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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Mybl1
Z-value: 1.81
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Transcription factors associated with Mybl1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mybl1 | mm39_v1_chr1_-_9770434_9770554 | 0.74 | 1.7e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mybl1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 70.7 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.6 | 28.6 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 1.1 | 23.9 | GO:0001675 | acrosome assembly(GO:0001675) |
| 1.0 | 20.9 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 6.2 | 18.5 | GO:0008358 | oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719) |
| 0.2 | 17.6 | GO:0030317 | sperm motility(GO:0030317) |
| 1.1 | 14.4 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 1.3 | 14.0 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.1 | 12.8 | GO:1901799 | negative regulation of proteasomal protein catabolic process(GO:1901799) |
| 4.0 | 12.1 | GO:1990918 | double-strand break repair involved in meiotic recombination(GO:1990918) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 30.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 29.9 | GO:0036126 | sperm flagellum(GO:0036126) |
| 1.9 | 19.4 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 19.4 | GO:0005730 | nucleolus(GO:0005730) |
| 1.7 | 19.1 | GO:0071546 | pi-body(GO:0071546) |
| 0.9 | 18.5 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.5 | 18.1 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 17.1 | GO:0005814 | centriole(GO:0005814) |
| 1.3 | 15.3 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.9 | 12.8 | GO:0000812 | Swr1 complex(GO:0000812) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 26.4 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 16.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 15.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.8 | 14.0 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
| 0.2 | 13.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 13.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 12.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.5 | 10.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.5 | 10.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 10.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 11.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 8.7 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 8.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.8 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 6.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.6 | 5.8 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 5.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 5.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.2 | 4.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 20.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 16.8 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 16.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.9 | 14.0 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.3 | 10.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 9.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.7 | 9.0 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.8 | 8.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.6 | 8.5 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.2 | 8.5 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |