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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Mef2d_Mef2a
Z-value: 6.16
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Transcription factors associated with Mef2d_Mef2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2d | mm39_v1_chr3_+_88049875_88049892 | 0.44 | 9.6e-05 | Click! |
| Mef2a | mm39_v1_chr7_-_66915756_66915910 | 0.43 | 1.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2d_Mef2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 411.4 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 5.3 | 355.5 | GO:0045214 | sarcomere organization(GO:0045214) |
| 28.2 | 281.9 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 31.1 | 218.0 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 4.0 | 167.6 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 19.2 | 153.5 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 1.9 | 147.9 | GO:0055013 | cardiac muscle cell development(GO:0055013) |
| 47.3 | 141.8 | GO:0042694 | muscle cell fate specification(GO:0042694) |
| 7.2 | 130.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.3 | 129.1 | GO:0044042 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 1090.6 | GO:0031674 | I band(GO:0031674) |
| 16.0 | 382.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 3.4 | 371.2 | GO:0030016 | myofibril(GO:0030016) |
| 34.9 | 279.2 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 10.4 | 187.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 13.3 | 173.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.5 | 167.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 38.4 | 153.5 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.6 | 139.8 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.3 | 123.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 22.0 | 660.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.6 | 438.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.5 | 362.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 41.4 | 207.1 | GO:0051373 | FATZ binding(GO:0051373) |
| 3.5 | 175.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 2.5 | 159.9 | GO:0042805 | actinin binding(GO:0042805) |
| 0.3 | 131.2 | GO:0003779 | actin binding(GO:0003779) |
| 9.8 | 128.0 | GO:0031432 | titin binding(GO:0031432) |
| 11.7 | 117.5 | GO:0031014 | troponin T binding(GO:0031014) |
| 11.7 | 116.7 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 141.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 2.7 | 105.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.0 | 103.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.0 | 74.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.3 | 66.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.8 | 58.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.7 | 54.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 39.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 29.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.7 | 24.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 949.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 3.7 | 182.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.6 | 180.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 3.5 | 100.7 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 3.6 | 90.3 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 2.3 | 74.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.0 | 66.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 2.2 | 62.6 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 3.6 | 60.9 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 2.8 | 58.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |