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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Nr1h4
Z-value: 2.31
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Transcription factors associated with Nr1h4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1h4 | mm39_v1_chr10_-_89369432_89369452 | 0.62 | 8.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr1h4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 87.4 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 1.4 | 67.1 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 9.2 | 64.1 | GO:0046618 | drug export(GO:0046618) |
| 12.4 | 49.4 | GO:0010901 | regulation of very-low-density lipoprotein particle remodeling(GO:0010901) |
| 0.7 | 49.0 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 6.3 | 43.8 | GO:0015886 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 4.4 | 39.2 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 3.5 | 39.0 | GO:1903278 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) positive regulation of inorganic anion transmembrane transport(GO:1903797) |
| 6.1 | 36.4 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 5.1 | 35.6 | GO:0019856 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 133.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 91.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 78.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 3.6 | 64.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 60.6 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 2.1 | 49.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.4 | 36.4 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.6 | 35.6 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.4 | 34.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 34.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 101.9 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.6 | 90.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 72.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 67.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 7.3 | 43.8 | GO:0015232 | heme transporter activity(GO:0015232) |
| 1.5 | 39.2 | GO:0019825 | oxygen binding(GO:0019825) |
| 0.5 | 39.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 5.2 | 36.4 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
| 11.9 | 35.6 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 2.6 | 31.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 90.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 70.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.1 | 39.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.4 | 28.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 1.3 | 25.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 12.4 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 8.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 7.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.4 | 4.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 59.3 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 1.7 | 49.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 2.8 | 39.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 2.6 | 36.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.5 | 36.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 27.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.8 | 23.6 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.4 | 22.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 17.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.2 | 14.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |