ISMARA results: Myod1

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Myod1

Z-value: 2.44

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Transcription factors associated with Myod1

Gene Symbol	Gene ID	Gene Info
Myod1 Ensembl NCBI MGI UniProt	ENSMUSG00000009471.5	Myod1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Myod1	mm39_v1_chr7_+_46025890_46025904	0.85	5.8e-21	Click!

Activity profile of Myod1 motif

Sorted Z-values of Myod1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myod1

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Promoter	Score	Transcript	Gene	Gene Info
chr8_+_23629173 Show fit	32.14	ENSMUST00000174435.2	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr8_+_23629046 Show fit	30.87	ENSMUST00000121075.8	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr8_+_23629080 Show fit	30.65	ENSMUST00000033947.15	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr7_+_126811831 Show fit	27.25	ENSMUST00000127710.3	Mylpf Ensembl NCBI MGI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr4_-_43523388 Show fit	26.67	ENSMUST00000107913.10 ENSMUST00000030184.12	Tpm2 Ensembl NCBI MGI UniProt Show fit	tropomyosin 2, beta
chr4_-_43523745 Show fit	26.00	ENSMUST00000150592.2	Tpm2 Ensembl NCBI MGI UniProt Show fit	tropomyosin 2, beta
chr2_-_52225763 Show fit	25.99	ENSMUST00000238288.2 ENSMUST00000238749.2	Neb Ensembl NCBI MGI UniProt Show fit	nebulin
chr2_+_152753231 Show fit	24.22	ENSMUST00000028970.8	Mylk2 Ensembl NCBI MGI UniProt Show fit	myosin, light polypeptide kinase 2, skeletal muscle
chr7_+_141995545 Show fit	23.90	ENSMUST00000105971.8 ENSMUST00000145287.8	Tnni2 Ensembl NCBI MGI UniProt Show fit	troponin I, skeletal, fast 2
chr4_-_43523595 Show fit	22.26	ENSMUST00000107914.10	Tpm2 Ensembl NCBI MGI UniProt Show fit	tropomyosin 2, beta

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	96.3	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
1.8	91.2	GO:0003009	skeletal muscle contraction(GO:0003009)
0.3	67.2	GO:0007519	skeletal muscle tissue development(GO:0007519)
0.2	58.3	GO:0006936	muscle contraction(GO:0006936)
0.8	57.7	GO:0045214	sarcomere organization(GO:0045214)
4.6	51.1	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
10.3	41.3	GO:0031448	regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
1.5	38.3	GO:0005980	glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
3.7	33.6	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.5	24.5	GO:0010831	positive regulation of myotube differentiation(GO:0010831)

Showing 1 to 10 of 248 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	183.2	GO:0031430	M band(GO:0031430)
0.8	84.4	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.5	83.4	GO:0030018	Z disc(GO:0030018)
5.1	76.0	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
3.0	56.5	GO:0005861	troponin complex(GO:0005861)
2.3	38.7	GO:0005865	striated muscle thin filament(GO:0005865)
0.5	35.7	GO:0016459	myosin complex(GO:0016459)
1.3	24.6	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
1.3	22.5	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
7.3	21.9	GO:0042643	actomyosin, actin portion(GO:0042643)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	185.3	GO:0008307	structural constituent of muscle(GO:0008307)
9.4	93.7	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
1.3	42.3	GO:0005212	structural constituent of eye lens(GO:0005212)
13.5	40.6	GO:0004133	glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
4.0	39.6	GO:0031014	troponin T binding(GO:0031014)
1.6	33.9	GO:0005523	tropomyosin binding(GO:0005523)
1.2	31.9	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.8	24.6	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
3.5	24.2	GO:0032027	myosin light chain binding(GO:0032027)
3.8	22.5	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)

Showing 1 to 10 of 159 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	52.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.7	23.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.5	19.8	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	18.8	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	15.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.3	15.0	PID AURORA B PATHWAY	Aurora B signaling
0.0	10.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	9.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	8.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	7.9	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	201.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.7	86.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.9	39.6	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.5	31.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.9	27.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.9	21.6	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.9	21.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
1.2	17.9	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.5	17.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.4	17.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions

Showing 1 to 10 of 69 entries

Results for Myod1

Z-value: 2.44

Motif logo

Transcription factors associated with Myod1

Activity-expression correlation:

Activity profile of Myod1 motif

Sorted Z-values of Myod1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myod1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: