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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Irx4

Z-value: 0.51

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Transcription factors associated with Irx4

Gene Symbol Gene ID Gene Info
Irx4
ENSMUSG00000021604.16 Irx4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx4mm39_v1_chr13_+_73408591_734086160.104.3e-01Click!

Activity profile of Irx4 motif

Sorted Z-values of Irx4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_105048856 4.40 ENSMUST00000041973.7
Cmtm2b
CKLF-like MARVEL transmembrane domain containing 2B
chr6_-_3494587 4.27 ENSMUST00000049985.15
Hepacam2
HEPACAM family member 2
chr8_-_25215778 3.71 ENSMUST00000171438.8
ENSMUST00000171611.9
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr18_+_44467133 3.69 ENSMUST00000025349.12
ENSMUST00000115498.2
Myot
myotilin
chr4_+_48663504 3.27 ENSMUST00000030033.5
Cavin4
caveolae associated 4
chr8_-_25215856 3.07 ENSMUST00000033958.15
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr1_+_45350698 3.07 ENSMUST00000087883.13
Col3a1
collagen, type III, alpha 1
chr11_-_11920540 2.73 ENSMUST00000109653.8
Grb10
growth factor receptor bound protein 10
chr16_+_16964801 1.99 ENSMUST00000232479.2
ENSMUST00000232344.2
ENSMUST00000069064.7
Ydjc
YdjC homolog (bacterial)
chr12_-_114252202 1.84 ENSMUST00000195124.6
ENSMUST00000103481.3
Ighv3-6
immunoglobulin heavy variable 3-6
chr6_-_69584812 1.49 ENSMUST00000103359.3
Igkv4-55
immunoglobulin kappa variable 4-55
chr2_-_79738773 1.37 ENSMUST00000102652.10
ENSMUST00000102651.10
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr8_+_27937128 1.24 ENSMUST00000209669.2
Gm45861
predicted gene 45861
chr3_+_27371206 1.19 ENSMUST00000174840.2
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr2_-_79738734 1.07 ENSMUST00000090756.11
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr2_+_24235300 1.02 ENSMUST00000114485.9
ENSMUST00000114482.3
Il1rn
interleukin 1 receptor antagonist
chr7_+_106413336 0.95 ENSMUST00000166880.3
ENSMUST00000075414.8
Olfr701
olfactory receptor 701
chr3_+_27371168 0.90 ENSMUST00000046383.12
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr15_-_35938155 0.90 ENSMUST00000156915.3
Cox6c
cytochrome c oxidase subunit 6C
chr17_-_27352876 0.83 ENSMUST00000119227.3
ENSMUST00000025045.15
Uqcc2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr15_-_35938328 0.82 ENSMUST00000014457.15
Cox6c
cytochrome c oxidase subunit 6C
chrY_-_797405 0.75 ENSMUST00000189888.7
ENSMUST00000065545.6
Zfy1
zinc finger protein 1, Y-linked
chr6_-_83294526 0.72 ENSMUST00000005810.9
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr3_+_104974160 0.53 ENSMUST00000070584.5
4930564D02Rik
RIKEN cDNA 4930564D02 gene
chr9_-_58108988 0.38 ENSMUST00000163200.3
ENSMUST00000165276.2
ENSMUST00000214647.2
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr9_-_58109564 0.36 ENSMUST00000163897.8
ENSMUST00000215950.2
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr3_+_59832635 0.34 ENSMUST00000049476.3
Aadacl2fm1
AADACL2 family member 1
chr3_+_59637203 0.19 ENSMUST00000168156.3
Aadacl2fm2
AADACL2 family member 2
chr2_-_111253457 0.19 ENSMUST00000213210.2
ENSMUST00000184954.4
Olfr1286
olfactory receptor 1286
chr12_-_115825934 0.18 ENSMUST00000198777.2
Ighv1-77
immunoglobulin heavy variable 1-77
chr3_+_84832783 0.15 ENSMUST00000107675.8
Fbxw7
F-box and WD-40 domain protein 7
chr9_+_19716202 0.08 ENSMUST00000212540.3
ENSMUST00000217280.2
Olfr859
olfactory receptor 859
chr12_-_111946560 0.05 ENSMUST00000190680.2
Rd3l
retinal degeneration 3-like
chr8_+_105048199 0.05 ENSMUST00000109447.2
Gm11020
predicted gene 11020

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 2.7 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.2 1.0 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 6.8 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 3.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 2.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 2.1 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 4.3 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.7 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 2.0 GO:0006910 phagocytosis, recognition(GO:0006910)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 7.0 GO:0030018 Z disc(GO:0030018)
0.0 4.3 GO:0030496 midbody(GO:0030496)
0.0 2.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 6.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.2 2.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 3.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.7 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 2.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 3.5 GO:0003823 antigen binding(GO:0003823)
0.0 3.5 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.7 PID IGF1 PATHWAY IGF1 pathway
0.0 1.0 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 2.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 3.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling