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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Nfia
Z-value: 2.82
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Transcription factors associated with Nfia
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfia | mm39_v1_chr4_+_97665992_97666071 | 0.61 | 9.8e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfia
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 45.7 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 1.4 | 39.1 | GO:0017144 | drug metabolic process(GO:0017144) |
| 0.7 | 25.3 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 1.6 | 25.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.1 | 23.0 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.6 | 21.0 | GO:0014823 | response to activity(GO:0014823) |
| 0.2 | 20.9 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 3.5 | 20.7 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 6.6 | 19.9 | GO:1902617 | response to fluoride(GO:1902617) |
| 1.6 | 19.4 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 91.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 85.8 | GO:0043292 | contractile fiber(GO:0043292) |
| 0.2 | 54.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 53.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 50.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 34.4 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 2.0 | 29.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 1.3 | 25.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.2 | 21.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 21.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 77.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.7 | 44.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 31.1 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 27.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.9 | 26.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 4.3 | 25.9 | GO:0030294 | receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294) |
| 1.1 | 25.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.2 | 24.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 5.9 | 23.7 | GO:0004063 | aryldialkylphosphatase activity(GO:0004063) |
| 1.0 | 22.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 64.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 63.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 51.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 37.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 33.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.4 | 20.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 19.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.4 | 18.1 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 1.8 | 18.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.4 | 16.9 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 42.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.4 | 25.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 7.5 | 22.6 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.9 | 22.6 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.7 | 21.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.6 | 20.3 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.7 | 20.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.4 | 19.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.9 | 17.7 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 1.7 | 16.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |