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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Mef2c
Z-value: 4.43
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Transcription factors associated with Mef2c
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2c | mm39_v1_chr13_+_83720457_83720476 | 0.49 | 1.3e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2c
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 216.5 | GO:0045214 | sarcomere organization(GO:0045214) |
| 16.9 | 168.7 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 20.2 | 141.2 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 2.9 | 132.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 38.3 | 115.0 | GO:0042694 | muscle cell fate specification(GO:0042694) |
| 20.4 | 81.6 | GO:0007522 | visceral muscle development(GO:0007522) |
| 0.8 | 81.1 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 13.3 | 79.9 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 0.8 | 77.5 | GO:0044042 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
| 1.5 | 72.7 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 762.0 | GO:0031674 | I band(GO:0031674) |
| 10.5 | 252.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 9.7 | 174.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 11.9 | 154.1 | GO:0005861 | troponin complex(GO:0005861) |
| 1.1 | 119.4 | GO:0030016 | myofibril(GO:0030016) |
| 0.4 | 113.2 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 1.2 | 107.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 33.1 | 99.2 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 23.9 | 95.8 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 27.9 | 83.6 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.1 | 331.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.5 | 307.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 190.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 175.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.2 | 158.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 26.4 | 131.9 | GO:0051373 | FATZ binding(GO:0051373) |
| 15.5 | 108.3 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
| 1.7 | 105.8 | GO:0042805 | actinin binding(GO:0042805) |
| 9.7 | 96.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.4 | 88.4 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 115.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.5 | 59.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.4 | 54.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.4 | 42.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.9 | 29.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 27.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 14.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 13.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 10.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 6.3 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.4 | 610.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 2.6 | 127.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 119.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 3.6 | 75.0 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.6 | 59.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.5 | 42.8 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 2.7 | 37.3 | REACTOME DEFENSINS | Genes involved in Defensins |
| 1.2 | 31.0 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.4 | 29.7 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 1.7 | 29.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |