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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Klf6_Patz1
Z-value: 1.55
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Transcription factors associated with Klf6_Patz1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf6 | mm39_v1_chr13_+_5911481_5911521 | -0.30 | 1.1e-02 | Click! |
| Patz1 | mm39_v1_chr11_+_3239165_3239281 | -0.13 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf6_Patz1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 48.0 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.1 | 30.6 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.5 | 27.2 | GO:0048255 | mRNA stabilization(GO:0048255) |
| 1.5 | 16.7 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 3.3 | 13.3 | GO:1902081 | regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081) |
| 1.0 | 13.2 | GO:0060613 | fat pad development(GO:0060613) |
| 0.3 | 13.2 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.3 | 11.0 | GO:0009649 | entrainment of circadian clock(GO:0009649) |
| 0.2 | 10.7 | GO:0060612 | adipose tissue development(GO:0060612) |
| 2.0 | 9.8 | GO:0060128 | corticotropin hormone secreting cell differentiation(GO:0060128) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 118.5 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 59.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 53.5 | GO:0016604 | nuclear body(GO:0016604) |
| 0.6 | 45.2 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 21.3 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.1 | 18.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 18.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.5 | 13.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 13.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 3.2 | 12.8 | GO:0014802 | terminal cisterna(GO:0014802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 141.4 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.2 | 51.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 29.8 | GO:0003677 | DNA binding(GO:0003677) |
| 0.5 | 20.5 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.2 | 20.0 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.2 | 16.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 14.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 14.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 13.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.4 | 13.2 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 17.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 16.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 13.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 12.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 11.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 11.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 11.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 10.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.3 | 9.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 26.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.5 | 20.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 19.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.9 | 13.4 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.2 | 13.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 13.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 12.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 12.0 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.3 | 10.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.5 | 10.3 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |