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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Lhx8

Z-value: 1.12

Motif logo

Transcription factors associated with Lhx8

Gene Symbol Gene ID Gene Info
ENSMUSG00000096225.8 Lhx8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx8mm39_v1_chr3_-_154036180_1540362960.047.4e-01Click!

Activity profile of Lhx8 motif

Sorted Z-values of Lhx8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx8

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_+_137551774 9.38 ENSMUST00000136088.8
ENSMUST00000139395.8
actin-like 6B
chr11_+_110858842 9.05 ENSMUST00000180023.8
ENSMUST00000106636.8
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_-_52448552 8.62 ENSMUST00000102760.10
ENSMUST00000102761.9
calcium channel, voltage-dependent, beta 4 subunit
chr15_+_54609011 8.61 ENSMUST00000050027.9
cellular communication network factor 3
chr7_-_59654797 8.15 ENSMUST00000194059.2
SNRPN upstream reading frame
chr7_-_59654849 8.01 ENSMUST00000059305.17
small nuclear ribonucleoprotein N
chr4_-_96479793 7.61 ENSMUST00000055693.9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr3_+_130411097 7.53 ENSMUST00000166187.8
ENSMUST00000072271.13
ethanolamine phosphate phospholyase
chr4_-_129015682 7.52 ENSMUST00000139450.8
ENSMUST00000125931.9
ENSMUST00000116444.10
hippocalcin
chr5_+_137551790 7.45 ENSMUST00000136565.8
ENSMUST00000149292.8
ENSMUST00000125489.2
actin-like 6B
chr8_-_65146079 6.52 ENSMUST00000048967.9
carboxypeptidase E
chr5_-_87572060 6.31 ENSMUST00000072818.6
UDP glucuronosyltransferase 2 family, polypeptide B38
chr3_+_130411294 5.70 ENSMUST00000163620.8
ethanolamine phosphate phospholyase
chr3_-_72964276 5.58 ENSMUST00000192477.2
SLIT and NTRK-like family, member 3
chr11_+_110858882 5.57 ENSMUST00000125692.2
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_139115417 5.50 ENSMUST00000026973.14
protein kinase, cAMP dependent regulatory, type I beta
chr17_-_90395771 5.47 ENSMUST00000197268.5
ENSMUST00000173917.8
neurexin I
chr3_-_113368407 5.19 ENSMUST00000106540.8
amylase 1, salivary
chr2_+_65451100 5.06 ENSMUST00000144254.6
ENSMUST00000028377.14
sodium channel, voltage-gated, type II, alpha
chr10_+_5589210 4.85 ENSMUST00000019906.6
vasoactive intestinal polypeptide
chr7_+_90739904 4.57 ENSMUST00000107196.10
ENSMUST00000074273.10
discs large MAGUK scaffold protein 2
chr1_+_180878797 4.47 ENSMUST00000036819.7
RIKEN cDNA 9130409I23 gene
chr1_+_17215581 4.36 ENSMUST00000026879.8
ganglioside-induced differentiation-associated-protein 1
chr3_+_106020545 4.27 ENSMUST00000079132.12
ENSMUST00000139086.2
chitinase, acidic 1
chr18_+_23548534 4.21 ENSMUST00000221880.2
ENSMUST00000220904.2
ENSMUST00000047954.15
dystrobrevin alpha
chr8_+_46080746 4.18 ENSMUST00000145458.9
ENSMUST00000134321.8
sorbin and SH3 domain containing 2
chr19_+_39980868 4.11 ENSMUST00000049178.3
cytochrome P450, family 2. subfamily c, polypeptide 37
chr8_+_124169707 4.07 ENSMUST00000093049.10
ENSMUST00000065534.10
ENSMUST00000001522.10
ENSMUST00000124741.8
ENSMUST00000108832.8
ENSMUST00000132063.8
ENSMUST00000128424.8
differentially expressed in FDCP 8
chr11_+_16207705 3.98 ENSMUST00000109645.9
ENSMUST00000109647.3
V-set and transmembrane domain containing 2A
chr2_+_177200363 3.94 ENSMUST00000108940.3
predicted gene 14403
chr1_+_72323526 3.93 ENSMUST00000027380.12
ENSMUST00000141783.2
transmembrane protein 169
chr11_-_109886601 3.91 ENSMUST00000020948.15
ATP-binding cassette, sub-family A (ABC1), member 8b
chr1_+_21310803 3.75 ENSMUST00000027067.15
glutathione S-transferase, alpha 3
chr3_-_82957104 3.59 ENSMUST00000048246.5
fibrinogen beta chain
chr8_+_124170027 3.38 ENSMUST00000108830.2
differentially expressed in FDCP 8
chr2_-_174973657 3.36 ENSMUST00000108929.3
predicted gene 14399
chr1_+_107289659 3.33 ENSMUST00000027566.3
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr1_-_72323407 3.30 ENSMUST00000097698.5
peroxisomal trans-2-enoyl-CoA reductase
chr19_-_4092218 3.27 ENSMUST00000237999.2
ENSMUST00000042700.12
glutathione S-transferase, pi 2
chr5_-_87402659 3.25 ENSMUST00000075858.4
UDP glucuronosyltransferase 2 family, polypeptide B37
chr8_+_110806390 3.20 ENSMUST00000212754.2
ENSMUST00000058804.10
zinc finger protein 612
chr1_+_21310821 3.19 ENSMUST00000121676.8
ENSMUST00000124990.3
glutathione S-transferase, alpha 3
chr1_+_6557455 3.08 ENSMUST00000140079.8
ENSMUST00000131494.8
suppression of tumorigenicity 18
chr12_+_84034628 3.05 ENSMUST00000021649.8
acyl-CoA thioesterase 2
chr18_+_23548192 3.03 ENSMUST00000222515.2
dystrobrevin alpha
chr4_-_95965767 2.94 ENSMUST00000030305.13
ENSMUST00000107078.9
cytochrome P450, family 2, subfamily j, polypeptide 13
chr12_+_38833501 2.93 ENSMUST00000159334.8
ets variant 1
chr17_-_47143214 2.88 ENSMUST00000233537.2
BRD4 interacting chromatin remodeling complex associated protein like
chr1_-_72323464 2.77 ENSMUST00000027381.13
peroxisomal trans-2-enoyl-CoA reductase
chr4_-_95965747 2.77 ENSMUST00000097973.3
cytochrome P450, family 2, subfamily j, polypeptide 13
chr5_+_20433169 2.70 ENSMUST00000197553.5
ENSMUST00000208219.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_+_38833454 2.60 ENSMUST00000161980.8
ENSMUST00000160701.8
ets variant 1
chr3_+_75982890 2.60 ENSMUST00000160261.8
follistatin-like 5
chr7_+_89951444 2.58 ENSMUST00000207578.2
synaptotagmin-like 2
chr18_+_23548455 2.58 ENSMUST00000115832.4
dystrobrevin alpha
chr11_+_104122341 2.58 ENSMUST00000106993.10
microtubule-associated protein tau
chrM_+_7758 2.51 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
chr8_-_95929420 2.51 ENSMUST00000212842.2
kinesin family member C3
chr18_-_43820759 2.50 ENSMUST00000082254.8
janus kinase and microtubule interacting protein 2
chr1_-_130589349 2.46 ENSMUST00000027657.14
complement component 4 binding protein
chr1_+_107288928 2.45 ENSMUST00000191425.7
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr11_-_12414850 2.43 ENSMUST00000109650.8
cordon-bleu WH2 repeat
chr12_+_112940086 2.40 ENSMUST00000165079.8
ENSMUST00000221500.2
ENSMUST00000221104.2
ENSMUST00000002880.7
ENSMUST00000222209.2
BTB (POZ) domain containing 6
chr5_+_25964985 2.36 ENSMUST00000128727.8
ENSMUST00000088244.6
ARP3 actin-related protein 3B
chr6_-_136150491 2.29 ENSMUST00000111905.8
ENSMUST00000152012.8
ENSMUST00000143943.8
ENSMUST00000125905.2
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr8_+_72973560 2.17 ENSMUST00000003123.10
family with sequence similarity 32, member A
chr15_-_98118858 2.14 ENSMUST00000142443.8
ENSMUST00000170618.8
predicted gene 44579
olfactory receptor 287
chr17_+_35150229 2.10 ENSMUST00000007253.6
neuraminidase 1
chr5_-_145128376 2.09 ENSMUST00000037056.9
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr5_-_76511634 2.06 ENSMUST00000031146.3
neuromedin U
chrM_+_7779 2.05 ENSMUST00000082408.1
mitochondrially encoded ATP synthase 6
chr5_+_67464284 2.03 ENSMUST00000113676.6
ENSMUST00000162372.8
solute carrier family 30 (zinc transporter), member 9
chr2_+_172994841 2.00 ENSMUST00000029017.6
phosphoenolpyruvate carboxykinase 1, cytosolic
chr8_+_67933573 1.99 ENSMUST00000212171.2
N-acetyl transferase 1
chr9_-_43151179 1.98 ENSMUST00000034512.7
out at first homolog
chr17_-_24851549 1.88 ENSMUST00000227607.2
ENSMUST00000227509.2
ENSMUST00000227745.2
TSC complex subunit 2
chr2_+_73142945 1.87 ENSMUST00000090811.11
ENSMUST00000112050.2
secernin 3
chr16_-_58895441 1.85 ENSMUST00000071243.4
olfactory receptor 190
chr7_-_19093383 1.81 ENSMUST00000047036.10
CD3E antigen, epsilon polypeptide associated protein
chr5_-_145128321 1.78 ENSMUST00000161845.2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr12_-_108859123 1.78 ENSMUST00000161154.2
ENSMUST00000161410.8
tryptophanyl-tRNA synthetase
chr3_+_107198528 1.75 ENSMUST00000029502.14
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr2_-_110136074 1.75 ENSMUST00000046233.9
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
chr8_+_105558204 1.67 ENSMUST00000059449.7
carboxyesterase 2B
chr2_-_113844100 1.66 ENSMUST00000090275.5
gap junction protein, delta 2
chr9_+_38179147 1.64 ENSMUST00000212156.3
olfactory receptor 895
chr11_-_102469896 1.64 ENSMUST00000107080.2
predicted gene 11627
chr6_+_15185399 1.63 ENSMUST00000115474.8
ENSMUST00000115472.8
ENSMUST00000031545.14
forkhead box P2
chr3_+_116653113 1.60 ENSMUST00000040260.11
ferric-chelate reductase 1
chr9_+_39818632 1.60 ENSMUST00000214904.2
olfactory receptor 229
chr5_+_90666791 1.56 ENSMUST00000113179.9
ENSMUST00000128740.2
afamin
chr2_-_89675315 1.55 ENSMUST00000099762.2
olfactory receptor 48
chr4_-_144447974 1.51 ENSMUST00000036876.8
AADACL4 family member 3
chr15_+_21111428 1.50 ENSMUST00000075132.8
cadherin 12
chr13_+_22462487 1.47 ENSMUST00000091736.5
vomeronasal 1 receptor 195
chr3_-_94490023 1.46 ENSMUST00000029783.16
sorting nexin family member 27
chr3_-_57599956 1.45 ENSMUST00000238789.2
ENSMUST00000197088.5
ENSMUST00000099091.4
ankrin repeat and ubiquitin domain containing 1
chr8_+_89309408 1.42 ENSMUST00000211113.2
naked cuticle 1
chr18_-_32044877 1.42 ENSMUST00000054984.8
SFT2 domain containing 3
chr2_-_34760960 1.41 ENSMUST00000028225.12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr7_+_88079534 1.41 ENSMUST00000208478.2
RAB38, member RAS oncogene family
chr17_+_17594808 1.32 ENSMUST00000232396.2
ENSMUST00000232199.2
RIO kinase 2
chr10_-_4382311 1.31 ENSMUST00000126102.8
ENSMUST00000131853.2
ENSMUST00000042251.11
required for meiotic nuclear division 1 homolog
chr2_+_85519775 1.25 ENSMUST00000054868.2
olfactory receptor 1008
chr14_-_30213408 1.23 ENSMUST00000112250.6
calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_-_166907286 1.23 ENSMUST00000239138.2
FERM and PDZ domain containing 4
chr17_-_24851581 1.20 ENSMUST00000226398.2
ENSMUST00000226284.2
ENSMUST00000097373.2
ENSMUST00000228412.2
TSC complex subunit 2
chr8_-_49296915 1.19 ENSMUST00000211812.2
teneurin transmembrane protein 3
chr1_-_170695328 1.17 ENSMUST00000027974.7
activating transcription factor 6
chr14_+_48683581 1.15 ENSMUST00000227440.2
ENSMUST00000124720.8
ENSMUST00000226422.2
ENSMUST00000226400.2
transmembrane protein 260
chr5_-_77053310 1.10 ENSMUST00000146570.8
ENSMUST00000142450.2
ENSMUST00000120963.8
aminoadipate-semialdehyde dehydrogenase
chrX_+_100683662 1.09 ENSMUST00000119299.8
ENSMUST00000044475.5
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr8_+_105048199 1.08 ENSMUST00000109447.2
predicted gene 11020
chr2_+_111136546 1.06 ENSMUST00000090329.2
olfactory receptor 1279
chr8_-_41507808 1.03 ENSMUST00000093534.11
mitochondrial tumor suppressor 1
chr4_+_118522716 1.03 ENSMUST00000102666.5
olfactory receptor 62
chr7_-_12096691 1.03 ENSMUST00000086228.3
vomeronasal 1 receptor 84
chr10_-_4382283 1.00 ENSMUST00000155172.8
required for meiotic nuclear division 1 homolog
chr10_-_129448439 0.97 ENSMUST00000214584.3
olfactory receptor 796
chr2_+_89842475 0.97 ENSMUST00000214382.2
ENSMUST00000217065.3
olfactory receptor 1263
chr10_+_129219952 0.96 ENSMUST00000214064.2
olfactory receptor 784
chr1_-_59200718 0.96 ENSMUST00000078874.14
ENSMUST00000066374.14
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr3_+_20011405 0.96 ENSMUST00000108325.9
ceruloplasmin
chr18_+_44960813 0.95 ENSMUST00000037763.11
YTH domain containing 2
chr13_+_23433408 0.93 ENSMUST00000091719.2
vomeronasal 1 receptor 223
chr3_-_59118293 0.93 ENSMUST00000040622.3
purinergic receptor P2Y, G-protein coupled 13
chr6_-_119085508 0.92 ENSMUST00000188522.7
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr17_-_37481536 0.91 ENSMUST00000174673.3
olfactory receptor 753, pseudogene 1
chr4_-_113856697 0.88 ENSMUST00000169631.8
ENSMUST00000170105.8
ENSMUST00000171627.9
selection and upkeep of intraepithelial T cells 5
chr4_+_19818718 0.87 ENSMUST00000035890.8
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr2_-_13798843 0.86 ENSMUST00000003509.10
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr9_+_65102635 0.85 ENSMUST00000216702.2
poly (ADP-ribose) polymerase family, member 16
chr5_-_77053226 0.81 ENSMUST00000135954.2
aminoadipate-semialdehyde dehydrogenase
chr19_-_24938909 0.78 ENSMUST00000025815.10
COBW domain containing 1
chr6_+_132739094 0.76 ENSMUST00000069268.3
taste receptor, type 2, member 102
chr16_-_58647137 0.74 ENSMUST00000215069.2
ENSMUST00000079955.6
olfactory receptor 175
chr16_-_19390500 0.74 ENSMUST00000215040.2
ENSMUST00000216070.2
ENSMUST00000215476.2
olfactory receptor 169
chr2_-_111251294 0.74 ENSMUST00000099617.2
olfactory receptor 1286
chr19_-_12302465 0.71 ENSMUST00000207241.3
olfactory receptor 1437
chr5_+_138159333 0.71 ENSMUST00000019638.15
ENSMUST00000110951.8
COP9 signalosome subunit 6
chr19_+_13208692 0.70 ENSMUST00000207246.4
olfactory receptor 1463
chr7_-_48493388 0.69 ENSMUST00000167786.4
cysteine and glycine-rich protein 3
chr5_+_125080504 0.69 ENSMUST00000197746.2
refilin A
chr2_-_104680104 0.68 ENSMUST00000028593.11
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_+_40941688 0.68 ENSMUST00000076638.7
RIKEN cDNA 1810009J06 gene
chr11_+_102175985 0.65 ENSMUST00000156326.2
transmembrane and ubiquitin-like domain containing 2
chr7_+_88079465 0.64 ENSMUST00000107256.4
RAB38, member RAS oncogene family
chr7_-_104628324 0.61 ENSMUST00000217091.2
ENSMUST00000210963.3
olfactory receptor 671
chr2_-_89273344 0.61 ENSMUST00000216123.2
olfactory receptor 1240
chr16_+_23247883 0.60 ENSMUST00000038730.7
receptor transporter protein 1
chr10_-_129577771 0.60 ENSMUST00000215142.3
ENSMUST00000213239.2
olfactory receptor 806
chr17_+_33848054 0.57 ENSMUST00000166627.8
ENSMUST00000073570.12
ENSMUST00000170225.3
zinc finger protein 414
chr2_+_21210527 0.57 ENSMUST00000054591.10
ENSMUST00000102952.8
ENSMUST00000138965.8
ENSMUST00000138914.8
ENSMUST00000102951.2
threonine synthase-like 1 (bacterial)
chr9_+_23285228 0.57 ENSMUST00000214050.2
BMP-binding endothelial regulator
chr6_-_131664458 0.56 ENSMUST00000053652.6
taste receptor, type 2, member 105
chr2_-_88854443 0.55 ENSMUST00000099799.5
olfactory receptor 1217
chr6_+_11926757 0.54 ENSMUST00000133776.2
PHD finger protein 14
chr13_-_62771948 0.53 ENSMUST00000223338.2
ENSMUST00000201563.4
RIKEN cDNA 6720489N17 gene
chr19_-_57227742 0.51 ENSMUST00000111559.8
actin-binding LIM protein 1
chr3_-_100592747 0.50 ENSMUST00000008907.14
mannosidase, alpha, class 1A, member 2
chr11_+_101137786 0.49 ENSMUST00000107282.4
receptor (calcitonin) activity modifying protein 2
chr17_-_37422872 0.48 ENSMUST00000168659.2
olfactory receptor 92
chr6_+_67736650 0.43 ENSMUST00000103305.2
immunoglobulin kappa variable 1-132
chr6_-_129890129 0.43 ENSMUST00000169901.7
ENSMUST00000014683.13
killer cell lectin-like receptor, subfamily A, member 5
chr11_-_75828551 0.42 ENSMUST00000121287.8
rabphilin 3A-like (without C2 domains)
chr6_+_65502292 0.42 ENSMUST00000212402.2
TNFAIP3 interacting protein 3
chr10_+_103987773 0.38 ENSMUST00000180692.3
predicted gene 6763
chr10_+_103996282 0.38 ENSMUST00000181166.3
predicted gene 8764
chr2_+_85420854 0.37 ENSMUST00000052307.5
olfactory receptor 998
chr10_+_104030318 0.36 ENSMUST00000181036.2
predicted gene 4340
chr10_+_103979263 0.36 ENSMUST00000180664.2
predicted gene, 21293
chr10_+_104004791 0.36 ENSMUST00000180568.2
predicted gene, 21304
chr10_+_104013300 0.36 ENSMUST00000181239.2
predicted gene, 21312
chr10_+_104021809 0.36 ENSMUST00000181707.2
predicted gene, 20765
chr3_-_100591906 0.36 ENSMUST00000130066.2
mannosidase, alpha, class 1A, member 2
chr3_+_115681788 0.35 ENSMUST00000196804.5
ENSMUST00000106505.8
ENSMUST00000043342.10
diphthamide biosynthesis 5
chr17_+_17594526 0.35 ENSMUST00000024620.8
RIO kinase 2
chr10_+_129184719 0.35 ENSMUST00000213970.2
olfactory receptor 782
chr10_+_129493563 0.34 ENSMUST00000217094.2
olfactory receptor 800
chr10_+_104029903 0.34 ENSMUST00000181615.8
predicted gene 4340
chr2_-_88562710 0.34 ENSMUST00000213118.2
olfactory receptor 1197
chr10_+_103978848 0.34 ENSMUST00000181634.8
predicted gene, 21293
chr10_+_103987358 0.34 ENSMUST00000181287.5
predicted gene 6763
chr10_+_103995867 0.34 ENSMUST00000181179.5
predicted gene 8764
chr10_+_104004376 0.34 ENSMUST00000181059.8
predicted gene, 21304
chr10_+_104012885 0.34 ENSMUST00000180889.8
predicted gene, 21312
chr10_+_104021394 0.34 ENSMUST00000181703.8
predicted gene, 20765
chr7_+_114318746 0.34 ENSMUST00000182044.2
calcitonin-related polypeptide, beta
chr17_+_24851647 0.34 ENSMUST00000047611.4
nth (endonuclease III)-like 1 (E.coli)
chr2_-_88577230 0.32 ENSMUST00000099814.2
olfactory receptor 1198
chr7_+_12711760 0.32 ENSMUST00000108535.8
ENSMUST00000108537.8
ENSMUST00000045810.15
zinc finger protein 446
chr7_-_104651236 0.32 ENSMUST00000213942.3
olfactory receptor 672
chr13_+_95460110 0.32 ENSMUST00000221807.2
zinc finger, BED type containing 3
chr4_-_155729865 0.31 ENSMUST00000115821.3
predicted gene 10563
chr14_+_53743184 0.30 ENSMUST00000103583.5
T cell receptor alpha variable 10
chr16_-_88548523 0.29 ENSMUST00000053149.4
keratin associated protein 13
chr7_+_6200089 0.29 ENSMUST00000037553.6
galanin-like peptide
chr6_-_3763618 0.29 ENSMUST00000171613.8
calcitonin receptor
chr17_-_22127073 0.25 ENSMUST00000106026.3
zinc finger protein 995
chr4_+_53011880 0.24 ENSMUST00000015391.10
nipsnap homolog 3B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
2.3 6.9 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377)
2.2 6.5 GO:0030070 insulin processing(GO:0030070)
2.0 6.1 GO:0033306 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.9 5.5 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.9 3.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.8 4.0 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.6 8.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 3.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.5 2.0 GO:0006114 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.5 4.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.5 1.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.5 5.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.5 2.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 2.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.4 1.8 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.4 4.9 GO:0060406 positive regulation of penile erection(GO:0060406)
0.4 1.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 1.9 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.4 1.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 2.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 2.4 GO:0001757 somite specification(GO:0001757)
0.3 1.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.3 3.1 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.3 2.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.3 2.0 GO:1903232 platelet dense granule organization(GO:0060155) phagosome acidification(GO:0090383) melanosome assembly(GO:1903232)
0.3 5.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 13.7 GO:0010107 potassium ion import(GO:0010107)
0.3 5.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 2.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.2 1.2 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.2 0.7 GO:1903920 positive regulation of actin filament severing(GO:1903920)
0.2 4.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.2 1.7 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 1.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 2.3 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 2.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.2 0.7 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 3.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 0.9 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.1 2.1 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.8 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 4.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 4.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 4.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.6 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.3 GO:0006296 base-excision repair, AP site formation(GO:0006285) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.1 0.5 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.8 GO:0038042 dimeric G-protein coupled receptor signaling pathway(GO:0038042) calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.9 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.1 3.9 GO:0006754 ATP biosynthetic process(GO:0006754)
0.1 11.5 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.1 5.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 1.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 4.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.8 GO:0009303 rRNA transcription(GO:0009303)
0.1 1.2 GO:0097264 self proteolysis(GO:0097264)
0.1 1.5 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 1.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 5.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 2.0 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.7 GO:0000338 protein deneddylation(GO:0000338)
0.0 3.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 5.2 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 0.6 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.9 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.0 GO:0046688 response to copper ion(GO:0046688)
0.0 0.9 GO:0031280 negative regulation of cyclase activity(GO:0031280)
0.0 1.6 GO:0051180 vitamin transport(GO:0051180)
0.0 1.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 6.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 6.6 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.3 GO:0032098 regulation of appetite(GO:0032098)
0.0 1.0 GO:0035418 protein localization to synapse(GO:0035418)
0.0 3.3 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 1.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.8 GO:0016014 dystrobrevin complex(GO:0016014)
0.8 3.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.7 8.0 GO:0005687 U4 snRNP(GO:0005687)
0.6 16.8 GO:0016514 SWI/SNF complex(GO:0016514)
0.6 2.9 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.5 7.5 GO:0044327 dendritic spine head(GO:0044327)
0.5 8.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.4 8.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 3.6 GO:0005577 fibrinogen complex(GO:0005577)
0.3 5.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 6.5 GO:0031045 dense core granule(GO:0031045)
0.3 0.9 GO:0002095 caveolar macromolecular signaling complex(GO:0002095)
0.3 2.6 GO:0045298 tubulin complex(GO:0045298)
0.3 2.4 GO:1990357 terminal web(GO:1990357)
0.3 2.0 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 5.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 2.5 GO:0005915 zonula adherens(GO:0005915)
0.2 9.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.3 GO:0043083 synaptic cleft(GO:0043083)
0.1 4.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.8 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 1.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 4.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 2.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.5 GO:0071203 WASH complex(GO:0071203)
0.1 2.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 6.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.0 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 8.1 GO:0016607 nuclear speck(GO:0016607)
0.0 1.1 GO:0000791 euchromatin(GO:0000791)
0.0 3.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 7.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.1 GO:0043195 terminal bouton(GO:0043195)
0.0 0.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.2 GO:0043197 dendritic spine(GO:0043197)
0.0 4.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 20.0 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.5 6.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.1 4.5 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
1.1 3.3 GO:0035731 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
0.7 5.2 GO:0004556 alpha-amylase activity(GO:0004556)
0.7 2.0 GO:0036461 BLOC-2 complex binding(GO:0036461)
0.7 2.0 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.5 6.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.5 1.6 GO:0008431 vitamin E binding(GO:0008431)
0.5 2.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.5 4.3 GO:0004568 chitinase activity(GO:0004568)
0.5 2.7 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.4 1.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.4 2.1 GO:0052796 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.4 10.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 2.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.4 5.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.4 14.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.4 5.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 1.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.3 1.9 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.3 5.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 2.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 4.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 9.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 11.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 1.6 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 2.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 3.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.8 GO:0097643 amylin receptor activity(GO:0097643)
0.1 4.1 GO:0070330 aromatase activity(GO:0070330)
0.1 0.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.3 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 1.9 GO:0016805 dipeptidase activity(GO:0016805)
0.1 2.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 11.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 0.6 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 3.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 2.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 8.1 GO:0051117 ATPase binding(GO:0051117)
0.0 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 3.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 4.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 6.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.6 GO:0051087 chaperone binding(GO:0051087)
0.0 4.0 GO:0005179 hormone activity(GO:0005179)
0.0 1.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.7 GO:0031005 filamin binding(GO:0031005)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 1.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.7 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 1.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.9 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 1.3 GO:0005550 pheromone binding(GO:0005550)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 2.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 5.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 6.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 8.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 5.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 6.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 3.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 3.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 5.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.9 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 6.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 8.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 5.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)