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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Mecom

Z-value: 0.90

Motif logo

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Transcription factors associated with Mecom

Gene Symbol Gene ID Gene Info
Mecom
ENSMUSG00000027684.17 Mecom

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mecommm39_v1_chr3_-_30563919_305639710.038.2e-01Click!

Activity profile of Mecom motif

Sorted Z-values of Mecom motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_138117295 9.55 ENSMUST00000008684.11
Mgst1
microsomal glutathione S-transferase 1
chr4_-_61259801 8.62 ENSMUST00000125461.8
Mup14
major urinary protein 14
chr15_-_96947963 7.03 ENSMUST00000230907.2
Slc38a4
solute carrier family 38, member 4
chr4_-_62005498 5.64 ENSMUST00000107488.4
ENSMUST00000107472.8
ENSMUST00000084531.11
Mup3
major urinary protein 3
chr1_-_162812087 4.72 ENSMUST00000028010.9
Fmo3
flavin containing monooxygenase 3
chr8_+_46944000 4.45 ENSMUST00000110372.9
ENSMUST00000130563.2
Acsl1
acyl-CoA synthetase long-chain family member 1
chr18_-_43610829 4.17 ENSMUST00000057110.11
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr1_+_45350698 3.73 ENSMUST00000087883.13
Col3a1
collagen, type III, alpha 1
chr3_+_87265181 3.64 ENSMUST00000015998.8
Cd5l
CD5 antigen-like
chr11_+_108271990 3.62 ENSMUST00000146050.2
ENSMUST00000152958.8
Apoh
apolipoprotein H
chr11_-_59937302 3.56 ENSMUST00000000310.14
ENSMUST00000102693.9
ENSMUST00000148512.2
Pemt
phosphatidylethanolamine N-methyltransferase
chrX_+_21581135 3.55 ENSMUST00000033414.8
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr14_+_34097474 3.48 ENSMUST00000227130.2
Mmrn2
multimerin 2
chr10_+_5543769 3.42 ENSMUST00000051809.10
Myct1
myc target 1
chr7_+_140415170 3.40 ENSMUST00000211372.2
ENSMUST00000026554.11
ENSMUST00000185612.3
Urah
urate (5-hydroxyiso-) hydrolase
chr1_-_173740467 3.40 ENSMUST00000009340.10
Ifi211
interferon activated gene 211
chr8_+_108669276 3.36 ENSMUST00000220518.2
Zfhx3
zinc finger homeobox 3
chr1_-_173594475 3.22 ENSMUST00000111214.4
Ifi204
interferon activated gene 204
chr14_+_34097422 3.19 ENSMUST00000111908.3
Mmrn2
multimerin 2
chr7_+_140415431 2.77 ENSMUST00000209978.2
ENSMUST00000210916.2
Urah
urate (5-hydroxyiso-) hydrolase
chr13_-_58422647 2.68 ENSMUST00000225034.2
Gkap1
G kinase anchoring protein 1
chr3_+_99161070 2.58 ENSMUST00000029462.10
Tbx15
T-box 15
chr10_-_27492827 2.57 ENSMUST00000092639.12
Lama2
laminin, alpha 2
chr13_+_49697919 2.56 ENSMUST00000177948.2
ENSMUST00000021820.14
Aspn
asporin
chr9_-_35523237 2.56 ENSMUST00000034610.4
Pate4
prostate and testis expressed 4
chr8_-_43594523 2.50 ENSMUST00000059692.4
Triml1
tripartite motif family-like 1
chr3_-_151953894 2.46 ENSMUST00000196529.5
Nexn
nexilin
chr8_-_18791557 2.42 ENSMUST00000033846.7
Angpt2
angiopoietin 2
chr6_-_145156517 2.37 ENSMUST00000111728.8
ENSMUST00000204105.2
ENSMUST00000060797.10
Casc1
cancer susceptibility candidate 1
chr13_-_58423461 2.33 ENSMUST00000223811.2
Gkap1
G kinase anchoring protein 1
chr8_-_73188887 2.28 ENSMUST00000109974.2
Calr3
calreticulin 3
chr16_+_38182569 2.27 ENSMUST00000023494.13
ENSMUST00000114739.2
Popdc2
popeye domain containing 2
chr9_+_40059408 2.25 ENSMUST00000046333.9
ENSMUST00000238613.2
Tmem225
transmembrane protein 225
chr18_+_50411431 2.14 ENSMUST00000039121.4
ENSMUST00000238078.2
Fam170a
family with sequence similarity 170, member A
chr10_-_27492792 2.04 ENSMUST00000189575.2
Lama2
laminin, alpha 2
chr15_-_36140539 2.03 ENSMUST00000172831.8
Rgs22
regulator of G-protein signalling 22
chr11_-_68277799 1.98 ENSMUST00000135141.2
Ntn1
netrin 1
chr2_+_34764408 1.94 ENSMUST00000113068.9
ENSMUST00000047447.13
Cutal
cutA divalent cation tolerance homolog-like
chr10_-_80649315 1.88 ENSMUST00000181039.8
ENSMUST00000180438.2
Jsrp1
junctional sarcoplasmic reticulum protein 1
chrX_+_75307887 1.83 ENSMUST00000096389.5
Cldn34b3
claudin 34B3
chr10_-_107555840 1.81 ENSMUST00000050702.9
Ptprq
protein tyrosine phosphatase, receptor type, Q
chr8_-_43759973 1.78 ENSMUST00000211248.2
ENSMUST00000209356.2
Zfp42
zinc finger protein 42
chr8_-_46747629 1.78 ENSMUST00000058636.9
Helt
helt bHLH transcription factor
chr17_+_33651864 1.75 ENSMUST00000174088.3
Actl9
actin-like 9
chr14_+_54214610 1.72 ENSMUST00000199137.2
Trav23
T cell receptor alpha variable 23
chr2_+_34764496 1.69 ENSMUST00000028228.6
Cutal
cutA divalent cation tolerance homolog-like
chrX_+_11184495 1.67 ENSMUST00000179859.2
H2al1g
H2A histone family member L1G
chr4_+_41569775 1.63 ENSMUST00000102963.10
Dnai1
dynein axonemal intermediate chain 1
chr1_+_152275575 1.59 ENSMUST00000044311.9
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chrX_+_9216866 1.57 ENSMUST00000178196.3
H2al1k
H2A histone family member L1K
chrX_+_11165496 1.56 ENSMUST00000188439.2
H2al1a
H2A histone family member L1A
chr5_+_90920353 1.53 ENSMUST00000202625.2
Pf4
platelet factor 4
chr2_+_103800459 1.52 ENSMUST00000111143.8
ENSMUST00000138815.2
Lmo2
LIM domain only 2
chrX_+_9150003 1.50 ENSMUST00000073949.4
H2al1m
H2A histone family member L1M
chr4_-_92035446 1.48 ENSMUST00000107108.8
ENSMUST00000143542.2
Izumo3
IZUMO family member 3
chr2_+_103800553 1.37 ENSMUST00000111140.3
ENSMUST00000111139.3
Lmo2
LIM domain only 2
chr12_-_35584968 1.36 ENSMUST00000116436.9
Ahr
aryl-hydrocarbon receptor
chr7_+_126895463 1.34 ENSMUST00000106306.9
ENSMUST00000120857.8
Itgal
integrin alpha L
chrX_+_11187731 1.31 ENSMUST00000177926.3
H2al1h
H2A histone family member L1H
chr1_+_156666485 1.29 ENSMUST00000111720.2
Angptl1
angiopoietin-like 1
chrX_+_11178173 1.29 ENSMUST00000178979.2
H2al1e
H2A histone family member L1E
chrX_+_11181397 1.28 ENSMUST00000179004.2
H2al1f
H2A histone family member L1F
chrX_+_11190898 1.28 ENSMUST00000164729.3
H2al1i
H2A histone family member L1I
chr16_-_38533597 1.27 ENSMUST00000023487.5
Arhgap31
Rho GTPase activating protein 31
chrX_+_11175063 1.26 ENSMUST00000178595.2
H2al1d
H2A histone family member L1D
chrX_+_14077387 1.26 ENSMUST00000105137.4
H2al1n
H2A histone family member L1N
chrX_+_11168671 1.24 ENSMUST00000189531.2
H2al1b
H2A histone family member L1B
chr6_-_30680502 1.21 ENSMUST00000133373.8
Cep41
centrosomal protein 41
chr2_-_45000389 1.19 ENSMUST00000201804.4
ENSMUST00000028229.13
ENSMUST00000202187.4
ENSMUST00000153561.6
ENSMUST00000201490.2
Zeb2
zinc finger E-box binding homeobox 2
chr14_+_87654045 1.17 ENSMUST00000169504.8
ENSMUST00000168275.9
ENSMUST00000170865.8
Tdrd3
tudor domain containing 3
chr6_+_30401864 1.17 ENSMUST00000068240.13
ENSMUST00000068259.10
ENSMUST00000132581.8
Klhdc10
kelch domain containing 10
chr12_-_86125793 1.16 ENSMUST00000003687.8
Tgfb3
transforming growth factor, beta 3
chrX_-_88453295 1.12 ENSMUST00000113959.8
ENSMUST00000113960.3
Dcaf8l
DDB1 and CUL4 associated factor 8 like
chr8_-_43760017 1.09 ENSMUST00000082120.5
Zfp42
zinc finger protein 42
chr10_+_63293284 1.07 ENSMUST00000105440.8
Ctnna3
catenin (cadherin associated protein), alpha 3
chr5_-_136003294 1.04 ENSMUST00000154181.2
ENSMUST00000111152.8
ENSMUST00000111153.8
Ssc4d
scavenger receptor cysteine rich family, 4 domains
chrX_+_11171894 1.02 ENSMUST00000178806.2
H2al1c
H2A histone family member L1C
chr17_-_32639936 1.01 ENSMUST00000170392.9
ENSMUST00000237165.2
ENSMUST00000235892.2
ENSMUST00000114455.3
Pglyrp2
peptidoglycan recognition protein 2
chr10_+_3690348 1.00 ENSMUST00000120274.8
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr13_-_103901010 0.99 ENSMUST00000210489.2
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr4_+_65042411 0.98 ENSMUST00000084501.4
Pappa
pregnancy-associated plasma protein A
chr11_-_116517777 0.92 ENSMUST00000103028.8
Rhbdf2
rhomboid 5 homolog 2
chr5_-_106606032 0.90 ENSMUST00000086795.8
Barhl2
BarH like homeobox 2
chr18_+_4994600 0.90 ENSMUST00000140448.8
Svil
supervillin
chr8_-_37420293 0.89 ENSMUST00000179501.2
Dlc1
deleted in liver cancer 1
chr7_+_126895423 0.86 ENSMUST00000117762.8
Itgal
integrin alpha L
chr1_+_119934624 0.82 ENSMUST00000072886.11
ENSMUST00000189037.2
Sctr
secretin receptor
chr9_-_102496047 0.80 ENSMUST00000215253.2
Cep63
centrosomal protein 63
chr4_+_60003438 0.80 ENSMUST00000107517.8
ENSMUST00000107520.2
Mup6
major urinary protein 6
chr17_+_36179273 0.78 ENSMUST00000190496.2
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr9_+_72714156 0.74 ENSMUST00000055535.9
Prtg
protogenin
chr12_-_11258973 0.69 ENSMUST00000049877.3
Msgn1
mesogenin 1
chr6_+_24748324 0.68 ENSMUST00000031691.3
Hyal4
hyaluronoglucosaminidase 4
chr2_+_85409559 0.67 ENSMUST00000077075.5
Olfr996
olfactory receptor 996
chrX_-_153911405 0.67 ENSMUST00000076671.4
Cldn34b2
claudin 34B2
chr16_-_57575070 0.67 ENSMUST00000089332.5
Col8a1
collagen, type VIII, alpha 1
chr9_+_44309727 0.66 ENSMUST00000213268.2
Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr10_-_68114543 0.59 ENSMUST00000219238.2
Arid5b
AT rich interactive domain 5B (MRF1-like)
chrY_+_2599099 0.59 ENSMUST00000163651.2
H2al2c
H2A histone family member L2C
chr5_+_107656810 0.58 ENSMUST00000160160.6
Gm42669
predicted gene 42669
chr17_-_37397128 0.57 ENSMUST00000070808.3
Olfr90
olfactory receptor 90
chr6_+_41829799 0.55 ENSMUST00000120605.8
Sval2
seminal vesicle antigen-like 2
chrX_-_144288071 0.49 ENSMUST00000112835.8
ENSMUST00000143610.3
Amot
angiomotin
chr14_+_61836944 0.48 ENSMUST00000039562.8
Trim13
tripartite motif-containing 13
chrY_-_2720674 0.45 ENSMUST00000168551.2
H2al2b
H2A histone family member L2B
chr2_-_89170692 0.43 ENSMUST00000099784.5
Olfr1233
olfactory receptor 1233
chr2_-_45000250 0.36 ENSMUST00000201211.4
ENSMUST00000177302.8
Zeb2
zinc finger E-box binding homeobox 2
chr10_-_129948657 0.34 ENSMUST00000081469.2
Olfr823
olfactory receptor 823
chr5_-_151529486 0.33 ENSMUST00000233599.2
ENSMUST00000232905.2
Vmn2r18
vomeronasal 2, receptor 18
chr9_+_38725910 0.32 ENSMUST00000213164.2
Olfr922
olfactory receptor 922
chr1_+_34275665 0.31 ENSMUST00000194192.3
Dst
dystonin
chr14_-_52258158 0.29 ENSMUST00000228580.2
ENSMUST00000226554.2
ENSMUST00000067549.15
Zfp219
zinc finger protein 219
chrX_+_111513971 0.28 ENSMUST00000071814.13
Zfp711
zinc finger protein 711
chr9_+_37766116 0.26 ENSMUST00000086063.4
Olfr877
olfactory receptor 877
chr6_-_30936013 0.26 ENSMUST00000101589.5
Klf14
Kruppel-like factor 14
chr3_+_41697046 0.26 ENSMUST00000120167.8
ENSMUST00000108065.9
ENSMUST00000146165.8
ENSMUST00000192193.6
ENSMUST00000119572.8
ENSMUST00000026867.14
ENSMUST00000026868.13
D3Ertd751e
DNA segment, Chr 3, ERATO Doi 751, expressed
chr11_-_50844572 0.25 ENSMUST00000162420.2
ENSMUST00000051159.3
Prop1
paired like homeodomain factor 1
chrX_-_138772383 0.25 ENSMUST00000033811.14
ENSMUST00000087401.12
Morc4
microrchidia 4
chr7_-_102241093 0.24 ENSMUST00000213540.3
Olfr551
olfactory receptor 551
chr13_-_21476849 0.23 ENSMUST00000110491.9
Gpx5
glutathione peroxidase 5
chr13_+_104424359 0.23 ENSMUST00000065766.7
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr14_-_51311892 0.23 ENSMUST00000216202.2
Olfr750
olfactory receptor 750
chr11_-_82911615 0.22 ENSMUST00000038141.15
ENSMUST00000092838.11
Slfn8
schlafen 8
chrX_+_158410229 0.22 ENSMUST00000112456.9
Sh3kbp1
SH3-domain kinase binding protein 1
chr19_-_11313471 0.19 ENSMUST00000056035.9
ENSMUST00000067532.11
Ms4a7
membrane-spanning 4-domains, subfamily A, member 7
chr5_-_120605361 0.19 ENSMUST00000132916.2
Sdsl
serine dehydratase-like
chr11_-_82911548 0.17 ENSMUST00000108152.9
Slfn8
schlafen 8
chr11_-_82910912 0.15 ENSMUST00000130822.3
Slfn8
schlafen 8
chr5_+_65288418 0.13 ENSMUST00000101191.10
ENSMUST00000204348.3
Klhl5
kelch-like 5
chr5_+_34683141 0.13 ENSMUST00000125817.8
ENSMUST00000067638.14
Sh3bp2
SH3-domain binding protein 2
chr5_+_66417233 0.13 ENSMUST00000202994.4
ENSMUST00000201100.4
Nsun7
NOL1/NOP2/Sun domain family, member 7
chr4_-_141265745 0.10 ENSMUST00000078886.10
Spen
spen family transcription repressor
chr6_-_72343935 0.10 ENSMUST00000154098.3
Rnf181
ring finger protein 181
chrX_-_9438648 0.09 ENSMUST00000079952.4
H2al1o
H2A histone family member L1O
chr3_+_69914946 0.08 ENSMUST00000053013.6
Otol1
otolin 1
chr2_+_103799873 0.05 ENSMUST00000123437.8
Lmo2
LIM domain only 2
chr17_-_37430949 0.04 ENSMUST00000214994.2
ENSMUST00000216341.2
Olfr92
olfactory receptor 92
chr2_+_86338805 0.03 ENSMUST00000076263.2
Olfr1076
olfactory receptor 1076
chr7_+_6225277 0.02 ENSMUST00000072662.12
ENSMUST00000155314.2
Zscan5b
zinc finger and SCAN domain containing 5B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.5 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.7 3.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 3.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.6 5.0 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.5 2.6 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.5 3.6 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.5 2.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.5 2.3 GO:0060931 sinoatrial node cell development(GO:0060931)
0.5 3.6 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.4 6.7 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.4 1.2 GO:0003032 detection of oxygen(GO:0003032)
0.3 4.6 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.3 1.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.3 4.4 GO:0044539 long-chain fatty acid import(GO:0044539)
0.3 2.9 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 2.2 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.2 1.4 GO:0040010 positive regulation of growth rate(GO:0040010)
0.2 1.6 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 5.6 GO:0035634 response to stilbenoid(GO:0035634)
0.2 2.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 2.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.0 GO:0032827 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.2 0.5 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.2 4.7 GO:0017144 drug metabolic process(GO:0017144)
0.1 16.3 GO:0006342 chromatin silencing(GO:0006342)
0.1 4.3 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 7.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 1.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 2.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.8 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 1.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 0.7 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 1.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 1.9 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.1 3.2 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.3 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.0 0.6 GO:0060613 fat pad development(GO:0060613)
0.0 0.7 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.9 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.7 GO:0007379 segment specification(GO:0007379)
0.0 0.3 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.6 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.9 GO:0001709 cell fate determination(GO:0001709)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.9 GO:0006836 neurotransmitter transport(GO:0006836)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0070722 Tle3-Aes complex(GO:0070722)
0.4 2.2 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.3 3.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 1.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 4.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 4.6 GO:0005605 basal lamina(GO:0005605)
0.2 3.6 GO:0042627 chylomicron(GO:0042627)
0.1 14.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.5 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 7.1 GO:0031526 brush border membrane(GO:0031526)
0.1 6.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.1 GO:0005916 fascia adherens(GO:0005916)
0.0 6.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 15.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 3.4 GO:0034399 nuclear periphery(GO:0034399)
0.0 1.8 GO:0032421 stereocilium bundle(GO:0032421)
0.0 8.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.9 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.2 GO:0030315 T-tubule(GO:0030315)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.0 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.7 GO:0042383 sarcolemma(GO:0042383)
0.0 3.3 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0033971 hydroxyisourate hydrolase activity(GO:0033971)
0.9 4.4 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.7 3.6 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.6 3.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.4 2.2 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.4 4.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3 9.5 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.3 3.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.3 1.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 3.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 0.7 GO:0015152 glucose-6-phosphate transmembrane transporter activity(GO:0015152)
0.2 1.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.1 2.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.5 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 4.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.2 GO:0004794 L-threonine ammonia-lyase activity(GO:0004794)
0.1 2.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 4.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.1 2.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 7.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 5.6 GO:0005550 pheromone binding(GO:0005550)
0.0 2.3 GO:0030552 cAMP binding(GO:0030552)
0.0 3.6 GO:0005507 copper ion binding(GO:0005507)
0.0 2.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.9 GO:0070888 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 2.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 8.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0043274 phospholipase binding(GO:0043274)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 2.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.4 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 6.8 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 1.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 3.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 3.4 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 4.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 10.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.0 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 3.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 4.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 6.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+