ISMARA results: Mecp2

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Mecp2

Z-value: 3.14

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Transcription factors associated with Mecp2

Gene Symbol	Gene ID	Gene Info
Mecp2 Ensembl NCBI MGI UniProt	ENSMUSG00000031393.17	Mecp2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mecp2	mm39_v1_chrX_-_73129195_73129296	0.44	9.0e-05	Click!

Activity profile of Mecp2 motif

Sorted Z-values of Mecp2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecp2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_4412546 Show fit	9.75	ENSMUST00000014447.13	Glis2 Ensembl NCBI MGI UniProt Show fit	GLIS family zinc finger 2
chr10_+_79824418 Show fit	8.58	ENSMUST00000004784.11 ENSMUST00000105374.2	Cnn2 Ensembl NCBI MGI UniProt Show fit	calponin 2
chr11_-_75918551 Show fit	8.18	ENSMUST00000021207.7	Rflnb Ensembl NCBI MGI UniProt Show fit	refilin B
chr11_+_98303287 Show fit	7.92	ENSMUST00000058295.6	Erbb2 Ensembl NCBI MGI UniProt Show fit	erb-b2 receptor tyrosine kinase 2
chr9_-_44792575 Show fit	7.90	ENSMUST00000114689.8 ENSMUST00000002095.11 ENSMUST00000128768.3	Kmt2a Ensembl NCBI MGI UniProt Show fit	lysine (K)-specific methyltransferase 2A
chr17_-_7050145 Show fit	7.75	ENSMUST00000064234.7	Ezr Ensembl NCBI MGI UniProt Show fit	ezrin
chr9_+_92424276 Show fit	7.73	ENSMUST00000070522.14 ENSMUST00000160359.2	Plod2 Ensembl NCBI MGI UniProt Show fit	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr2_-_69416365 Show fit	7.58	ENSMUST00000100051.9 ENSMUST00000092551.5 ENSMUST00000080953.12	Lrp2 Ensembl NCBI MGI UniProt Show fit	low density lipoprotein receptor-related protein 2
chr16_-_76169902 Show fit	7.30	ENSMUST00000054178.8	Nrip1 Ensembl NCBI MGI UniProt Show fit	nuclear receptor interacting protein 1
chr11_-_100861713 Show fit	7.25	ENSMUST00000060792.6	Cavin1 Ensembl NCBI MGI UniProt Show fit	caveolae associated 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	34.0	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.4	28.9	GO:0002181	cytoplasmic translation(GO:0002181)
0.9	23.2	GO:0051639	actin filament network formation(GO:0051639)
0.7	22.5	GO:0000470	maturation of LSU-rRNA(GO:0000470)
0.1	22.0	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.3	20.7	GO:0070527	platelet aggregation(GO:0070527)
0.3	20.7	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.5	18.1	GO:0035329	hippo signaling(GO:0035329)
1.0	17.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.4	16.7	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)

Showing 1 to 10 of 1,229 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	245.8	GO:0070062	extracellular exosome(GO:0070062)
0.4	181.6	GO:0005925	focal adhesion(GO:0005925)
0.2	68.2	GO:0000785	chromatin(GO:0000785)
0.2	63.6	GO:0016607	nuclear speck(GO:0016607)
0.8	63.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	60.3	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4	46.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	35.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	34.9	GO:0031526	brush border membrane(GO:0031526)
1.2	33.1	GO:0070938	contractile ring(GO:0070938)

Showing 1 to 10 of 421 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	74.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	63.2	GO:0045296	cadherin binding(GO:0045296)
0.2	47.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3	45.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	37.1	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.3	35.5	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.6	26.7	GO:0046965	retinoid X receptor binding(GO:0046965)
0.8	24.8	GO:0043236	laminin binding(GO:0043236)
0.6	24.2	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	21.8	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 775 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	58.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	44.3	PID ILK PATHWAY	Integrin-linked kinase signaling
1.0	37.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.8	37.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
1.0	34.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.7	34.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.5	31.6	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	30.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	30.2	PID AURORA B PATHWAY	Aurora B signaling
0.3	28.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Showing 1 to 10 of 137 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	90.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.4	47.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	44.5	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.7	32.4	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.2	31.1	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.8	30.0	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4	29.1	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.4	26.9	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.3	26.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.5	22.4	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Showing 1 to 10 of 222 entries

Results for Mecp2

Z-value: 3.14

Motif logo

Transcription factors associated with Mecp2

Activity-expression correlation:

Activity profile of Mecp2 motif

Sorted Z-values of Mecp2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecp2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: