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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Irf5_Irf6

Z-value: 1.49

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Transcription factors associated with Irf5_Irf6

Gene Symbol Gene ID Gene Info
Irf5
ENSMUSG00000029771.13 Irf5
Irf6
ENSMUSG00000026638.16 Irf6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf6mm39_v1_chr1_+_192835414_1928355160.822.8e-18Click!
Irf5mm39_v1_chr6_+_29526679_29526723-0.104.2e-01Click!

Activity profile of Irf5_Irf6 motif

Sorted Z-values of Irf5_Irf6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_36293588 36.31 ENSMUST00000060128.7
Cldn23
claudin 23
chr9_+_44953723 20.95 ENSMUST00000034600.5
Mpzl2
myelin protein zero-like 2
chr11_+_69857722 15.45 ENSMUST00000151515.2
Cldn7
claudin 7
chr17_-_35081129 14.41 ENSMUST00000154526.8
Cfb
complement factor B
chr13_-_100689105 13.79 ENSMUST00000159459.8
Ocln
occludin
chr13_-_100689212 13.30 ENSMUST00000022140.12
Ocln
occludin
chr11_+_88890202 12.65 ENSMUST00000100627.9
ENSMUST00000107896.10
ENSMUST00000000284.7
Trim25
tripartite motif-containing 25
chr17_-_35081456 12.35 ENSMUST00000025229.11
ENSMUST00000176203.9
ENSMUST00000128767.8
Cfb
complement factor B
chr1_+_130754413 10.48 ENSMUST00000027675.14
ENSMUST00000133792.8
Pigr
polymeric immunoglobulin receptor
chr19_+_5618096 10.17 ENSMUST00000096318.4
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr13_-_100688949 9.78 ENSMUST00000159515.2
ENSMUST00000160859.8
ENSMUST00000069756.11
Ocln
occludin
chr3_-_142101418 9.76 ENSMUST00000029941.16
ENSMUST00000058626.9
Pdlim5
PDZ and LIM domain 5
chr17_-_7050145 9.14 ENSMUST00000064234.7
Ezr
ezrin
chr6_+_113448388 8.42 ENSMUST00000058300.14
Il17rc
interleukin 17 receptor C
chr4_-_46536088 6.94 ENSMUST00000102924.3
ENSMUST00000046897.13
Trim14
tripartite motif-containing 14
chr7_-_140846328 6.81 ENSMUST00000106023.8
ENSMUST00000097952.9
ENSMUST00000026571.11
Irf7
interferon regulatory factor 7
chr19_+_5618029 6.72 ENSMUST00000235575.2
ENSMUST00000235542.2
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr6_-_39095144 6.66 ENSMUST00000038398.7
Parp12
poly (ADP-ribose) polymerase family, member 12
chr17_-_34506744 6.29 ENSMUST00000174751.2
ENSMUST00000040655.14
H2-Aa
histocompatibility 2, class II antigen A, alpha
chr11_-_78875657 5.90 ENSMUST00000073001.5
Lgals9
lectin, galactose binding, soluble 9
chr11_-_78875689 5.82 ENSMUST00000108269.10
ENSMUST00000108268.10
Lgals9
lectin, galactose binding, soluble 9
chr17_+_31652029 5.76 ENSMUST00000136384.9
Pde9a
phosphodiesterase 9A
chr16_-_35691914 5.59 ENSMUST00000042665.9
Parp14
poly (ADP-ribose) polymerase family, member 14
chr19_-_5610628 5.29 ENSMUST00000025861.3
Ovol1
ovo like zinc finger 1
chr17_+_31652073 5.25 ENSMUST00000237363.2
Pde9a
phosphodiesterase 9A
chr17_-_79190002 5.18 ENSMUST00000024884.5
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr11_+_101473062 5.05 ENSMUST00000039581.14
ENSMUST00000100403.9
ENSMUST00000107194.8
ENSMUST00000128614.2
Tmem106a
transmembrane protein 106A
chr2_-_69416365 4.83 ENSMUST00000100051.9
ENSMUST00000092551.5
ENSMUST00000080953.12
Lrp2
low density lipoprotein receptor-related protein 2
chr1_-_75294234 4.65 ENSMUST00000066668.14
ENSMUST00000185797.7
Dnpep
aspartyl aminopeptidase
chr6_+_4505493 4.29 ENSMUST00000031668.10
Col1a2
collagen, type I, alpha 2
chr16_+_35758836 4.22 ENSMUST00000114878.8
Parp9
poly (ADP-ribose) polymerase family, member 9
chr6_-_38331187 4.18 ENSMUST00000114900.8
ENSMUST00000143702.5
Zc3hav1
zinc finger CCCH type, antiviral 1
chr12_+_119354110 3.88 ENSMUST00000222058.2
Macc1
metastasis associated in colon cancer 1
chr7_-_65020655 3.82 ENSMUST00000032729.8
Tjp1
tight junction protein 1
chr5_-_91550853 3.80 ENSMUST00000121044.6
Btc
betacellulin, epidermal growth factor family member
chr16_-_55659194 3.70 ENSMUST00000096026.9
ENSMUST00000036273.13
ENSMUST00000114457.8
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr14_+_78141679 3.68 ENSMUST00000022591.16
ENSMUST00000169978.2
ENSMUST00000227903.2
Epsti1
epithelial stromal interaction 1 (breast)
chr3_-_142101339 3.66 ENSMUST00000198381.5
ENSMUST00000090134.12
ENSMUST00000196908.5
Pdlim5
PDZ and LIM domain 5
chr5_+_92957231 3.57 ENSMUST00000113054.9
Shroom3
shroom family member 3
chr7_+_128125339 3.26 ENSMUST00000033136.9
Bag3
BCL2-associated athanogene 3
chr11_-_86091970 3.22 ENSMUST00000044423.4
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr12_-_32000169 3.20 ENSMUST00000176520.8
Hbp1
high mobility group box transcription factor 1
chr1_+_182236728 3.17 ENSMUST00000117245.2
Trp53bp2
transformation related protein 53 binding protein 2
chr1_-_75293942 3.05 ENSMUST00000187075.7
Dnpep
aspartyl aminopeptidase
chr15_-_76127600 3.04 ENSMUST00000165738.8
ENSMUST00000075689.7
Parp10
poly (ADP-ribose) polymerase family, member 10
chr7_-_26928029 2.94 ENSMUST00000003850.8
Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr17_+_35780977 2.90 ENSMUST00000174525.8
ENSMUST00000068291.7
H2-Q10
histocompatibility 2, Q region locus 10
chr6_-_70313491 2.87 ENSMUST00000103388.4
Igkv6-20
immunoglobulin kappa variable 6-20
chr1_-_75293997 2.78 ENSMUST00000189282.3
ENSMUST00000191254.7
Dnpep
aspartyl aminopeptidase
chr8_+_62381115 2.56 ENSMUST00000154398.8
ENSMUST00000156980.8
ENSMUST00000093485.3
ENSMUST00000070631.15
Ddx60
DExD/H box helicase 60
chr19_+_44744484 2.51 ENSMUST00000174490.9
Pax2
paired box 2
chr1_-_75293447 2.47 ENSMUST00000189551.7
Dnpep
aspartyl aminopeptidase
chr16_-_35759461 2.43 ENSMUST00000081933.14
ENSMUST00000114885.3
Dtx3l
deltex 3-like, E3 ubiquitin ligase
chr12_-_32000209 2.35 ENSMUST00000176084.2
ENSMUST00000176103.8
ENSMUST00000167458.9
Hbp1
high mobility group box transcription factor 1
chr1_-_75293637 2.32 ENSMUST00000185419.7
ENSMUST00000187000.7
Dnpep
aspartyl aminopeptidase
chr17_+_23898633 2.24 ENSMUST00000233364.2
Cldn6
claudin 6
chr17_-_32408431 2.24 ENSMUST00000087721.10
ENSMUST00000162117.3
Ephx3
epoxide hydrolase 3
chr1_-_75293793 2.15 ENSMUST00000187836.7
Dnpep
aspartyl aminopeptidase
chr4_-_40239700 2.13 ENSMUST00000142055.2
Ddx58
DEAD/H box helicase 58
chr15_+_96185399 2.13 ENSMUST00000134985.9
ENSMUST00000096250.5
Arid2
AT rich interactive domain 2 (ARID, RFX-like)
chr1_-_105284383 2.11 ENSMUST00000058688.7
Rnf152
ring finger protein 152
chr14_-_20784625 1.85 ENSMUST00000223679.2
Ndst2
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chr16_+_11131676 1.83 ENSMUST00000023140.6
Tnfrsf17
tumor necrosis factor receptor superfamily, member 17
chr17_+_23898223 1.78 ENSMUST00000024699.4
ENSMUST00000232719.2
Cldn6
claudin 6
chr4_-_40239778 1.72 ENSMUST00000037907.13
Ddx58
DEAD/H box helicase 58
chr7_-_80037622 1.64 ENSMUST00000206698.2
Fes
feline sarcoma oncogene
chr13_-_59970383 1.63 ENSMUST00000225987.2
Tut7
terminal uridylyl transferase 7
chr1_-_163141278 1.62 ENSMUST00000027878.14
Prrx1
paired related homeobox 1
chr9_+_56979307 1.59 ENSMUST00000169879.8
Sin3a
transcriptional regulator, SIN3A (yeast)
chr6_-_38331482 1.59 ENSMUST00000031850.10
ENSMUST00000114898.3
Zc3hav1
zinc finger CCCH type, antiviral 1
chr1_+_52158693 1.58 ENSMUST00000189347.7
Stat1
signal transducer and activator of transcription 1
chr1_-_105284407 1.52 ENSMUST00000172299.2
Rnf152
ring finger protein 152
chr6_-_13607963 1.52 ENSMUST00000031554.9
ENSMUST00000149123.3
Tmem168
transmembrane protein 168
chr4_-_116508842 1.52 ENSMUST00000030455.15
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr1_-_75293589 1.51 ENSMUST00000113605.10
Dnpep
aspartyl aminopeptidase
chr8_+_72943455 1.36 ENSMUST00000072097.14
Hsh2d
hematopoietic SH2 domain containing
chr5_-_99391073 1.30 ENSMUST00000166484.2
Rasgef1b
RasGEF domain family, member 1B
chr3_+_135144859 1.26 ENSMUST00000197539.5
ENSMUST00000197134.3
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr6_-_146855880 1.23 ENSMUST00000111622.2
ENSMUST00000036592.15
1700034J05Rik
RIKEN cDNA 1700034J05 gene
chr11_+_72580823 1.13 ENSMUST00000155998.2
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr12_-_73160181 1.12 ENSMUST00000043208.8
ENSMUST00000175693.3
Six4
sine oculis-related homeobox 4
chr1_+_175459559 1.10 ENSMUST00000040250.15
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_+_135144481 1.09 ENSMUST00000199582.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr6_-_84564623 1.06 ENSMUST00000205228.3
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr5_-_100126707 1.06 ENSMUST00000170912.2
Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr5_-_100126773 1.01 ENSMUST00000112939.10
ENSMUST00000171786.8
ENSMUST00000072750.13
ENSMUST00000019128.15
ENSMUST00000172361.8
Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr1_+_52158599 0.93 ENSMUST00000186574.7
ENSMUST00000070968.14
ENSMUST00000191435.7
ENSMUST00000186857.7
ENSMUST00000188681.7
Stat1
signal transducer and activator of transcription 1
chr12_-_26506422 0.91 ENSMUST00000020970.10
Rsad2
radical S-adenosyl methionine domain containing 2
chr1_-_184464810 0.87 ENSMUST00000048572.7
Hlx
H2.0-like homeobox
chr6_-_28449250 0.84 ENSMUST00000164519.9
ENSMUST00000171089.9
ENSMUST00000031718.14
Pax4
paired box 4
chr7_-_125995884 0.69 ENSMUST00000075671.5
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr12_-_32000534 0.66 ENSMUST00000172314.9
Hbp1
high mobility group box transcription factor 1
chrM_+_8603 0.62 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr9_-_123691077 0.51 ENSMUST00000182350.3
Xcr1
chemokine (C motif) receptor 1
chr2_-_6327884 0.49 ENSMUST00000238876.2
1700014B07Rik
RIKEN cDNA 1700014B07 gene
chr10_+_80085275 0.49 ENSMUST00000020361.7
Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
chr1_+_175459735 0.46 ENSMUST00000097458.4
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr13_-_59930059 0.38 ENSMUST00000225581.2
Gm49354
predicted gene, 49354
chr2_-_77349909 0.36 ENSMUST00000111830.9
Zfp385b
zinc finger protein 385B
chr5_+_21391282 0.36 ENSMUST00000036031.13
ENSMUST00000198937.2
Gsap
gamma-secretase activating protein
chr4_+_108317197 0.33 ENSMUST00000097925.9
Tut4
terminal uridylyl transferase 4
chr1_+_52158721 0.29 ENSMUST00000186057.7
Stat1
signal transducer and activator of transcription 1
chr2_-_77000878 0.16 ENSMUST00000111833.3
Ccdc141
coiled-coil domain containing 141
chr7_+_130294403 0.07 ENSMUST00000207282.2
Tacc2
transforming, acidic coiled-coil containing protein 2
chr16_-_91443794 0.05 ENSMUST00000232367.2
ENSMUST00000231380.2
ENSMUST00000231444.2
ENSMUST00000232289.2
ENSMUST00000120450.2
ENSMUST00000023684.14
Gart
phosphoribosylglycinamide formyltransferase
chr7_-_80037688 0.00 ENSMUST00000080932.8
Fes
feline sarcoma oncogene

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414)
2.3 11.7 GO:0043321 regulation of natural killer cell degranulation(GO:0043321)
2.3 9.1 GO:1902896 terminal web assembly(GO:1902896)
2.2 8.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.0 36.9 GO:0070673 response to interleukin-18(GO:0070673)
1.8 5.3 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
1.6 26.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.1 6.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
1.1 3.2 GO:1990918 meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705) double-strand break repair involved in meiotic recombination(GO:1990918)
0.9 2.8 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
0.8 2.5 GO:0061360 optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.8 3.9 GO:0009597 detection of virus(GO:0009597)
0.7 15.5 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.6 8.3 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.5 12.6 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.5 11.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.4 5.2 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689) regulation of hematopoietic stem cell proliferation(GO:1902033) regulation of hematopoietic stem cell differentiation(GO:1902036)
0.4 2.1 GO:1901355 response to rapamycin(GO:1901355)
0.4 1.6 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.4 6.9 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 1.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.3 7.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.3 4.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 1.5 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.3 6.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.3 6.2 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.3 4.3 GO:0043589 skin morphogenesis(GO:0043589)
0.3 1.1 GO:0061055 myotome development(GO:0061055)
0.3 3.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 0.9 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.2 3.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 3.8 GO:0035810 positive regulation of urine volume(GO:0035810)
0.2 4.8 GO:0045056 transcytosis(GO:0045056)
0.2 13.4 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 1.1 GO:0090160 endosome localization(GO:0032439) Golgi to lysosome transport(GO:0090160)
0.2 2.1 GO:0060982 coronary artery morphogenesis(GO:0060982)
0.2 1.1 GO:0035981 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.2 0.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 3.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.2 19.7 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.2 3.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 1.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 1.8 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 1.2 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 2.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 2.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 1.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 16.8 GO:0016197 endosomal transport(GO:0016197)
0.0 0.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 3.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 1.8 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 4.0 GO:0045216 cell-cell junction organization(GO:0045216)
0.0 10.5 GO:0006518 peptide metabolic process(GO:0006518)
0.0 0.8 GO:0031016 pancreas development(GO:0031016)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.5 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
1.8 60.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
1.4 4.3 GO:0005584 collagen type I trimer(GO:0005584)
0.5 6.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 16.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.2 10.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 2.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 40.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 44.6 GO:0072562 blood microparticle(GO:0072562)
0.1 3.6 GO:0043296 apical junction complex(GO:0043296)
0.1 1.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.5 GO:0034451 centriolar satellite(GO:0034451)
0.1 16.7 GO:0030018 Z disc(GO:0030018)
0.1 4.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 11.0 GO:0042383 sarcolemma(GO:0042383)
0.0 2.1 GO:0090544 BAF-type complex(GO:0090544)
0.0 10.7 GO:0016607 nuclear speck(GO:0016607)
0.0 10.2 GO:0016604 nuclear body(GO:0016604)
0.0 2.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 11.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.0 GO:0005770 late endosome(GO:0005770)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.3 GO:0031301 integral component of organelle membrane(GO:0031301)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0042954 lipoprotein transporter activity(GO:0042954)
1.3 11.7 GO:0016936 galactoside binding(GO:0016936)
1.3 5.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.9 8.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.9 10.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.8 25.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 12.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.5 13.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.5 13.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.5 9.1 GO:0044548 S100 protein binding(GO:0044548)
0.4 11.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.3 2.9 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.3 3.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 3.8 GO:0071253 connexin binding(GO:0071253)
0.3 4.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 2.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 9.2 GO:0042605 peptide antigen binding(GO:0042605)
0.2 1.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 2.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 1.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.6 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.2 1.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 4.0 GO:0001618 virus receptor activity(GO:0001618)
0.1 2.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 26.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 4.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 3.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 51.8 GO:0005198 structural molecule activity(GO:0005198)
0.1 6.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 12.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 6.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.7 GO:0031386 protein tag(GO:0031386)
0.0 36.9 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 26.8 ST G ALPHA S PATHWAY G alpha s Pathway
0.3 36.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 2.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 22.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 9.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 4.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 6.2 PID MYC PATHWAY C-MYC pathway
0.1 11.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 3.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 5.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 2.4 PID BARD1 PATHWAY BARD1 signaling events
0.1 8.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 10.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 26.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.8 40.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
1.1 23.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.5 19.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.3 11.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 4.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 9.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 3.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 2.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 4.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 3.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 2.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 5.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 1.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation