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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Mnx1_Lhx6_Lmx1a
Z-value: 0.62
Motif logo
Transcription factors associated with Mnx1_Lhx6_Lmx1a
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
Mnx1
|
ENSMUSG00000001566.10 | Mnx1 |
|
Lhx6
|
ENSMUSG00000026890.20 | Lhx6 |
|
Lmx1a
|
ENSMUSG00000026686.15 | Lmx1a |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Lmx1a | mm39_v1_chr1_+_167517114_167517146 | 0.27 | 2.3e-02 | Click! |
| Mnx1 | mm39_v1_chr5_-_29683468_29683595 | 0.25 | 3.2e-02 | Click! |
| Lhx6 | mm39_v1_chr2_-_35994819_35994903 | 0.10 | 4.1e-01 | Click! |
Activity profile of Mnx1_Lhx6_Lmx1a motif
Sorted Z-values of Mnx1_Lhx6_Lmx1a motif
Network of associatons between targets according to the STRING database.
First level regulatory network of Mnx1_Lhx6_Lmx1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 1.5 | 4.6 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 1.2 | 3.7 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 1.1 | 5.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.1 | 3.2 | GO:0060618 | nipple development(GO:0060618) |
| 0.9 | 2.8 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.9 | 2.6 | GO:1904117 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 0.8 | 2.4 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.7 | 2.1 | GO:0060448 | dichotomous subdivision of terminal units involved in lung branching(GO:0060448) |
| 0.5 | 2.0 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.4 | 1.3 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.4 | 2.2 | GO:0045726 | positive regulation of integrin biosynthetic process(GO:0045726) |
| 0.4 | 2.6 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.4 | 1.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.4 | 3.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.4 | 2.5 | GO:2001205 | negative regulation of osteoclast development(GO:2001205) |
| 0.4 | 2.5 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.3 | 1.0 | GO:2000536 | negative regulation of entry of bacterium into host cell(GO:2000536) |
| 0.3 | 1.3 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.3 | 3.0 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.3 | 1.5 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.3 | 1.2 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.3 | 0.9 | GO:1900239 | regulation of phenotypic switching(GO:1900239) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724) |
| 0.3 | 0.9 | GO:0001966 | thigmotaxis(GO:0001966) |
| 0.3 | 1.4 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.3 | 0.8 | GO:1904268 | regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751) |
| 0.2 | 2.0 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.2 | 1.0 | GO:0003017 | lymph circulation(GO:0003017) |
| 0.2 | 1.4 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.2 | 0.7 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 0.2 | 1.3 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.2 | 0.8 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
| 0.2 | 0.6 | GO:0061193 | taste bud development(GO:0061193) |
| 0.2 | 0.7 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
| 0.2 | 3.4 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.2 | 1.1 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.2 | 0.7 | GO:1905053 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.2 | 2.8 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 0.5 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.2 | 0.7 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.2 | 1.4 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
| 0.2 | 0.5 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 0.2 | 0.8 | GO:0002358 | pre-B cell allelic exclusion(GO:0002331) B cell homeostatic proliferation(GO:0002358) |
| 0.2 | 0.5 | GO:0045660 | positive regulation of neutrophil differentiation(GO:0045660) |
| 0.2 | 0.5 | GO:0061033 | bronchiole development(GO:0060435) secretion by lung epithelial cell involved in lung growth(GO:0061033) |
| 0.2 | 0.6 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.2 | 1.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.2 | 0.5 | GO:2001200 | positive regulation of dendritic cell differentiation(GO:2001200) |
| 0.2 | 0.5 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.1 | 0.4 | GO:0061076 | camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870) |
| 0.1 | 1.0 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 6.8 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.1 | 2.1 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.1 | 0.8 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 0.4 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 0.1 | 0.5 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
| 0.1 | 0.5 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.1 | 0.4 | GO:0032685 | negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685) |
| 0.1 | 0.9 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 0.3 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 0.5 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 0.4 | GO:1904566 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.1 | 1.5 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.1 | 0.8 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 0.8 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 1.5 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 0.3 | GO:0035638 | patched ligand maturation(GO:0007225) signal maturation(GO:0035638) |
| 0.1 | 0.8 | GO:0061621 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.1 | 0.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.2 | GO:0051795 | positive regulation of catagen(GO:0051795) |
| 0.1 | 0.7 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.1 | 0.8 | GO:0021815 | modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815) |
| 0.1 | 1.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.4 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 1.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 0.6 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 1.2 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.1 | 2.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.2 | GO:2000583 | regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584) |
| 0.1 | 2.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.5 | GO:0007527 | adult somatic muscle development(GO:0007527) |
| 0.1 | 0.6 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.1 | GO:1901994 | negative regulation of meiotic cell cycle phase transition(GO:1901994) |
| 0.1 | 0.2 | GO:1900135 | positive regulation of renin secretion into blood stream(GO:1900135) |
| 0.1 | 1.0 | GO:0090336 | negative regulation of granulocyte differentiation(GO:0030853) positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 3.1 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.1 | 0.7 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) |
| 0.1 | 0.8 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.2 | GO:0045963 | negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) |
| 0.1 | 0.5 | GO:0032596 | protein transport into membrane raft(GO:0032596) |
| 0.1 | 0.9 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.1 | 0.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 1.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 3.2 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 0.8 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.0 | 0.2 | GO:0070173 | regulation of enamel mineralization(GO:0070173) |
| 0.0 | 0.2 | GO:0048022 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.0 | 0.6 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.0 | 1.7 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 1.1 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 0.3 | GO:0046013 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 0.5 | GO:0010909 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) |
| 0.0 | 4.5 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.0 | 1.1 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 2.1 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.0 | 0.4 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
| 0.0 | 1.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.6 | GO:0035729 | cellular response to hepatocyte growth factor stimulus(GO:0035729) |
| 0.0 | 0.7 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.0 | 0.1 | GO:0046005 | positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005) |
| 0.0 | 0.3 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.0 | 2.6 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.1 | GO:0006649 | phospholipid transfer to membrane(GO:0006649) |
| 0.0 | 0.7 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.0 | 0.4 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 0.0 | 0.3 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 0.1 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.0 | 0.7 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.7 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 0.1 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.0 | 0.1 | GO:0050973 | detection of mechanical stimulus involved in equilibrioception(GO:0050973) |
| 0.0 | 1.1 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 3.7 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 0.4 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.0 | 1.7 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.1 | GO:0021524 | visceral motor neuron differentiation(GO:0021524) |
| 0.0 | 0.9 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.0 | 0.8 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.0 | 0.9 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.0 | 0.9 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.1 | GO:0061146 | Peyer's patch morphogenesis(GO:0061146) |
| 0.0 | 0.4 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.0 | 0.4 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.0 | 0.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.6 | GO:0008210 | luteinization(GO:0001553) estrogen metabolic process(GO:0008210) |
| 0.0 | 0.4 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 2.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 1.2 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.3 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 0.3 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.0 | 0.1 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.0 | 0.1 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.0 | 1.4 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 1.5 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 0.9 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.8 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.4 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.0 | 0.5 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.9 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.0 | 0.5 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.0 | 0.2 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.0 | 0.1 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.0 | 0.7 | GO:0043276 | anoikis(GO:0043276) |
| 0.0 | 1.0 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 0.2 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.0 | 1.6 | GO:0030148 | sphingolipid biosynthetic process(GO:0030148) |
| 0.0 | 0.2 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.0 | 1.6 | GO:0046488 | phosphatidylinositol metabolic process(GO:0046488) |
| 0.0 | 0.4 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
| 0.0 | 0.1 | GO:0097062 | dendritic spine maintenance(GO:0097062) |
| 0.0 | 0.8 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 1.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 0.5 | GO:0046834 | lipid phosphorylation(GO:0046834) |
| 0.0 | 0.2 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.1 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.3 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 0.0 | GO:0046851 | negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851) |
| 0.0 | 0.6 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.6 | GO:0016014 | dystrobrevin complex(GO:0016014) |
| 0.7 | 2.1 | GO:0060187 | cell pole(GO:0060187) |
| 0.6 | 3.7 | GO:0031523 | Myb complex(GO:0031523) |
| 0.5 | 1.6 | GO:1904511 | cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511) |
| 0.5 | 3.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.4 | 1.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.4 | 1.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.3 | 2.2 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.3 | 4.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 0.7 | GO:0060205 | secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205) |
| 0.2 | 2.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 4.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.8 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 7.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.8 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 1.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.7 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.1 | 0.7 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.1 | 3.0 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 0.8 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 1.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.4 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 3.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 2.8 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 2.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 0.9 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.1 | 1.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.5 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.8 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 0.3 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 0.8 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 2.2 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.9 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 1.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.9 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 6.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 1.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.2 | GO:0071664 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.0 | 2.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 2.4 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 7.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.3 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 0.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.8 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 1.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.3 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 0.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 3.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.2 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 0.2 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.2 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.7 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 2.0 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 1.8 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.8 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 5.4 | GO:0005912 | adherens junction(GO:0005912) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.6 | 3.7 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.6 | 2.4 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.6 | 10.9 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.5 | 1.6 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.5 | 4.6 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.4 | 2.6 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.4 | 2.6 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.4 | 2.2 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.3 | 3.0 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.3 | 3.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 0.7 | GO:0070698 | type I activin receptor binding(GO:0070698) |
| 0.2 | 0.7 | GO:0004500 | dopamine beta-monooxygenase activity(GO:0004500) |
| 0.2 | 2.8 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.2 | 1.8 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 0.6 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.2 | 3.3 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.2 | 4.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 1.9 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 0.7 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.2 | 0.5 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.1 | 3.0 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.1 | 0.8 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 10.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 3.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 1.0 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 0.4 | GO:0071820 | N-box binding(GO:0071820) |
| 0.1 | 1.0 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.1 | 1.3 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 2.1 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 0.3 | GO:0000171 | ribonuclease MRP activity(GO:0000171) |
| 0.1 | 0.5 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 0.8 | GO:0019158 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 0.3 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.1 | 0.7 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 1.1 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 4.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.5 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 3.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 1.4 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 0.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 1.3 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 0.3 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
| 0.1 | 1.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 0.5 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 0.5 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.1 | 0.4 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 0.8 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 0.6 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 2.0 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 1.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.7 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.0 | 0.1 | GO:0090555 | phosphatidylethanolamine-translocating ATPase activity(GO:0090555) |
| 0.0 | 1.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.7 | GO:0035014 | phosphatidylinositol 3-kinase regulator activity(GO:0035014) |
| 0.0 | 1.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.3 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 1.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.1 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.0 | 1.2 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.6 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 2.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 6.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.4 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 9.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.0 | 2.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.2 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.7 | GO:0016208 | AMP binding(GO:0016208) |
| 0.0 | 1.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 0.2 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.0 | 10.9 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 2.2 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.3 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 0.1 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.0 | 0.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 0.7 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 4.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.1 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.0 | 0.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.6 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.3 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.2 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.0 | 0.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.1 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.0 | 1.1 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 1.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.5 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.1 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.0 | 0.2 | GO:0045295 | gamma-catenin binding(GO:0045295) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 19.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 0.8 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 3.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 2.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.8 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 3.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 2.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.1 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.2 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 1.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 1.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 0.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 5.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 2.6 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 1.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 3.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 5.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 1.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 1.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 0.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 7.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.0 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 2.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.9 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.7 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 3.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.5 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.9 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 0.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.4 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.9 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 5.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.0 | 4.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 1.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 3.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.7 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.9 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |