	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.1	1.6	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.1	4.1	GO:0008203	cholesterol metabolic process(GO:0008203)
0.1	0.8	GO:0021842	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1	1.4	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.1	0.6	GO:0061462	protein localization to lysosome(GO:0061462)
0.1	0.2	GO:0060467	negative regulation of fertilization(GO:0060467)
0.1	0.5	GO:0090234	regulation of kinetochore assembly(GO:0090234)
0.1	1.0	GO:0006054	N-acetylneuraminate metabolic process(GO:0006054)
0.1	0.2	GO:0002034	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.1	5.1	GO:0002250	adaptive immune response(GO:0002250)
0.1	0.7	GO:0061727	methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1	7.5	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.1	16.1	GO:0009617	response to bacterium(GO:0009617)
0.1	3.7	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.1	0.4	GO:0036337	Fas signaling pathway(GO:0036337)
0.1	0.1	GO:0071169	establishment of protein localization to chromatin(GO:0071169)
0.1	0.5	GO:0035729	cellular response to hepatocyte growth factor stimulus(GO:0035729)
0.1	1.0	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1	2.6	GO:0006270	DNA replication initiation(GO:0006270)
0.1	0.8	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.1	0.5	GO:0002155	thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.1	0.2	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.1	1.9	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.1	0.8	GO:0007220	Notch receptor processing(GO:0007220)
0.1	0.5	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.1	2.3	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1	0.7	GO:0052696	flavonoid metabolic process(GO:0009812) flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1	0.1	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1	0.3	GO:0070914	UV-damage excision repair(GO:0070914)
0.1	1.4	GO:0000305	response to oxygen radical(GO:0000305)
0.1	1.2	GO:0001893	maternal placenta development(GO:0001893)
0.1	1.8	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1	0.4	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.1	2.9	GO:0006939	smooth muscle contraction(GO:0006939)
0.1	1.1	GO:0030033	microvillus assembly(GO:0030033)
0.1	5.8	GO:0042098	T cell proliferation(GO:0042098)
0.1	0.7	GO:0051418	interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1	1.2	GO:0044783	mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783)
0.1	0.4	GO:1900037	regulation of cellular response to hypoxia(GO:1900037)
0.1	2.8	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	0.8	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.1	1.8	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1	2.1	GO:0003170	heart valve development(GO:0003170)
0.1	4.0	GO:0045766	positive regulation of angiogenesis(GO:0045766)
0.0	0.4	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.9	GO:0030238	male sex determination(GO:0030238)
0.0	0.4	GO:0035067	negative regulation of histone acetylation(GO:0035067)
0.0	1.5	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	1.5	GO:0001702	gastrulation with mouth forming second(GO:0001702)
0.0	1.0	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.6	GO:0042761	very long-chain fatty acid biosynthetic process(GO:0042761)
0.0	0.4	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	2.1	GO:0051972	regulation of telomerase activity(GO:0051972)
0.0	0.4	GO:0015961	diadenosine polyphosphate catabolic process(GO:0015961)
0.0	0.3	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.3	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	1.7	GO:0044380	protein localization to cytoskeleton(GO:0044380)
0.0	2.9	GO:0071774	response to fibroblast growth factor(GO:0071774)
0.0	0.7	GO:0045056	transcytosis(GO:0045056)
0.0	0.8	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	2.0	GO:0006909	phagocytosis(GO:0006909)
0.0	0.4	GO:0006105	succinate metabolic process(GO:0006105)
0.0	2.4	GO:0006637	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0	1.2	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.5	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0	0.3	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	1.0	GO:0030488	tRNA methylation(GO:0030488)
0.0	5.1	GO:0030308	negative regulation of cell growth(GO:0030308)
0.0	0.6	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.5	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	1.8	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.1	GO:0061090	positive regulation of sequestering of zinc ion(GO:0061090)
0.0	0.2	GO:0040033	miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0	3.0	GO:0009791	post-embryonic development(GO:0009791)
0.0	0.4	GO:0046415	urate metabolic process(GO:0046415)
0.0	2.5	GO:0050821	protein stabilization(GO:0050821)
0.0	0.1	GO:2000535	exocyst assembly(GO:0001927) entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	1.7	GO:0034101	erythrocyte homeostasis(GO:0034101)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	1.6	GO:0007098	centrosome cycle(GO:0007098)
0.0	0.7	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
0.0	1.0	GO:0042113	B cell activation(GO:0042113)
0.0	0.7	GO:0042158	protein lipidation(GO:0006497) lipoprotein biosynthetic process(GO:0042158)
0.0	0.9	GO:0008033	tRNA processing(GO:0008033)
0.0	0.2	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.2	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
13.7	191.3	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
9.3	74.4	GO:0042825	TAP complex(GO:0042825)
8.4	118.1	GO:0042612	MHC class I protein complex(GO:0042612)
8.4	16.9	GO:0020003	symbiont-containing vacuole(GO:0020003)
8.0	48.2	GO:1990111	spermatoproteasome complex(GO:1990111)
7.7	30.8	GO:0097169	AIM2 inflammasome complex(GO:0097169)
7.5	44.7	GO:0008537	proteasome activator complex(GO:0008537)
5.8	23.2	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
3.0	27.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
3.0	14.8	GO:0072557	IPAF inflammasome complex(GO:0072557)
2.5	7.6	GO:0032127	dense core granule membrane(GO:0032127)
2.4	7.1	GO:0097132	cyclin D2-CDK6 complex(GO:0097132)
2.3	22.7	GO:0030478	actin cap(GO:0030478)
2.2	6.5	GO:0070557	PCNA-p21 complex(GO:0070557)
2.1	14.8	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
2.1	33.9	GO:0043020	NADPH oxidase complex(GO:0043020)
2.0	20.3	GO:1990462	omegasome(GO:1990462)
1.8	30.1	GO:0035631	CD40 receptor complex(GO:0035631)
1.7	8.7	GO:0030915	Smc5-Smc6 complex(GO:0030915)
1.6	21.0	GO:0042611	MHC protein complex(GO:0042611)
1.5	9.2	GO:0005663	DNA replication factor C complex(GO:0005663)
1.4	4.3	GO:0097224	sperm connecting piece(GO:0097224)
1.4	5.8	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
1.4	21.9	GO:0044754	autolysosome(GO:0044754)
1.3	3.9	GO:1990622	CHOP-ATF3 complex(GO:1990622)
1.2	14.7	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
1.2	4.8	GO:0097447	dendritic tree(GO:0097447)
1.1	36.4	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
1.1	13.9	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
1.1	3.2	GO:0005588	collagen type V trimer(GO:0005588)
1.0	3.1	GO:0000814	ESCRT II complex(GO:0000814)
1.0	13.5	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.9	129.7	GO:0016605	PML body(GO:0016605)
0.9	4.6	GO:0005577	fibrinogen complex(GO:0005577)
0.9	8.7	GO:0000796	condensin complex(GO:0000796)
0.8	5.9	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.8	0.8	GO:0042788	polysomal ribosome(GO:0042788)
0.8	20.6	GO:0000145	exocyst(GO:0000145)
0.8	2.4	GO:1990666	PCSK9-LDLR complex(GO:1990666)
0.8	29.9	GO:0035861	site of double-strand break(GO:0035861)
0.8	3.1	GO:0043202	lysosomal lumen(GO:0043202)
0.8	4.5	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.7	2.2	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.7	2.2	GO:0070992	translation initiation complex(GO:0070992)
0.7	5.0	GO:0072487	MSL complex(GO:0072487)
0.7	9.3	GO:1990635	proximal dendrite(GO:1990635)
0.7	51.8	GO:0072562	blood microparticle(GO:0072562)
0.6	6.5	GO:0019815	B cell receptor complex(GO:0019815)
0.5	2.7	GO:0017177	glucosidase II complex(GO:0017177)
0.5	279.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.5	30.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.5	4.0	GO:0045293	mRNA editing complex(GO:0045293)
0.5	12.6	GO:0043196	varicosity(GO:0043196)
0.5	15.0	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.4	2.7	GO:0061617	MICOS complex(GO:0061617)
0.4	1.7	GO:0060171	stereocilium membrane(GO:0060171)
0.4	4.3	GO:0005677	chromatin silencing complex(GO:0005677)
0.4	2.1	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.4	3.9	GO:0042382	paraspeckles(GO:0042382)
0.4	0.4	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.4	16.0	GO:0055038	recycling endosome membrane(GO:0055038)
0.4	4.2	GO:0070531	BRCA1-A complex(GO:0070531)
0.4	3.3	GO:0045298	tubulin complex(GO:0045298)
0.4	212.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.4	48.7	GO:0032587	ruffle membrane(GO:0032587)
0.4	1.8	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.4	9.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.3	2.7	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3	3.0	GO:0042587	glycogen granule(GO:0042587)
0.3	1.6	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.3	3.4	GO:0061700	GATOR2 complex(GO:0061700)
0.3	2.1	GO:1990357	terminal web(GO:1990357)
0.3	0.9	GO:0030896	checkpoint clamp complex(GO:0030896)
0.3	1.1	GO:0002142	stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.3	1.4	GO:0031251	PAN complex(GO:0031251)
0.3	334.6	GO:0005730	nucleolus(GO:0005730)
0.3	1.9	GO:0036157	outer dynein arm(GO:0036157)
0.3	4.8	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.3	2.4	GO:0005579	membrane attack complex(GO:0005579)
0.3	1.5	GO:0033503	HULC complex(GO:0033503)
0.2	29.7	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	6.3	GO:0031616	spindle pole centrosome(GO:0031616)
0.2	2.4	GO:0008385	IkappaB kinase complex(GO:0008385)
0.2	2.3	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.2	1.4	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.2	1.6	GO:0043657	host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.2	4.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.2	15.9	GO:0016363	nuclear matrix(GO:0016363)
0.2	1.4	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2	45.6	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.2	1.0	GO:0005914	spot adherens junction(GO:0005914)
0.2	11.6	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	4.4	GO:0031528	microvillus membrane(GO:0031528)
0.2	2.8	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.2	1.1	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2	1.7	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2	5.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	2.6	GO:0042555	MCM complex(GO:0042555)
0.2	7.7	GO:0001772	immunological synapse(GO:0001772)
0.1	11.9	GO:0005581	collagen trimer(GO:0005581)
0.1	2.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.1	2.7	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.1	1.6	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	1.8	GO:0031209	SCAR complex(GO:0031209)
0.1	2.9	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	4.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	0.6	GO:0044307	dendritic branch(GO:0044307)
0.1	0.4	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1	9.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	1.7	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1	70.4	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1	2.5	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.1	0.2	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	0.4	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1	0.6	GO:0043293	apoptosome(GO:0043293)
0.1	1.4	GO:0017119	Golgi transport complex(GO:0017119)
0.1	3.0	GO:0009925	basal plasma membrane(GO:0009925)
0.1	1.2	GO:0070938	contractile ring(GO:0070938)
0.1	13.8	GO:0000775	chromosome, centromeric region(GO:0000775)
0.1	3.9	GO:0031201	SNARE complex(GO:0031201)
0.1	0.8	GO:0098645	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1	14.0	GO:0005604	basement membrane(GO:0005604)
0.1	0.3	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1	0.9	GO:0051286	cell tip(GO:0051286)
0.1	0.3	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.1	2.0	GO:0097470	ribbon synapse(GO:0097470)
0.1	0.9	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	0.6	GO:0044327	dendritic spine head(GO:0044327)
0.1	0.7	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1	0.7	GO:0005642	annulate lamellae(GO:0005642)
0.1	1.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	6.1	GO:0030175	filopodium(GO:0030175)
0.1	1.0	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1	23.0	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.1	3.2	GO:1990391	DNA repair complex(GO:1990391)
0.1	315.2	GO:0005829	cytosol(GO:0005829)
0.1	3.3	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	0.7	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.1	2.1	GO:0015935	small ribosomal subunit(GO:0015935)
0.1	0.8	GO:0070765	gamma-secretase complex(GO:0070765)
0.1	0.9	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.1	4.7	GO:0005884	actin filament(GO:0005884)
0.1	1.1	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.1	1.8	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	2.3	GO:0045095	keratin filament(GO:0045095)
0.1	1.9	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0	1.9	GO:0005811	lipid particle(GO:0005811)
0.0	23.1	GO:0009986	cell surface(GO:0009986)
0.0	1.0	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	6.1	GO:0031965	nuclear membrane(GO:0031965)
0.0	1.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	2.6	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.6	GO:0031010	ISWI-type complex(GO:0031010)
0.0	3.6	GO:0005635	nuclear envelope(GO:0005635)
0.0	0.9	GO:0031901	early endosome membrane(GO:0031901)
0.0	136.0	GO:0005576	extracellular region(GO:0005576)
0.0	1.4	GO:0005871	kinesin complex(GO:0005871)
0.0	0.3	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	0.3	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	1.0	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	2.2	GO:0005903	brush border(GO:0005903)
0.0	0.6	GO:0001726	ruffle(GO:0001726)
0.0	0.5	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.2	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.8	GO:0031970	organelle envelope lumen(GO:0031970)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
16.7	50.1	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
12.4	37.3	GO:0003692	left-handed Z-DNA binding(GO:0003692)
10.2	51.1	GO:0008859	exoribonuclease II activity(GO:0008859)
6.4	95.8	GO:0046977	TAP binding(GO:0046977)
6.4	76.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
5.9	53.2	GO:0016936	galactoside binding(GO:0016936)
5.8	174.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
5.6	27.8	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
5.1	96.9	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
4.5	13.5	GO:0005174	CD40 receptor binding(GO:0005174)
4.4	48.9	GO:0061133	endopeptidase activator activity(GO:0061133)
3.8	11.3	GO:0032394	MHC class Ib receptor activity(GO:0032394)
3.7	18.7	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
3.6	21.3	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
3.4	37.9	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
3.4	6.8	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
3.3	39.9	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
2.9	47.0	GO:0031386	protein tag(GO:0031386)
2.9	8.7	GO:0019002	GMP binding(GO:0019002)
2.9	40.4	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
2.9	17.1	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
2.8	33.9	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
2.8	94.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
2.7	10.9	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
2.6	15.5	GO:0042296	ISG15 transferase activity(GO:0042296)
2.6	7.7	GO:0030337	DNA polymerase processivity factor activity(GO:0030337)
2.5	7.5	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
2.5	22.4	GO:0031849	olfactory receptor binding(GO:0031849)
2.4	14.7	GO:0042289	MHC class II protein binding(GO:0042289)
2.4	23.9	GO:0019763	immunoglobulin receptor activity(GO:0019763)
2.3	13.6	GO:0030881	beta-2-microglobulin binding(GO:0030881)
2.3	6.8	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
2.3	22.7	GO:1901612	cardiolipin binding(GO:1901612)
2.2	6.6	GO:0042015	interleukin-20 binding(GO:0042015)
2.1	21.0	GO:0050700	CARD domain binding(GO:0050700)
2.1	12.4	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
2.0	46.6	GO:0070628	proteasome binding(GO:0070628)
1.8	7.1	GO:0098770	FBXO family protein binding(GO:0098770)
1.8	8.8	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
1.8	5.3	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
1.8	5.3	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
1.7	41.8	GO:0048020	CCR chemokine receptor binding(GO:0048020)
1.7	42.9	GO:0042605	peptide antigen binding(GO:0042605)
1.7	8.3	GO:0004974	leukotriene receptor activity(GO:0004974)
1.6	6.6	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.6	9.4	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
1.5	13.8	GO:0005138	interleukin-6 receptor binding(GO:0005138)
1.5	4.5	GO:0045142	triplex DNA binding(GO:0045142)
1.4	4.3	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
1.4	7.1	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
1.4	35.2	GO:0051400	BH domain binding(GO:0051400)
1.4	1.4	GO:0031852	mu-type opioid receptor binding(GO:0031852)
1.4	4.2	GO:0016749	5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
1.4	6.8	GO:0031996	thioesterase binding(GO:0031996)
1.3	21.5	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
1.3	14.7	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.3	5.3	GO:0070976	TIR domain binding(GO:0070976)
1.3	3.8	GO:1990698	palmitoleoyltransferase activity(GO:1990698)
1.2	22.4	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
1.2	4.8	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
1.1	8.0	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
1.1	25.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
1.1	45.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
1.1	4.2	GO:0031752	D5 dopamine receptor binding(GO:0031752)
1.0	4.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
1.0	3.1	GO:0035175	histone kinase activity (H3-S10 specific)(GO:0035175)
1.0	8.3	GO:0000293	ferric-chelate reductase activity(GO:0000293)
1.0	372.9	GO:0003924	GTPase activity(GO:0003924)
1.0	14.4	GO:0050897	cobalt ion binding(GO:0050897)
1.0	276.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0	5.0	GO:0045322	unmethylated CpG binding(GO:0045322)
1.0	4.8	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.9	5.7	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.9	3.7	GO:0004127	cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.9	4.6	GO:0045340	mercury ion binding(GO:0045340)
0.9	6.9	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.8	10.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.8	9.2	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.8	20.9	GO:0005537	mannose binding(GO:0005537)
0.8	6.7	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.8	5.8	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.8	4.9	GO:0038051	glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.8	2.5	GO:0004510	tryptophan 5-monooxygenase activity(GO:0004510)
0.8	7.0	GO:0048019	receptor antagonist activity(GO:0048019)
0.8	4.7	GO:0034618	arginine binding(GO:0034618)
0.8	3.0	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8	2.3	GO:0004912	interleukin-3 receptor activity(GO:0004912) interleukin-3 binding(GO:0019978)
0.7	2.2	GO:0047651	hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.7	3.7	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.7	2.9	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.7	7.7	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.7	4.8	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.7	3.4	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.7	13.0	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.6	8.4	GO:0001069	regulatory region RNA binding(GO:0001069)
0.6	4.3	GO:0032027	myosin light chain binding(GO:0032027)
0.6	1.8	GO:0008775	acetate CoA-transferase activity(GO:0008775)
0.6	5.9	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.6	2.9	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.6	4.1	GO:0015265	urea channel activity(GO:0015265)
0.6	1.8	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.6	6.9	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.6	3.3	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.5	52.1	GO:0003725	double-stranded RNA binding(GO:0003725)
0.5	1.6	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.5	6.6	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.5	3.8	GO:0043515	kinetochore binding(GO:0043515)
0.5	2.7	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.5	2.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.5	4.3	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.5	3.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.5	63.0	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5	5.5	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.5	4.0	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.5	2.0	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.5	2.0	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.5	25.0	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.5	1.9	GO:0001512	dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
0.5	3.8	GO:0070412	R-SMAD binding(GO:0070412)
0.5	2.4	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.5	1.4	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.5	17.9	GO:0001968	fibronectin binding(GO:0001968)
0.5	22.6	GO:0005044	scavenger receptor activity(GO:0005044)
0.5	3.7	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.5	8.7	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5	22.3	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.5	24.8	GO:0001786	phosphatidylserine binding(GO:0001786)
0.4	1.3	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.4	4.4	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.4	2.6	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.4	9.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.4	55.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	5.4	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.4	13.6	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.4	2.9	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.4	90.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.4	31.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.4	4.8	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4	0.4	GO:0061628	H3K27me3 modified histone binding(GO:0061628)
0.4	5.2	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.4	1.4	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.3	3.5	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.3	3.1	GO:0055104	ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.3	18.7	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3	3.3	GO:0070513	death domain binding(GO:0070513)
0.3	1.0	GO:0016426	tRNA (adenine) methyltransferase activity(GO:0016426)
0.3	2.3	GO:0004849	uridine kinase activity(GO:0004849)
0.3	3.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.3	9.4	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.3	3.4	GO:0015217	ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3	2.4	GO:0003996	acyl-CoA ligase activity(GO:0003996)
0.3	16.1	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
0.3	12.4	GO:0015036	disulfide oxidoreductase activity(GO:0015036)
0.3	11.8	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3	1.4	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.3	16.7	GO:0019843	rRNA binding(GO:0019843)
0.3	2.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.3	2.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974) histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3	0.8	GO:0004637	phosphoribosylamine-glycine ligase activity(GO:0004637)
0.3	3.1	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2	16.3	GO:0016836	hydro-lyase activity(GO:0016836)
0.2	27.9	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2	1.4	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.2	1.6	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2	2.3	GO:0039706	co-receptor binding(GO:0039706)
0.2	0.2	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2	3.9	GO:0003993	acid phosphatase activity(GO:0003993)
0.2	12.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.2	5.4	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	2.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2	1.3	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.2	3.3	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2	2.0	GO:0030267	hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2	0.8	GO:0030629	U6 snRNA 3'-end binding(GO:0030629)
0.2	3.9	GO:0008266	poly(U) RNA binding(GO:0008266)
0.2	2.4	GO:0019957	C-C chemokine binding(GO:0019957)
0.2	1.4	GO:0050694	galactose 3-O-sulfotransferase activity(GO:0050694)
0.2	9.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	17.5	GO:0042805	actinin binding(GO:0042805)
0.2	1.5	GO:0017040	ceramidase activity(GO:0017040)
0.2	1.0	GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.2	22.1	GO:0033613	activating transcription factor binding(GO:0033613)
0.2	1.7	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.2	1.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.2	0.4	GO:0046965	retinoid X receptor binding(GO:0046965)
0.2	1.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2	1.2	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.2	0.4	GO:0033906	hyaluronoglucuronidase activity(GO:0033906)
0.2	0.3	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.2	3.6	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.2	0.5	GO:0031531	thyrotropin-releasing hormone receptor binding(GO:0031531)
0.2	1.5	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.2	0.5	GO:0070698	type I activin receptor binding(GO:0070698)
0.2	2.2	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.2	24.7	GO:0004386	helicase activity(GO:0004386)
0.2	1.4	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.2	0.3	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2	1.9	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.1	0.6	GO:0031489	myosin V binding(GO:0031489)
0.1	1.9	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	3.1	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1	1.2	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	1.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	3.2	GO:0070840	dynein complex binding(GO:0070840)
0.1	3.6	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.9	GO:0004568	chitinase activity(GO:0004568)
0.1	2.8	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	0.4	GO:0032217	riboflavin transporter activity(GO:0032217)
0.1	0.9	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.1	1.7	GO:0070182	DNA polymerase binding(GO:0070182)
0.1	1.0	GO:0032184	SUMO polymer binding(GO:0032184)
0.1	2.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.1	1.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	33.0	GO:0030246	carbohydrate binding(GO:0030246)
0.1	0.5	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.1	2.5	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.1	0.9	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	6.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	1.2	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1	11.2	GO:0004540	ribonuclease activity(GO:0004540)
0.1	1.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1	1.0	GO:0004126	cytidine deaminase activity(GO:0004126)
0.1	16.0	GO:0070851	growth factor receptor binding(GO:0070851)
0.1	0.3	GO:0036004	GAF domain binding(GO:0036004)
0.1	0.6	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
0.1	20.3	GO:0042393	histone binding(GO:0042393)
0.1	0.4	GO:0047710	bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.1	2.7	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1	11.5	GO:0005178	integrin binding(GO:0005178)
0.1	1.5	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.1	0.9	GO:0001594	trace-amine receptor activity(GO:0001594)
0.1	1.0	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1	5.3	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	0.2	GO:0070573	metallodipeptidase activity(GO:0070573)
0.1	0.8	GO:0000217	DNA secondary structure binding(GO:0000217)
0.1	0.3	GO:0089720	caspase binding(GO:0089720)
0.1	2.4	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	3.4	GO:0050699	WW domain binding(GO:0050699)
0.1	0.4	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.1	1.5	GO:0051011	microtubule minus-end binding(GO:0051011)
0.1	1.8	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	1.7	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1	0.3	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1	0.6	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.1	3.5	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1	0.3	GO:0070736	protein-glycine ligase activity, initiating(GO:0070736)
0.1	0.9	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.1	2.4	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.1	2.9	GO:0046332	SMAD binding(GO:0046332)
0.1	1.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.1	0.6	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1	0.3	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.1	35.7	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1	15.3	GO:0003712	transcription cofactor activity(GO:0003712)
0.1	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1	1.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1	2.7	GO:0043531	ADP binding(GO:0043531)
0.1	1.5	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1	0.3	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	2.3	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.1	0.7	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	0.2	GO:0033814	propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.1	1.7	GO:0051059	NF-kappaB binding(GO:0051059)
0.1	0.4	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1	3.1	GO:0008146	sulfotransferase activity(GO:0008146)
0.1	1.1	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.1	0.7	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.1	1.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	3.2	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0	1.6	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.4	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0	1.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	4.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	65.9	GO:0003677	DNA binding(GO:0003677)
0.0	0.5	GO:0005186	pheromone activity(GO:0005186)
0.0	1.2	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0	0.7	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	5.7	GO:0020037	heme binding(GO:0020037)
0.0	0.2	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:1990254	keratin filament binding(GO:1990254)
0.0	1.1	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	7.5	GO:0051015	actin filament binding(GO:0051015)
0.0	0.2	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.0	1.5	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	3.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	5.2	GO:0061135	endopeptidase regulator activity(GO:0061135)
0.0	0.3	GO:0016278	lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0	0.3	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	0.9	GO:0017022	myosin binding(GO:0017022)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.3	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.4	GO:0015149	glucose transmembrane transporter activity(GO:0005355) hexose transmembrane transporter activity(GO:0015149)
0.0	0.3	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.8	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.7	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	0.5	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.2	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.3	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.7	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.0	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.0	GO:0045131	pre-mRNA branch point binding(GO:0045131)
0.0	0.3	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.9	42.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
2.0	31.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
1.4	127.7	PID IL12 2PATHWAY	IL12-mediated signaling events
1.3	20.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.1	52.3	PID TRAIL PATHWAY	TRAIL signaling pathway
1.1	27.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.0	37.6	ST GA12 PATHWAY	G alpha 12 Pathway
0.9	18.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.7	28.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.6	17.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.6	22.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.5	10.9	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.5	6.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.5	3.7	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5	20.7	PID MYC PATHWAY	C-MYC pathway
0.5	31.0	PID PLK1 PATHWAY	PLK1 signaling events
0.5	5.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	91.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	2.9	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4	28.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.4	55.2	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.4	31.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.4	66.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.4	7.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.3	8.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.3	8.8	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.3	10.5	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.3	14.6	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	7.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	17.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	6.8	PID BARD1 PATHWAY	BARD1 signaling events
0.3	9.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3	6.1	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.2	6.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	4.7	PID ATM PATHWAY	ATM pathway
0.2	10.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	2.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.2	8.1	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.2	8.3	PID ENDOTHELIN PATHWAY	Endothelins
0.2	3.9	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	4.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	4.4	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	6.7	PID E2F PATHWAY	E2F transcription factor network
0.1	4.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	1.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	6.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	5.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	2.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	33.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	1.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	3.5	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.1	0.9	ST GA13 PATHWAY	G alpha 13 Pathway
0.1	3.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	2.9	PID RAS PATHWAY	Regulation of Ras family activation
0.1	1.0	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	1.7	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	2.0	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.1	0.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	3.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	1.2	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	0.7	PID RHOA PATHWAY	RhoA signaling pathway
0.0	1.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	2.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	1.7	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.6	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	1.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.4	PID NOTCH PATHWAY	Notch signaling pathway
0.0	8.0	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0	0.7	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.1	45.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
6.1	448.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
5.7	68.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
4.7	80.5	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
3.7	151.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
3.4	63.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
3.2	44.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
2.7	10.9	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
2.7	37.6	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
2.7	53.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
2.4	33.5	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
1.6	22.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
1.5	127.7	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
1.5	82.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.5	63.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
1.2	13.1	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
1.1	26.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
1.0	17.4	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.9	46.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.9	60.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.7	5.2	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
0.7	8.7	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.7	22.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6	4.0	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.6	8.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.6	10.5	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.5	9.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.5	4.2	REACTOME DEFENSINS	Genes involved in Defensins
0.5	6.6	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5	4.0	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.5	1.4	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.5	3.2	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.4	3.4	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.4	10.9	REACTOME AMYLOIDS	Genes involved in Amyloids
0.4	5.8	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.4	5.7	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4	7.0	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.4	12.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.3	4.6	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.3	7.3	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.3	4.1	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.3	3.2	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3	8.7	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.3	7.7	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.3	14.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	3.9	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.3	7.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	2.9	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.3	3.6	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3	5.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	5.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.2	21.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	13.1	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	2.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.2	2.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2	4.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.2	6.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.2	2.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.2	4.8	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	3.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	1.7	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2	5.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.2	5.9	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.2	7.8	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2	2.9	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.2	1.9	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.2	9.9	REACTOME INTERFERON SIGNALING	Genes involved in Interferon Signaling
0.2	3.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	2.6	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	5.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	32.7	REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	Genes involved in Class I MHC mediated antigen processing & presentation
0.1	10.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	3.1	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.1	2.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	6.8	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	2.8	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	1.6	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.1	2.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1	4.4	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.1	2.8	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	6.6	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.1	2.8	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.1	2.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	1.0	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	1.9	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	1.5	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1	1.8	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.1	3.0	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.1	1.4	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1	3.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	6.3	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	2.5	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.1	3.9	REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.1	5.4	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	0.8	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	0.8	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.1	1.4	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.1	1.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	1.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	5.0	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	1.4	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.8	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.6	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	4.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.6	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	2.7	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.7	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.5	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	1.2	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.0	0.5	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.12

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: