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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Max_Mycn
Z-value: 1.77
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Transcription factors associated with Max_Mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Max | mm39_v1_chr12_-_77008799_77008832 | -0.38 | 1.1e-03 | Click! |
| Mycn | mm39_v1_chr12_-_12991828_12991915 | -0.05 | 7.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Max_Mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 52.4 | GO:0048232 | male gamete generation(GO:0048232) |
| 2.1 | 42.1 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.9 | 21.6 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 20.2 | GO:0007286 | spermatid development(GO:0007286) |
| 0.6 | 18.0 | GO:0048255 | mRNA stabilization(GO:0048255) |
| 4.5 | 17.9 | GO:0000239 | pachytene(GO:0000239) |
| 0.3 | 16.7 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.6 | 14.0 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 1.7 | 13.9 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 2.6 | 13.1 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 38.4 | GO:0031514 | motile cilium(GO:0031514) |
| 0.1 | 34.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 34.3 | GO:0016604 | nuclear body(GO:0016604) |
| 0.4 | 33.8 | GO:0005844 | polysome(GO:0005844) |
| 2.9 | 32.3 | GO:0071546 | pi-body(GO:0071546) |
| 0.2 | 31.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 27.1 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 26.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 18.3 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.2 | 17.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 58.8 | GO:0003677 | DNA binding(GO:0003677) |
| 4.1 | 20.4 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.7 | 18.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.4 | 18.2 | GO:0045182 | translation regulator activity(GO:0045182) |
| 1.6 | 17.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 16.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 14.0 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 1.9 | 13.6 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.2 | 13.6 | GO:0003724 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.3 | 13.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 17.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 12.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 10.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 10.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 9.9 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 9.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 9.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 8.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 5.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 18.0 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.4 | 14.8 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.3 | 13.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 12.8 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 12.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 12.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.7 | 11.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 11.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.8 | 10.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |