ISMARA results: Myog

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Myog_Tcf12

Z-value: 2.85

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Transcription factors associated with Myog_Tcf12

Gene Symbol	Gene ID	Gene Info
Myog Ensembl NCBI MGI UniProt	ENSMUSG00000026459.6	Myog
Tcf12 Ensembl NCBI MGI UniProt	ENSMUSG00000032228.17	Tcf12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Myog	mm39_v1_chr1_+_134217727_134217753	0.37	1.6e-03	Click!
Tcf12	mm39_v1_chr9_-_72019053_72019103	0.08	5.2e-01	Click!

Activity profile of Myog_Tcf12 motif

Sorted Z-values of Myog_Tcf12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myog_Tcf12

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Promoter	Score	Transcript	Gene	Gene Info
chr2_-_121637505 Show fit	31.53	ENSMUST00000138157.8	Frmd5 Ensembl NCBI MGI UniProt Show fit	FERM domain containing 5
chr2_-_121637469 Show fit	28.89	ENSMUST00000110592.2	Frmd5 Ensembl NCBI MGI UniProt Show fit	FERM domain containing 5
chr1_+_75483721 Show fit	26.56	ENSMUST00000037330.5	Inha Ensembl NCBI MGI UniProt Show fit	inhibin alpha
chr8_+_94879235 Show fit	25.75	ENSMUST00000034211.10 ENSMUST00000211930.2 ENSMUST00000211915.2	Mt3 Ensembl NCBI MGI UniProt Show fit	metallothionein 3
chr8_+_31581635 Show fit	23.02	ENSMUST00000161713.2	Dusp26 Ensembl NCBI MGI UniProt Show fit	dual specificity phosphatase 26 (putative)
chr3_+_75464837 Show fit	22.72	ENSMUST00000161776.8 ENSMUST00000029423.9	Serpini1 Ensembl NCBI MGI UniProt Show fit	serine (or cysteine) peptidase inhibitor, clade I, member 1
chr7_-_30826184 Show fit	22.20	ENSMUST00000211945.2	Scn1b Ensembl NCBI MGI UniProt Show fit	sodium channel, voltage-gated, type I, beta
chr1_-_75482975 Show fit	21.76	ENSMUST00000113567.10 ENSMUST00000113565.3	Obsl1 Ensembl NCBI MGI UniProt Show fit	obscurin-like 1
chr2_+_14878480 Show fit	21.71	ENSMUST00000114719.7	Cacnb2 Ensembl NCBI MGI UniProt Show fit	calcium channel, voltage-dependent, beta 2 subunit
chr7_+_121888520 Show fit	21.54	ENSMUST00000064989.12 ENSMUST00000064921.5	Prkcb Ensembl NCBI MGI UniProt Show fit	protein kinase C, beta

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	55.9	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.4	47.4	GO:0098953	receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
2.4	42.3	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
13.8	41.4	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
0.5	41.2	GO:0055013	cardiac muscle cell development(GO:0055013)
0.8	35.2	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.7	35.0	GO:0002026	regulation of the force of heart contraction(GO:0002026)
4.8	33.8	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
2.2	33.0	GO:0045161	neuronal ion channel clustering(GO:0045161)
2.1	32.1	GO:0036376	sodium ion export from cell(GO:0036376)

Showing 1 to 10 of 478 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	156.0	GO:0031430	M band(GO:0031430)
0.3	96.5	GO:0045211	postsynaptic membrane(GO:0045211)
1.9	67.5	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.3	63.4	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.7	63.1	GO:0016529	sarcoplasmic reticulum(GO:0016529)
1.0	54.4	GO:0032809	neuronal cell body membrane(GO:0032809)
0.3	53.7	GO:0008021	synaptic vesicle(GO:0008021)
1.5	49.8	GO:0031672	A band(GO:0031672)
11.9	47.4	GO:0099573	glutamatergic postsynaptic density(GO:0099573)
1.7	45.5	GO:0001518	voltage-gated sodium channel complex(GO:0001518)

Showing 1 to 10 of 176 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	61.5	GO:0015459	potassium channel regulator activity(GO:0015459)
1.1	53.7	GO:0003785	actin monomer binding(GO:0003785)
3.6	47.4	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3	45.0	GO:0005178	integrin binding(GO:0005178)
14.1	42.3	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1	38.3	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
3.4	34.0	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
3.6	32.8	GO:0034711	inhibin binding(GO:0034711)
1.5	32.3	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
10.1	30.4	GO:0004698	calcium-dependent protein kinase C activity(GO:0004698)

Showing 1 to 10 of 303 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	68.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.6	58.5	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.2	55.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	36.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.6	33.4	PID ATR PATHWAY	ATR signaling pathway
0.6	29.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.4	20.8	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	20.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	18.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	18.1	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	84.3	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.6	81.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
2.2	51.9	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.7	39.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.8	37.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	33.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6	33.6	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
2.7	29.9	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.6	26.8	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4	24.4	REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases

Showing 1 to 10 of 100 entries

Results for Myog_Tcf12

Z-value: 2.85

Motif logo

Transcription factors associated with Myog_Tcf12

Activity-expression correlation:

Activity profile of Myog_Tcf12 motif

Sorted Z-values of Myog_Tcf12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myog_Tcf12

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: