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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Irx5

Z-value: 1.12

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
Irx5
ENSMUSG00000031737.12 Irx5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm39_v1_chr8_+_93084253_930843790.123.2e-01Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_87074380 12.46 ENSMUST00000031183.3
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
chrX_+_20416019 10.47 ENSMUST00000023832.7
Rgn
regucalcin
chr15_+_82336535 10.13 ENSMUST00000089129.7
ENSMUST00000229313.2
ENSMUST00000231136.2
Cyp2d9
cytochrome P450, family 2, subfamily d, polypeptide 9
chr4_+_104623505 9.79 ENSMUST00000031663.10
ENSMUST00000065072.7
C8b
complement component 8, beta polypeptide
chr7_-_14172434 9.12 ENSMUST00000210396.2
ENSMUST00000168252.9
Sult2a8
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr8_-_45715049 8.54 ENSMUST00000034064.5
F11
coagulation factor XI
chr5_-_87485023 7.38 ENSMUST00000031195.3
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr5_-_87402659 7.37 ENSMUST00000075858.4
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr3_+_20011201 6.99 ENSMUST00000091309.12
ENSMUST00000108329.8
ENSMUST00000003714.13
Cp
ceruloplasmin
chr19_-_7779943 6.77 ENSMUST00000120522.8
Slc22a26
solute carrier family 22 (organic cation transporter), member 26
chr15_-_82648376 6.60 ENSMUST00000055721.6
Cyp2d40
cytochrome P450, family 2, subfamily d, polypeptide 40
chr11_-_110142565 6.54 ENSMUST00000044003.14
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr4_+_141473983 5.66 ENSMUST00000038161.5
Agmat
agmatine ureohydrolase (agmatinase)
chr8_-_73188887 5.46 ENSMUST00000109974.2
Calr3
calreticulin 3
chr3_+_20011405 5.06 ENSMUST00000108325.9
Cp
ceruloplasmin
chr13_+_25127127 4.74 ENSMUST00000021773.13
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr3_+_20011251 4.62 ENSMUST00000108328.8
Cp
ceruloplasmin
chr2_-_101451383 4.19 ENSMUST00000090513.11
Iftap
intraflagellar transport associated protein
chr2_+_172994841 3.97 ENSMUST00000029017.6
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr15_-_82278223 3.85 ENSMUST00000170255.2
Cyp2d11
cytochrome P450, family 2, subfamily d, polypeptide 11
chr8_-_58249608 3.84 ENSMUST00000204067.3
Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr14_-_59380335 3.78 ENSMUST00000022548.10
ENSMUST00000162674.8
ENSMUST00000159858.2
ENSMUST00000162271.2
1700129C05Rik
RIKEN cDNA 1700129C05 gene
chr19_-_28945194 3.47 ENSMUST00000162110.8
Spata6l
spermatogenesis associated 6 like
chr17_+_72076678 3.47 ENSMUST00000230427.2
ENSMUST00000229952.2
ENSMUST00000230333.2
Clip4
CAP-GLY domain containing linker protein family, member 4
chr6_+_50087826 3.40 ENSMUST00000167628.2
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr17_+_72076728 3.28 ENSMUST00000230305.2
Clip4
CAP-GLY domain containing linker protein family, member 4
chr11_-_58346806 3.10 ENSMUST00000055204.6
Olfr30
olfactory receptor 30
chr1_-_160986880 3.06 ENSMUST00000135643.8
ENSMUST00000178511.3
Tex50
testis expressed 50
chr2_-_73456080 3.05 ENSMUST00000070579.7
Chn1
chimerin 1
chr11_-_103395423 2.95 ENSMUST00000153273.3
Lrrc37a
leucine rich repeat containing 37A
chr2_+_116709167 2.92 ENSMUST00000123598.8
ENSMUST00000155470.8
Tmco5
transmembrane and coiled-coil domains 5
chr18_-_35348049 2.79 ENSMUST00000091636.5
ENSMUST00000236680.2
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr19_+_39499288 2.76 ENSMUST00000025968.5
Cyp2c39
cytochrome P450, family 2, subfamily c, polypeptide 39
chr10_+_86614864 2.69 ENSMUST00000099396.3
Nt5dc3
5'-nucleotidase domain containing 3
chr3_+_138911648 2.67 ENSMUST00000062306.7
Stpg2
sperm tail PG rich repeat containing 2
chr4_-_58009118 2.56 ENSMUST00000102897.11
ENSMUST00000239406.2
Txndc8
thioredoxin domain containing 8
chr6_-_129303659 2.47 ENSMUST00000203159.2
Clec2m
C-type lectin domain family 2, member m
chr14_+_48358267 2.46 ENSMUST00000073150.6
Peli2
pellino 2
chr3_-_126792056 2.45 ENSMUST00000044443.15
Ank2
ankyrin 2, brain
chr11_+_78067537 2.42 ENSMUST00000098545.12
Tlcd1
TLC domain containing 1
chr1_+_132155922 2.40 ENSMUST00000191418.2
Lemd1
LEM domain containing 1
chr14_-_4506874 2.34 ENSMUST00000224934.2
Thrb
thyroid hormone receptor beta
chr19_+_26600820 2.30 ENSMUST00000176584.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_107655487 2.29 ENSMUST00000143074.2
Gm42669
predicted gene 42669
chr3_+_87265181 2.29 ENSMUST00000015998.8
Cd5l
CD5 antigen-like
chr3_-_88669551 2.14 ENSMUST00000183267.2
Syt11
synaptotagmin XI
chr6_-_113694633 2.12 ENSMUST00000204533.3
Ghrl
ghrelin
chr11_+_42312150 2.10 ENSMUST00000192403.2
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr11_-_69286159 2.01 ENSMUST00000108660.8
ENSMUST00000051620.5
Cyb5d1
cytochrome b5 domain containing 1
chr10_-_63039709 2.00 ENSMUST00000095580.3
Mypn
myopalladin
chr12_+_85335365 1.95 ENSMUST00000059341.5
Zc2hc1c
zinc finger, C2HC-type containing 1C
chr12_-_85335193 1.85 ENSMUST00000121930.2
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr4_-_43653539 1.82 ENSMUST00000084646.11
Spag8
sperm associated antigen 8
chr2_-_111062182 1.79 ENSMUST00000099620.5
Olfr1275
olfactory receptor 1275
chr12_-_67269323 1.79 ENSMUST00000037181.16
Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr5_-_121641461 1.79 ENSMUST00000079368.5
Adam1b
a disintegrin and metallopeptidase domain 1b
chr8_-_43594523 1.78 ENSMUST00000059692.4
Triml1
tripartite motif family-like 1
chr11_-_121410152 1.77 ENSMUST00000092298.6
Zfp750
zinc finger protein 750
chr1_+_86354045 1.66 ENSMUST00000046004.6
Tex44
testis expressed 44
chr2_+_121991181 1.63 ENSMUST00000036089.8
Trim69
tripartite motif-containing 69
chr14_-_70449438 1.63 ENSMUST00000227929.2
Sorbs3
sorbin and SH3 domain containing 3
chr2_+_152269532 1.63 ENSMUST00000128737.2
6820408C15Rik
RIKEN cDNA 6820408C15 gene
chr4_-_43653559 1.63 ENSMUST00000107870.3
Spag8
sperm associated antigen 8
chr4_-_114991174 1.58 ENSMUST00000051400.8
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr1_-_169796709 1.57 ENSMUST00000027989.13
ENSMUST00000111353.4
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr11_+_74174562 1.50 ENSMUST00000214048.3
ENSMUST00000143976.4
ENSMUST00000205790.2
ENSMUST00000206659.2
Olfr59
olfactory receptor 59
chr11_+_69286473 1.50 ENSMUST00000144531.2
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chrX_+_133088238 1.46 ENSMUST00000064476.5
Arl13a
ADP-ribosylation factor-like 13A
chr7_-_86016045 1.43 ENSMUST00000213255.2
ENSMUST00000216700.2
ENSMUST00000213869.2
Olfr305
olfactory receptor 305
chr2_-_136229849 1.42 ENSMUST00000035264.9
ENSMUST00000077200.4
Pak5
p21 (RAC1) activated kinase 5
chr11_+_68989763 1.33 ENSMUST00000021271.14
Per1
period circadian clock 1
chr5_-_74189898 1.31 ENSMUST00000152408.3
Usp46
ubiquitin specific peptidase 46
chr4_+_109092459 1.31 ENSMUST00000106631.9
Calr4
calreticulin 4
chrX_+_37861548 1.21 ENSMUST00000050744.6
6030498E09Rik
RIKEN cDNA 6030498E09 gene
chr9_+_110948492 1.20 ENSMUST00000217341.3
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr19_+_6130059 1.17 ENSMUST00000149347.8
ENSMUST00000143303.2
Tmem262
transmembrane protein 262
chr11_+_62737887 1.12 ENSMUST00000036085.11
Fbxw10
F-box and WD-40 domain protein 10
chr7_+_55889488 1.10 ENSMUST00000032633.12
ENSMUST00000155533.2
ENSMUST00000156886.8
Oca2
oculocutaneous albinism II
chr7_+_102289455 1.07 ENSMUST00000098221.2
Olfr554
olfactory receptor 554
chr13_+_22462487 1.06 ENSMUST00000091736.5
Vmn1r195
vomeronasal 1 receptor 195
chr16_+_3408906 1.01 ENSMUST00000216259.2
Olfr161
olfactory receptor 161
chr10_-_99595498 1.00 ENSMUST00000056085.6
Csl
citrate synthase like
chr2_+_85409559 0.99 ENSMUST00000077075.5
Olfr996
olfactory receptor 996
chr11_+_62737936 0.99 ENSMUST00000150989.8
ENSMUST00000176577.2
Fbxw10
F-box and WD-40 domain protein 10
chr11_+_73244561 0.96 ENSMUST00000108465.4
Olfr20
olfactory receptor 20
chr2_+_89711138 0.90 ENSMUST00000060795.3
Olfr1257
olfactory receptor 1257
chr2_+_103858066 0.89 ENSMUST00000028603.10
Fbxo3
F-box protein 3
chr7_+_102319108 0.89 ENSMUST00000098219.3
Olfr556
olfactory receptor 556
chr3_-_32419609 0.87 ENSMUST00000139660.2
ENSMUST00000168566.3
ENSMUST00000029199.11
Zmat3
zinc finger matrin type 3
chr4_+_8535604 0.81 ENSMUST00000060232.8
Rab2a
RAB2A, member RAS oncogene family
chr10_+_129376408 0.80 ENSMUST00000076575.4
Olfr792
olfactory receptor 792
chr6_+_71470987 0.80 ENSMUST00000114179.3
Rnf103
ring finger protein 103
chr7_-_106341650 0.79 ENSMUST00000217734.2
Olfr697
olfactory receptor 697
chr8_+_4290105 0.76 ENSMUST00000110994.9
ENSMUST00000110995.8
Map2k7
mitogen-activated protein kinase kinase 7
chr2_-_85478663 0.71 ENSMUST00000099920.2
Olfr1002
olfactory receptor 1002
chr7_+_48038274 0.67 ENSMUST00000056676.5
Mrgprb8
MAS-related GPR, member B8
chr12_-_108859123 0.66 ENSMUST00000161154.2
ENSMUST00000161410.8
Wars
tryptophanyl-tRNA synthetase
chr12_-_81426238 0.64 ENSMUST00000062182.8
Gm4787
predicted gene 4787
chr7_-_10292412 0.62 ENSMUST00000236246.2
Vmn1r68
vomeronasal 1 receptor 68
chr14_-_40726472 0.58 ENSMUST00000153830.8
Prxl2a
peroxiredoxin like 2A
chr10_+_129611696 0.56 ENSMUST00000059891.3
ENSMUST00000218237.2
Olfr809
olfactory receptor 809
chr6_+_40470463 0.52 ENSMUST00000038750.7
Tas2r108
taste receptor, type 2, member 108
chr9_-_18667005 0.51 ENSMUST00000066997.4
Olfr24
olfactory receptor 24
chr2_+_85597442 0.48 ENSMUST00000216397.3
Olfr1013
olfactory receptor 1013
chr9_+_37683153 0.47 ENSMUST00000215128.2
Olfr875
olfactory receptor 875
chr16_-_22630327 0.46 ENSMUST00000040592.6
Crygs
crystallin, gamma S
chr14_+_8348779 0.43 ENSMUST00000022256.5
Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr6_-_57938488 0.42 ENSMUST00000228097.2
Vmn1r24
vomeronasal 1 receptor 24
chr12_+_29988035 0.41 ENSMUST00000122328.8
ENSMUST00000118321.3
Pxdn
peroxidasin
chr2_+_103858168 0.40 ENSMUST00000111135.8
ENSMUST00000111136.8
ENSMUST00000102565.4
Fbxo3
F-box protein 3
chr6_+_56926317 0.40 ENSMUST00000227073.2
Vmn1r4
vomeronasal 1 receptor 4
chr11_+_74150634 0.39 ENSMUST00000217016.2
ENSMUST00000214303.2
Olfr406
olfactory receptor 406
chr17_-_35954573 0.38 ENSMUST00000095467.4
Mucl3
mucin like 3
chr7_-_5325456 0.37 ENSMUST00000207520.2
Nlrp2
NLR family, pyrin domain containing 2
chr7_-_66915756 0.34 ENSMUST00000207715.2
Mef2a
myocyte enhancer factor 2A
chr19_-_55229668 0.34 ENSMUST00000069183.8
Gucy2g
guanylate cyclase 2g
chr4_-_43700807 0.29 ENSMUST00000055545.5
Olfr70
olfactory receptor 70
chr19_+_12186932 0.29 ENSMUST00000072316.5
Olfr1431
olfactory receptor 1431
chr10_+_97400990 0.28 ENSMUST00000038160.6
Lum
lumican
chr19_+_13745671 0.28 ENSMUST00000061669.3
Olfr1495
olfactory receptor 1495
chr15_-_76906832 0.28 ENSMUST00000019037.10
ENSMUST00000169226.9
Mb
myoglobin
chr7_-_133384449 0.26 ENSMUST00000063669.8
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr17_+_87332978 0.25 ENSMUST00000024959.10
Cript
cysteine-rich PDZ-binding protein
chr19_-_12219023 0.23 ENSMUST00000087818.2
Olfr262
olfactory receptor 262
chr6_+_56974228 0.20 ENSMUST00000228285.2
ENSMUST00000227847.2
ENSMUST00000226689.2
ENSMUST00000227131.2
ENSMUST00000227631.2
ENSMUST00000227188.2
Vmn1r6
vomeronasal 1 receptor 6
chr10_+_3822667 0.17 ENSMUST00000136671.8
ENSMUST00000042438.13
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr17_-_27841759 0.14 ENSMUST00000176458.2
ENSMUST00000114886.8
Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr4_+_148123554 0.12 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr2_-_155661324 0.12 ENSMUST00000124586.2
BC029722
cDNA sequence BC029722
chr6_-_57306479 0.06 ENSMUST00000227283.2
ENSMUST00000228356.2
Vmn1r16
vomeronasal 1 receptor 16
chr3_-_79645101 0.03 ENSMUST00000078527.13
Rxfp1
relaxin/insulin-like family peptide receptor 1
chr17_-_87332780 0.03 ENSMUST00000024957.7
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr18_+_44403169 0.02 ENSMUST00000042747.4
Npy6r
neuropeptide Y receptor Y6
chr17_+_33395390 0.01 ENSMUST00000112168.4
Olfr55
olfactory receptor 55
chr18_+_37939442 0.01 ENSMUST00000076807.7
Pcdhgc3
protocadherin gamma subfamily C, 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:0018879 biphenyl metabolic process(GO:0018879)
2.6 10.5 GO:1903630 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.7 8.5 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.2 4.7 GO:0010982 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
1.0 4.0 GO:0006114 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.9 5.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.6 9.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.5 2.1 GO:1905154 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.5 2.1 GO:1904344 regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768) negative regulation of energy homeostasis(GO:2000506)
0.5 7.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.5 6.8 GO:0015747 urate transport(GO:0015747)
0.5 16.7 GO:0046688 copper ion transport(GO:0006825) response to copper ion(GO:0046688)
0.4 2.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 2.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 2.4 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 19.3 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.2 1.2 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.2 2.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 1.3 GO:0097167 circadian regulation of translation(GO:0097167)
0.2 0.7 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 2.6 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 1.3 GO:0008343 adult feeding behavior(GO:0008343)
0.1 2.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 2.0 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 3.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.8 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.1 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.0 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 1.1 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 5.5 GO:0006457 protein folding(GO:0006457)
0.0 2.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 3.3 GO:0032092 positive regulation of protein binding(GO:0032092)
0.0 1.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 1.6 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 1.9 GO:0019236 response to pheromone(GO:0019236)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716) positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 5.6 GO:0006869 lipid transport(GO:0006869)
0.0 0.0 GO:0060618 nipple development(GO:0060618)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.8 GO:0005579 membrane attack complex(GO:0005579)
0.4 1.5 GO:0031417 NatC complex(GO:0031417)
0.2 16.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.1 GO:0032009 early phagosome(GO:0032009)
0.1 1.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 4.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.1 2.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.4 GO:0031430 M band(GO:0031430)
0.0 4.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 7.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.8 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 16.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
1.3 4.0 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.7 2.1 GO:0031768 ghrelin receptor binding(GO:0031768)
0.7 27.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.5 4.7 GO:0004630 phospholipase D activity(GO:0004630)
0.5 1.6 GO:0005148 prolactin receptor binding(GO:0005148)
0.5 18.3 GO:0070330 aromatase activity(GO:0070330)
0.5 5.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.5 8.5 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.5 1.8 GO:0003998 acylphosphatase activity(GO:0003998)
0.4 6.8 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 2.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.2 2.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2 2.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 0.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 5.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 3.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.8 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.4 GO:0032090 Pyrin domain binding(GO:0032090)
0.1 2.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 2.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 2.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 2.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 2.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 6.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 6.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 1.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.9 GO:0005550 pheromone binding(GO:0005550)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 3.8 GO:0005549 odorant binding(GO:0005549)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 16.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 3.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 16.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.4 8.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 9.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.3 5.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 6.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 4.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation