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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Junb_Jund
Z-value: 3.05
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Transcription factors associated with Junb_Jund
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Jund | mm39_v1_chr8_+_71151581_71151599 | 0.11 | 3.7e-01 | Click! |
| Junb | mm39_v1_chr8_-_85705338_85705355 | -0.08 | 4.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Junb_Jund
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 165.7 | GO:0007286 | spermatid development(GO:0007286) |
| 5.8 | 110.2 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.2 | 100.2 | GO:0007283 | spermatogenesis(GO:0007283) |
| 1.8 | 84.7 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.9 | 60.8 | GO:0030317 | sperm motility(GO:0030317) |
| 3.1 | 50.0 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 7.0 | 41.8 | GO:0060474 | positive regulation of sperm motility involved in capacitation(GO:0060474) |
| 1.7 | 41.3 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 13.2 | 39.6 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 2.4 | 37.7 | GO:0007343 | egg activation(GO:0007343) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 155.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 3.9 | 112.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 73.9 | GO:0005634 | nucleus(GO:0005634) |
| 3.3 | 52.1 | GO:0044754 | autolysosome(GO:0044754) |
| 1.1 | 44.7 | GO:0097546 | ciliary base(GO:0097546) |
| 0.8 | 40.3 | GO:0031430 | M band(GO:0031430) |
| 0.5 | 36.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 2.3 | 36.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 36.1 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 34.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 122.6 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.3 | 63.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.8 | 60.9 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 1.1 | 60.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 5.2 | 57.1 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.9 | 51.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.5 | 51.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 1.7 | 44.7 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 2.3 | 41.7 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.6 | 36.7 | GO:0070063 | RNA polymerase binding(GO:0070063) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 34.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.6 | 32.7 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.6 | 31.7 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.5 | 27.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.9 | 19.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.3 | 10.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 9.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 7.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 7.3 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 7.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 37.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.5 | 34.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.6 | 29.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 24.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 20.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.8 | 20.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.0 | 19.0 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 18.7 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.8 | 18.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.6 | 16.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |