ISMARA results: Klf4

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Klf4_Sp3

Z-value: 3.17

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Transcription factors associated with Klf4_Sp3

Gene Symbol	Gene ID	Gene Info
Klf4 Ensembl NCBI MGI UniProt	ENSMUSG00000003032.9	Klf4
Sp3 Ensembl NCBI MGI UniProt	ENSMUSG00000027109.17	Sp3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf4	mm39_v1_chr4_-_55532453_55532485	0.78	3.6e-16	Click!
Sp3	mm39_v1_chr2_-_72810782_72810811	0.49	9.9e-06	Click!

Activity profile of Klf4_Sp3 motif

Sorted Z-values of Klf4_Sp3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf4_Sp3

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Promoter	Score	Transcript	Gene	Gene Info
chr12_+_113115632 Show fit	33.19	ENSMUST00000006523.12 ENSMUST00000200553.2	Crip1 Ensembl NCBI MGI UniProt Show fit	cysteine-rich protein 1 (intestinal)
chr6_-_72935171 Show fit	29.46	ENSMUST00000114049.2	Tmsb10 Ensembl NCBI MGI UniProt Show fit	thymosin, beta 10
chr7_-_80453033 Show fit	27.76	ENSMUST00000167377.3	Iqgap1 Ensembl NCBI MGI UniProt Show fit	IQ motif containing GTPase activating protein 1
chr3_+_90520408 Show fit	26.65	ENSMUST00000198128.2	S100a6 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A6 (calcyclin)
chr6_-_72935382 Show fit	25.59	ENSMUST00000144337.2	Tmsb10 Ensembl NCBI MGI UniProt Show fit	thymosin, beta 10
chr11_-_100036792 Show fit	25.08	ENSMUST00000007317.8	Krt19 Ensembl NCBI MGI UniProt Show fit	keratin 19
chr5_-_114046746 Show fit	24.88	ENSMUST00000004646.13	Coro1c Ensembl NCBI MGI UniProt Show fit	coronin, actin binding protein 1C
chr4_+_62398262 Show fit	24.18	ENSMUST00000030088.12 ENSMUST00000107449.4	Bspry Ensembl NCBI MGI UniProt Show fit	B-box and SPRY domain containing
chr6_-_72935468 Show fit	23.67	ENSMUST00000114050.8	Tmsb10 Ensembl NCBI MGI UniProt Show fit	thymosin, beta 10
chrX_-_73289970 Show fit	23.57	ENSMUST00000130007.8	Flna Ensembl NCBI MGI UniProt Show fit	filamin, alpha

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	91.2	GO:0043297	apical junction assembly(GO:0043297)
1.0	72.9	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
3.8	64.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
2.3	62.9	GO:1990845	adaptive thermogenesis(GO:1990845)
2.5	61.4	GO:0045063	T-helper 1 cell differentiation(GO:0045063)
2.6	60.4	GO:0000920	cell separation after cytokinesis(GO:0000920)
1.9	54.4	GO:0044458	motile cilium assembly(GO:0044458)
3.8	53.2	GO:0071493	cellular response to UV-B(GO:0071493)
5.1	51.4	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.3	51.0	GO:0009615	response to virus(GO:0009615)

Showing 1 to 10 of 1,368 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	361.3	GO:0005925	focal adhesion(GO:0005925)
0.1	234.6	GO:0005634	nucleus(GO:0005634)
0.7	203.6	GO:0000790	nuclear chromatin(GO:0000790)
1.0	190.6	GO:0043296	apical junction complex(GO:0043296)
0.4	182.7	GO:0009897	external side of plasma membrane(GO:0009897)
1.2	151.9	GO:0032432	actin filament bundle(GO:0032432)
0.7	133.9	GO:0000775	chromosome, centromeric region(GO:0000775)
0.3	110.7	GO:0005667	transcription factor complex(GO:0005667)
2.0	97.8	GO:0002102	podosome(GO:0002102)
0.1	96.7	GO:0005654	nucleoplasm(GO:0005654)

Showing 1 to 10 of 413 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	297.3	GO:0051015	actin filament binding(GO:0051015)
0.7	168.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5	161.6	GO:0045296	cadherin binding(GO:0045296)
2.4	141.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4	131.7	GO:0003682	chromatin binding(GO:0003682)
0.6	117.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	109.7	GO:0001067	regulatory region nucleic acid binding(GO:0001067)
2.2	108.2	GO:0003785	actin monomer binding(GO:0003785)
0.1	93.9	GO:0003677	DNA binding(GO:0003677)
4.5	85.7	GO:0008301	DNA binding, bending(GO:0008301)

Showing 1 to 10 of 757 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	166.1	PID AURORA B PATHWAY	Aurora B signaling
2.0	165.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
1.9	162.2	PID ILK PATHWAY	Integrin-linked kinase signaling
1.9	113.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.9	109.1	PID PLK1 PATHWAY	PLK1 signaling events
0.5	94.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	90.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
1.4	85.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
2.3	74.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
2.3	69.8	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway

Showing 1 to 10 of 144 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	157.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.5	148.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
2.1	107.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.7	104.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
1.9	99.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
1.4	94.9	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
2.6	81.7	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
4.7	74.5	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.6	73.4	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
1.7	71.6	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions

Showing 1 to 10 of 221 entries

Results for Klf4_Sp3

Z-value: 3.17

Motif logo

Transcription factors associated with Klf4_Sp3

Activity-expression correlation:

Activity profile of Klf4_Sp3 motif

Sorted Z-values of Klf4_Sp3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf4_Sp3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: