ISMARA results: Maz

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Maz_Zfp281

Z-value: 2.23

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Transcription factors associated with Maz_Zfp281

Gene Symbol	Gene ID	Gene Info
Maz Ensembl NCBI MGI UniProt	ENSMUSG00000030678.8	Maz
Zfp281 Ensembl NCBI MGI UniProt	ENSMUSG00000041483.15	Zfp281

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zfp281	mm39_v1_chr1_+_136552639_136552688	0.60	2.9e-08	Click!
Maz	mm39_v1_chr7_-_126625739_126625780	0.58	8.9e-08	Click!

Activity profile of Maz_Zfp281 motif

Sorted Z-values of Maz_Zfp281 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Maz_Zfp281

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Promoter	Score	Transcript	Gene	Gene Info
chr10_+_126914755 Show fit	14.23	ENSMUST00000039259.7 ENSMUST00000217941.2	Agap2 Ensembl NCBI MGI UniProt Show fit	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_69909245 Show fit	13.74	ENSMUST00000231415.2 ENSMUST00000108588.9	Dlg4 Ensembl NCBI MGI UniProt Show fit	discs large MAGUK scaffold protein 4
chr15_-_89033761 Show fit	13.53	ENSMUST00000088823.5	Mapk11 Ensembl NCBI MGI UniProt Show fit	mitogen-activated protein kinase 11
chrX_-_134111421 Show fit	13.12	ENSMUST00000033783.2	Tceal6 Ensembl NCBI MGI UniProt Show fit	transcription elongation factor A (SII)-like 6
chr9_+_43954681 Show fit	11.91	ENSMUST00000114840.2	Thy1 Ensembl NCBI MGI UniProt Show fit	thymus cell antigen 1, theta
chr7_-_105230395 Show fit	11.61	ENSMUST00000188726.2 ENSMUST00000188440.7	Apbb1 Ensembl NCBI MGI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family B, member 1
chr2_-_180798785 Show fit	11.34	ENSMUST00000055990.8	Eef1a2 Ensembl NCBI MGI UniProt Show fit	eukaryotic translation elongation factor 1 alpha 2
chr7_-_105230479 Show fit	10.85	ENSMUST00000191601.7	Apbb1 Ensembl NCBI MGI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family B, member 1
chrX_+_135567124 Show fit	10.21	ENSMUST00000060904.11 ENSMUST00000113100.2 ENSMUST00000128040.2	Tceal3 Ensembl NCBI MGI UniProt Show fit	transcription elongation factor A (SII)-like 3
chr8_+_96404713 Show fit	9.88	ENSMUST00000041318.14	Ndrg4 Ensembl NCBI MGI UniProt Show fit	N-myc downstream regulated gene 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	87.3	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.9	43.8	GO:0050771	negative regulation of axonogenesis(GO:0050771)
2.8	39.7	GO:0098953	receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
6.4	38.2	GO:0050757	thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
1.1	36.0	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
1.6	34.3	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6	34.0	GO:0007019	microtubule depolymerization(GO:0007019)
0.6	32.5	GO:0045761	regulation of adenylate cyclase activity(GO:0045761)
0.9	31.2	GO:0035640	exploration behavior(GO:0035640)
0.8	30.5	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)

Showing 1 to 10 of 1,093 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	142.7	GO:0014069	postsynaptic density(GO:0014069)
0.3	134.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.8	85.8	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
1.8	83.8	GO:0032590	dendrite membrane(GO:0032590)
0.7	67.4	GO:0016528	sarcoplasm(GO:0016528)
0.8	65.8	GO:0043198	dendritic shaft(GO:0043198)
3.0	62.6	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.5	60.1	GO:0008021	synaptic vesicle(GO:0008021)
1.5	51.1	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
4.2	46.7	GO:1990761	growth cone lamellipodium(GO:1990761)

Showing 1 to 10 of 381 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	135.5	GO:0015631	tubulin binding(GO:0015631)
0.4	54.0	GO:0044325	ion channel binding(GO:0044325)
0.5	53.0	GO:0005518	collagen binding(GO:0005518)
0.4	46.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.3	43.4	GO:0048156	tau protein binding(GO:0048156)
0.5	41.0	GO:0015459	potassium channel regulator activity(GO:0015459)
0.2	40.4	GO:0017124	SH3 domain binding(GO:0017124)
0.8	39.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.7	38.9	GO:0050699	WW domain binding(GO:0050699)
0.1	38.6	GO:0005096	GTPase activator activity(GO:0005096)

Showing 1 to 10 of 626 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	94.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	48.5	PID REELIN PATHWAY	Reelin signaling pathway
0.6	39.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.9	36.9	ST GA12 PATHWAY	G alpha 12 Pathway
0.7	36.9	PID RAS PATHWAY	Regulation of Ras family activation
0.5	36.3	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.7	29.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.6	28.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.6	26.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	23.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Showing 1 to 10 of 116 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	68.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.1	58.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.9	56.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.9	51.2	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.9	45.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.8	43.9	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
1.8	43.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.7	41.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5	40.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.8	37.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 146 entries

Results for Maz_Zfp281

Z-value: 2.23

Motif logo

Transcription factors associated with Maz_Zfp281

Activity-expression correlation:

Activity profile of Maz_Zfp281 motif

Sorted Z-values of Maz_Zfp281 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Maz_Zfp281

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: