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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Mybl2
Z-value: 1.89
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Transcription factors associated with Mybl2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mybl2 | mm39_v1_chr2_+_162916551_162916665 | 0.73 | 5.4e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mybl2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 32.9 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.7 | 18.6 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.3 | 18.5 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.4 | 17.8 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.7 | 16.5 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 2.0 | 14.0 | GO:0034093 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) |
| 4.6 | 13.7 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
| 0.1 | 13.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 13.2 | GO:0051321 | meiotic cell cycle(GO:0051321) |
| 0.6 | 12.8 | GO:0035404 | histone-serine phosphorylation(GO:0035404) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 51.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 5.7 | 34.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 33.7 | GO:0005694 | chromosome(GO:0005694) |
| 0.3 | 22.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 17.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 1.5 | 14.8 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.2 | 14.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.5 | 13.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.5 | 13.1 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.4 | 12.8 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 19.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.5 | 18.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 4.6 | 13.7 | GO:0001160 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) |
| 0.1 | 13.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.6 | 12.8 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.1 | 12.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 12.2 | GO:0019894 | kinesin binding(GO:0019894) |
| 1.1 | 11.9 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 10.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 30.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 19.7 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 14.3 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.2 | 11.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 9.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 9.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 8.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 7.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 6.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 5.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 43.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.8 | 25.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.5 | 18.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 14.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 12.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.6 | 10.9 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.6 | 10.7 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.6 | 10.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.4 | 10.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.9 | 9.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |