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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Isl1

Z-value: 1.09

Motif logo

Transcription factors associated with Isl1

Gene Symbol Gene ID Gene Info
ENSMUSG00000042258.14 Isl1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Isl1mm39_v1_chr13_-_116446166_1164462350.132.8e-01Click!

Activity profile of Isl1 motif

Sorted Z-values of Isl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Isl1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr14_+_54457978 6.28 ENSMUST00000103740.2
ENSMUST00000198398.5
T cell receptor alpha constant
chr12_-_113802603 6.02 ENSMUST00000103458.3
ENSMUST00000193652.2
immunoglobulin heavy variable 5-16
chr17_-_52117894 5.71 ENSMUST00000176669.8
special AT-rich sequence binding protein 1
chr9_+_53678801 5.37 ENSMUST00000048670.10
solute carrier family 35, member F2
chr12_-_113790741 4.97 ENSMUST00000103457.3
ENSMUST00000192877.2
immunoglobulin heavy variable 5-15
chr10_+_101517348 4.71 ENSMUST00000179929.8
ENSMUST00000219195.2
ENSMUST00000127504.9
MGAT4 family, member C
chr1_-_79417732 4.57 ENSMUST00000185234.2
ENSMUST00000049972.6
secretogranin II
chr12_-_113700190 4.54 ENSMUST00000103452.3
ENSMUST00000192264.2
immunoglobulin heavy variable 5-9-1
chr9_-_112016966 4.35 ENSMUST00000178410.2
ENSMUST00000172380.10
cyclic AMP-regulated phosphoprotein, 21
chrX_+_95498965 4.31 ENSMUST00000033553.14
hephaestin
chr10_+_28544356 4.24 ENSMUST00000060409.13
ENSMUST00000056097.11
ENSMUST00000105516.9
thymocyte selection associated
chrX_+_162923474 3.96 ENSMUST00000073973.11
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr1_-_173105344 3.83 ENSMUST00000111224.5
mucosal pentraxin 2
chr17_-_78991691 3.81 ENSMUST00000145480.2
striatin, calmodulin binding protein
chr11_-_76400245 3.62 ENSMUST00000094012.11
active BCR-related gene
chr3_+_103739877 3.58 ENSMUST00000062945.12
BCLl2-like 15
chr11_-_6180127 3.48 ENSMUST00000004505.3
NPC1 like intracellular cholesterol transporter 1
chr4_-_94538370 3.28 ENSMUST00000053419.9
leucine rich repeat containing 19
chrX_+_162873183 3.22 ENSMUST00000015545.10
collectrin, amino acid transport regulator
chr12_-_113823290 3.21 ENSMUST00000103459.5
immunoglobulin heavy variable 5-17
chr4_-_94538329 3.21 ENSMUST00000107101.2
leucine rich repeat containing 19
chr1_+_172168764 3.19 ENSMUST00000056136.4
potassium inwardly-rectifying channel, subfamily J, member 10
chr9_-_40257586 3.17 ENSMUST00000121357.8
GRAM domain containing 1B
chr13_+_76727787 3.16 ENSMUST00000126960.8
ENSMUST00000109583.9
multiple C2 domains, transmembrane 1
chr2_+_124994425 3.13 ENSMUST00000110494.9
ENSMUST00000110495.3
ENSMUST00000028630.9
solute carrier family 12, member 1
chr2_+_109522781 3.10 ENSMUST00000111050.10
brain derived neurotrophic factor
chr9_-_95697441 2.97 ENSMUST00000119760.2
plastin 1 (I-isoform)
chr19_-_8816530 2.96 ENSMUST00000096259.6
guanine nucleotide binding protein (G protein), gamma 3
chr10_-_18890281 2.80 ENSMUST00000146388.2
tumor necrosis factor, alpha-induced protein 3
chr4_+_41903610 2.74 ENSMUST00000098128.4
chemokine (C-C motif) ligand 21D
chr4_+_42255693 2.71 ENSMUST00000178864.3
chemokine (C-C motif) ligand 21B (leucine)
chr18_-_47466378 2.70 ENSMUST00000126684.2
ENSMUST00000156422.8
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_+_42114817 2.67 ENSMUST00000098123.4
predicted gene 13304
chr16_+_36514334 2.60 ENSMUST00000023617.13
ENSMUST00000089618.10
immunoglobulin-like domain containing receptor 1
chr9_-_82856321 2.52 ENSMUST00000189985.2
pleckstrin homology domain interacting protein
chr9_+_113641615 2.47 ENSMUST00000111838.10
ENSMUST00000166734.10
ENSMUST00000214522.2
ENSMUST00000163895.3
CLIP associating protein 2
chr2_+_91376650 2.46 ENSMUST00000099716.11
ENSMUST00000046769.16
ENSMUST00000111337.3
cytoskeleton associated protein 5
chr5_-_43978980 2.42 ENSMUST00000114047.10
F-box and leucine-rich repeat protein 5
chr5_+_129661233 2.41 ENSMUST00000031390.10
matrix metallopeptidase 17
chr10_+_28544556 2.37 ENSMUST00000161345.2
thymocyte selection associated
chr6_+_41928559 2.37 ENSMUST00000031898.5
seminal vesicle antigen-like 1
chr10_+_18345706 2.32 ENSMUST00000162891.8
ENSMUST00000100054.4
NHS-like 1
chr14_-_121976273 2.28 ENSMUST00000212376.3
ENSMUST00000239077.2
dedicator of cytokinesis 9
chr5_+_24679154 2.25 ENSMUST00000199856.2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr10_-_12490424 2.21 ENSMUST00000217994.2
utrophin
chr1_-_64160557 2.20 ENSMUST00000055001.10
ENSMUST00000114086.8
Kruppel-like factor 7 (ubiquitous)
chr2_-_58050494 2.11 ENSMUST00000028175.7
cytohesin 1 interacting protein
chr6_+_136509922 2.11 ENSMUST00000187429.4
activating transcription factor 7 interacting protein
chr12_-_72455708 2.09 ENSMUST00000078505.14
reticulon 1
chr13_-_51947685 2.05 ENSMUST00000110040.9
ENSMUST00000021900.14
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr10_-_108846816 1.99 ENSMUST00000105276.8
ENSMUST00000064054.14
synaptotagmin I
chr9_-_112046411 1.95 ENSMUST00000161412.8
cyclic AMP-regulated phosphoprotein, 21
chrX_+_56257374 1.95 ENSMUST00000033466.2
CD40 ligand
chr9_+_37278647 1.94 ENSMUST00000051839.9
hepatocyte cell adhesion molecule
chr12_-_113666198 1.93 ENSMUST00000103450.4
immunoglobulin heavy variable 5-12
chr7_+_143792455 1.93 ENSMUST00000239495.2
SH3 and multiple ankyrin repeat domains 2
chr7_+_100435548 1.91 ENSMUST00000216021.2
family with sequence similarity 168, member A
chr9_-_71803354 1.87 ENSMUST00000184448.8
transcription factor 12
chr10_+_75983285 1.86 ENSMUST00000020450.4
solute carrier family 5, member 4a
chr11_+_98277276 1.85 ENSMUST00000041301.8
phenylethanolamine-N-methyltransferase
chr11_+_78192355 1.78 ENSMUST00000045026.4
sperm associated antigen 5
chr14_-_78866714 1.73 ENSMUST00000228362.2
ENSMUST00000227767.2
diacylglycerol kinase, eta
chr5_+_20433169 1.67 ENSMUST00000197553.5
ENSMUST00000208219.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_+_70332836 1.63 ENSMUST00000103390.3
immunoglobulin kappa variable 8-18
chr15_-_93417380 1.61 ENSMUST00000109255.3
prickle planar cell polarity protein 1
chr5_+_81169049 1.58 ENSMUST00000117253.8
ENSMUST00000120128.8
adhesion G protein-coupled receptor L3
chr8_-_65489834 1.51 ENSMUST00000142822.4
apelin receptor early endogenous ligand
chr2_-_59778560 1.50 ENSMUST00000153136.2
bromodomain adjacent to zinc finger domain, 2B
chr3_+_109481223 1.50 ENSMUST00000106576.3
vav 3 oncogene
chr3_-_7678796 1.50 ENSMUST00000192202.6
interleukin 7
chr11_-_99313078 1.49 ENSMUST00000017741.4
keratin 12
chr11_+_4959515 1.49 ENSMUST00000101613.3
adaptor protein complex AP-1, beta 1 subunit
chr9_+_3403592 1.48 ENSMUST00000027027.7
CWF19-like 2, cell cycle control (S. pombe)
chr10_+_58230203 1.48 ENSMUST00000105468.2
LIM and senescent cell antigen-like domains 1
chr14_+_53497035 1.47 ENSMUST00000197614.2
T cell receptor alpha variable 14N-2
chr3_-_144511566 1.43 ENSMUST00000199029.2
chloride channel accessory 3A2
chr11_-_109188892 1.41 ENSMUST00000106706.8
regulator of G-protein signaling 9
chr10_+_87926932 1.40 ENSMUST00000048621.8
pro-melanin-concentrating hormone
chr15_-_36496880 1.39 ENSMUST00000228601.2
ENSMUST00000057486.9
ankyrin repeat domain 46
chr14_-_28691423 1.38 ENSMUST00000225985.2
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr14_+_53153256 1.36 ENSMUST00000197007.2
ENSMUST00000103593.3
T cell receptor alpha variable 12D-2
chr14_+_10123804 1.34 ENSMUST00000022262.6
ENSMUST00000224714.2
Fez family zinc finger 2
chr2_+_158636727 1.33 ENSMUST00000029186.14
ENSMUST00000109478.9
ENSMUST00000156893.2
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr3_+_61269059 1.31 ENSMUST00000049064.4
RAP2B, member of RAS oncogene family
chr4_-_116228921 1.30 ENSMUST00000239239.2
ENSMUST00000239177.2
microtubule associated serine/threonine kinase 2
chr2_+_29533799 1.30 ENSMUST00000238899.2
Rap guanine nucleotide exchange factor (GEF) 1
chr4_+_57821050 1.28 ENSMUST00000238994.2
paralemmin A kinase anchor protein
chr1_+_87731360 1.27 ENSMUST00000177757.2
ENSMUST00000077772.12
S-antigen, retina and pineal gland (arrestin)
chr14_-_36657517 1.27 ENSMUST00000183038.8
coiled-coil serine rich 2
chr13_-_103901010 1.25 ENSMUST00000210489.2
splicing regulatory glutamine/lysine-rich protein 1
chr4_+_41966058 1.24 ENSMUST00000108026.3
family with sequence similarity 205, member A4
chr3_-_75177378 1.23 ENSMUST00000039047.5
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr6_+_142244145 1.23 ENSMUST00000041993.3
islet amyloid polypeptide
chr16_-_96971905 1.23 ENSMUST00000056102.9
DS cell adhesion molecule
chr5_+_107655487 1.23 ENSMUST00000143074.2
predicted gene 42669
chr5_+_44070486 1.19 ENSMUST00000122204.3
ENSMUST00000200338.2
predicted pseudogene 7879
chr3_+_134947971 1.16 ENSMUST00000197369.3
centromere protein E
chr18_-_35348049 1.14 ENSMUST00000091636.5
ENSMUST00000236680.2
leucine rich repeat transmembrane neuronal 2
chr3_+_116388600 1.14 ENSMUST00000198386.5
ENSMUST00000198311.5
ENSMUST00000197335.2
SAS-6 centriolar assembly protein
chr8_-_65489791 1.12 ENSMUST00000124790.8
apelin receptor early endogenous ligand
chr15_-_50746202 1.12 ENSMUST00000184885.8
transcriptional repressor GATA binding 1
chr3_-_7678785 1.11 ENSMUST00000194279.6
interleukin 7
chrX_+_113384008 1.11 ENSMUST00000113371.8
ENSMUST00000040504.12
kelch-like 4
chr10_-_70491764 1.06 ENSMUST00000162144.2
ENSMUST00000162793.8
phytanoyl-CoA hydroxylase interacting protein-like
chr17_+_71511642 1.05 ENSMUST00000126681.8
lipin 2
chr2_+_71042285 1.05 ENSMUST00000112144.9
ENSMUST00000100028.10
ENSMUST00000112136.2
dynein cytoplasmic 1 intermediate chain 2
chr1_-_182929025 1.05 ENSMUST00000171366.7
dispatched RND transporter family member 1
chr4_+_3940747 1.04 ENSMUST00000119403.2
coiled-coil-helix-coiled-coil-helix domain containing 7
chr11_+_90078485 1.02 ENSMUST00000124877.3
ENSMUST00000153734.2
ENSMUST00000134929.8
predicted gene 45716
chr2_+_57887896 1.02 ENSMUST00000112616.8
ENSMUST00000166729.2
polypeptide N-acetylgalactosaminyltransferase 5
chr14_+_53167246 1.01 ENSMUST00000177703.3
T cell receptor alpha variable 12D-3
chr18_+_37858753 1.00 ENSMUST00000066149.9
protocadherin gamma subfamily A, 8
chr1_-_58009263 1.00 ENSMUST00000114410.10
potassium channel tetramerisation domain containing 18
chr14_+_53775648 1.00 ENSMUST00000200115.2
ENSMUST00000103650.3
T cell receptor alpha variable 12-1
chr3_+_90383425 0.96 ENSMUST00000001042.10
interleukin enhancer binding factor 2
chr9_-_119038162 0.95 ENSMUST00000084797.6
solute carrier family 22 (organic cation transporter), member 13
chr5_-_5315968 0.94 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
cyclin-dependent kinase 14
chr9_+_35334878 0.94 ENSMUST00000154652.8
cell adhesion molecule-related/down-regulated by oncogenes
chr1_-_58009191 0.93 ENSMUST00000159826.2
ENSMUST00000164963.8
potassium channel tetramerisation domain containing 18
chr3_-_49711706 0.92 ENSMUST00000191794.2
protocadherin 18
chr12_-_25147139 0.91 ENSMUST00000221761.2
inhibitor of DNA binding 2
chr3_-_116388334 0.91 ENSMUST00000197190.5
ENSMUST00000198454.2
tRNA methyltransferase 13
chr18_+_35347983 0.90 ENSMUST00000235449.2
ENSMUST00000235269.2
catenin (cadherin associated protein), alpha 1
chr10_+_34359513 0.90 ENSMUST00000170771.3
fyn-related kinase
chr4_+_73931679 0.86 ENSMUST00000098006.9
ENSMUST00000084474.6
FERM domain containing 3
chr14_+_67148619 0.84 ENSMUST00000089236.11
ENSMUST00000122431.3
paraneoplastic antigen MA2
chr2_+_71042050 0.78 ENSMUST00000112142.8
ENSMUST00000112139.8
ENSMUST00000112140.8
ENSMUST00000112138.8
dynein cytoplasmic 1 intermediate chain 2
chr9_+_94551929 0.78 ENSMUST00000033463.10
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr18_+_4375582 0.78 ENSMUST00000025077.7
mitochondrial poly(A) polymerase
chr1_+_12788720 0.77 ENSMUST00000088585.10
sulfatase 1
chr10_+_34359395 0.77 ENSMUST00000019913.15
fyn-related kinase
chr8_-_5155347 0.75 ENSMUST00000023835.3
solute carrier family 10, member 2
chr14_-_70867588 0.74 ENSMUST00000228009.2
dematin actin binding protein
chr3_-_104725853 0.74 ENSMUST00000106775.8
ENSMUST00000166979.8
Mov10 RISC complex RNA helicase
chr10_-_13264497 0.71 ENSMUST00000105546.8
phosphatase and actin regulator 2
chr3_+_5815863 0.68 ENSMUST00000192045.2
predicted pseudogene 8797
chr10_+_101517556 0.68 ENSMUST00000156751.8
MGAT4 family, member C
chr1_+_133109059 0.66 ENSMUST00000187285.7
pleckstrin homology domain containing, family A member 6
chr18_-_68562385 0.63 ENSMUST00000052347.8
melanocortin 2 receptor
chr2_+_71042172 0.60 ENSMUST00000081710.12
dynein cytoplasmic 1 intermediate chain 2
chr16_-_90866032 0.58 ENSMUST00000035689.8
ENSMUST00000114076.2
RIKEN cDNA 4932438H23 gene
chr5_+_20112704 0.57 ENSMUST00000115267.7
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_+_47536075 0.54 ENSMUST00000227554.2
mitogen-activated protein kinase 1 interacting protein 1-like
chr7_-_117715351 0.54 ENSMUST00000128482.8
ENSMUST00000131840.3
ribosomal protein S15A
chr13_+_76727799 0.52 ENSMUST00000109589.3
multiple C2 domains, transmembrane 1
chr3_-_49711765 0.52 ENSMUST00000035931.13
protocadherin 18
chr9_-_44679136 0.51 ENSMUST00000034607.10
archain 1
chr17_-_71153283 0.50 ENSMUST00000156484.2
TGFB-induced factor homeobox 1
chr6_-_129428746 0.48 ENSMUST00000204012.2
ENSMUST00000037481.10
C-type lectin domain family 1, member a
chr18_+_77032080 0.46 ENSMUST00000026485.15
ENSMUST00000150990.9
ENSMUST00000148955.3
haloacid dehalogenase-like hydrolase domain containing 2
chr11_-_109188917 0.46 ENSMUST00000106704.3
regulator of G-protein signaling 9
chr6_+_54794433 0.45 ENSMUST00000127331.2
zinc and ring finger 2
chrX_-_42363663 0.45 ENSMUST00000016294.8
teneurin transmembrane protein 1
chr13_+_93444514 0.44 ENSMUST00000079086.8
homer scaffolding protein 1
chr4_+_150321272 0.43 ENSMUST00000080926.13
enolase 1, alpha non-neuron
chr11_+_117157024 0.41 ENSMUST00000019038.15
septin 9
chr5_+_23992689 0.38 ENSMUST00000120869.6
ENSMUST00000030852.13
ENSMUST00000117783.8
ENSMUST00000115113.3
RAD50 interactor 1
chr18_+_37143758 0.38 ENSMUST00000115657.10
ENSMUST00000192447.6
protocadherin alpha 11
chr10_+_26648473 0.37 ENSMUST00000039557.9
Rho GTPase activating protein 18
chr14_+_53081922 0.36 ENSMUST00000181360.3
ENSMUST00000183652.2
T cell receptor alpha variable 12D-1
chr8_-_123187406 0.34 ENSMUST00000006762.7
snail family zinc finger 3
chr7_-_84059170 0.33 ENSMUST00000208995.2
aryl hydrocarbon receptor nuclear translocator 2
chr3_-_127019496 0.33 ENSMUST00000182064.9
ENSMUST00000182452.8
ankyrin 2, brain
chr14_+_47535717 0.32 ENSMUST00000166743.9
mitogen-activated protein kinase 1 interacting protein 1-like
chr6_-_129428869 0.32 ENSMUST00000203162.3
C-type lectin domain family 1, member a
chr18_-_15851103 0.29 ENSMUST00000053017.13
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr19_+_4036562 0.27 ENSMUST00000236224.2
ENSMUST00000236510.2
ENSMUST00000237910.2
ENSMUST00000235612.2
ENSMUST00000054030.8
aspartoacylase (aminoacylase) 3
chr10_-_41894360 0.27 ENSMUST00000162405.8
ENSMUST00000095729.11
ENSMUST00000161081.2
ENSMUST00000160262.9
armadillo repeat containing 2
chrX_-_103900834 0.26 ENSMUST00000033575.7
MAGE family member E2
chr10_+_40225272 0.24 ENSMUST00000044672.11
ENSMUST00000095743.4
cyclin-dependent kinase 19
chr8_-_34237752 0.23 ENSMUST00000179364.3
small integral membrane protein 18
chr17_-_35454729 0.22 ENSMUST00000048994.7
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chrX_-_151820545 0.22 ENSMUST00000051484.5
MAGE family member H1
chr19_-_40260286 0.22 ENSMUST00000182432.2
PDZ and LIM domain 1 (elfin)
chr18_-_42712717 0.21 ENSMUST00000054738.5
G protein-coupled receptor 151
chr2_+_153003212 0.21 ENSMUST00000089027.3
transmembrane 9 superfamily member 4
chr4_-_137493785 0.20 ENSMUST00000139951.8
alkaline phosphatase, liver/bone/kidney
chr3_-_123484499 0.20 ENSMUST00000154668.8
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr11_-_84058292 0.18 ENSMUST00000050771.8
predicted gene 11437
chr3_-_123483772 0.18 ENSMUST00000172537.3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_-_24752683 0.17 ENSMUST00000061764.14
RAB26, member RAS oncogene family
chr5_-_123663440 0.16 ENSMUST00000197682.6
predicted gene, 49027
chr15_+_91722458 0.15 ENSMUST00000109277.8
submandibular gland protein C
chr17_+_28945057 0.14 ENSMUST00000233003.2
predicted gene 4356
chr2_-_120946877 0.14 ENSMUST00000110675.3
transglutaminase 7
chr4_-_41723129 0.12 ENSMUST00000171641.2
ENSMUST00000030158.11
dynactin 3
chrX_+_105964224 0.12 ENSMUST00000060576.8
lysophosphatidic acid receptor 4
chrX_-_142716200 0.09 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
doublecortin
chr19_-_11816583 0.09 ENSMUST00000214887.2
olfactory receptor 1417
chr1_-_75110511 0.09 ENSMUST00000027405.6
solute carrier family 23 (nucleobase transporters), member 3
chr2_+_67578556 0.08 ENSMUST00000180887.2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr3_-_95662134 0.08 ENSMUST00000198289.5
ENSMUST00000196868.5
ENSMUST00000074339.13
ENSMUST00000163530.8
ENSMUST00000029752.15
ENSMUST00000195929.5
ENSMUST00000199570.2
ENSMUST00000098857.9
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr10_-_92917458 0.07 ENSMUST00000212902.2
ENSMUST00000168617.3
ENSMUST00000168110.8
ENSMUST00000020200.14
cilia and flagella associated protein 54
chr1_+_81055201 0.07 ENSMUST00000123285.2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr4_+_43406435 0.06 ENSMUST00000098106.9
ENSMUST00000139198.2
RUN and SH3 domain containing 2
chr14_+_53497357 0.06 ENSMUST00000103623.3
T cell receptor alpha variable 14N-2
chr4_+_94627513 0.06 ENSMUST00000073939.13
ENSMUST00000102798.8
TEK receptor tyrosine kinase
chr1_-_170695328 0.05 ENSMUST00000027974.7
activating transcription factor 6
chr2_-_17465410 0.04 ENSMUST00000145492.2
nebulette
chr16_-_21980200 0.02 ENSMUST00000115379.2
insulin-like growth factor 2 mRNA binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0061193 taste bud development(GO:0061193)
1.0 4.0 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.9 2.8 GO:0002632 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.8 3.2 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.7 3.0 GO:1902896 terminal web assembly(GO:1902896)
0.6 1.9 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.6 3.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.5 1.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.5 2.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.5 1.9 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.5 1.4 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.5 3.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.4 1.2 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.4 2.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 1.9 GO:0042414 epinephrine metabolic process(GO:0042414)
0.3 1.0 GO:0035638 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.3 2.2 GO:0007527 adult somatic muscle development(GO:0007527)
0.3 4.6 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.3 0.9 GO:0001966 thigmotaxis(GO:0001966)
0.3 6.6 GO:0043383 negative T cell selection(GO:0043383)
0.3 1.8 GO:0090235 regulation of metaphase plate congression(GO:0090235)
0.2 5.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 2.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 2.3 GO:0097475 motor neuron migration(GO:0097475)
0.2 2.0 GO:0005513 detection of calcium ion(GO:0005513)
0.2 2.4 GO:2000582 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 2.3 GO:0030578 PML body organization(GO:0030578)
0.2 1.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.7 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 3.5 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.2 1.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 2.6 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 0.9 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 2.4 GO:0042756 drinking behavior(GO:0042756)
0.1 2.5 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 20.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 1.9 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 0.5 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.4 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 0.7 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.1 4.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.9 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.3 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 2.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.5 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 6.3 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.7 GO:0046473 phosphatidic acid metabolic process(GO:0046473)
0.1 6.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 2.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 2.2 GO:0002360 T cell lineage commitment(GO:0002360)
0.1 2.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.8 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.1 1.0 GO:0015747 urate transport(GO:0015747)
0.1 1.9 GO:0071625 vocalization behavior(GO:0071625)
0.1 1.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 1.6 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 1.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.7 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 1.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0 1.4 GO:0043276 anoikis(GO:0043276)
0.0 1.1 GO:0007099 centriole replication(GO:0007099)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 1.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 4.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 1.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 3.0 GO:0007601 visual perception(GO:0007601)
0.0 1.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 2.1 GO:0090277 positive regulation of peptide hormone secretion(GO:0090277)
0.0 0.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 4.8 GO:0016358 dendrite development(GO:0016358)
0.0 1.9 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:1904511 cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511)
0.3 3.0 GO:1990357 terminal web(GO:1990357)
0.3 6.6 GO:0031045 dense core granule(GO:0031045)
0.3 2.6 GO:0061689 tricellular tight junction(GO:0061689)
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 20.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 3.1 GO:0030061 mitochondrial crista(GO:0030061)
0.2 1.1 GO:0098536 deuterosome(GO:0098536)
0.1 1.9 GO:0005883 neurofilament(GO:0005883)
0.1 3.2 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.4 GO:0070939 Dsl1p complex(GO:0070939)
0.1 3.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 6.1 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 4.2 GO:0035371 microtubule plus-end(GO:0035371)
0.1 2.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.2 GO:0070938 contractile ring(GO:0070938)
0.1 1.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 1.9 GO:0043196 varicosity(GO:0043196)
0.1 1.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 4.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 5.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.4 GO:0031526 brush border membrane(GO:0031526)
0.0 2.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 2.3 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 2.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.8 3.1 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.7 2.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.7 4.0 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.7 2.6 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.6 1.9 GO:0005174 CD40 receptor binding(GO:0005174)
0.5 5.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 3.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 4.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 2.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 1.3 GO:0002046 opsin binding(GO:0002046)
0.2 2.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.2 GO:0043515 kinetochore binding(GO:0043515)
0.2 4.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 4.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 3.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.8 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 1.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 20.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 3.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 3.5 GO:0031489 myosin V binding(GO:0031489)
0.1 4.6 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.9 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 3.1 GO:0017166 vinculin binding(GO:0017166)
0.1 2.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 2.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.0 GO:0015197 peptide transporter activity(GO:0015197)
0.1 0.3 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.2 GO:0019002 GMP binding(GO:0019002)
0.1 0.4 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 6.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 1.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 6.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.3 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 2.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 1.0 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.9 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 1.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 6.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 6.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)
0.0 1.7 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 4.7 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 5.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 2.2 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 3.8 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 3.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 3.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.9 PID AURORA A PATHWAY Aurora A signaling
0.0 2.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 5.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 4.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.0 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 6.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 4.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 5.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 5.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 5.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 2.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors