ISMARA results: Myb

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Myb

Z-value: 3.80

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Transcription factors associated with Myb

Gene Symbol	Gene ID	Gene Info
Myb Ensembl NCBI MGI UniProt	ENSMUSG00000019982.16	Myb

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Myb	mm39_v1_chr10_-_21036792_21036810	0.41	2.9e-04	Click!

Activity profile of Myb motif

Sorted Z-values of Myb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myb

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr14_-_66315144 Show fit	47.80	ENSMUST00000022618.6	Adam2 Ensembl NCBI MGI UniProt Show fit	a disintegrin and metallopeptidase domain 2
chr8_+_84116507 Show fit	42.43	ENSMUST00000109831.3	Clgn Ensembl NCBI MGI UniProt Show fit	calmegin
chr14_+_70077841 Show fit	41.81	ENSMUST00000022678.5	Pebp4 Ensembl NCBI MGI UniProt Show fit	phosphatidylethanolamine binding protein 4
chr8_+_84116463 Show fit	39.14	ENSMUST00000002259.13	Clgn Ensembl NCBI MGI UniProt Show fit	calmegin
chr7_+_15795735 Show fit	31.66	ENSMUST00000209369.2	Zfp541 Ensembl NCBI MGI UniProt Show fit	zinc finger protein 541
chr8_-_73302068 Show fit	30.17	ENSMUST00000058534.7	Med26 Ensembl NCBI MGI UniProt Show fit	mediator complex subunit 26
chr4_-_118294521 Show fit	26.99	ENSMUST00000006565.13	Cdc20 Ensembl NCBI MGI UniProt Show fit	cell division cycle 20
chr2_+_29780532 Show fit	26.55	ENSMUST00000113764.4	Odf2 Ensembl NCBI MGI UniProt Show fit	outer dense fiber of sperm tails 2
chr6_+_145561483 Show fit	26.31	ENSMUST00000087445.7	Tuba3b Ensembl NCBI MGI UniProt Show fit	tubulin, alpha 3B
chr3_+_116388600 Show fit	25.91	ENSMUST00000198386.5 ENSMUST00000198311.5 ENSMUST00000197335.2	Sass6 Ensembl NCBI MGI UniProt Show fit	SAS-6 centriolar assembly protein

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	196.2	GO:0007286	spermatid development(GO:0007286)
2.5	140.0	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.2	111.3	GO:0007283	spermatogenesis(GO:0007283)
3.4	60.4	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
2.5	55.9	GO:0034587	piRNA metabolic process(GO:0034587)
0.4	51.1	GO:0008542	visual learning(GO:0008542)
13.4	40.1	GO:0008358	oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
3.7	36.7	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
2.0	34.8	GO:0036159	inner dynein arm assembly(GO:0036159)
4.1	33.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)

Showing 1 to 10 of 188 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	125.4	GO:0005634	nucleus(GO:0005634)
0.8	85.2	GO:0005814	centriole(GO:0005814)
0.2	79.2	GO:0005813	centrosome(GO:0005813)
0.2	76.4	GO:0005635	nuclear envelope(GO:0005635)
5.2	73.3	GO:0036128	CatSper complex(GO:0036128)
2.1	68.6	GO:0034451	centriolar satellite(GO:0034451)
1.4	66.1	GO:0035371	microtubule plus-end(GO:0035371)
0.8	58.1	GO:0005844	polysome(GO:0005844)
0.8	57.9	GO:0005871	kinesin complex(GO:0005871)
0.4	56.5	GO:0000795	synaptonemal complex(GO:0000795)

Showing 1 to 10 of 120 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	158.0	GO:0003677	DNA binding(GO:0003677)
2.4	97.4	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.5	65.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	59.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
1.0	56.3	GO:0045182	translation regulator activity(GO:0045182)
1.7	51.9	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5	43.5	GO:0003777	microtubule motor activity(GO:0003777)
0.1	43.1	GO:0008270	zinc ion binding(GO:0008270)
0.3	38.7	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
1.4	35.8	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)

Showing 1 to 10 of 132 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	120.6	PID PLK1 PATHWAY	PLK1 signaling events
0.6	53.0	PID ILK PATHWAY	Integrin-linked kinase signaling
1.2	47.8	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
1.5	32.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.6	28.2	PID FANCONI PATHWAY	Fanconi anemia pathway
0.4	19.7	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.4	18.6	PID AURORA B PATHWAY	Aurora B signaling
0.1	16.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	12.6	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.2	12.1	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	67.0	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.6	56.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.3	41.9	REACTOME KINESINS	Genes involved in Kinesins
1.3	35.9	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.3	32.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.7	29.1	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
1.1	21.7	REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.6	19.4	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.6	18.6	REACTOME TELOMERE MAINTENANCE	Genes involved in Telomere Maintenance
2.1	14.4	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection

Showing 1 to 10 of 45 entries

Results for Myb

Z-value: 3.80

Motif logo

Transcription factors associated with Myb

Activity-expression correlation:

Activity profile of Myb motif

Sorted Z-values of Myb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myb

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: