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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Nfatc1
Z-value: 1.82
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Transcription factors associated with Nfatc1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc1 | mm39_v1_chr18_-_80751327_80751395 | 0.74 | 1.7e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfatc1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_88675700 Show fit | 11.62 |
ENSMUST00000087033.6
|
immunoglobulin joining chain |
|
| chr2_+_35172392 Show fit | 11.56 |
ENSMUST00000028239.8
|
gelsolin |
|
| chr17_-_48739874 Show fit | 10.92 |
ENSMUST00000046549.5
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 |
|
| chr3_-_106126794 Show fit | 10.38 |
ENSMUST00000082219.6
|
chitinase-like 4 |
|
| chr15_-_41733099 Show fit | 10.25 |
ENSMUST00000054742.7
|
actin-binding Rho activating protein |
|
| chr4_-_43523595 Show fit | 9.72 |
ENSMUST00000107914.10
|
tropomyosin 2, beta |
|
| chr15_+_78810919 Show fit | 9.18 |
ENSMUST00000089377.6
|
lectin, galactose binding, soluble 1 |
|
| chr1_+_75336965 Show fit | 9.14 |
ENSMUST00000027409.10
|
desmin |
|
| chr12_-_101784727 Show fit | 8.40 |
ENSMUST00000222587.2
|
fibulin 5 |
|
| chr15_-_83135920 Show fit | 8.10 |
ENSMUST00000229687.2
ENSMUST00000164614.3 ENSMUST00000049530.14 |
alpha 1,4-galactosyltransferase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.5 | 16.4 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 1.3 | 15.9 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.4 | 15.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.6 | 14.0 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.1 | 13.3 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.4 | 13.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 13.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.0 | 12.3 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.1 | 12.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.2 | GO:0030017 | sarcomere(GO:0030017) |
| 0.3 | 35.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 34.8 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 31.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 24.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 23.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 21.8 | GO:0016459 | myosin complex(GO:0016459) |
| 1.2 | 18.3 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 16.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 15.3 | GO:0005884 | actin filament(GO:0005884) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 47.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 31.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 23.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 18.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.8 | 18.0 | GO:0044548 | S100 protein binding(GO:0044548) |
| 3.9 | 15.7 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 14.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 4.1 | 12.2 | GO:0035717 | chemokine (C-C motif) ligand 7 binding(GO:0035717) |
| 0.0 | 11.9 | GO:0003779 | actin binding(GO:0003779) |
| 0.9 | 11.8 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 16.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 16.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 15.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 15.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.4 | 14.8 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.3 | 14.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 12.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 12.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 11.9 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 46.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 23.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.6 | 22.1 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.3 | 17.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 13.7 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.4 | 11.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.4 | 10.4 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 1.0 | 9.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 8.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 8.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |