ISMARA results: Klf1

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Klf1

Z-value: 2.67

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Transcription factors associated with Klf1

Gene Symbol	Gene ID	Gene Info
Klf1 Ensembl NCBI MGI UniProt	ENSMUSG00000054191.10	Klf1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf1	mm39_v1_chr8_+_85628557_85628621	-0.12	3.3e-01	Click!

Activity profile of Klf1 motif

Sorted Z-values of Klf1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr3_+_90520408 Show fit	28.56	ENSMUST00000198128.2	S100a6 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A6 (calcyclin)
chr11_-_100036792 Show fit	24.97	ENSMUST00000007317.8	Krt19 Ensembl NCBI MGI UniProt Show fit	keratin 19
chr8_-_106198112 Show fit	20.41	ENSMUST00000014990.13	Tppp3 Ensembl NCBI MGI UniProt Show fit	tubulin polymerization-promoting protein family member 3
chr2_+_121188195 Show fit	18.56	ENSMUST00000125812.8 ENSMUST00000078222.9 ENSMUST00000125221.3 ENSMUST00000150271.8	Ckmt1 Ensembl NCBI MGI UniProt Show fit	creatine kinase, mitochondrial 1, ubiquitous
chr6_+_86605146 Show fit	14.26	ENSMUST00000043400.9	Asprv1 Ensembl NCBI MGI UniProt Show fit	aspartic peptidase, retroviral-like 1
chr8_-_36293588 Show fit	14.14	ENSMUST00000060128.7	Cldn23 Ensembl NCBI MGI UniProt Show fit	claudin 23
chr3_+_90434160 Show fit	13.94	ENSMUST00000199538.5 ENSMUST00000164481.7 ENSMUST00000167598.6	S100a14 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A14
chr12_-_76842263 Show fit	13.18	ENSMUST00000082431.6	Gpx2 Ensembl NCBI MGI UniProt Show fit	glutathione peroxidase 2
chr3_+_92158054 Show fit	12.78	ENSMUST00000071805.4	Sprr2a2 Ensembl NCBI MGI UniProt Show fit	small proline-rich protein 2A2
chr4_-_133329479 Show fit	12.77	ENSMUST00000057311.4	Sfn Ensembl NCBI MGI UniProt Show fit	stratifin

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	28.2	GO:0060706	cell differentiation involved in embryonic placenta development(GO:0060706)
0.3	24.2	GO:0046785	microtubule polymerization(GO:0046785)
0.6	23.7	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.5	23.2	GO:0030834	regulation of actin filament depolymerization(GO:0030834)
0.9	21.4	GO:0019731	antibacterial humoral response(GO:0019731)
0.2	19.7	GO:0007596	blood coagulation(GO:0007596)
0.3	19.1	GO:1902476	chloride transmembrane transport(GO:1902476)
0.3	18.9	GO:0045103	intermediate filament-based process(GO:0045103)
3.7	18.6	GO:0001951	intestinal D-glucose absorption(GO:0001951)
6.1	18.3	GO:1905000	regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)

Showing 1 to 10 of 676 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	142.3	GO:0070062	extracellular exosome(GO:0070062)
0.5	103.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	69.3	GO:0030055	focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.3	39.1	GO:0032432	actin filament bundle(GO:0032432)
0.1	35.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.8	34.5	GO:0045095	keratin filament(GO:0045095)
0.2	32.7	GO:0005923	bicellular tight junction(GO:0005923)
1.4	30.4	GO:0031143	pseudopodium(GO:0031143)
1.6	26.5	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
2.6	23.3	GO:1990357	terminal web(GO:1990357)

Showing 1 to 10 of 239 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	83.7	GO:0051015	actin filament binding(GO:0051015)
3.4	74.6	GO:0044548	S100 protein binding(GO:0044548)
0.4	72.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	59.8	GO:0005198	structural molecule activity(GO:0005198)
0.8	55.1	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	37.5	GO:0005509	calcium ion binding(GO:0005509)
0.5	36.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.2	35.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.0	33.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5	30.5	GO:0005154	epidermal growth factor receptor binding(GO:0005154)

Showing 1 to 10 of 436 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	100.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	67.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	42.3	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.4	32.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.5	29.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.4	24.5	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.3	22.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	21.3	PID NOTCH PATHWAY	Notch signaling pathway
0.7	21.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.9	20.8	PID S1P S1P4 PATHWAY	S1P4 pathway

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	37.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.4	30.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	22.8	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	22.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.8	21.9	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.7	19.0	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.2	17.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	17.4	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.4	16.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	15.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 143 entries

Results for Klf1

Z-value: 2.67

Motif logo

Transcription factors associated with Klf1

Activity-expression correlation:

Activity profile of Klf1 motif

Sorted Z-values of Klf1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: