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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Nkx2-1

Z-value: 0.72

Motif logo

Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
ENSMUSG00000001496.16 Nkx2-1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1mm39_v1_chr12_-_56581823_565818910.309.8e-03Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_+_96429665 6.54 ENSMUST00000073139.14
ENSMUST00000080666.8
ENSMUST00000212160.2
N-myc downstream regulated gene 4
chr16_-_4340920 5.66 ENSMUST00000090500.10
ENSMUST00000023161.8
sarcalumenin
chr6_+_72281587 5.63 ENSMUST00000183018.8
ENSMUST00000182014.10
surfactant associated protein B
chr9_-_121621544 4.57 ENSMUST00000035110.11
hedgehog acyltransferase-like
chr7_+_34885782 3.78 ENSMUST00000135452.8
ENSMUST00000001854.12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr8_+_55024446 3.49 ENSMUST00000239166.2
ENSMUST00000239106.2
ENSMUST00000239152.2
ankyrin repeat and SOCs box-containing 5
chr9_-_37058590 3.39 ENSMUST00000080754.12
ENSMUST00000188057.7
ENSMUST00000039674.13
Pbx/knotted 1 homeobox 2
chr9_+_110595224 3.23 ENSMUST00000136695.3
myosin, light polypeptide 3
chr3_+_68491487 3.14 ENSMUST00000182997.3
schwannomin interacting protein 1
chr14_-_70761507 3.09 ENSMUST00000022692.5
surfactant associated protein C
chr1_+_12788720 2.87 ENSMUST00000088585.10
sulfatase 1
chr2_+_158452651 2.86 ENSMUST00000045738.5
solute carrier family 32 (GABA vesicular transporter), member 1
chr14_+_40853734 2.83 ENSMUST00000022314.10
ENSMUST00000170719.2
surfactant associated protein A1
chr4_-_41517326 2.72 ENSMUST00000030152.13
ENSMUST00000095126.5
RIKEN cDNA 1110017D15 gene
chr12_+_103281188 2.59 ENSMUST00000189885.2
ENSMUST00000179363.2
family with sequence similarity 181, member A
chr19_-_8816530 2.57 ENSMUST00000096259.6
guanine nucleotide binding protein (G protein), gamma 3
chr19_-_58781709 2.56 ENSMUST00000166692.2
RIKEN cDNA 1700019N19 gene
chr12_-_84745388 2.48 ENSMUST00000221905.2
ENSMUST00000222422.2
ENSMUST00000095550.4
synapse differentiation inducing 1 like
chr7_-_28824440 2.36 ENSMUST00000214374.2
ENSMUST00000179893.9
ENSMUST00000032813.10
ryanodine receptor 1, skeletal muscle
chr9_+_110075133 2.31 ENSMUST00000199736.2
chondroitin sulfate proteoglycan 5
chr1_-_163552693 2.14 ENSMUST00000159679.8
methyltransferase like 11B
chr2_-_73605684 2.04 ENSMUST00000112024.10
ENSMUST00000180045.8
chimerin 1
chr10_+_22520910 1.98 ENSMUST00000042261.5
solute carrier family 2 (facilitated glucose transporter), member 12
chr5_-_24806960 1.96 ENSMUST00000030791.12
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chrX_-_101950075 1.96 ENSMUST00000120808.8
ENSMUST00000121197.8
DMRT-like family C1a
chr7_-_30443106 1.93 ENSMUST00000182634.8
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr17_+_69071546 1.91 ENSMUST00000233625.2
L3MBTL4 histone methyl-lysine binding protein
chr11_+_7013422 1.90 ENSMUST00000020706.5
adenylate cyclase 1
chr16_+_17716480 1.89 ENSMUST00000055374.8
testis-specific serine kinase 2
chr3_+_135053762 1.87 ENSMUST00000159658.8
ENSMUST00000078568.12
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr19_-_5452521 1.86 ENSMUST00000235569.2
testis specific 10 interacting protein
chr2_+_67276338 1.83 ENSMUST00000239060.2
ENSMUST00000028410.4
ENSMUST00000112347.8
ENSMUST00000238878.2
xin actin-binding repeat containing 2
chr9_-_4796217 1.78 ENSMUST00000027020.13
ENSMUST00000163309.2
glutamate receptor, ionotropic, AMPA4 (alpha 4)
chr6_-_41613322 1.73 ENSMUST00000031902.7
transient receptor potential cation channel, subfamily V, member 6
chr15_+_66542598 1.71 ENSMUST00000065916.14
thyroglobulin
chr13_+_110039620 1.61 ENSMUST00000120664.8
phosphodiesterase 4D, cAMP specific
chr2_+_177760959 1.58 ENSMUST00000108916.8
phosphatase and actin regulator 3
chr2_-_73722874 1.53 ENSMUST00000136958.8
ENSMUST00000112010.9
ENSMUST00000128531.8
ENSMUST00000112017.8
activating transcription factor 2
chr15_-_76419131 1.52 ENSMUST00000230604.2
transmembrane protein 249
chr18_+_37276556 1.51 ENSMUST00000047479.3
protocadherin alpha subfamily C, 2
chr11_+_101046708 1.49 ENSMUST00000043654.10
tubulin, gamma 2
chr19_-_11243530 1.46 ENSMUST00000169159.3
membrane-spanning 4-domains, subfamily A, member 1
chr13_+_93441447 1.45 ENSMUST00000109497.8
ENSMUST00000109498.8
ENSMUST00000060490.11
ENSMUST00000109492.9
ENSMUST00000109496.8
ENSMUST00000109495.8
homer scaffolding protein 1
chrX_+_55391749 1.45 ENSMUST00000101560.4
zinc finger protein 449
chr15_-_64254754 1.42 ENSMUST00000177374.8
ENSMUST00000110114.10
ENSMUST00000110115.9
ENSMUST00000023008.16
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr1_-_80191649 1.42 ENSMUST00000058748.2
family with sequence similarity 124, member B
chr7_+_28392456 1.41 ENSMUST00000151227.2
ENSMUST00000108281.8
F-box protein 27
chr7_-_34974953 1.40 ENSMUST00000238407.2
WD repeat domain 88
chr9_-_4796142 1.38 ENSMUST00000063508.15
glutamate receptor, ionotropic, AMPA4 (alpha 4)
chr2_+_177760768 1.31 ENSMUST00000108917.8
phosphatase and actin regulator 3
chr7_-_4755971 1.23 ENSMUST00000183971.8
ENSMUST00000182173.2
ENSMUST00000182738.8
ENSMUST00000182111.8
ENSMUST00000184143.8
ENSMUST00000182048.2
ENSMUST00000063324.14
cytochrome c oxidase subunit 6B2
chrX_+_110154017 1.22 ENSMUST00000210720.3
cylicin, basic protein of sperm head cytoskeleton 1
chr1_-_54233207 1.22 ENSMUST00000120904.8
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr17_+_34062059 1.22 ENSMUST00000002379.15
CD320 antigen
chr18_+_24842493 1.20 ENSMUST00000037097.9
ENSMUST00000234526.2
ENSMUST00000234834.2
formin homology 2 domain containing 3
chr11_+_68989763 1.19 ENSMUST00000021271.14
period circadian clock 1
chr1_+_74193138 1.18 ENSMUST00000027372.8
ENSMUST00000106899.4
chemokine (C-X-C motif) receptor 2
chr18_-_66993567 1.15 ENSMUST00000057942.4
melanocortin 4 receptor
chr16_-_38649107 1.15 ENSMUST00000122078.3
testis expressed 55
chr15_-_7427759 1.15 ENSMUST00000058593.10
EGF-like, fibronectin type III and laminin G domains
chr15_-_7427815 1.13 ENSMUST00000096494.5
EGF-like, fibronectin type III and laminin G domains
chr2_-_73722932 1.11 ENSMUST00000154456.8
ENSMUST00000090802.11
ENSMUST00000055833.12
ENSMUST00000112007.8
ENSMUST00000112016.9
activating transcription factor 2
chr12_+_85871404 1.11 ENSMUST00000177188.8
ENSMUST00000095536.10
ENSMUST00000110220.9
ENSMUST00000040179.14
tubulin tyrosine ligase-like family, member 5
chr11_+_69920849 1.05 ENSMUST00000143920.4
discs large MAGUK scaffold protein 4
chr1_+_75427343 1.04 ENSMUST00000037708.10
acid-sensing (proton-gated) ion channel family member 4
chr15_-_64254585 1.03 ENSMUST00000176384.8
ENSMUST00000175799.8
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr11_+_69920956 0.99 ENSMUST00000232115.2
discs large MAGUK scaffold protein 4
chrX_-_100463395 0.95 ENSMUST00000117901.8
ENSMUST00000120201.8
ENSMUST00000117637.8
ENSMUST00000134005.2
ENSMUST00000121520.8
zinc finger, MYM-type 3
chr7_+_28466160 0.92 ENSMUST00000122915.8
ENSMUST00000072965.5
ENSMUST00000170068.9
sirtuin 2
chr4_+_45203914 0.92 ENSMUST00000107804.2
FERM and PDZ domain containing 1
chr13_+_105218625 0.88 ENSMUST00000022232.6
5' nucleotidase, ecto-like
chr14_+_67470884 0.87 ENSMUST00000176161.8
early B cell factor 2
chr11_+_70323452 0.87 ENSMUST00000084954.13
ENSMUST00000108568.10
ENSMUST00000079056.9
ENSMUST00000102564.11
ENSMUST00000124943.8
ENSMUST00000150076.8
ENSMUST00000102563.2
arrestin, beta 2
chr15_+_80118269 0.86 ENSMUST00000229138.2
ENSMUST00000166030.2
mitochondrial elongation factor 1
chr2_+_89642395 0.85 ENSMUST00000214508.2
olfactory receptor 1255
chr17_-_26080429 0.84 ENSMUST00000079461.15
ENSMUST00000176923.9
WD repeat domain 90
chr9_+_55997246 0.84 ENSMUST00000059206.8
proline-serine-threonine phosphatase-interacting protein 1
chr1_+_43973167 0.83 ENSMUST00000087933.10
ENSMUST00000188313.7
tripeptidyl peptidase II
chr9_+_56344700 0.83 ENSMUST00000239472.2
ubiquitin-conjugating enzyme E2S (Ube2s) retrogene
chr2_-_121304521 0.82 ENSMUST00000056732.4
microfibrillar-associated protein 1B
chr6_-_98319684 0.81 ENSMUST00000164491.3
MyoD family inhibitor domain containing 2
chr15_+_81686622 0.79 ENSMUST00000109553.10
thyrotroph embryonic factor
chr1_-_173363523 0.75 ENSMUST00000139092.8
interferon activated gene 214
chrX_-_100463810 0.75 ENSMUST00000118092.8
ENSMUST00000119699.8
zinc finger, MYM-type 3
chr1_+_75427080 0.73 ENSMUST00000113577.8
acid-sensing (proton-gated) ion channel family member 4
chr1_+_85945790 0.71 ENSMUST00000149469.3
spermatogenesis associated 3
chr9_-_119812042 0.70 ENSMUST00000214058.2
cysteine-serine-rich nuclear protein 1
chr1_-_136273811 0.65 ENSMUST00000048309.12
calmodulin regulated spectrin-associated protein family, member 2
chr8_-_46747629 0.64 ENSMUST00000058636.9
helt bHLH transcription factor
chr9_-_45923908 0.64 ENSMUST00000217514.2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr11_-_96868483 0.63 ENSMUST00000107624.8
Sp2 transcription factor
chr3_+_37474422 0.63 ENSMUST00000029277.13
ENSMUST00000198968.2
spermatogenesis associated 5
chr1_+_178356678 0.57 ENSMUST00000161017.8
kinesin family member 26B
chr8_-_40739994 0.57 ENSMUST00000034014.14
fibroblast growth factor 20
chr4_+_9269285 0.56 ENSMUST00000038841.14
clavesin 1
chr4_-_124744943 0.53 ENSMUST00000185036.2
RIKEN cDNA 1110065P20 gene
chr14_+_51351880 0.52 ENSMUST00000100645.5
epididymal protein 3B
chr2_-_170248421 0.52 ENSMUST00000154650.8
breast carcinoma amplified sequence 1
chr17_+_6156738 0.50 ENSMUST00000142030.8
tubby like protein 4
chr11_+_68858942 0.50 ENSMUST00000102606.10
ENSMUST00000018884.6
solute carrier family 25, member 35
chr2_-_57004933 0.48 ENSMUST00000028166.9
nuclear receptor subfamily 4, group A, member 2
chr17_-_27060539 0.47 ENSMUST00000015723.5
NK2 homeobox 5
chr4_+_129948803 0.45 ENSMUST00000123617.8
collagen, type XVI, alpha 1
chr17_+_47983587 0.44 ENSMUST00000152724.2
ubiquitin specific peptidase 49
chr11_-_83353787 0.40 ENSMUST00000021020.13
ENSMUST00000119346.2
ENSMUST00000103209.10
ENSMUST00000108137.9
matrix metallopeptidase 28 (epilysin)
chr15_+_76594810 0.40 ENSMUST00000136840.8
ENSMUST00000127208.8
ENSMUST00000036423.15
ENSMUST00000137649.8
ENSMUST00000155225.2
ENSMUST00000155735.2
leucine rich repeat containing 14
chr8_-_37419567 0.39 ENSMUST00000163663.3
deleted in liver cancer 1
chrX_+_113384008 0.38 ENSMUST00000113371.8
ENSMUST00000040504.12
kelch-like 4
chr17_+_6157154 0.36 ENSMUST00000149756.8
tubby like protein 4
chrX_+_57075981 0.35 ENSMUST00000088627.11
zinc finger protein of the cerebellum 3
chr7_+_30262721 0.35 ENSMUST00000166960.8
ENSMUST00000163330.3
ENSMUST00000043273.16
ENSMUST00000163654.8
ENSMUST00000166510.8
ENSMUST00000163482.8
ENSMUST00000167361.8
ENSMUST00000166257.8
ENSMUST00000163464.8
ENSMUST00000171850.8
ENSMUST00000168931.8
ENSMUST00000167202.8
U2 small nuclear RNA auxiliary factor 1-like 4
chr9_+_40092216 0.33 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
olfactory receptor 986
chr2_-_156848923 0.31 ENSMUST00000146413.8
ENSMUST00000103129.9
ENSMUST00000103130.8
DSN1 homolog, MIS12 kinetochore complex component
chr2_-_121337120 0.31 ENSMUST00000089926.6
microfibrillar-associated protein 1A
chr6_-_38276157 0.30 ENSMUST00000058524.3
zinc finger CCCH-type, antiviral 1-like
chr4_+_12140263 0.28 ENSMUST00000050069.9
ENSMUST00000069128.8
RNA binding motif protein 12 B1
chrX_+_57076359 0.28 ENSMUST00000088631.11
ENSMUST00000088629.4
zinc finger protein of the cerebellum 3
chr3_-_108108113 0.25 ENSMUST00000106655.2
ENSMUST00000065664.7
cytochrome b-561 domain containing 1
chr5_-_97259447 0.23 ENSMUST00000069453.9
ENSMUST00000112968.2
progestin and adipoQ receptor family member III
chr15_-_10470575 0.22 ENSMUST00000136591.8
DnaJ heat shock protein family (Hsp40) member C21
chr2_+_121337226 0.20 ENSMUST00000099473.10
ENSMUST00000110602.9
WD repeat domain 76
chr7_-_144761806 0.19 ENSMUST00000208788.2
small integral membrane protein 38
chr14_+_26959975 0.19 ENSMUST00000049206.6
Rho guanine nucleotide exchange factor (GEF) 3
chr7_-_28465870 0.16 ENSMUST00000085851.12
ENSMUST00000032815.11
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
chr7_+_138448061 0.15 ENSMUST00000041097.13
protein phosphatase 2, regulatory subunit B, delta
chr4_-_44703413 0.15 ENSMUST00000186542.2
paired box 5
chr7_-_79381911 0.14 ENSMUST00000178257.3
perilipin 1
chr2_-_88937158 0.14 ENSMUST00000099806.3
ENSMUST00000213288.2
olfactory receptor 1220
chr10_+_87926932 0.13 ENSMUST00000048621.8
pro-melanin-concentrating hormone
chr3_-_37180093 0.12 ENSMUST00000029275.6
interleukin 2
chr5_+_145020640 0.12 ENSMUST00000031625.15
actin related protein 2/3 complex, subunit 1A
chr7_+_138448308 0.12 ENSMUST00000155672.8
protein phosphatase 2, regulatory subunit B, delta
chrX_+_113384297 0.09 ENSMUST00000133447.2
kelch-like 4
chr11_-_99228756 0.08 ENSMUST00000100482.3
keratin 26
chr2_+_71811526 0.07 ENSMUST00000090826.12
ENSMUST00000102698.10
Rap guanine nucleotide exchange factor (GEF) 4
chr11_-_118139312 0.06 ENSMUST00000100181.11
cytohesin 1
chr3_+_90201388 0.06 ENSMUST00000199607.5
GATA zinc finger domain containing 2B
chr4_-_109522502 0.04 ENSMUST00000063531.5
cyclin dependent kinase inhibitor 2C
chr11_-_120344299 0.04 ENSMUST00000026452.3
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr7_+_101875019 0.03 ENSMUST00000142873.8
post-GPI attachment to proteins 2
chr4_-_9643636 0.03 ENSMUST00000108333.8
ENSMUST00000108334.8
ENSMUST00000108335.8
ENSMUST00000152526.8
ENSMUST00000103004.10
aspartate-beta-hydroxylase
chr11_+_80319424 0.02 ENSMUST00000173938.8
ENSMUST00000017572.14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr4_-_98271469 0.02 ENSMUST00000143116.2
ENSMUST00000030292.12
ENSMUST00000102793.11
TM2 domain containing 1
chr11_-_99979052 0.01 ENSMUST00000107419.2
keratin 32
chr6_+_113303929 0.01 ENSMUST00000032406.15
8-oxoguanine DNA-glycosylase 1
chr13_+_55782814 0.01 ENSMUST00000172272.8
ENSMUST00000099479.4
ENSMUST00000223736.2
DEAD box helicase 46

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
1.4 5.7 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
1.3 3.8 GO:0015825 L-serine transport(GO:0015825)
0.7 2.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.5 2.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.5 6.5 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.4 2.5 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.3 0.9 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.3 2.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.3 2.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.3 2.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 2.8 GO:0008228 opsonization(GO:0008228)
0.2 0.5 GO:0003162 atrioventricular node development(GO:0003162)
0.2 1.2 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.2 1.2 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.2 2.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.7 GO:0015705 iodide transport(GO:0015705)
0.1 3.0 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 1.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.7 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 3.1 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 2.0 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 0.4 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.9 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.6 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.3 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.1 3.2 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 5.6 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 1.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 3.2 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.9 GO:0045821 positive regulation of glycolytic process(GO:0045821)
0.1 1.2 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 1.9 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.7 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 2.0 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.6 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 1.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.0 1.8 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 1.2 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.0 1.9 GO:0030317 sperm motility(GO:0030317)
0.0 0.1 GO:0001777 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.9 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.4 GO:0033622 integrin activation(GO:0033622)
0.0 1.9 GO:0007286 spermatid development(GO:0007286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.7 GO:0097208 alveolar lamellar body(GO:0097208)
0.6 2.4 GO:0014802 terminal cisterna(GO:0014802)
0.6 2.9 GO:0044316 cone cell pedicle(GO:0044316)
0.4 3.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 1.2 GO:0043159 acrosomal matrix(GO:0043159)
0.2 2.7 GO:0002177 manchette(GO:0002177)
0.1 0.9 GO:0033010 paranodal junction(GO:0033010)
0.1 1.2 GO:0042629 mast cell granule(GO:0042629)
0.1 0.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.3 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 1.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.8 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.0 GO:0071564 npBAF complex(GO:0071564)
0.1 2.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 3.8 GO:0097440 apical dendrite(GO:0097440)
0.1 1.1 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.8 GO:0005771 multivesicular body(GO:0005771)
0.1 1.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.6 GO:0035861 site of double-strand break(GO:0035861)
0.1 5.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 0.4 GO:0089701 U2AF(GO:0089701)
0.1 0.7 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.3 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 3.2 GO:0031672 A band(GO:0031672)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.0 2.5 GO:0002102 podosome(GO:0002102)
0.0 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.8 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 7.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.6 2.9 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.4 2.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 3.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.4 1.2 GO:0019959 interleukin-8 binding(GO:0019959)
0.4 1.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 3.8 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 0.9 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.3 1.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 2.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 1.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.3 1.3 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.9 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.2 0.8 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 6.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 1.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.2 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.9 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 0.6 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 2.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 2.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 2.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 2.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.8 GO:0005272 sodium channel activity(GO:0005272)
0.0 1.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.7 GO:0043531 ADP binding(GO:0043531)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.2 GO:0008276 protein methyltransferase activity(GO:0008276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.8 PID ARF 3PATHWAY Arf1 pathway
0.1 2.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 11.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 2.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 3.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 3.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 3.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 3.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 5.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 2.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases