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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Nrf1
Z-value: 3.80
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | mm39_v1_chr6_+_30048061_30048150 | 0.74 | 1.3e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 65.3 | GO:0008380 | RNA splicing(GO:0008380) |
| 2.8 | 25.5 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 3.1 | 24.8 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 1.3 | 24.4 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 1.7 | 22.7 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.1 | 20.8 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.3 | 20.2 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 1.2 | 19.1 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.8 | 19.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.5 | 19.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 101.7 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 42.5 | GO:0005874 | microtubule(GO:0005874) |
| 0.3 | 42.0 | GO:0098687 | chromosomal region(GO:0098687) |
| 0.4 | 37.0 | GO:0072686 | mitotic spindle(GO:0072686) |
| 1.0 | 35.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.4 | 33.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 30.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 28.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 25.5 | GO:0031514 | motile cilium(GO:0031514) |
| 0.3 | 25.3 | GO:0000776 | kinetochore(GO:0000776) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 82.3 | GO:0003677 | DNA binding(GO:0003677) |
| 0.1 | 43.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 35.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 32.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 29.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.6 | 24.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.7 | 23.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.2 | 22.9 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 21.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 18.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 14.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 14.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 13.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.5 | 12.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 12.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 12.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 11.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 10.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.6 | 10.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 42.2 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.5 | 41.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.8 | 32.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.7 | 23.9 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.3 | 22.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 21.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.7 | 19.1 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.7 | 16.9 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.6 | 16.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.6 | 16.7 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |