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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Irf3

Z-value: 1.96

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Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
Irf3
ENSMUSG00000003184.16 Irf3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf3mm39_v1_chr7_+_44647072_446471260.706.0e-12Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_83421333 26.65 ENSMUST00000035938.3
Ccl5
chemokine (C-C motif) ligand 5
chr2_-_173060647 19.47 ENSMUST00000109116.3
ENSMUST00000029018.14
Zbp1
Z-DNA binding protein 1
chr15_-_77417512 17.50 ENSMUST00000062562.7
ENSMUST00000230863.2
Apol7c
apolipoprotein L 7c
chr11_-_48955028 17.33 ENSMUST00000046745.7
Tgtp2
T cell specific GTPase 2
chr9_-_22041894 15.72 ENSMUST00000115315.3
Acp5
acid phosphatase 5, tartrate resistant
chr7_-_103964662 15.37 ENSMUST00000106837.8
ENSMUST00000106839.9
ENSMUST00000070943.7
Trim12a
tripartite motif-containing 12A
chr7_-_104002534 15.07 ENSMUST00000130139.3
ENSMUST00000059037.15
Trim12c
tripartite motif-containing 12C
chr1_-_85247864 14.82 ENSMUST00000159582.8
ENSMUST00000161267.8
C130026I21Rik
RIKEN cDNA C130026I21 gene
chr17_+_34406523 14.82 ENSMUST00000170086.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_34406193 13.97 ENSMUST00000173831.3
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr6_-_3399451 13.90 ENSMUST00000120087.6
Samd9l
sterile alpha motif domain containing 9-like
chr5_+_115034997 13.78 ENSMUST00000031542.13
ENSMUST00000146072.8
ENSMUST00000150361.2
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr7_-_103937301 13.65 ENSMUST00000098179.9
Trim5
tripartite motif-containing 5
chr17_+_34406762 13.53 ENSMUST00000041633.15
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_78563513 13.22 ENSMUST00000038142.15
Isg20
interferon-stimulated protein
chr1_+_85528392 12.81 ENSMUST00000080204.11
Sp140
Sp140 nuclear body protein
chr5_-_121045568 12.75 ENSMUST00000080322.8
Oas1a
2'-5' oligoadenylate synthetase 1A
chr16_-_35691914 12.45 ENSMUST00000042665.9
Parp14
poly (ADP-ribose) polymerase family, member 14
chr8_-_71219299 12.38 ENSMUST00000222087.4
Ifi30
interferon gamma inducible protein 30
chr7_+_78563964 12.37 ENSMUST00000120331.4
Isg20
interferon-stimulated protein
chr11_-_48883053 12.25 ENSMUST00000059930.3
ENSMUST00000068063.4
Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr5_-_121025645 12.20 ENSMUST00000086368.12
Oas1g
2'-5' oligoadenylate synthetase 1G
chr18_-_32692967 12.00 ENSMUST00000174000.2
ENSMUST00000174459.2
Gypc
glycophorin C
chr3_+_142236086 11.59 ENSMUST00000171263.8
ENSMUST00000045097.11
Gbp7
guanylate binding protein 7
chr4_-_156285247 11.56 ENSMUST00000085425.6
Isg15
ISG15 ubiquitin-like modifier
chr16_-_10603389 11.40 ENSMUST00000229866.2
ENSMUST00000038099.6
Socs1
suppressor of cytokine signaling 1
chr5_+_120950690 10.86 ENSMUST00000086377.9
Oas1b
2'-5' oligoadenylate synthetase 1B
chr1_-_85526517 10.84 ENSMUST00000093508.7
Sp110
Sp110 nuclear body protein
chr7_-_140846328 10.55 ENSMUST00000106023.8
ENSMUST00000097952.9
ENSMUST00000026571.11
Irf7
interferon regulatory factor 7
chr7_+_78564062 10.34 ENSMUST00000205981.2
Isg20
interferon-stimulated protein
chr14_-_66071412 9.33 ENSMUST00000022613.10
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr5_-_120950570 9.20 ENSMUST00000117193.8
Oas1c
2'-5' oligoadenylate synthetase 1C
chr2_-_62476487 8.82 ENSMUST00000112459.4
ENSMUST00000028259.12
Ifih1
interferon induced with helicase C domain 1
chr11_-_100595019 8.66 ENSMUST00000017974.13
Dhx58
DEXH (Asp-Glu-X-His) box polypeptide 58
chrX_+_100473161 8.64 ENSMUST00000033673.7
Nono
non-POU-domain-containing, octamer binding protein
chr16_+_35759346 8.60 ENSMUST00000023622.13
Parp9
poly (ADP-ribose) polymerase family, member 9
chr17_-_36331416 8.37 ENSMUST00000174063.2
ENSMUST00000113760.10
H2-T24
histocompatibility 2, T region locus 24
chr7_+_103893658 7.94 ENSMUST00000106849.9
ENSMUST00000060315.12
Trim34a
tripartite motif-containing 34A
chr7_+_78563184 7.87 ENSMUST00000121645.8
Isg20
interferon-stimulated protein
chr13_+_74787952 7.83 ENSMUST00000221822.2
ENSMUST00000221526.2
Erap1
endoplasmic reticulum aminopeptidase 1
chr1_-_85087567 7.61 ENSMUST00000161675.3
ENSMUST00000160792.8
A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr8_-_71990085 7.56 ENSMUST00000051672.9
Bst2
bone marrow stromal cell antigen 2
chr11_+_58090382 7.48 ENSMUST00000035266.11
ENSMUST00000094169.11
ENSMUST00000168280.2
ENSMUST00000058704.9
Igtp
Irgm2
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr8_-_124045292 7.43 ENSMUST00000118395.2
ENSMUST00000035495.15
Fanca
Fanconi anemia, complementation group A
chr5_-_137145030 7.33 ENSMUST00000054384.6
ENSMUST00000152207.2
Trim56
tripartite motif-containing 56
chr7_-_102214636 7.12 ENSMUST00000106913.3
ENSMUST00000033264.12
Trim21
tripartite motif-containing 21
chr2_+_121978156 7.01 ENSMUST00000102476.5
B2m
beta-2 microglobulin
chr16_-_35759461 6.97 ENSMUST00000081933.14
ENSMUST00000114885.3
Dtx3l
deltex 3-like, E3 ubiquitin ligase
chr1_-_85248264 6.85 ENSMUST00000093506.12
ENSMUST00000064341.9
C130026I21Rik
RIKEN cDNA C130026I21 gene
chr17_+_57665691 6.70 ENSMUST00000086763.13
ENSMUST00000233376.2
ENSMUST00000233840.2
ENSMUST00000232808.2
ENSMUST00000004850.8
Adgre1
adhesion G protein-coupled receptor E1
chr14_+_55815999 6.63 ENSMUST00000172738.2
ENSMUST00000089619.13
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_+_103893672 6.63 ENSMUST00000106848.8
Trim34a
tripartite motif-containing 34A
chr7_-_44785480 6.56 ENSMUST00000211246.2
ENSMUST00000210197.2
Flt3l
FMS-like tyrosine kinase 3 ligand
chr7_-_100164007 6.49 ENSMUST00000207405.2
Dnajb13
DnaJ heat shock protein family (Hsp40) member B13
chr14_+_55815879 6.02 ENSMUST00000174563.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_55815817 5.86 ENSMUST00000174259.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_-_104725853 5.56 ENSMUST00000106775.8
ENSMUST00000166979.8
Mov10
Mov10 RISC complex RNA helicase
chr15_+_77613239 5.43 ENSMUST00000230979.2
ENSMUST00000109775.4
Apol9b
apolipoprotein L 9b
chr3_+_142266113 5.42 ENSMUST00000106221.8
Gbp3
guanylate binding protein 3
chr6_-_125208738 5.37 ENSMUST00000043422.8
Tapbpl
TAP binding protein-like
chr11_+_20597149 5.32 ENSMUST00000109585.2
Sertad2
SERTA domain containing 2
chr15_-_77295234 5.32 ENSMUST00000089452.6
ENSMUST00000081776.11
Apol9a
apolipoprotein L 9a
chr9_-_35087348 4.88 ENSMUST00000119847.2
ENSMUST00000034539.12
Dcps
decapping enzyme, scavenger
chr3_-_151455514 4.75 ENSMUST00000029671.9
Ifi44
interferon-induced protein 44
chr5_-_120950549 4.71 ENSMUST00000125547.2
Oas1c
2'-5' oligoadenylate synthetase 1C
chr11_-_48762170 4.57 ENSMUST00000049519.4
ENSMUST00000097271.4
Irgm1
immunity-related GTPase family M member 1
chr11_+_109253598 4.57 ENSMUST00000106702.4
ENSMUST00000020930.14
Gna13
guanine nucleotide binding protein, alpha 13
chr3_-_104725581 4.47 ENSMUST00000168015.8
Mov10
Mov10 RISC complex RNA helicase
chr3_+_142265904 4.31 ENSMUST00000128609.8
ENSMUST00000029935.14
Gbp3
guanylate binding protein 3
chr14_+_55815580 4.30 ENSMUST00000174484.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr15_-_82128538 4.00 ENSMUST00000229747.2
ENSMUST00000230408.2
Cenpm
centromere protein M
chr3_+_27371168 3.92 ENSMUST00000046383.12
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr2_+_93017916 3.88 ENSMUST00000090554.11
Trp53i11
transformation related protein 53 inducible protein 11
chr4_-_40239778 3.81 ENSMUST00000037907.13
Ddx58
DEAD/H box helicase 58
chr2_-_145776934 3.75 ENSMUST00000001818.5
Crnkl1
crooked neck pre-mRNA splicing factor 1
chr14_-_55828511 3.70 ENSMUST00000161807.8
ENSMUST00000111378.10
ENSMUST00000159687.2
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_-_40239700 3.61 ENSMUST00000142055.2
Ddx58
DEAD/H box helicase 58
chr2_+_93017887 3.55 ENSMUST00000150462.8
ENSMUST00000111266.8
Trp53i11
transformation related protein 53 inducible protein 11
chr7_-_44785603 3.44 ENSMUST00000209467.2
Gm45713
predicted gene 45713
chr1_+_171216480 3.41 ENSMUST00000056449.9
Arhgap30
Rho GTPase activating protein 30
chr3_+_142265787 3.35 ENSMUST00000199325.5
ENSMUST00000106222.9
Gbp3
guanylate binding protein 3
chr7_-_44785709 3.02 ENSMUST00000211429.2
Flt3l
FMS-like tyrosine kinase 3 ligand
chr6_-_54949587 3.01 ENSMUST00000060655.15
Nod1
nucleotide-binding oligomerization domain containing 1
chr11_+_119283887 2.91 ENSMUST00000093902.12
ENSMUST00000131035.10
Rnf213
ring finger protein 213
chr14_-_66071337 2.77 ENSMUST00000225853.2
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr16_-_19525122 2.75 ENSMUST00000081880.7
Lamp3
lysosomal-associated membrane protein 3
chr6_-_38331187 2.52 ENSMUST00000114900.8
ENSMUST00000143702.5
Zc3hav1
zinc finger CCCH type, antiviral 1
chr17_+_75485791 2.26 ENSMUST00000135447.8
ENSMUST00000112516.8
Ltbp1
latent transforming growth factor beta binding protein 1
chr12_+_77285770 2.14 ENSMUST00000062804.8
Fut8
fucosyltransferase 8
chr10_+_128106414 2.11 ENSMUST00000085708.3
ENSMUST00000105238.10
Stat2
signal transducer and activator of transcription 2
chr19_+_6096606 1.85 ENSMUST00000138532.8
ENSMUST00000129081.8
ENSMUST00000156550.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr6_-_38331482 1.78 ENSMUST00000031850.10
ENSMUST00000114898.3
Zc3hav1
zinc finger CCCH type, antiviral 1
chr19_-_32085532 1.57 ENSMUST00000236030.2
ENSMUST00000237104.2
ENSMUST00000236208.2
ENSMUST00000235273.2
Asah2
N-acylsphingosine amidohydrolase 2
chr17_+_75485906 1.42 ENSMUST00000112514.2
Ltbp1
latent transforming growth factor beta binding protein 1
chr3_-_104725535 1.38 ENSMUST00000002297.12
Mov10
Mov10 RISC complex RNA helicase
chr10_-_87329513 1.34 ENSMUST00000020243.10
Ascl1
achaete-scute family bHLH transcription factor 1
chr7_+_103064279 1.33 ENSMUST00000106892.2
Usp17lc
ubiquitin specific peptidase 17-like C
chr1_+_61677977 1.26 ENSMUST00000075374.10
Pard3b
par-3 family cell polarity regulator beta
chr17_+_21229165 1.23 ENSMUST00000232473.2
ENSMUST00000231482.2
ENSMUST00000088811.7
ENSMUST00000232354.2
ENSMUST00000232595.2
ENSMUST00000232320.2
Zfp160
zinc finger protein 160
chr15_+_38976260 1.23 ENSMUST00000022909.10
Dcaf13
DDB1 and CUL4 associated factor 13
chr6_-_39095144 1.20 ENSMUST00000038398.7
Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_-_126775136 1.18 ENSMUST00000028844.11
Sppl2a
signal peptide peptidase like 2A
chr13_+_42205790 1.15 ENSMUST00000220525.2
Hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr4_+_115595610 1.15 ENSMUST00000106524.4
Efcab14
EF-hand calcium binding domain 14
chr6_+_34840057 1.13 ENSMUST00000074949.4
Tmem140
transmembrane protein 140
chr8_-_81466126 1.13 ENSMUST00000043359.9
Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr6_-_56774746 1.04 ENSMUST00000114321.2
Kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr3_+_27371206 1.03 ENSMUST00000174840.2
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr14_+_30438334 1.00 ENSMUST00000228006.2
Sfmbt1
Scm-like with four mbt domains 1
chr16_-_38162174 0.99 ENSMUST00000114740.3
Cfap91
cilia and flagella associated protein 91
chr11_+_72192455 0.97 ENSMUST00000151440.8
ENSMUST00000146233.8
ENSMUST00000140842.9
Xaf1
XIAP associated factor 1
chr1_-_85087170 0.82 ENSMUST00000161724.8
A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr2_+_38888312 0.71 ENSMUST00000112872.2
Wdr38
WD repeat domain 38
chr16_+_23428650 0.68 ENSMUST00000038423.6
ENSMUST00000211349.2
Rtp4
receptor transporter protein 4
chr18_+_24122689 0.67 ENSMUST00000074941.8
Zfp35
zinc finger protein 35
chr14_-_8457069 0.62 ENSMUST00000022257.4
Atxn7
ataxin 7
chr19_+_34560922 0.57 ENSMUST00000102825.4
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr11_+_83743746 0.55 ENSMUST00000108113.3
Hnf1b
HNF1 homeobox B
chr6_+_34840151 0.49 ENSMUST00000202010.2
Tmem140
transmembrane protein 140
chr17_+_21229279 0.47 ENSMUST00000232663.2
Zfp160
zinc finger protein 160
chr6_-_34294377 0.44 ENSMUST00000154655.2
ENSMUST00000102980.11
Akr1b3
aldo-keto reductase family 1, member B3 (aldose reductase)
chr10_-_81332163 0.33 ENSMUST00000020463.14
Ncln
nicalin
chr12_-_83643964 0.29 ENSMUST00000048319.6
Zfyve1
zinc finger, FYVE domain containing 1
chr10_-_81332147 0.21 ENSMUST00000118498.8
Ncln
nicalin
chr7_-_126194097 0.18 ENSMUST00000058429.6
Il27
interleukin 27
chr1_-_174079627 0.16 ENSMUST00000214725.2
Olfr419
olfactory receptor 419

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 28.4 GO:0046967 cytosol to ER transport(GO:0046967)
7.3 43.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
6.7 26.6 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
5.4 5.4 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
3.5 7.0 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
3.1 12.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.9 11.4 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
2.7 16.2 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
2.5 7.5 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
2.4 12.1 GO:0034421 post-translational protein acetylation(GO:0034421)
2.0 15.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
1.9 9.6 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
1.8 10.6 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
1.6 11.4 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
1.6 4.9 GO:0036245 cellular response to menadione(GO:0036245)
1.6 6.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
1.4 11.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.4 8.7 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
1.4 13.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.2 19.5 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
1.1 12.4 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
1.0 26.5 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
1.0 47.8 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.0 8.6 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.8 7.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.7 7.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.7 8.5 GO:0035456 response to interferon-beta(GO:0035456)
0.7 8.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.6 9.4 GO:0034340 response to type I interferon(GO:0034340)
0.6 11.6 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.5 2.6 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.5 4.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.4 1.3 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) olfactory pit development(GO:0060166)
0.4 0.4 GO:0051595 response to methylglyoxal(GO:0051595)
0.4 3.0 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.3 22.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.3 4.3 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.3 2.1 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.3 1.1 GO:0016584 nucleosome positioning(GO:0016584)
0.3 2.7 GO:0035455 response to interferon-alpha(GO:0035455)
0.3 2.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 57.5 GO:0051607 defense response to virus(GO:0051607)
0.1 0.6 GO:0061296 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.1 0.7 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 9.4 GO:0048525 negative regulation of viral process(GO:0048525)
0.1 12.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 4.8 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 3.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 1.8 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 0.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 3.8 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.2 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 6.7 GO:0002250 adaptive immune response(GO:0002250)
0.0 1.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 5.3 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)
0.0 1.0 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 8.4 GO:0045087 innate immune response(GO:0045087)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 22.8 GO:0008537 proteasome activator complex(GO:0008537)
3.5 28.4 GO:0042825 TAP complex(GO:0042825)
2.9 29.0 GO:1990462 omegasome(GO:1990462)
2.3 13.6 GO:1990111 spermatoproteasome complex(GO:1990111)
2.0 32.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
1.2 3.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.9 2.7 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.9 8.6 GO:0042382 paraspeckles(GO:0042382)
0.6 12.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 30.0 GO:0015030 Cajal body(GO:0015030)
0.5 7.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 7.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.4 1.8 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 3.8 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.3 9.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.3 4.6 GO:0044754 autolysosome(GO:0044754)
0.2 25.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 1.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 2.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 7.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 7.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 4.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 12.8 GO:0001650 fibrillar center(GO:0001650)
0.1 3.7 GO:0000502 proteasome complex(GO:0000502)
0.1 9.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 6.5 GO:0005930 axoneme(GO:0005930)
0.1 30.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 7.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 28.7 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 7.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0032040 small-subunit processome(GO:0032040)
0.0 4.0 GO:0000776 kinetochore(GO:0000776)
0.0 5.2 GO:0005769 early endosome(GO:0005769)
0.0 6.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 28.4 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
8.9 26.6 GO:0031726 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
8.8 43.8 GO:0008859 exoribonuclease II activity(GO:0008859)
6.5 19.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
4.4 52.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
2.4 26.5 GO:0061133 endopeptidase activator activity(GO:0061133)
1.2 28.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
1.1 4.6 GO:0031752 D5 dopamine receptor binding(GO:0031752)
1.1 12.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.9 3.7 GO:0050436 microfibril binding(GO:0050436)
0.9 26.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.9 10.5 GO:0050700 CARD domain binding(GO:0050700)
0.9 15.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.8 7.8 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.7 11.6 GO:0031386 protein tag(GO:0031386)
0.6 14.0 GO:0070628 proteasome binding(GO:0070628)
0.3 7.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 12.4 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.3 4.9 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 11.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 8.4 GO:0042605 peptide antigen binding(GO:0042605)
0.2 1.6 GO:0017040 ceramidase activity(GO:0017040)
0.2 35.8 GO:0004386 helicase activity(GO:0004386)
0.2 2.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 47.2 GO:0003924 GTPase activity(GO:0003924)
0.1 1.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 1.8 GO:1990381 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) ubiquitin-specific protease binding(GO:1990381)
0.1 4.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 9.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 9.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 0.7 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 9.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 6.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 26.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 5.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 12.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 26.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.3 8.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 11.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 4.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 2.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 7.4 PID BARD1 PATHWAY BARD1 signaling events
0.2 12.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 13.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 28.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 7.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 10.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 3.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.9 36.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.2 26.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.0 70.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.7 19.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.7 37.4 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.5 26.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 4.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 11.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 4.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 11.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.3 7.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 3.0 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.2 8.7 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 14.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 4.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 2.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 4.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 7.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development