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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Nfatc4

Z-value: 0.42

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Transcription factors associated with Nfatc4

Gene Symbol Gene ID Gene Info
Nfatc4
ENSMUSG00000023411.13 Nfatc4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfatc4mm39_v1_chr14_+_56062252_560623480.132.9e-01Click!

Activity profile of Nfatc4 motif

Sorted Z-values of Nfatc4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_+_33071964 2.81 ENSMUST00000219211.2
Trdn
triadin
chr9_+_77543776 1.90 ENSMUST00000057781.8
Klhl31
kelch-like 31
chr11_-_47270201 1.50 ENSMUST00000077221.6
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr13_+_83652352 1.41 ENSMUST00000198916.5
ENSMUST00000200123.5
ENSMUST00000005722.14
ENSMUST00000163888.8
Mef2c
myocyte enhancer factor 2C
chr5_-_112542671 1.36 ENSMUST00000196256.2
Asphd2
aspartate beta-hydroxylase domain containing 2
chrX_+_7504913 1.36 ENSMUST00000128890.2
Syp
synaptophysin
chr4_+_48049080 1.29 ENSMUST00000153369.2
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr14_+_70793340 1.28 ENSMUST00000163060.2
Hr
lysine demethylase and nuclear receptor corepressor
chr1_-_150341911 1.18 ENSMUST00000162367.8
ENSMUST00000161611.8
ENSMUST00000161320.8
ENSMUST00000159035.2
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr16_+_38182569 1.16 ENSMUST00000023494.13
ENSMUST00000114739.2
Popdc2
popeye domain containing 2
chr12_-_84497718 1.16 ENSMUST00000085192.7
ENSMUST00000220491.2
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr13_+_83652150 1.14 ENSMUST00000198199.5
Mef2c
myocyte enhancer factor 2C
chr2_-_73490719 1.06 ENSMUST00000154258.8
Chn1
chimerin 1
chr13_+_83652280 1.04 ENSMUST00000199450.5
Mef2c
myocyte enhancer factor 2C
chr19_-_8816530 0.97 ENSMUST00000096259.6
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr2_+_55325931 0.93 ENSMUST00000067101.10
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr3_-_20329823 0.86 ENSMUST00000011607.6
Cpb1
carboxypeptidase B1 (tissue)
chrX_+_162923474 0.86 ENSMUST00000073973.11
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr9_+_113641615 0.83 ENSMUST00000111838.10
ENSMUST00000166734.10
ENSMUST00000214522.2
ENSMUST00000163895.3
Clasp2
CLIP associating protein 2
chr19_-_4993060 0.82 ENSMUST00000133504.2
ENSMUST00000133254.2
ENSMUST00000120475.8
ENSMUST00000025834.15
Peli3
pellino 3
chr12_+_84498196 0.79 ENSMUST00000137170.3
Lin52
lin-52 homolog (C. elegans)
chr2_+_61876806 0.79 ENSMUST00000102735.10
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr13_-_53135064 0.66 ENSMUST00000071065.8
Nfil3
nuclear factor, interleukin 3, regulated
chr19_+_8828132 0.66 ENSMUST00000235683.2
ENSMUST00000096257.3
Lrrn4cl
LRRN4 C-terminal like
chr5_+_117501557 0.63 ENSMUST00000111959.2
Wsb2
WD repeat and SOCS box-containing 2
chr17_+_48037758 0.63 ENSMUST00000024782.12
ENSMUST00000144955.2
Pgc
progastricsin (pepsinogen C)
chr10_-_44334683 0.62 ENSMUST00000105490.3
Prdm1
PR domain containing 1, with ZNF domain
chrX_-_23231245 0.62 ENSMUST00000115313.8
Klhl13
kelch-like 13
chr12_-_86125793 0.61 ENSMUST00000003687.8
Tgfb3
transforming growth factor, beta 3
chr6_-_21851827 0.60 ENSMUST00000202353.2
ENSMUST00000134635.2
ENSMUST00000123116.8
ENSMUST00000120965.8
ENSMUST00000143531.2
Tspan12
tetraspanin 12
chr14_+_120513106 0.60 ENSMUST00000227012.2
ENSMUST00000167459.3
Mbnl2
muscleblind like splicing factor 2
chr3_+_84832783 0.59 ENSMUST00000107675.8
Fbxw7
F-box and WD-40 domain protein 7
chr7_-_79570342 0.54 ENSMUST00000075657.8
Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr1_-_169938298 0.52 ENSMUST00000192312.6
Ddr2
discoidin domain receptor family, member 2
chr18_+_73996743 0.50 ENSMUST00000134847.2
Mro
maestro
chr1_-_169938060 0.48 ENSMUST00000027985.8
ENSMUST00000194690.6
Ddr2
discoidin domain receptor family, member 2
chr10_-_12689345 0.47 ENSMUST00000217899.2
Utrn
utrophin
chr1_+_34044940 0.47 ENSMUST00000187486.7
ENSMUST00000182697.8
Dst
dystonin
chr10_+_21869776 0.46 ENSMUST00000092673.11
Sgk1
serum/glucocorticoid regulated kinase 1
chrX_-_166907286 0.45 ENSMUST00000239138.2
Frmpd4
FERM and PDZ domain containing 4
chr2_+_174171799 0.45 ENSMUST00000109085.8
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr6_+_21986445 0.44 ENSMUST00000115382.8
Cped1
cadherin-like and PC-esterase domain containing 1
chr2_+_174171860 0.43 ENSMUST00000109087.8
ENSMUST00000109084.8
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr14_+_120513076 0.43 ENSMUST00000088419.13
Mbnl2
muscleblind like splicing factor 2
chr10_-_44334711 0.41 ENSMUST00000039174.11
Prdm1
PR domain containing 1, with ZNF domain
chr2_+_124978518 0.41 ENSMUST00000238754.2
Ctxn2
cortexin 2
chr14_-_79718890 0.41 ENSMUST00000022601.7
Wbp4
WW domain binding protein 4
chr8_-_41494890 0.39 ENSMUST00000051379.14
Mtus1
mitochondrial tumor suppressor 1
chr1_-_168259710 0.37 ENSMUST00000072863.6
Pbx1
pre B cell leukemia homeobox 1
chr2_+_124978612 0.36 ENSMUST00000099452.3
ENSMUST00000238377.2
Ctxn2
cortexin 2
chr2_+_3115250 0.36 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr7_+_91321500 0.32 ENSMUST00000238619.2
ENSMUST00000238467.2
Dlg2
discs large MAGUK scaffold protein 2
chr9_+_114159203 0.29 ENSMUST00000066460.5
Bcl2a1c
B cell leukemia/lymphoma 2 related protein A1c
chr8_-_68270936 0.27 ENSMUST00000120071.8
Psd3
pleckstrin and Sec7 domain containing 3
chr4_-_148244299 0.27 ENSMUST00000151127.8
ENSMUST00000105705.9
Fbxo44
F-box protein 44
chr1_-_126758369 0.26 ENSMUST00000112583.8
ENSMUST00000094609.10
Nckap5
NCK-associated protein 5
chr3_-_96501443 0.26 ENSMUST00000145001.2
ENSMUST00000091924.10
Polr3gl
polymerase (RNA) III (DNA directed) polypeptide G like
chr2_-_66240408 0.26 ENSMUST00000112366.8
Scn1a
sodium channel, voltage-gated, type I, alpha
chr17_-_49871291 0.25 ENSMUST00000224595.2
ENSMUST00000057610.8
Daam2
dishevelled associated activator of morphogenesis 2
chr8_-_39128662 0.24 ENSMUST00000118896.2
Sgcz
sarcoglycan zeta
chr3_-_151899470 0.24 ENSMUST00000050073.13
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
chr8_+_129085719 0.21 ENSMUST00000026917.10
Nrp1
neuropilin 1
chr15_-_79816717 0.19 ENSMUST00000177044.2
ENSMUST00000109615.8
Cbx7
chromobox 7
chr6_-_128599779 0.14 ENSMUST00000203275.3
Klrb1a
killer cell lectin-like receptor subfamily B member 1A
chr11_-_89587671 0.13 ENSMUST00000128717.9
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr9_+_107869662 0.13 ENSMUST00000177173.8
Cdhr4
cadherin-related family member 4
chr6_+_134958681 0.13 ENSMUST00000167323.3
Apold1
apolipoprotein L domain containing 1
chr18_+_42186713 0.12 ENSMUST00000072008.11
Sh3rf2
SH3 domain containing ring finger 2
chr7_+_80764564 0.11 ENSMUST00000119083.2
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chrX_+_56144946 0.11 ENSMUST00000141936.2
Vgll1
vestigial like family member 1
chr13_+_25127127 0.11 ENSMUST00000021773.13
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr2_-_73284262 0.11 ENSMUST00000102679.8
Wipf1
WAS/WASL interacting protein family, member 1
chr12_+_103564479 0.09 ENSMUST00000190151.2
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr15_-_79816785 0.09 ENSMUST00000089293.11
ENSMUST00000109616.9
Cbx7
chromobox 7
chr7_+_80764547 0.06 ENSMUST00000026820.11
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr14_-_65187287 0.06 ENSMUST00000067843.10
ENSMUST00000176489.8
ENSMUST00000175905.8
ENSMUST00000022544.14
ENSMUST00000175744.8
ENSMUST00000176128.8
Hmbox1
homeobox containing 1
chr12_+_76580386 0.06 ENSMUST00000219063.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr10_+_23727325 0.05 ENSMUST00000020190.8
Vnn3
vanin 3
chr3_-_86455575 0.04 ENSMUST00000077524.4
Mab21l2
mab-21-like 2
chr18_+_42186757 0.03 ENSMUST00000074679.4
Sh3rf2
SH3 domain containing ring finger 2
chr11_-_99412084 0.03 ENSMUST00000076948.2
Krt39
keratin 39
chr16_+_3656839 0.02 ENSMUST00000080917.2
Olfr15
olfactory receptor 15
chr11_-_99412162 0.00 ENSMUST00000107445.8
Krt39
keratin 39

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.5 1.4 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.3 1.0 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.3 1.3 GO:1900623 positive regulation of mast cell cytokine production(GO:0032765) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 3.6 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.3 1.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.2 1.2 GO:0060931 sinoatrial node cell development(GO:0060931)
0.2 0.9 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.2 0.6 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.6 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.1 1.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 0.6 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.5 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.2 GO:0097374 cell migration involved in vasculogenesis(GO:0035441) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) sensory neuron axon guidance(GO:0097374)
0.1 0.5 GO:0007527 adult somatic muscle development(GO:0007527)
0.1 1.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.5 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.2 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.8 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:0010982 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0 0.1 GO:0080163 regulation of protein serine/threonine phosphatase activity(GO:0080163)
0.0 0.5 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 0.7 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0 0.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.3 0.8 GO:1903754 cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511)
0.2 1.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.8 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.8 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.0 1.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.8 GO:0030017 sarcomere(GO:0030017)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 3.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.9 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.2 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 0.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 1.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.2 GO:0030552 cAMP binding(GO:0030552)
0.0 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 1.2 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.7 GO:0044325 ion channel binding(GO:0044325)
0.0 1.4 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 1.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 0.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.9 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis