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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Nkx2-6

Z-value: 0.45

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Transcription factors associated with Nkx2-6

Gene Symbol Gene ID Gene Info
Nkx2-6
ENSMUSG00000044186.11 Nkx2-6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-6mm39_v1_chr14_+_69409251_69409414-0.171.5e-01Click!

Activity profile of Nkx2-6 motif

Sorted Z-values of Nkx2-6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_119060366 3.22 ENSMUST00000076084.6
Ppp1r14d
protein phosphatase 1, regulatory inhibitor subunit 14D
chr6_-_41681273 3.19 ENSMUST00000031899.14
Kel
Kell blood group
chr2_-_119060330 2.92 ENSMUST00000110820.3
Ppp1r14d
protein phosphatase 1, regulatory inhibitor subunit 14D
chr12_-_11485639 2.62 ENSMUST00000220506.2
Vsnl1
visinin-like 1
chr4_+_46039202 2.54 ENSMUST00000156200.8
Tmod1
tropomodulin 1
chr12_-_114263874 2.20 ENSMUST00000103482.2
ENSMUST00000194159.2
Ighv9-4
immunoglobulin heavy variable 9-4
chr5_-_8417982 1.50 ENSMUST00000088761.11
ENSMUST00000115386.8
ENSMUST00000050166.14
ENSMUST00000046838.14
ENSMUST00000115388.9
ENSMUST00000088744.12
ENSMUST00000115385.2
Adam22
a disintegrin and metallopeptidase domain 22
chr15_+_73594965 1.41 ENSMUST00000165541.8
ENSMUST00000167582.8
Ptp4a3
protein tyrosine phosphatase 4a3
chr15_-_37734579 1.29 ENSMUST00000145909.9
ENSMUST00000153775.9
Gm49397
Ncald
predicted gene, 49397
neurocalcin delta
chr15_+_73595012 1.26 ENSMUST00000230044.2
Ptp4a3
protein tyrosine phosphatase 4a3
chr4_+_62537750 1.01 ENSMUST00000084521.11
ENSMUST00000107424.2
Rgs3
regulator of G-protein signaling 3
chr12_-_114073050 0.97 ENSMUST00000103472.4
Ighv9-2
immunoglobulin heavy variable V9-2
chr19_+_55240357 0.85 ENSMUST00000225551.2
Acsl5
acyl-CoA synthetase long-chain family member 5
chr11_+_103664976 0.84 ENSMUST00000000127.6
Wnt3
wingless-type MMTV integration site family, member 3
chr3_+_87432879 0.84 ENSMUST00000170036.8
ENSMUST00000117293.2
Etv3
ets variant 3
chr5_+_110478558 0.76 ENSMUST00000112481.2
Pole
polymerase (DNA directed), epsilon
chr3_+_62327089 0.69 ENSMUST00000161057.2
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_+_145063568 0.63 ENSMUST00000138922.2
Arpc1b
actin related protein 2/3 complex, subunit 1B
chr19_+_8779903 0.62 ENSMUST00000172175.3
Zbtb3
zinc finger and BTB domain containing 3
chr1_+_179788675 0.61 ENSMUST00000076687.12
ENSMUST00000097450.10
ENSMUST00000212756.2
Cdc42bpa
CDC42 binding protein kinase alpha
chr9_-_10904714 0.55 ENSMUST00000162484.8
ENSMUST00000160216.8
Cntn5
contactin 5
chr2_+_85715984 0.49 ENSMUST00000213441.3
Olfr1023
olfactory receptor 1023
chr2_+_3115250 0.49 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr2_-_147028309 0.43 ENSMUST00000067075.7
Nkx2-2
NK2 homeobox 2
chr7_-_115630282 0.42 ENSMUST00000206034.2
ENSMUST00000106612.8
Sox6
SRY (sex determining region Y)-box 6
chr15_-_78657640 0.41 ENSMUST00000018313.6
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_91288221 0.39 ENSMUST00000102799.10
Elavl2
ELAV like RNA binding protein 1
chr10_+_4297762 0.31 ENSMUST00000215696.2
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr14_-_73286535 0.28 ENSMUST00000169168.3
Cysltr2
cysteinyl leukotriene receptor 2
chr14_-_73286504 0.13 ENSMUST00000044664.12
Cysltr2
cysteinyl leukotriene receptor 2
chr14_+_54598283 0.01 ENSMUST00000000985.7
Oxa1l
oxidase assembly 1-like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.4 2.5 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.3 0.8 GO:1904954 Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.3 0.8 GO:0045004 DNA replication proofreading(GO:0045004)
0.2 0.9 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.1 0.4 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 2.7 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 2.6 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.8 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0 0.4 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 1.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 6.1 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 0.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 3.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.6 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0036284 tubulobulbar complex(GO:0036284)
0.2 0.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.8 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 2.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 3.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 6.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.5 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.4 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.8 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 2.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 2.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells