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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Klf16_Sp8
Z-value: 2.39
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Transcription factors associated with Klf16_Sp8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf16 | mm39_v1_chr10_-_80413119_80413161 | -0.13 | 2.7e-01 | Click! |
| Sp8 | mm39_v1_chr12_+_118811306_118811321 | 0.09 | 4.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf16_Sp8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 119.0 | GO:0007283 | spermatogenesis(GO:0007283) |
| 1.8 | 99.6 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 3.0 | 81.4 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.6 | 66.8 | GO:0007286 | spermatid development(GO:0007286) |
| 6.0 | 66.4 | GO:0097460 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 3.9 | 47.0 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 7.7 | 46.3 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 4.9 | 43.9 | GO:0006559 | L-phenylalanine catabolic process(GO:0006559) tyrosine catabolic process(GO:0006572) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 4.2 | 41.6 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 3.7 | 40.8 | GO:0043691 | reverse cholesterol transport(GO:0043691) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 205.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.8 | 175.5 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.4 | 105.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 3.2 | 87.6 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.2 | 81.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 25.9 | 77.7 | GO:0044317 | rod spherule(GO:0044317) |
| 0.2 | 66.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 5.0 | 64.7 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 1.0 | 61.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.6 | 52.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 85.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.9 | 50.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.4 | 47.1 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 3.9 | 47.0 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 7.8 | 46.8 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.9 | 43.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 8.6 | 42.8 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 3.7 | 41.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 37.1 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 8.9 | 35.4 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.6 | 24.0 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.3 | 17.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 15.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.2 | 14.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 13.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 12.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 8.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 6.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 1.5 | 6.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 279.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 3.8 | 94.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 2.5 | 84.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 2.8 | 64.8 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 2.7 | 53.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 52.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 46.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 44.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.4 | 42.7 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.7 | 36.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |